JP2008302092A - Apparatus and method for administering radioactive medicine solution - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an administration apparatus and an injection method for radioactive medicine solution which achieve a precise administration of the radioactive medicine solution. <P>SOLUTION: The administration apparatus includes suction and discharge means 45 for sucking and storing radioactive medicine solution from a vial 6 and for discharging the stored radioactive medicine solution for administration, control means 35 for controlling suction and discharge of the radioactive medicine solution by the suction and discharge means 45, and a first detection unit 37 for detecting a radioactive intensity of the radioactive medicine solution stored in the suction and discharge means 45. The control means 35 controls the amount of the radioactive medicine solution sucked by the suction and discharge means 45 on the basis of the radioactive intensity detected by the first detection unit 37 and dispenses and administers a necessary amount of the radioactive medicine solution precisely. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an administration device and an administration method for administering a radioactive drug solution.

  When administering a radiopharmaceutical labeled with a short half-life radionuclide to a subject in a hospital laboratory, etc., the radiation dose of the handler is prevented, and a prescribed dose is administered accurately and at a constant rate. There is a need to. Therefore, for example, a dispensing device described in Patent Document 1 is used. The dispensing device includes a radioactive chemical solution storage container and a raw food storage container, a syringe for sucking the radioactive chemical solution from the radioactive chemical solution storage container, an injection needle for administering the radioactive chemical solution to a subject, each storage container, and a syringe. And a tube for connecting an injection needle and the like. In this dispensing apparatus, the radioactive chemical solution is automatically sucked by the syringe, and the necessary concentration of the radioactive chemical solution is obtained by detecting the radioactivity concentration of the radioactive chemical solution passing through the tube. In this dispensing apparatus, when the required amount of suction with the syringe is completed, the sucked radioactive drug solution is discharged from the syringe and administered to the subject.

JP 2002-306609 A

  However, in the conventional dispensing device, the required concentration is obtained so that the radioactivity concentration of the radiopharmaceutical solution passing through the tube becomes a predetermined radioactivity intensity, and the amount corresponding to the required amount is sucked with a syringe or the like. Because of this, there is a risk of variations in accuracy in administering the radiopharmaceutical because it is easily affected by individual differences such as tubes and syringes.

  An object of the present invention is to solve the above-described problems, and an object thereof is to provide a radiopharmaceutical solution administration apparatus and injection method capable of accurately administering a radiopharmaceutical solution.

  The present invention relates to a radiopharmaceutical administration device that sucks and administers a required amount of a radiopharmaceutical from a radiopharmaceutical container, and sucks and stores the radiopharmaceutical from the container and discharges the stored radiochemical for administration. Means, a control means for controlling the suction and discharge of the radioactive chemical liquid by the suction and discharge means, and a detection means for detecting the radioactivity intensity of the radioactive chemical liquid stored in the suction and discharge means, and the control means is detected by the detection means The amount of the radioactive chemical liquid sucked by the sucking and discharging means is controlled based on the radioactivity intensity.

  In this radioactive drug solution administration device, the radioactive drug solution is sucked from the storage container by the suction / discharge means and temporarily stored. Then, the radioactivity intensity of the radioactive chemical stored in the intake / exhaust means is directly detected by the detection means, and the control means controls the suction amount of the intake / exhaust means based on the detected radioactivity intensity. Therefore, it becomes difficult to be influenced by individual differences in the suction and discharge means, and a necessary amount corresponding to a predetermined radioactivity intensity required for administration can be accurately sucked by the suction and discharge means. As a result, the radiopharmaceutical solution can be administered with high accuracy.

  Further, the apparatus further includes auxiliary detection means for detecting the radioactivity intensity of the radioactive chemical liquid sucked by the suction / exhaust means, and the control means adds the radioactivity intensity detected by the auxiliary detection means to the radioactivity intensity detected by the detection means. Based on this, it is preferable to control the suction and discharge of the radioactive chemical liquid by the suction and discharge means. When a malfunction occurs in the detection means, the radioactivity intensity of the radiopharmaceutical solution stored in the intake / exhaust means has a larger error than the predetermined radioactivity intensity required for administration. So, according to the said structure, the detection intensity of a detection means can be monitored indirectly by detecting a radioactivity intensity | strength by an auxiliary | assistant detection means, and the inappropriate administration of a radioactive chemical | medical solution can be avoided.

  Furthermore, it is preferable that the suction / discharge means has a syringe that sucks and discharges the radioactive chemical liquid by a piston sliding in the cylinder, and the detection means is arranged along the cylinder. Since the radioactive chemical solution is stored in the cylinder, the detection accuracy is improved by arranging the detection means along the cylinder.

