IL262930B2 - Myeloperoxidase compositions and methods for inhibition of lipopolysaccharides and lipid a - Google Patents
Myeloperoxidase compositions and methods for inhibition of lipopolysaccharides and lipid aInfo
- Publication number
- IL262930B2 IL262930B2 IL262930A IL26293018A IL262930B2 IL 262930 B2 IL262930 B2 IL 262930B2 IL 262930 A IL262930 A IL 262930A IL 26293018 A IL26293018 A IL 26293018A IL 262930 B2 IL262930 B2 IL 262930B2
- Authority
- IL
- Israel
- Prior art keywords
- myeloperoxidase
- endotoxin
- lipid
- composition
- oxidase
- Prior art date
Links
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- 235000014655 lactic acid Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- DWKPPFQULDPWHX-GSVOUGTGSA-N methyl (2r)-2-aminopropanoate Chemical compound COC(=O)[C@@H](C)N DWKPPFQULDPWHX-GSVOUGTGSA-N 0.000 description 1
- HQEIPVHJHZTMDP-JEDNCBNOSA-N methyl (2s)-pyrrolidine-2-carboxylate;hydrochloride Chemical class Cl.COC(=O)[C@@H]1CCCN1 HQEIPVHJHZTMDP-JEDNCBNOSA-N 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229960005266 polymyxin b Drugs 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 229940118376 tetanus toxin Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/02—Oxidoreductases acting on a peroxide as acceptor (1.11) with H2O2 as acceptor, one oxygen atom of which is incorporated into the product (1.11.2)
- C12Y111/02002—Myeloperoxidase (1.11.2.2)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662342382P | 2016-05-27 | 2016-05-27 | |
| PCT/US2017/027458 WO2017204918A1 (en) | 2016-05-27 | 2017-04-13 | Myeloperoxidase compositions and methods for inhibition of lipopolysaccharides and lipid a |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL262930A IL262930A (en) | 2018-12-31 |
| IL262930B1 IL262930B1 (en) | 2023-07-01 |
| IL262930B2 true IL262930B2 (en) | 2023-11-01 |
Family
ID=60411564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL262930A IL262930B2 (en) | 2016-05-27 | 2017-04-13 | Myeloperoxidase compositions and methods for inhibition of lipopolysaccharides and lipid a |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11389514B2 (enExample) |
| EP (1) | EP3463431B1 (enExample) |
| JP (3) | JP6713546B2 (enExample) |
| CN (1) | CN109414485B (enExample) |
| AU (1) | AU2017269582B2 (enExample) |
| CA (1) | CA3022426C (enExample) |
| IL (1) | IL262930B2 (enExample) |
| MX (1) | MX392701B (enExample) |
| WO (1) | WO2017204918A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3820996A4 (en) * | 2018-07-13 | 2022-04-27 | Robert C. Allen | HALOPEROXIDASES COMPOSITIONS AND USES THEREOF |
| WO2022103565A1 (en) * | 2020-11-13 | 2022-05-19 | Exoxemis, Inc. | Myeloperoxidase-containing compositions and uses thereof |
| EP4633655A1 (en) * | 2022-12-14 | 2025-10-22 | Universite De Bordeaux | Artificial bifunctional enzyme comprising a myeloperoxidase activity and a glucose oxidase activity and applications thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888505A (en) * | 1991-02-21 | 1999-03-30 | Eoe, Inc. | Method for selectively inhibiting the growth of microbes using a haloperoxidase-halide-peroxide system |
| US6294168B1 (en) * | 1991-02-21 | 2001-09-25 | Exoxemis, Inc. | Method for inhibiting pathogenic microbes in an animal using a haloperoxidase-halide-peroxide system |
