JP6713546B2 - リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法 - Google Patents

リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法 Download PDF

Info

Publication number
JP6713546B2
JP6713546B2 JP2018549315A JP2018549315A JP6713546B2 JP 6713546 B2 JP6713546 B2 JP 6713546B2 JP 2018549315 A JP2018549315 A JP 2018549315A JP 2018549315 A JP2018549315 A JP 2018549315A JP 6713546 B2 JP6713546 B2 JP 6713546B2
Authority
JP
Japan
Prior art keywords
composition
alanine
myeloperoxidase
oxidase
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018549315A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019515881A (ja
JP2019515881A5 (enExample
Inventor
ロバート シー． アレン，
ロバート シー． アレン，
Original Assignee
エクソゼミス，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エクソゼミス，インコーポレイテッド filed Critical エクソゼミス，インコーポレイテッド
Publication of JP2019515881A publication Critical patent/JP2019515881A/ja
Publication of JP2019515881A5 publication Critical patent/JP2019515881A5/ja
Application granted granted Critical
Publication of JP6713546B2 publication Critical patent/JP6713546B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/02—Oxidoreductases acting on a peroxide as acceptor (1.11) with H2O2 as acceptor, one oxygen atom of which is incorporated into the product (1.11.2)
    • C12Y111/02002—Myeloperoxidase (1.11.2.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2018549315A 2016-05-27 2017-04-13 リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法 Active JP6713546B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662342382P 2016-05-27 2016-05-27
US62/342,382 2016-05-27
PCT/US2017/027458 WO2017204918A1 (en) 2016-05-27 2017-04-13 Myeloperoxidase compositions and methods for inhibition of lipopolysaccharides and lipid a

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020077140A Division JP2020111620A (ja) 2016-05-27 2020-04-24 リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法

Publications (3)

Publication Number Publication Date
JP2019515881A JP2019515881A (ja) 2019-06-13
JP2019515881A5 JP2019515881A5 (enExample) 2019-10-24
JP6713546B2 true JP6713546B2 (ja) 2020-06-24

Family

ID=60411564

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018549315A Active JP6713546B2 (ja) 2016-05-27 2017-04-13 リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法
JP2020077140A Withdrawn JP2020111620A (ja) 2016-05-27 2020-04-24 リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法
JP2021139289A Withdrawn JP2021181500A (ja) 2016-05-27 2021-08-27 リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020077140A Withdrawn JP2020111620A (ja) 2016-05-27 2020-04-24 リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法
JP2021139289A Withdrawn JP2021181500A (ja) 2016-05-27 2021-08-27 リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法

Country Status (9)

Country Link
US (1) US11389514B2 (enExample)
EP (1) EP3463431B1 (enExample)
JP (3) JP6713546B2 (enExample)
CN (1) CN109414485B (enExample)
AU (1) AU2017269582B2 (enExample)
CA (1) CA3022426C (enExample)
IL (1) IL262930B2 (enExample)
MX (1) MX392701B (enExample)
WO (1) WO2017204918A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3820996A4 (en) * 2018-07-13 2022-04-27 Robert C. Allen HALOPEROXIDASES COMPOSITIONS AND USES THEREOF
WO2022103565A1 (en) * 2020-11-13 2022-05-19 Exoxemis, Inc. Myeloperoxidase-containing compositions and uses thereof
EP4633655A1 (en) * 2022-12-14 2025-10-22 Universite De Bordeaux Artificial bifunctional enzyme comprising a myeloperoxidase activity and a glucose oxidase activity and applications thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2108387B (en) 1979-12-28 1984-03-21 Green Cross Corp A pharmaceutical composition containing myeloperoxidase
US5089274A (en) * 1989-02-14 1992-02-18 Incyte Pharmaceuticals, Inc. Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders
US5622848A (en) * 1990-05-23 1997-04-22 Medical Discoveries, Inc. Electrically hydrolyzed salines as microbiocides for in vitro treatment of contaminated fluids containing blood
WO1992014484A1 (en) 1991-02-21 1992-09-03 Exoxemis, Inc. Methods and compositions for the treatment of infection and control of flora
US5389369A (en) * 1991-02-21 1995-02-14 Exoxemis, Inc. Halo peroxidase containing compositions for killing yeast and sporular microorganisms
US5888505A (en) * 1991-02-21 1999-03-30 Eoe, Inc. Method for selectively inhibiting the growth of microbes using a haloperoxidase-halide-peroxide system
US5565197A (en) * 1991-02-21 1996-10-15 Exoxemis, Inc. Method which utilizes a haloperoxidase composition to inhibit the growth of microorganisms which cause sexually transmitted diseases
US8945540B2 (en) * 2008-05-09 2015-02-03 Exoxemis, Inc. Compositions for enhancing the antibacterial activity of myeloperoxidase and methods of use thereof
BR112014000542A2 (pt) * 2011-07-11 2017-02-14 Exoxemis Inc composições de peroxidase eosinofílica e métodos de uso das mesmas

Also Published As

Publication number Publication date
IL262930B1 (en) 2023-07-01
CN109414485B (zh) 2022-08-12
US11389514B2 (en) 2022-07-19
EP3463431C0 (en) 2024-09-18
CA3022426C (en) 2023-05-16
JP2019515881A (ja) 2019-06-13
EP3463431B1 (en) 2024-09-18
JP2020111620A (ja) 2020-07-27
WO2017204918A1 (en) 2017-11-30
IL262930B2 (en) 2023-11-01
EP3463431A4 (en) 2020-01-15
CA3022426A1 (en) 2017-11-30
MX392701B (es) 2025-03-24
AU2017269582B2 (en) 2023-12-21
MX2018013925A (es) 2019-03-28
JP2021181500A (ja) 2021-11-25
CN109414485A (zh) 2019-03-01
IL262930A (en) 2018-12-31
US20190183983A1 (en) 2019-06-20
AU2017269582A1 (en) 2018-10-04
EP3463431A1 (en) 2019-04-10

Similar Documents

Publication Publication Date Title
Gaca et al. Adaptation to adversity: the intermingling of stress tolerance and pathogenesis in enterococci
JP5643189B2 (ja) ミエロペルオキシダーゼの抗菌活性を増強するための組成物、およびそれらの使用方法
JP2021181500A (ja) リポ多糖およびリピドａの阻害のためのミエロペルオキシダーゼ組成物および方法
JP2014520853A (ja) 好酸球ペルオキシダーゼ組成物およびその使用方法
BRPI0712964A2 (pt) processo para a erradicação de elementos patogênicos compreendendo gerar iodo molecular no local
JP2017502093A (ja) 生物活性のヘム−ハロペルオキシダーゼ組成物およびその使用方法
Ansorg et al. Influence of Mucin on the Activity of the Antiseptic Lavasept® against Staphylococcus aureus
JP2021531333A (ja) ハロペルオキシダーゼ組成物およびその使用
HK40005977B (en) Myeloperoxidase compositions and methods for inhibition of lipopolysaccharides and lipid a
HK40005977A (en) Myeloperoxidase compositions and methods for inhibition of lipopolysaccharides and lipid a
BRPI0909447B1 (pt) Composição para inibir o crescimento de microrganismos grampositivos e gram-negativos e uso de uma composição

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181023

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181023

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190913

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191127

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200226

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200424

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200601

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200603

R150 Certificate of patent or registration of utility model

Ref document number: 6713546

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250