  Further, it is preferable that the detection means has a plurality of RI sensors, and the plurality of RI sensors are arranged along the axis of the cylinder. The closer the RI sensor is to the cylindrical body, the higher the detection accuracy, but the range that can be detected becomes narrower. Therefore, by arranging a plurality of RI sensors along the axis of the cylinder, each RI sensor can be easily brought close to the cylinder, and the detection accuracy in a wide range along the axis of the cylinder can be improved.

  Furthermore, it is preferable that the detector further includes a shield part that shields the transmission of radiation, and the shield part is formed with an opening through which the radiation passes on the side facing the cylinder. The radioactivity intensity from the radioactive chemical stored in the cylinder is detected from the radiation passing through the opening of the shield part, and the other radiation is shielded by the shield part. As a result, the detection accuracy of the radioactivity intensity of the radioactive chemical stored in the cylinder is improved.

  In addition, in the radioactive chemical solution administration method in which a necessary amount of radioactive chemical solution is aspirated and administered from the radioactive chemical solution storage container, the radioactive chemical solution is aspirated and stored from the storage container, and the detection of the radioactivity intensity of the stored radioactive chemical solution is detected. The step and the radioactivity intensity detected in the detection step are compared with the target value, and when the radioactivity intensity detected in the detection step reaches the target value, the suction stop step for stopping the suction of the radiopharmaceutical solution, and the storage Administering a radiopharmaceutical solution.

  According to this radiopharmaceutical solution administration method, the radioactivity intensity of the radiopharmaceutical liquid sucked from the storage container and temporarily stored is directly detected, and when the detected radioactivity intensity reaches the target value The suction of the radiopharmaceutical is stopped, and the stored radiochemical is administered. Therefore, a necessary amount of the radiopharmaceutical solution corresponding to the target value can be accurately aspirated from the container, and the radiopharmaceutical solution can be administered with high accuracy.

  Furthermore, between the aspiration stop step and the administration step, the redetection step for redetecting the radioactivity intensity of the radiopharmaceutical solution stored in the aspiration stop step and the radioactivity intensity redetected in the redetection step and the target value are compared. If the re-detected radioactivity intensity is less than the target value, the radio-chemical solution is re-aspirated from the storage container, and the adjustment amount detection step for detecting the radio-activity intensity of the radio-chemical solution stored by re-aspiration and adjustment It is preferable to further include a re-suction stop step for stopping re-suction of the radiopharmaceutical solution when the radioactivity intensity detected in the amount detection step reaches the target value.

  The radioactivity intensity decreases with time. Therefore, when a predetermined waiting time is required between the stop of the suction of the radiopharmaceutical and the administration, the radiopharmaceutical may be less than the target value as the predetermined waiting time elapses. . According to the above method, after the elapse of the standby time, the radioactivity intensity is re-detected, and if the re-detected radioactivity intensity is less than the target value, the radiochemical solution is re-suctioned from the storage container and adjusted. This makes it easier to accurately administer the radiopharmaceutical solution.

  Further, the method further includes a target value changing step for changing the target value to a new target value between the suction stop step and the re-detection step. In the adjustment amount detection step, the re-detected radioactivity intensity and the new target value are In the re-suction stop step, when the radioactivity intensity detected in the adjustment amount detection step reaches a new target value, it is preferable to stop the re-suction of the radioactive drug solution. According to this method, the target value can be changed, and the radiation intensity necessary for administration can be corrected before administration.

  According to the present invention, it is possible to accurately administer a radioactive drug solution.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings.

  FIG. 1 is a view showing a radioactive drug solution administration device according to the present invention. As shown in FIG. 1, the radioactive drug solution administration device 1 includes a saline solution line 7 that connects a saline solution pack 3 containing physiological saline (or distilled water for injection) and a winged needle 5, and a radioactive drug solution. A chemical liquid line 9 that communicates the accommodated vial (accommodating container) 6 with the raw food line 7 and a waste liquid line 11 that communicates the waste liquid bottle 10 and the raw food line 7 are provided. The main part of the radioactive drug solution administration device 1 excluding the winged needle 5 is accommodated in a housing 13. The vial 6 is accommodated in a shield case 15 that shields radiation, and the shield case 15 is further disposed in the first shielding chamber 16. The main part of the chemical liquid line 9 is disposed in the second shielding chamber 17, and the waste liquid bottle 10 is disposed in the third shielding chamber 18.