| WO2013009910A2 (en) * | 2011-07-11 | 2013-01-17 | Exoxemis, Inc. | Eosinophil peroxidase compositions and methods of their use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2108387B (en) | 1979-12-28 | 1984-03-21 | Green Cross Corp | A pharmaceutical composition containing myeloperoxidase |
| US5089274A (en) * | 1989-02-14 | 1992-02-18 | Incyte Pharmaceuticals, Inc. | Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders |
| US5622848A (en) * | 1990-05-23 | 1997-04-22 | Medical Discoveries, Inc. | Electrically hydrolyzed salines as microbiocides for in vitro treatment of contaminated fluids containing blood |
| US5389369A (en) * | 1991-02-21 | 1995-02-14 | Exoxemis, Inc. | Halo peroxidase containing compositions for killing yeast and sporular microorganisms |
| US5565197A (en) * | 1991-02-21 | 1996-10-15 | Exoxemis, Inc. | Method which utilizes a haloperoxidase composition to inhibit the growth of microorganisms which cause sexually transmitted diseases |
| US8945540B2 (en) * | 2008-05-09 | 2015-02-03 | Exoxemis, Inc. | Compositions for enhancing the antibacterial activity of myeloperoxidase and methods of use thereof |
-
2017
- 2017-04-13 CA CA3022426A patent/CA3022426C/en active Active
- 2017-04-13 CN CN201780032711.9A patent/CN109414485B/zh active Active
- 2017-04-13 EP EP17803212.4A patent/EP3463431B1/en active Active
- 2017-04-13 IL IL262930A patent/IL262930B2/en unknown
- 2017-04-13 AU AU2017269582A patent/AU2017269582B2/en active Active
- 2017-04-13 MX MX2018013925A patent/MX392701B/es unknown
- 2017-04-13 US US16/302,449 patent/US11389514B2/en active Active
- 2017-04-13 JP JP2018549315A patent/JP6713546B2/ja active Active
- 2017-04-13 WO PCT/US2017/027458 patent/WO2017204918A1/en not_active Ceased
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2020
- 2020-04-24 JP JP2020077140A patent/JP2020111620A/ja not_active Withdrawn
-
2021
- 2021-08-27 JP JP2021139289A patent/JP2021181500A/ja not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888505A (en) * | 1991-02-21 | 1999-03-30 | Eoe, Inc. | Method for selectively inhibiting the growth of microbes using a haloperoxidase-halide-peroxide system |
| US6294168B1 (en) * | 1991-02-21 | 2001-09-25 | Exoxemis, Inc. | Method for inhibiting pathogenic microbes in an animal using a haloperoxidase-halide-peroxide system |
| WO2013009910A2 (en) * | 2011-07-11 | 2013-01-17 | Exoxemis, Inc. | Eosinophil peroxidase compositions and methods of their use |
Non-Patent Citations (1)
| Title |
|---|
| DENYS G ET AL,, IN VITRO CHARACTERIZATION OF E-101 SOLUTION, A NOVEL MYELOPEROXIDASE-BASED ANTIMICROBIAL AGENT, 28 October 2008 (2008-10-28) * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL262930B1 (en) | 2023-07-01 |
| CN109414485B (zh) | 2022-08-12 |
| US11389514B2 (en) | 2022-07-19 |
| EP3463431C0 (en) | 2024-09-18 |
| JP6713546B2 (ja) | 2020-06-24 |
| CA3022426C (en) | 2023-05-16 |
| JP2019515881A (ja) | 2019-06-13 |
| EP3463431B1 (en) | 2024-09-18 |
| JP2020111620A (ja) | 2020-07-27 |
| WO2017204918A1 (en) | 2017-11-30 |
| EP3463431A4 (en) | 2020-01-15 |
| CA3022426A1 (en) | 2017-11-30 |
| MX392701B (es) | 2025-03-24 |
| AU2017269582B2 (en) | 2023-12-21 |
| MX2018013925A (es) | 2019-03-28 |
| JP2021181500A (ja) | 2021-11-25 |
| CN109414485A (zh) | 2019-03-01 |
| IL262930A (en) | 2018-12-31 |
| US20190183983A1 (en) | 2019-06-20 |
| AU2017269582A1 (en) | 2018-10-04 |
| EP3463431A1 (en) | 2019-04-10 |
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