CA2967432A1 - Animal model for dry eye and methods of use of such animals - Google Patents

Animal model for dry eye and methods of use of such animals Download PDF

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Publication number
CA2967432A1
CA2967432A1 CA2967432A CA2967432A CA2967432A1 CA 2967432 A1 CA2967432 A1 CA 2967432A1 CA 2967432 A CA2967432 A CA 2967432A CA 2967432 A CA2967432 A CA 2967432A CA 2967432 A1 CA2967432 A1 CA 2967432A1
Authority
CA
Canada
Prior art keywords
candidate agent
scopolamine
administered
benzalkonium chloride
dry eye
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2967432A
Other languages
English (en)
French (fr)
Inventor
Ming Yuan
Ying Hu
Jingtai Cao
Carmelo Romano
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Publication of CA2967432A1 publication Critical patent/CA2967432A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medical Informatics (AREA)
  • Educational Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Educational Administration (AREA)
  • Business, Economics & Management (AREA)
  • Pure & Applied Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Mathematical Optimization (AREA)
CA2967432A 2014-12-02 2015-12-01 Animal model for dry eye and methods of use of such animals Abandoned CA2967432A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086263P 2014-12-02 2014-12-02
US62/086,263 2014-12-02
PCT/US2015/063084 WO2016089807A1 (en) 2014-12-02 2015-12-01 Animal model for dry eye and methods of use of such animals

Publications (1)

Publication Number Publication Date
CA2967432A1 true CA2967432A1 (en) 2016-06-09

Family

ID=55024246

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2967432A Abandoned CA2967432A1 (en) 2014-12-02 2015-12-01 Animal model for dry eye and methods of use of such animals

Country Status (14)

Country Link
US (1) US20170360013A1 (https=)
EP (1) EP3226853B1 (https=)
JP (1) JP6692808B2 (https=)
KR (1) KR20170100483A (https=)
CN (1) CN107106553A (https=)
AU (1) AU2015355169A1 (https=)
CA (1) CA2967432A1 (https=)
ES (1) ES2759729T3 (https=)
IL (1) IL252077A0 (https=)
MX (1) MX2017007295A (https=)
RU (1) RU2706787C2 (https=)
SG (1) SG11201703572SA (https=)
WO (1) WO2016089807A1 (https=)
ZA (1) ZA201703052B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190240251A1 (en) * 2016-10-14 2019-08-08 i.com medical GmbH Method for establishing, restoring, and preserving homeostasis of the ocular surface
CN112292135A (zh) 2018-04-18 2021-01-29 I.Com医疗有限责任公司 用于治疗和预防严重眼表疾病的高分子量透明质酸
US12268706B2 (en) 2019-01-31 2025-04-08 i.com medical GmbH Hyaluronic acid for relief of idiopathic ocular pain
KR102429281B1 (ko) * 2020-05-25 2022-08-05 (주)노바셀테크놀로지 신규 안구건조증 치료용 약학적 조성물
CN113519461A (zh) * 2021-07-06 2021-10-22 江西中洪博元生物技术有限公司 伴刀豆球蛋白a诱导的小鼠干眼症模型的构建方法及应用
WO2023215261A1 (en) * 2022-05-02 2023-11-09 Ocular Services On Demand, Llc Mammalian eye models

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2384679A1 (en) * 1999-09-08 2001-03-15 Srinivasan Venkateshwaran Using quaternary ammonium salts for transdermal drug delivery
WO2012013884A1 (fr) * 2010-07-29 2012-02-02 Laboratoires Fournier Sa Composes pour le traitement/la prevention des maladies inflammatoires oculaires

Also Published As

Publication number Publication date
IL252077A0 (en) 2017-07-31
AU2015355169A1 (en) 2017-05-25
ZA201703052B (en) 2019-03-27
RU2017118978A (ru) 2019-01-09
EP3226853B1 (en) 2019-09-04
JP6692808B2 (ja) 2020-05-13
RU2017118978A3 (https=) 2019-06-04
EP3226853A1 (en) 2017-10-11
SG11201703572SA (en) 2017-05-30
CN107106553A (zh) 2017-08-29
KR20170100483A (ko) 2017-09-04
JP2018500546A (ja) 2018-01-11
RU2706787C2 (ru) 2019-11-21
MX2017007295A (es) 2018-03-12
WO2016089807A1 (en) 2016-06-09
ES2759729T3 (es) 2020-05-12
US20170360013A1 (en) 2017-12-21

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20220222