  The raw food line 7 includes a first tube 19A, a second tube 19B, a third tube 19C, and a fourth tube 19D that transfer physiological saline for dilution from the raw food pack 3 to the winged needle 5. Each of the first tube 19A, the second tube 19B, the third tube 19C, and the fourth tube 19D is a sterilized extension tube. An injection needle 20 connected to the raw food pack 3 is provided at the proximal end of the first tube 19A. In addition, a winged needle 5 for administering a radiopharmaceutical solution to a subject is provided at the tip of the fourth tube 19D.

  The first tube 19A and the second tube 19B are connected via a first T-shaped tube 21. The first T-shaped tube 21 is provided with a first check valve 21a for preventing physiological saline or the like from flowing back to the first tube 19A. Moreover, the 2nd tube 19B and the 3rd tube 19C are connected via the 2nd T-shaped tube 23, and a physiological saline etc. will flow backward into the 2nd T-tube 23 to the 2nd tube 19B. A second check valve 23a is provided to prevent this. The third tube 19C and the fourth tube 19D are connected via a third T-shaped tube 25. A passage sensor 26 is provided in the vicinity of the fourth tube 19D to detect the radioactive chemical solution passing through the fourth tube 19D.

  A saline eating syringe 27 is connected to the branch portion of the first T-shaped tube 21. For example, a syringe drive device (not shown) using a pulse motor is connected to the raw food syringe 27. In the raw saline syringe 27, the pusher portion is moved by driving the syringe driving device, and the physiological saline or the like in the first tube 19A is pushed into the second tube 19B, the third tube 19C, and the fourth tube 19D.

  As shown in FIGS. 1 to 3, the chemical liquid line 9 sucks and sucks the chemical liquid tube 29 that transfers the radioactive chemical liquid dispensed from the vial 6 and the chemical liquid tube 29 through the chemical liquid tube 29. An RI syringe 31 that discharges the radiopharmaceutical solution to the saline line 7 for administration, an actuator 33 that moves the RI syringe 31, and a control unit 35 that controls driving of the actuator 33 are provided. Furthermore, the chemical liquid line 9 includes a first detection unit (detection means) 37 and a second detection unit (auxiliary detection means) 39 that detect the radioactivity intensity of the radioactive chemical liquid sucked by the RI syringe 31.

  The vial 6 contains a radioactive drug solution such as FDG (2-deoxy-18F-fluoro-glucose) used for PET (positron tomography), for example, about 500 mCi / 20 ml to 1 Ci / 20 ml. The chemical liquid tube 29 is an extension tube, and a catalan needle inserted into the vial 6 is provided at the proximal end of the chemical liquid tube 29. The distal end portion of the chemical liquid tube 29 is connected to the first conduit 41 a of the three-way branch pipe 41. The first conduit 41 a is provided with a chemical check valve 41 b that prevents the backflow of the radioactive chemical into the vial 6.

  The second pipe 41 c of the three-way branch pipe 41 is connected to the branch portion of the second T-shaped pipe 23 of the raw eating line 7. Further, the second conduit 41c is provided with a saline check valve 41d that prevents entry of physiological saline or the like.

  A third pipe 41 f of the three-way branch pipe 41 is connected to the RI syringe 31. The RI syringe 31 includes an outer cylinder part (cylinder part) 31a and a pusher part (piston part) 31b that slides within the outer cylinder part 31a. An intake / exhaust port 31c communicating with the third pipe line 41f is provided at the distal end of the outer cylindrical portion 31a, and a flange 31d is provided at the proximal end. The outer cylinder part 31 a is accommodated in the holder part 43. The holder portion 43 is provided with a holding bracket 43a formed so that the flange 31d is inserted. The outer cylinder part 31a is prevented from coming off by the flange 31d being held by the holding bracket 43a. By the movement of the pusher portion 31b, the radioactive chemical liquid is sucked into the outer cylinder portion 31a, and the sucked radioactive chemical liquid is discharged.

  The actuator 33 is composed of a pulse motor or the like, and has a movable bracket 33a. The pusher portion 31b of the RI syringe 31 is fixed to the movable bracket 33a. The actuator 33 reciprocates the movable bracket 33a to reciprocate the pusher portion 31b. The intake / exhaust means 45 is constituted by the RI syringe 31 and the actuator 33.

