JP6692808B2 - ドライアイ用動物モデルおよびこうした動物の使用方法 - Google Patents

ドライアイ用動物モデルおよびこうした動物の使用方法 Download PDF

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Publication number
JP6692808B2
JP6692808B2 JP2017525337A JP2017525337A JP6692808B2 JP 6692808 B2 JP6692808 B2 JP 6692808B2 JP 2017525337 A JP2017525337 A JP 2017525337A JP 2017525337 A JP2017525337 A JP 2017525337A JP 6692808 B2 JP6692808 B2 JP 6692808B2
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JP
Japan
Prior art keywords
scopolamine
administered
benzalkonium chloride
rodent
dry eye
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2017525337A
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English (en)
Japanese (ja)
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JP2018500546A (ja
JP2018500546A5 (https=
Inventor
ミン ユアン，
ミン ユアン，
イン フー，
イン フー，
ジンタイ カオ，
ジンタイ カオ，
カーメロ ロマーノ，
カーメロ ロマーノ，
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of JP2018500546A5 publication Critical patent/JP2018500546A5/ja
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medical Informatics (AREA)
  • Educational Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Educational Administration (AREA)
  • Business, Economics & Management (AREA)
  • Pure & Applied Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Mathematical Optimization (AREA)
JP2017525337A 2014-12-02 2015-12-01 ドライアイ用動物モデルおよびこうした動物の使用方法 Expired - Fee Related JP6692808B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086263P 2014-12-02 2014-12-02
US62/086,263 2014-12-02
PCT/US2015/063084 WO2016089807A1 (en) 2014-12-02 2015-12-01 Animal model for dry eye and methods of use of such animals

Publications (3)

Publication Number Publication Date
JP2018500546A JP2018500546A (ja) 2018-01-11
JP2018500546A5 JP2018500546A5 (https=) 2018-12-27
JP6692808B2 true JP6692808B2 (ja) 2020-05-13

Family

ID=55024246

Family Applications (1)

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JP2017525337A Expired - Fee Related JP6692808B2 (ja) 2014-12-02 2015-12-01 ドライアイ用動物モデルおよびこうした動物の使用方法

Country Status (14)

Country Link
US (1) US20170360013A1 (https=)
EP (1) EP3226853B1 (https=)
JP (1) JP6692808B2 (https=)
KR (1) KR20170100483A (https=)
CN (1) CN107106553A (https=)
AU (1) AU2015355169A1 (https=)
CA (1) CA2967432A1 (https=)
ES (1) ES2759729T3 (https=)
IL (1) IL252077A0 (https=)
MX (1) MX2017007295A (https=)
RU (1) RU2706787C2 (https=)
SG (1) SG11201703572SA (https=)
WO (1) WO2016089807A1 (https=)
ZA (1) ZA201703052B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190240251A1 (en) * 2016-10-14 2019-08-08 i.com medical GmbH Method for establishing, restoring, and preserving homeostasis of the ocular surface
CN112292135A (zh) 2018-04-18 2021-01-29 I.Com医疗有限责任公司 用于治疗和预防严重眼表疾病的高分子量透明质酸
US12268706B2 (en) 2019-01-31 2025-04-08 i.com medical GmbH Hyaluronic acid for relief of idiopathic ocular pain
KR102429281B1 (ko) * 2020-05-25 2022-08-05 (주)노바셀테크놀로지 신규 안구건조증 치료용 약학적 조성물
CN113519461A (zh) * 2021-07-06 2021-10-22 江西中洪博元生物技术有限公司 伴刀豆球蛋白a诱导的小鼠干眼症模型的构建方法及应用
WO2023215261A1 (en) * 2022-05-02 2023-11-09 Ocular Services On Demand, Llc Mammalian eye models

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2384679A1 (en) * 1999-09-08 2001-03-15 Srinivasan Venkateshwaran Using quaternary ammonium salts for transdermal drug delivery
WO2012013884A1 (fr) * 2010-07-29 2012-02-02 Laboratoires Fournier Sa Composes pour le traitement/la prevention des maladies inflammatoires oculaires

Also Published As

Publication number Publication date
IL252077A0 (en) 2017-07-31
AU2015355169A1 (en) 2017-05-25
ZA201703052B (en) 2019-03-27
RU2017118978A (ru) 2019-01-09
EP3226853B1 (en) 2019-09-04
RU2017118978A3 (https=) 2019-06-04
EP3226853A1 (en) 2017-10-11
SG11201703572SA (en) 2017-05-30
CN107106553A (zh) 2017-08-29
KR20170100483A (ko) 2017-09-04
JP2018500546A (ja) 2018-01-11
RU2706787C2 (ru) 2019-11-21
MX2017007295A (es) 2018-03-12
WO2016089807A1 (en) 2016-06-09
ES2759729T3 (es) 2020-05-12
CA2967432A1 (en) 2016-06-09
US20170360013A1 (en) 2017-12-21

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