JP6694819B2 - 表面に結合した単一特異性四量体抗体複合体の組成物を使用して、試料から標的実体を分離する方法 - Google Patents

表面に結合した単一特異性四量体抗体複合体の組成物を使用して、試料から標的実体を分離する方法 Download PDF

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JP6694819B2
JP6694819B2 JP2016547613A JP2016547613A JP6694819B2 JP 6694819 B2 JP6694819 B2 JP 6694819B2 JP 2016547613 A JP2016547613 A JP 2016547613A JP 2016547613 A JP2016547613 A JP 2016547613A JP 6694819 B2 JP6694819 B2 JP 6694819B2
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cells
antibody
target entity
monospecific
sample
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JP2017504026A (ja
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イサム コカジ，アンディー
イサム コカジ，アンディー
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ステムセル テクノロジーズ インコーポレイテッド
ステムセル テクノロジーズ インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • General Physics & Mathematics (AREA)
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  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2016547613A 2014-01-21 2015-01-21 表面に結合した単一特異性四量体抗体複合体の組成物を使用して、試料から標的実体を分離する方法 Active JP6694819B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461929581P 2014-01-21 2014-01-21
US61/929,581 2014-01-21
PCT/CA2015/000036 WO2015109389A1 (en) 2014-01-21 2015-01-21 Method for separating target entities from a sample using a composition of mono-specific tetrameric antibody complexes coupled to a surface

Publications (2)

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JP2017504026A JP2017504026A (ja) 2017-02-02
JP6694819B2 true JP6694819B2 (ja) 2020-05-20

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JP2016547613A Active JP6694819B2 (ja) 2014-01-21 2015-01-21 表面に結合した単一特異性四量体抗体複合体の組成物を使用して、試料から標的実体を分離する方法

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US (1) US9970849B2 (cg-RX-API-DMAC7.html)
EP (1) EP3097187B1 (cg-RX-API-DMAC7.html)
JP (1) JP6694819B2 (cg-RX-API-DMAC7.html)
CN (1) CN106414725B (cg-RX-API-DMAC7.html)
BR (1) BR112016016740B1 (cg-RX-API-DMAC7.html)
CA (1) CA2936914C (cg-RX-API-DMAC7.html)
IL (1) IL246834B (cg-RX-API-DMAC7.html)
WO (1) WO2015109389A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2946925C (en) * 2014-05-05 2023-08-15 Noviosmart Method for the serological diagnosis of rheumatoid arthritis.
CN107709366B (zh) * 2015-06-10 2021-10-26 干细胞技术公司 用于双功能免疫复合物的原位形成的方法
US12692308B2 (en) * 2018-06-06 2026-07-28 Stemcell Technologies Canada Inc. Kits, compositions and methods for cell enrichment
CN110514850B (zh) * 2019-07-23 2022-07-19 中国科学院苏州生物医学工程技术研究所 一种血型抗体复合物、制备方法
JP2023125973A (ja) * 2022-02-28 2023-09-07 シスメックス株式会社 測定試料の調製方法および試料調製装置
WO2024186904A2 (en) * 2023-03-06 2024-09-12 The Regents Of The University Of Colorado A Body Corporate Methods and compositions for functionalizing the surface of elastomeric particles

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230685A (en) 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
US6117985A (en) * 1995-06-16 2000-09-12 Stemcell Technologies Inc. Antibody compositions for preparing enriched cell preparations
US6008002A (en) * 1997-09-29 1999-12-28 Bodey; Bela Immunomagnetic detection and isolation of cancer cells
US7135335B2 (en) * 1999-05-28 2006-11-14 Stemcell Technologies Inc. Method for separating cells using immunorosettes
CN1218182C (zh) * 1999-05-28 2005-09-07 干细胞技术公司 利用免疫玫瑰花结分离细胞的方法
EP1227321A1 (en) 2000-12-28 2002-07-31 Institut für Bioanalytik GmbH Reversible MHC multimer staining for functional purification of antigen-specific T cells
EP1377353A4 (en) * 2001-04-10 2005-08-31 Bioergonomics Inc CELL SEPARATION COMPOSITIONS AND METHODS
US7135340B2 (en) * 2001-11-07 2006-11-14 Stemcell Technologies Inc. Tetrameric antibody complexes for blocking non-specific labeling of antigens
US20060024824A1 (en) * 2004-07-16 2006-02-02 Steven Woodside Magnetic cell separation method
CA2559513A1 (en) * 2005-09-12 2007-03-12 Stemcell Technologies Inc. Modified colony assay
GB0616508D0 (en) * 2006-08-18 2006-09-27 Iti Scotland Ltd Analyte manipulation and detection
CA2815259A1 (en) * 2010-10-27 2012-05-03 Quantibact A/S Capture of target dna and rna by probes comprising intercalator molecules
EP2597153B1 (en) 2011-11-25 2016-10-05 Miltenyi Biotec GmbH Cell separation method
EP2634195B1 (en) * 2012-03-01 2017-02-01 Miltenyi Biotec GmbH Separation of living untouched neurons
EP2970906B1 (en) * 2013-03-15 2019-08-21 Stemcell Technologies Inc. Method for separating cells using immunorosettes and magnetic particles
BR112017004270B1 (pt) * 2014-09-04 2023-03-07 Stemcell Technologies Inc Método de ativação de células t ou células nk

Also Published As

Publication number Publication date
CN106414725B (zh) 2020-12-18
IL246834B (en) 2019-06-30
CA2936914C (en) 2020-08-18
CN106414725A (zh) 2017-02-15
WO2015109389A1 (en) 2015-07-30
US9970849B2 (en) 2018-05-15
EP3097187B1 (en) 2018-07-04
IL246834A0 (en) 2016-08-31
BR112016016740A2 (cg-RX-API-DMAC7.html) 2017-08-08
CA2936914A1 (en) 2015-07-30
JP2017504026A (ja) 2017-02-02
US20150204765A1 (en) 2015-07-23
EP3097187A1 (en) 2016-11-30
BR112016016740B1 (pt) 2024-02-20
EP3097187A4 (en) 2017-01-25

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