  Control means 35 is connected to the actuator 33. The control means 35 corresponds to a PC (Personal Computer) or the like, is configured by hardware such as a CPU (Central Processing Unit) or a memory, and is connected to the actuator 33 so as to be able to transmit and receive electrical signals. The control means 35 controls the drive of the actuator 33, thereby controlling the suction for dispensing the radiopharmaceutical solution by the RI syringe 31 and the discharge for administration. The control means 35 is also connected to the first detection unit 37 and the second detection unit 39 and can receive an output value output from the first detection unit 37 or the second detection unit 39.

  A first detection unit 37 and a second detection unit 39 are provided outside the holder portion 43 that holds the RI syringe 31 along the outer cylinder portion 31 a of the RI syringe 31. The first detection unit 37 and the second detection unit 39 are disposed to face each other with the RI syringe 31 interposed therebetween. The first detection unit 37 is provided to determine the amount of the radioactive chemical solution sucked by the RI syringe 31, and the second detection unit 39 determines whether or not to perform administration by monitoring the first detection unit 37. Is provided to do.

  The first detection unit 37 includes a first RI sensor 47A, a second RI sensor 47B, and a third RI sensor 47C. RI (Radioisotope) is an isotope that emits radiation and changes (disintegrates) into other types of nuclei. The first RI sensor 47A detects the decay variable (Bq) per second, that is, the radioactivity intensity. This is a sensor that outputs an electrical signal. The same applies to the second RI sensor 47B and the third RI sensor 47C. The first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C each independently detect the radioactivity intensity of the radioactive chemical stored in the outer cylindrical portion 31a of the RI syringe 31.

  The closer the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C are to the outer cylinder portion 31a, the higher the detection accuracy, but the narrower the range that can be accurately detected. Therefore, the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C are arranged vertically along the axis L of the outer cylinder portion 31a, the first RI sensor 47A is closer to the tip, the second RI sensor 47B is the center, The 3RI sensor 47C is disposed near the base end. With such an arrangement, the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C can be easily brought close to the outer cylinder portion 31a, and the detection accuracy in a wide range along the axis L of the outer cylinder portion 31a can be improved. . Hereinafter, a specific description will be given with reference to FIGS. 4 and 5.

  FIG. 4 shows a case where a predetermined amount of liquid corresponding to a radioactivity intensity of 100 (MBq) is sucked by the RI syringe 31 and detected independently by the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C. It is a table | surface which shows the output value (mV) and average value (mV). Furthermore, in FIG. 4, as a predetermined liquid amount corresponding to the radioactivity intensity 100 (MBq), 0.2 (ml), 1.1 (ml), 2.1 (ml), 3 (ml), 4 ( ml) and 5 (ml).

  FIG. 5 is a graph corresponding to FIG. 4, where the horizontal axis indicates the liquid amount (ml) and the vertical axis indicates the output value (mV). 5A shows the detection result of the first RI sensor 47A, FIG. 5B shows the detection result of the second RI sensor 47B, FIG. 5C shows the detection result of the third RI sensor 47C, and FIG. FIG. 6 is a graph showing average values of output values (mV) detected by the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C.

  As shown in FIG. 4 and FIG. 5 (a), when the amount of the radioactive chemical solution is 0.2 (ml) and becomes 100 (MBq), the radioactivity concentration is very high, and the first RI sensor 47A The output value of is 50 (mV). However, when the radioactivity concentration of the radiopharmaceutical solution decreases and the liquid volume increases, the output value at the first RI sensor 47A decreases. For example, when the liquid volume of the radiochemical liquid is 5 (ml), the output The value is 26 (mV). Thus, when it is going to detect with the 1st RI sensor 47A single-piece | unit, variation will arise in an output value according to the liquid quantity of a radioactive chemical | medical solution. Similarly, in the second RI sensor 47B (see FIG. 5 (b)), when the liquid amount to be 100 (MBq) is 3 (ml), the output value is the largest at 43 (mV), and the liquid amount is 0.2. The output value in the case of (ml) is the smallest at 34 (mV). Further, in the third RI sensor 47C (see FIG. 5C), the output value is 34 (mV), which is the largest when the liquid amount to be 100 (MBq) is 5 (ml), and is 0.2 (ml). In this case, the output value is the smallest at 15 (mV). In this way, the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C each have a variation in output value depending on the liquid amount even if the liquid amount has the same radioactivity intensity of 100 (MBq). End up.

