JP6712566B2 - Radiopharmaceutical administration device and piping device for radiopharmaceutical administration device - Google Patents

Description

The present invention relates to a radiopharmaceutical administration device and a piping device for the radiopharmaceutical administration device.

Conventionally, a radiopharmaceutical administration device described in Patent Document 1 below is known as a technique in this field. In this device, a transport line for transporting the transport liquid connects the transport liquid syringe and the winged needle. A drug line for supplying a radiopharmaceutical joins the transportation line. The desired dose of radiopharmaceutical is delivered from the drug syringe to the transport line through the drug line, and then pushed out together with the transport liquid by the transport liquid syringe to administer the radiopharmaceutical to the patient through the transport line and winged needle. To be done. Here, a check valve is provided in the drug line to prevent backflow from the transport line to the drug syringe side.

JP 2013-144065 JP

As described above, the radiopharmaceutical administration device is designed to administer a desired amount of radiopharmaceutical. However, a part of the radiopharmaceutical delivered at the time of administration remains in the part connecting the check valve on the drug line to the confluence of the transportation line and the drug line. The radiopharmaceutical remaining in this portion is mixed with the transport liquid at the time of administration, so that the radioactivity varies. Then, at the time of the next administration, the radiopharmaceutical having an indefinite amount of radioactivity as described above will be sent on the transportation line as a part of the radiopharmaceutical to be administered. As a result, the dose of radioactivity administered also varies.

In view of such problems, it is an object of the present invention to provide a radiopharmaceutical administration device and a piping device for the radiopharmaceutical administration device that can make the amount of radioactivity of the radiopharmaceutical administered to be accurate.

The radiopharmaceutical administration device of the present invention is a transport liquid syringe capable of inhaling and discharging a transport liquid for transporting a radiopharmaceutical, and a transport liquid syringe connected to a dosing unit connectable to a destination of administration of the radiopharmaceutical. A reverse line, a drug syringe capable of inhaling and discharging a radioactive drug, a drug line connecting the drug syringe and the transportation line, and a check valve provided at a connection portion between the drug line and the transportation line. A tip portion of the valve body of the stop valve, in which the fluid outlet is formed, enters the inside of the transportation line.

Further, the valve body is a duck bill valve formed so that the fluid outlet is elongated in one direction at the tip, and the extending direction of the fluid outlet is substantially parallel to the flow direction of the transport liquid in the transport line. You may

Further, the pipe body forming the drug line may be provided with a valve body support portion that supports the valve body in the extending direction of the tip portion of the valve body.

A piping device for a radiopharmaceutical administration device of the present invention includes a transport liquid syringe capable of inhaling and discharging a transport liquid for transporting a radiopharmaceutical, and a transport liquid syringe for an administration unit connectable to a destination of administration of the radiopharmaceutical. A transport line connecting the two, a drug syringe capable of inhaling and discharging a radiopharmaceutical, a drug line connecting the drug syringe and the transport line, and a check valve provided at a connection part between the drug line and the transport line, And a tip portion of the valve body of the check valve in which the fluid outlet is formed enters the inside of the transportation line.

According to the present invention, it is possible to provide a radiopharmaceutical administration device and a piping device for the radiopharmaceutical administration device that can make the amount of radioactivity of the administered radiopharmaceutical accurate.

It is a figure showing typically one embodiment of a radiopharmaceutical administration device. It is sectional drawing which expands and shows the vicinity of the junction part of the radiopharmaceutical administration apparatus of FIG. (A) is sectional drawing which looked at the valve body from the front, (b) is sectional drawing which looked at the valve body from the side surface. It is a figure which expands and shows the vicinity of the junction part of the conventional radiopharmaceutical administration apparatus.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.

The radiopharmaceutical administration device 1 (hereinafter, simply referred to as “device 1”) shown in FIG. 1 is a device that administers the radiopharmaceutical R to a subject (administration destination) who undergoes a PET (positron tomography) test. The device 1 includes a drug vial 3 containing a radiopharmaceutical R, and a drug syringe 5 for inhaling the radiopharmaceutical R from the drug vial 3 and discharging the inhaled radiopharmaceutical R. The device 1 also includes a saline pack 7 containing a saline solution (transport liquid) Q, and a saline syringe 9 (transport fluid syringe) that inhales the saline solution Q from the saline pack 7 and discharges the inhaled saline solution Q. ), and are provided.