  On the other hand, the average value of 0.2 (ml) output values in the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C is 33.0 (mV). Similarly, the average value of each output value of 1.1 (ml) is 34.0 (mV), the average value of each output value of 2.1 (ml) is 34.7 (mV), 3 (ml ) The average value of each output value is 35.0 (mV), the average value of each output value of 4 (ml) is 34.7 (mV), the average value of each output value of 5 (ml) is 34.7 (mV). Thus, in the average value of each output value of the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C, there is almost no variation due to the liquid volume, and it is not affected by the liquid volume of the radioactive chemical liquid, and the detection accuracy of the radioactivity intensity Can be improved. As a result, the detection accuracy in a wide range along the axis of the outer cylinder portion 31a can be improved.

  Further, as shown in FIG. 4, the total average of the output values corresponding to the respective liquid amounts in the case of the radioactivity intensity of 100 (MBq) is 34.3 (mV), and the standard deviation is 0.7. is there. In this embodiment, when 100 (MBq) of radioactivity intensity is administered to a subject, 34.3 (mV), which is the total average of output values, is set as the target value. Note that when the radioactivity intensity administered to the subject increases, the output values of the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C also increase, so the output value set as the target value increases, and the administration to the subject increases. When the radioactivity intensity is low, the output value set as the target value is low.

  As shown in FIGS. 2 and 3, the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C are accommodated in a lead-made first shield chamber (shield portion) 49. In the first shield chamber 49, a first opening 49a through which radiation passes is formed on the side facing the outer cylinder portion 31a with the holder portion 43 interposed therebetween. The intensity of radioactivity from the radioactive chemical stored in the outer cylinder portion 31 a is detected from the radiation passing through the first opening 49 a of the first shield chamber 49. Other radiation is shielded by the first shield chamber 49. As a result, the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C are unlikely to receive radiation that becomes noise, and the detection accuracy of the radioactivity intensity from the radioactive chemical stored in the outer cylinder portion 31a. Will improve. Note that the shape of the first shield chamber 49 and the wall thickness can be determined as appropriate. For example, the thickness of the periphery of the first RI sensor 47A close to the chemical liquid tube 29 through which the radioactive chemical liquid flows is made thicker than the surroundings of the other second RI sensor 47B and the third RI sensor 47C, so that noise is difficult to enter. You can also.

  The second detection unit 39 includes a fourth RI sensor 47D, a fifth RI sensor 47E, and a sixth RI sensor 47F arranged along the axis L of the outer cylinder portion 31a. The fourth RI sensor 47D, the fifth RI sensor 47E, and the sixth RI sensor 47F are accommodated in the lead second shield chamber 51. In the second shield chamber 51, a second opening 51a through which radiation passes is formed on the side facing the outer cylinder portion 31a with the holder portion 43 interposed therebetween. The fourth RI sensor 47D, the fifth RI sensor 47E, and the sixth RI sensor 47F have the same configurations as the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C, and thus description thereof is omitted. The second shield chamber 51 has the same configuration as that of the first shield chamber 49, and a description thereof will be omitted.

  As shown in FIG. 1, the waste liquid line 11 includes a waste liquid tube 53 made of an extension tube, and the waste liquid tube 53 is connected to the waste liquid bottle 10 via a waste liquid pipe 55. A first pinch valve 56A and a second pinch valve 56B are provided on the waste liquid tube 53 and the fourth tube 19D of the saline feed line 7, respectively. At the time of administration of the radiopharmaceutical solution, the first pinch valve 56A is opened and the second pinch valve 56B is closed, and when the radiochemical solution is discarded, the first pinch valve 56A is closed and the second pinch valve 56B is opened.

  Next, a radiopharmaceutical administration method using the radiopharmaceutical administration device 1 will be described with reference to FIG. 6 or FIG. FIG. 6 is a flowchart showing the procedure of the first administration process, and the step is abbreviated as S. FIG. 7 is a flowchart showing the procedure of the second administration process, and step is abbreviated as S. First, the radioactive drug solution administration method according to the procedure of the first administration process will be described with reference to FIG.

  As shown in FIG. 6, when the first administration process is started, a preparation process is first performed, and the first tube 19A, the second tube 19B, the third tube 19C, and the fourth tube 19D of the saline line 7 are filled with physiological saline. The chemical solution tube 29 of the chemical solution line 9 is filled with the radioactive chemical solution (step 1).

  Next, the operator operates an operation means (not shown) to set and input the radioactivity intensity to be administered to the subject as a target value. Data input via the operating means is input to the control means 35, and the control means 35 stores the target value in the memory (step 2).

  Thereafter, the control means 35 drives the actuator 33 to start sucking the radioactive chemical liquid by the RI syringe 31, and stores the radioactive chemical liquid in the outer cylinder portion 31a (step 3). Moreover, the 1st detection unit 37 detects the radioactivity intensity | strength of the radioactive chemical | medical solution stored in the outer cylinder part 31a of RI syringe 31 (step 4). In step 4, the first RI sensor 47 </ b> A, the second RI sensor 47 </ b> B, and the third RI sensor 47 </ b> C each independently detect the radioactivity intensity, and input the output value to the control means 35. The control means 35 calculates the average value of the output values of the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C. Steps 3 and 4 correspond to detection steps.

  The control means 35 compares the average value calculated in Step 4 with the target value stored in advance (Step 5), and repeatedly executes Step 3 and Step 4 until the average value reaches the target value. The amount of suction by 31 is controlled. When determining that the average value has reached the target value, the control means 35 instructs the actuator 33 to stop the suction by the RI syringe 31 (step 6). Steps 5 and 6 correspond to a suction stop step.

  Next, the fourth RI sensor 47D, the fifth RI sensor 47E, and the sixth RI sensor 47F of the second detection unit 39 detect (re-detect) the radioactivity intensity of the radioactive chemical stored in the outer cylinder portion 31a of the RI syringe 31. And the output value is input to the control means 35. The control means 35 calculates the average value of the output values of the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C (step 7).

  Next, the control means 35 compares the calculated average value with the target value stored in advance (step 8), and if the average value is outside the predetermined error range of the target value, the RI syringe 31 In order to discard the stored radiochemical solution, the radiochemical solution is discharged from the RI syringe 31 (step 11). On the other hand, when the average value is within a predetermined error range of the target value, the radioactive chemical stored in the outer cylinder portion 31a is discharged from the RI syringe 31 (step 9), and further from the saline syringe 27 The physiological saline is discharged and administration to the subject is performed (step 10). Steps 9 and 10 correspond to administration steps.

  When a malfunction occurs in the first detection unit 37, the radioactivity intensity of the radiopharmaceutical solution stored in the RI syringe 31 has a larger error than the predetermined radioactivity intensity required for administration. In the first administration process, the detection accuracy of the first detection unit 37 is indirectly monitored by detecting the radioactivity intensity of the radioactive drug solution by the second detection unit 39, and inappropriate administration of the radioactive drug solution is performed. It is avoiding.

  Next, a radiopharmaceutical solution administration method according to the procedure of the second administration process will be described with reference to FIG. As shown in FIG. 7, when the second administration process is started, as in the first administration process, the preparation process (step 21), the target value setting input (step 22), the aspiration of the radioactive drug solution by the RI syringe 31 (step 23) The radioactivity intensity of the radioactive chemical stored in the RI syringe 31 is detected (step 24). Steps 23 and 24 correspond to detection steps.

  Next, as in the first administration process, the control means 35 compares the average value calculated in step 24 with the target value stored in advance (step 25), and steps until the average value reaches the target value. 23 and step 24 are repeatedly executed, and the amount of suction by the RI syringe 31 is controlled. When determining that the average value has reached the target value, the control means 35 instructs the actuator 33 to stop the suction by the RI syringe 31 (step 26). Steps 25 and 26 correspond to a suction stop step.

  Thereafter, the control means 35 accepts a target value setting change as required (step 27). For example, if the initial setting input is incorrect, the handler operates the operating means (not shown) to set and input a new target value to correct the target value. When a new target value is input, the control unit 35 updates the already stored target value to the new target value. When the target value setting is not changed, the operator operates the operation means to perform an operation indicating no change. Step 27 corresponds to a target value changing step.

  Subsequently, immediately before administration to the subject, the fourth RI sensor 47D, the fifth RI sensor 47E, and the sixth RI sensor 47F of the second detection unit 39 emit the radioactive chemical solution stored in the outer cylindrical portion 31a of the RI syringe 31. The performance intensity is detected (re-detected), and the output value is input to the control means 35. The control means 35 calculates the average value of the output values of the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C (step 28). Step 28 corresponds to a re-detection step.

  Next, the control means 35 compares the average value calculated in step 28 with the target value stored in advance (step 29), and if the average value is less than the target value, instructs the actuator 33. Re-suction is performed by the RI syringe 31 (step 30). The first detection unit 37 detects the radioactivity intensity of the radioactive chemical stored in the outer cylinder portion 31 a of the RI syringe 31 by re-suction, and inputs the output value to the control means 35. The control means 35 calculates the average value of the output values of the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C (step 31). Step 29, step 30 and step 31 correspond to an adjustment amount detection step.