The device 1 includes a saline intake line 13 that connects the saline pack 7 and the saline syringe 9, and a transportation line 15 that connects the saline syringe 9 and the winged needle 11 (administration part). The saline intake line 13 and the transport line 15 may partially overlap in the vicinity of the entrance and exit of the saline syringe 9. The saline intake line 13 includes a collection needle 13 a that is inserted into the saline pack 7. The device 1 also includes a drug suction line 17 that connects the drug vial 3 and the drug syringe 5, and a drug line 19 that connects the drug syringe 5 and the transportation line 15. The drug line 19 joins the transport line 15 at a joining portion 21 between the saline syringe 9 and the winged needle 11. The drug suction line 17 and the drug line 19 may partially overlap in the vicinity of the entrance and exit of the drug syringe 5. The drug inhalation line 17 includes a collection needle 17 a that is inserted into the drug vial 3.

Further, the device 1 includes a waste liquid line 27 branched from the transportation line 15 at a branch portion 23 between the merging portion 21 and the winged needle 11. The end of the waste liquid line 27 is connected to the waste liquid bottle 10. A waste liquid buffer 28 is also provided in the middle of the waste liquid line 27. Hereinafter, in the transport line 15, the portion from the saline syringe 9 to the merging portion 21 is the transport line upstream portion 15 a, the portion from the merging portion 21 to the branch portion 23 is the transport line middle-stream portion 15 b, and the branch portion 23 to the winged needle 11. The portion up to is referred to as the transport line downstream portion 15c.

The device 1 is equipped with four check valves V13, V15, V17 and V19. The check valve V13 is provided on the saline intake line 13. The check valve V13 restricts the flow of the physiological saline solution Q in the saline inhalation line 13 to one direction from the saline pack 7 to the saline syringe 9 and prohibits the reverse flow. The check valve V15 is provided on the transport line upstream portion 15a. The check valve V15 restricts the flow of the physiological saline solution Q in the upstream portion 15a of the transportation line in one direction from the saline syringe 9 to the winged needle 11 and prohibits backflow. The check valve V17 is provided on the medicine inhalation line 17. The check valve V17 restricts the flow of the radiopharmaceutical R in the drug inhalation line 17 to one direction from the drug vial 3 to the drug syringe 5, and prohibits the backflow. The check valve V19 is provided in the merging portion 21. The check valve V19 allows the flow of the radiopharmaceutical R from the drug line 19 to the transportation line 15, and prohibits the reverse flow of the physiological saline solution Q from the transportation line 15 to the drug line 19. As the structure of the check valves V13, V15, V17, V19, for example, a duck bill valve structure may be adopted.

Around the drug syringe 5, a measurement unit 31 that measures the amount of radioactivity of the radiopharmaceutical R inhaled into the drug syringe 5 is provided. Further, an openable/closable pinch valve 33 is provided on the downstream portion 15c of the transportation line, and an openable/closeable pinch valve 35 is provided on the waste liquid line 27. A passage sensor 37 that detects passage of the radiopharmaceutical R is provided on the downstream portion 15c of the transportation line. A filter 39 is provided immediately upstream of the winged needle 11 on the transportation line downstream portion 15c. In addition, the device 1 has a shielding chamber 43 for storing the drug vial 3, a shielding chamber 45 for storing the drug syringe 5, and a shielding chamber 47 for storing the waste liquid bottle 10 in order to shield the radiation from the radiopharmaceutical R. I have it.

The apparatus 1 also includes a control unit 41 that drives the pistons of the drug syringe 5 and the saline syringe 9 to control suction and discharge of liquid by the drug syringe 5 and the saline syringe 9. The control unit 41 further controls the opening/closing operation of the pinch valves 33, 35.