  Next, the control means 35 compares the average value calculated in step 31 with the target value stored in advance (step 32), and repeatedly executes steps 30 and 31 until the average value reaches the target value. . When determining that the average value has reached the target value, the control unit 35 instructs the actuator 33 to stop the re-suction by the RI syringe 31 (step 33). Step 33 corresponds to a re-suction stop step.

  Next, the control means 35 instructs the actuator 33 to discharge the radioactive chemical stored in the outer cylinder portion 31a (step 34). Further, the physiological saline is discharged from the saline syringe 27 and administered to the subject (step 35). Steps 34 and 35 correspond to administration steps.

  The radioactivity intensity of the radiopharmaceutical solution decreases with time. Therefore, the radioactivity intensity of the radiopharmaceutical solution may become less than the target value after a lapse of a predetermined time from when the suction of the radiopharmaceutical solution by the RI syringe 31 is stopped until administration to the subject. In the second administration process, the radioactivity concentration is detected in the second detection unit 39 immediately before administration to the subject (step 28). If the average value of the detected values is less than the target value, the RI syringe 31 is detected. Is re-suctioned (step 30), and the radioactivity intensity is finely adjusted. As a result, in the second administration process, even if the radioactivity intensity of the radiopharmaceutical solution decreases with time, the radioactivity intensity can be finely adjusted. Therefore, there is no waste compared with the case of re-suctioning, and the radioactive drug solution can be efficiently administered.

  In the radiopharmaceutical solution administration device 1 described above, the radiopharmaceutical solution is sucked from the vial 6 by the RI syringe 31 and temporarily stored. Then, the radioactivity intensity of the radioactive chemical stored in the RI syringe 31 is directly detected by the first detection unit 37, and the suction amount of the RI syringe 31 is controlled by the control means 35 based on the detected radioactivity intensity. Is done. Therefore, it becomes difficult to be affected by individual differences of the RI syringes 31 and the necessary amount corresponding to the predetermined radioactivity intensity required for administration can be accurately aspirated by the suction / discharge means 45. As a result, the radiopharmaceutical solution can be administered with high accuracy.

  In particular, the RI syringe 31 is fixed at a predetermined position, and the first detection unit 37 and the second detection unit 39 detect the radioactivity intensity of the radioactive chemical stored in the RI syringe 31. As a result, the first detection unit 37 and the second detection unit 39 can perform stable detection as compared with, for example, the case where the radioactivity intensity of a radioactive chemical flowing in a flexible tube is detected.

  Furthermore, the first RI sensor 47A, the second RI sensor 47B, and the third RI sensor 47C of the first detection unit 37 are aggregated along the outer cylinder portion 31a of the RI syringe 31, and the fourth RI sensor 47D, Similarly, the 5RI sensor 47E and the sixth RI sensor 47F are aggregated along the outer cylinder portion 31a of the RI syringe 31. As a result, it is possible to shield locally as compared with the case where they are arranged in a distributed manner, which is effective in reducing the size and weight.

  Further, like the first detection unit 37, the second detection unit 39 is disposed in the vicinity of the outer cylindrical portion 31a of the RI syringe 31, and stops the suction of the radioactive chemical liquid based on the output value of the first detection unit 37. In addition, the radioactivity intensity of the radiopharmaceutical solution for confirmation by the second detection unit 39 can be detected. As a result, it is effective for shortening the time from the stop of suction to administration.

  Furthermore, since the first detection unit 37 and the second detection unit 39 are provided at the same distance from the outer cylinder part 31a so as to sandwich the RI syringe 31, it is easy to perform calibration at the same time.

  Furthermore, according to the radiopharmaceutical solution administration method based on the first administration process or the second administration process, the radioactivity intensity of the radiopharmaceutical solution sucked from the vial 6 and temporarily stored is directly detected and detected. When the measured radioactivity intensity reaches the target value, the suction of the radiopharmaceutical solution is stopped, and the stored radiochemical solution is administered. Therefore, a necessary amount of the radiopharmaceutical solution corresponding to the target value can be accurately aspirated from the vial 6 and the radiopharmaceutical solution can be administered with high accuracy.

  The present invention is not limited to the above embodiment. For example, the number of RI sensors of the detection means or auxiliary detection means is not limited to three, and may be less than three or four or more. In particular, when the detection range of the RI sensor is large enough to cover the entire longitudinal direction of the outer cylindrical portion of the RI syringe, the number may be one.

It is a figure which shows typically the radioactive chemical | medical solution administration device which concerns on this invention. It is sectional drawing which shows RI syringe, a 1st detection unit, and a 2nd detection unit. It is sectional drawing along the III-III line of FIG. It is a figure which shows the table | surface which matched the liquid amount of the radioactive chemical | medical solution, and the output value detected with the 1st RI sensor, the 2nd RI sensor, and the 3rd RI sensor. FIG. 5 is a graph corresponding to FIG. 4, where (a) is the detection result of the first RI sensor, (b) is the detection result of the second RI sensor, (c) is the detection result of the third RI sensor, and (d) is the first to first sensors. It is a figure which shows the average of the output value detected by 3RI sensor. It is a flowchart which shows the procedure of a 1st administration process. It is a flowchart which shows the procedure of a 2nd administration process.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Radiopharmaceutical solution administration apparatus, 6 ... Vial (container), 31 ... RI syringe (syringe), 31a ... Outer cylinder part (cylinder part), 31b ... Pusher part (piston part), 35 ... Control means, 37 ... 1st detection unit (detection means), 39 ... 2nd detection unit (auxiliary detection means), 45 ... Intake / exhaust means, 47A ... 1st RI sensor, 47B ... 2nd RI sensor, 47C ... 3rd RI sensor, 47D ... 4th RI sensor, 47E ... 5th RI sensor, 47F ... 6th RI sensor, 49 ... 1st shield chamber (shield part), 49a ... 1st opening (opening), L ... axis line.

Claims (8)

In a radiopharmaceutical administration device that sucks and administers a required amount of the radiopharmaceutical from a radioactive drug solution container,
Inhalation and discharge means for sucking and storing the radioactive drug solution from the storage container, and discharging the stored radioactive drug solution for administration,
Control means for controlling suction and discharge of the radioactive chemical liquid by the suction and discharge means;
Detecting means for detecting the radioactivity intensity of the radioactive chemical stored in the suction and discharge means,
The radiopharmaceutical administration device characterized in that the control means controls the amount of the radiochemical liquid aspirated by the suction / exhaust means based on the radioactivity intensity detected by the detection means. Auxiliary detection means for detecting the radioactivity intensity of the radioactive chemical liquid sucked by the suction and discharge means further comprises
The control means includes
The suction and discharge of the radiopharmaceutical solution by the suction and discharge means is controlled based on the radioactivity intensity detected by the auxiliary detection means in addition to the radiation intensity detected by the detection means. Item 2. The radiopharmaceutical solution administration device according to Item 1. The suction / exhaust means is
It has a syringe that sucks and discharges the radioactive chemical liquid by a piston that slides inside the cylinder,
The detection means includes
The radiopharmaceutical administration device according to claim 1, wherein the radiopharmaceutical administration device is arranged along the cylindrical body. The detection means has a plurality of RI sensors,
The radiopharmaceutical administration device according to claim 3, wherein the plurality of RI sensors are arranged along an axis of the cylinder. And further comprising a shield part that houses the detection means and shields transmission of radiation,
The radioactive drug solution administration device according to claim 3 or 4, wherein an opening through which the radiation passes is formed in the shield part on a side facing the cylindrical body. In a method of administering a radiopharmaceutical solution, aspirating and administering a required amount of the radiopharmaceutical solution from a radioactive drug solution storage container,
Aspirating and storing the radioactive drug solution from the storage container, and detecting the radioactivity intensity of the stored radioactive drug solution;
A suction stop step of comparing the radioactivity intensity detected in the detection step with a target value, and stopping the suction of the radiopharmaceutical solution when the radioactivity intensity detected in the detection step reaches the target value. When,
An administration step of administering the stored radiopharmaceutical solution;
A method of administering a radiopharmaceutical solution. Between the suction stop step and the administration step,
A re-detection step of re-detecting the radioactivity intensity of the radioactive chemical stored in the suction stop step;
The radioactivity intensity re-detected in the re-detection step is compared with the target value, and when the radioactivity intensity detected again is less than the target value, the radioactive drug solution is re-aspirated from the storage container. An adjustment amount detection step for detecting the radioactivity intensity of the radioactive chemical stored by re-suction; and
When the radioactivity intensity detected in the adjustment amount detection step reaches the target value, a re-suction stop step for stopping re-suction of the radioactive chemical solution;
The method for administering a radiopharmaceutical solution according to claim 6, further comprising: Between the suction stop step and the re-detection step,
A target value changing step of changing the target value to a new target value;
In the adjustment amount detection step, the re-detected radioactivity intensity is compared with the new target value,
8. The re-suction stop step stops the re-suction of the radioactive drug solution when the radioactivity intensity detected in the adjustment amount detection step reaches the new target value. Administration method of radiopharmaceutical.

Images