Each line (raw food inhalation line 13, transportation line 15, drug inhalation line 17, drug line 19, etc.) is formed by a tubular body such as a sterilized extension tube. In addition, for example, a governmental material such as a T-shaped pipe is appropriately inserted in the connection portion or the branch portion of each line.

Then, operation|movement of the apparatus 1 is demonstrated. The device 1 operates as follows by driving the drug syringe 5, the saline syringe 9, the pinch valves 33, 35, and the like under the control of the control unit 41. The state where the transportation line 15 is filled with the physiological saline Q is referred to as an initial state. From this initial state, the winged needle 11 is inserted into the subject. Then, when the piston of the drug syringe 5 is pulled down, the radioactive drug R in the drug vial 3 is sucked into the drug syringe 5 through the drug suction line 17.

Then, with the pinch valve 33 closed and the pinch valve 35 open, the piston of the drug syringe 5 is pushed up. As a result, the radiopharmaceutical R is pushed into the transportation line 15 from the drug syringe 5 through the drug line 19 and the check valve V19. At this time, the excess physiological saline solution Q in the transportation line 15 is discharged to the waste liquid bottle 10 through the waste liquid line 27. By this operation, a part of the physiological saline solution Q on the transportation line 15 is replaced with the radiopharmaceutical R. The substituted radiopharmaceutical R is housed in the midstream portion 15b of the transportation line, for example. Here, since the radioactivity amount of the radiopharmaceutical R is measured by the measurement unit 31, the amount of the radiopharmaceutical R to be administered to the subject is calculated according to the radioactivity amount, and the radiopharmaceutical R of the amount to be administered is It is pushed into the transportation line 15.

After that, when the piston of the saline diet syringe 9 is pulled down, the physiological saline Q of the saline diet pack 7 is sucked into the saline saline syringe 9 through the saline saline suction line 13. Then, with the pinch valve 33 opened and the pinch valve 35 closed, the piston of the saline syringe 9 is pushed up. As a result, the radiopharmaceutical R in the transportation line 15 is administered into the body of the subject together with the physiological saline Q through the winged needle 11 by the pressure from the saline syringe 9.

Subsequently, the structure in the vicinity of the confluence portion 21 will be described with reference to FIG. As shown in FIG. 2, each flow path in the vicinity of the merging portion is formed by a hard flow path unit 51 including check valves V15, V17, V19. The flow path unit 51 includes a flow path block 53 (tubular body) that forms a part of the transport line 15 and a part of the drug line 19 as an inner cavity, and another part of the drug line 19 and the drug inhalation line 17. And a flow path block 55 forming the portion as an inner cavity. The valve body 65 of the check valve V15, the valve body 67 of the check valve V17, and the valve body 69 of the check valve V19 are duckbill valves. Valve bodies 65 and 69 are held and fixed at predetermined positions with respect to the flow path block 53. Further, the valve body 67 is held and fixed at a predetermined position with respect to the flow path block 55.

The structure of the check valve V19 will be described below as a feature of the radiopharmaceutical administration device 1 of the present embodiment in the flow path unit 51. The check valves V15 and V17 may have the same structure as the check valve V19.

As shown in FIG. 3, the valve body 69 of the check valve V19 is a duckbill valve, and the valve body 69 has a cylindrical body portion 71 and a tip portion 73 protruding upward from the center of the upper end of the body portion 71. It has and. The tip portion 73 has two plate pieces 73a and 73a extending upward from the body portion 71, and a thin flow path 75 formed as a gap between the plate pieces 73a and 73a. The hollow portion 71a of the body portion 71 communicates with the flow passage 75, and a fluid outlet 77 of the flow passage 75 is formed on the upper end surface of the tip portion 73. The fluid outlet 77 is elongated in the radial direction of the body 71. With this structure, the fluid entering from the hollow portion 71a of the valve body 69 passes upward while expanding the flow path 75, and is discharged from the fluid outlet 77. On the contrary, when the fluid is going to enter from the fluid outlet 77 side, the plate pieces 73a and 73a are pushed from the outside by the pressure of the fluid, and the flow path 75 is compressed and closed, so that the reverse flow of the fluid is prohibited. ..

The valve body 69 is installed so that the tip portion 73 of the valve body 69 as described above enters the inside of the transportation line 15. That is, the tip portion 73 of the valve body 69 is positioned so as to project radially inward from the inner wall surface of the column forming the transportation line 15. The fluid outlet 77 located on the front end face of the tip portion 73 is located near the center of the flow path cross section of the transportation line 15.

Further, as shown in FIG. 2, the valve body 69 is oriented such that the extending direction of the fluid outlet 77 is parallel to the flow direction of the physiological saline solution Q in the transportation line 15 (left-right direction in FIG. 2). Is installed. In addition, it is not essential that the flow direction of the physiological saline Q in the transportation line 15 and the extending direction of the fluid outlet 77 are substantially parallel, and they may be substantially parallel. Due to such an installation mode of the valve body 69, the area of the tip portion 73 viewed from the flow direction of the physiological saline Q in the transportation line 15 is made as small as possible, and the resistance of the tip portion 73 to the flow of the physiological saline Q is reduced. Can be kept small.

The valve body 69 is fitted into the concave portion of the flow path block 53 from below, so that the valve body 69 is positioned with the tip 73 protruding into the transportation line 15 as described above. Further, by fitting the valve disc retainer 81 below the valve disc 69 in the recess, the valve disc 69 is sandwiched and fixed by the flow path block 53 and the valve disc retainer 81. The hollow portion of the valve body retainer 81 forms a part of the medicine line 19, and the tip 81a of the valve body retainer 81 has a cylindrical shape protruding upward. The tip portion 81a is inserted and fitted into the hollow portion 71a of the valve body 69 from below. The upper end surface 81b of the tip portion 81a may abut against the upper wall surface 71b that partitions the hollow portion 71a.

The tip 81 a of the valve retainer 81 functions as a valve support that supports the valve 69 in the extending direction (vertical direction) of the tip 73 of the valve 69. The presence of the tip portion 81a fitted in the hollow portion 71a reduces the load acting on the valve body 69 from the transportation line 15 side. That is, when the pressure of the transportation line 15 becomes high and the downward pressure acts on the valve body 69 from the transportation line 15, the load caused by the pressure is also carried by the tip portion 81a, and therefore the valve is caused by the above-mentioned load. Buckling of body 69 is avoided. The state in which the pressure of the transportation line 15 is high appears, for example, when the radiopharmaceutical R is extruded toward the winged needle 11 by the pressure from the saline syringe 9.

As shown in FIG. 1, when assembling the device 1 as described above, the drug vial 3, the saline pack 7, and the waste liquid bottle 10 are installed in the housing 2, and the piping device 91 is installed. Is assembled. Then, the drug vial 3, the saline pack 7, the waste liquid bottle 10, and the like are appropriately connected by the piping provided in the piping device 91, and the circuit for administering the radiopharmaceutical R to the subject is formed as described above.

The piping device 91 includes the components listed below.
Partial drug line 19 of the drug inhalation line 17 excluding the sampling needle 17a
Raw food inhalation line 13
Transport line upstream part 15a
Middle part of transport line 15b
Partial chemical syringe 5 connecting the branch part 23 and the waste liquid buffer 28 of the partial waste liquid line 27 connecting the branch part 23 and the filter 39 of the transport line downstream part 15c.
Raw syringe 9

The piping device 91 is configured by previously integrally connecting extension tubes, syringes, and the like for forming the above-described components. Then, the piping device 91 is appropriately replaced as a consumable item.

Next, the action and effect of the device 1 of the present embodiment will be described in comparison with a conventional radiopharmaceutical administration device. FIG. 4 is a diagram showing the vicinity of a drug line 19 in a conventional radiopharmaceutical administration device. As shown in FIG. 4, in the conventional device, the check valve V19 on the drug line 19 is provided at a position between the drug syringe 5 and the merging portion 21. Hereinafter, of the medicine line 19, a portion from the medicine syringe 5 to the check valve V19 is referred to as a medicine line upstream portion 19a, and a portion from the check valve V19 to the confluence portion 21 is referred to as a medicine line downstream portion 19b.

According to the structure shown in FIG. 4, after the operation of pushing the radiopharmaceutical R from the medicine syringe 5 to the transportation line 15 (hereinafter, “medicine pushing operation”) is completed, the middle portion 15b of the transportation line is moved to the downstream portion of the medicine line. The radiopharmaceutical R is present so as to be continuous over 19b. From this state, the radiopharmaceutical R and the physiological saline Q in the transportation line 15 are transported toward the winged needle 11 by the pressure from the saline syringe 9 and administered to the subject (hereinafter referred to as “administration operation”). Done. Here, after the administration operation is completed, as shown by hatching in FIG. 4, the radioactive drug R remains in the drug line downstream portion 19b. The residual radiopharmaceutical R (hereinafter, “residual drug R1”) is not completely insulated from the transportation line 15, and therefore physiological saline Q is mixed and diluted during the administration operation. As a result, in the drug pushing operation in the next administration, the residual drug R1 whose radioactivity concentration is indefinite is pushed into the transportation line as a part of the radioactive drug R to be administered. Then, the radioactivity of the radiopharmaceutical R administered to the subject also varies.

On the other hand, in the device 1 of the present embodiment, as shown in FIGS. 1 and 2, the check valve V19 is provided in the merging portion 21, and the tip portion 73 of the valve body 69 of the check valve V19. Has entered the transportation line 15. Therefore, in the drug pushing operation, all the radiopharmaceutical R to be administered to the subject is pushed into the transportation line 15, and in the administration action, all the pushed radiopharmaceutical R is administered to the subject. As a result, generation of the residual drug R1 as in the conventional device is avoided, and the radioactivity of the administered radiopharmaceutical can be made accurate.

The present invention can be implemented in various modes including various modifications and improvements based on the knowledge of those skilled in the art, including the above-described embodiment. In addition, it is possible to configure a modified example of the example by utilizing the technical matters described in the above-described embodiment. The configurations of the respective embodiments may be appropriately combined and used.

DESCRIPTION OF SYMBOLS 1... Radiopharmaceutical administration device, 5... Drug syringe, 9... Saline syringe (transport liquid syringe), 11... Winged needle (administration part), 15... Transport line, 19... Drug line, 21... Confluence part (connection part) , 53... Flow path block (tubular body), 69... Valve body (duck bill valve), 73... Tip part, 77... Fluid outlet, 81a... Tip part (valve body support part), 91... Piping device, Q... Saline Water (transport liquid), R... Radiopharmaceutical, V19... Check valve.

Claims (4)

A transport liquid syringe capable of inhaling and discharging a transport liquid for transporting a radiopharmaceutical,
A transport line connecting the transport liquid syringe to an administration part connectable to the administration destination of the radiopharmaceutical,
A drug syringe capable of inhaling and discharging the radioactive drug,
A drug line connecting the drug syringe and the transport line,
A check valve provided at a connection portion between the drug line and the transportation line,
The radiopharmaceutical administration device, wherein a tip portion of the valve body of the check valve in which a fluid outlet is formed enters the inside of the transportation line. The valve body is a duckbill valve formed such that the fluid outlet at the tip portion is elongated in one direction.
The radiopharmaceutical administration device according to claim 1, wherein the extending direction of the fluid outlet is substantially parallel to the flow direction of the transport liquid in the transport line. The tubular body forming the drug line includes
The radiopharmaceutical administration device according to claim 1, further comprising a valve body support portion that supports the valve body in an extending direction of the tip portion of the valve body. A transport liquid syringe capable of inhaling and discharging a transport liquid for transporting a radiopharmaceutical,
A transport line connecting the transport liquid syringe to an administration part connectable to the administration destination of the radiopharmaceutical,
A drug syringe capable of inhaling and discharging the radioactive drug,
A drug line connecting the drug syringe and the transport line,
A check valve provided at a connection portion between the drug line and the transportation line,
A piping device for a radiopharmaceutical administration device, wherein a tip portion of the valve body of the check valve, in which a fluid outlet is formed, enters the inside of the transportation line.

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