JP6687548B2 - 変性された潜在関連蛋白質構成物 - Google Patents
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
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| GBGB1411506.7A GB201411506D0 (en) | 2014-06-27 | 2014-06-27 | Modified latency associated protein construct |
| GB1411506.7 | 2014-06-27 | ||
| PCT/GB2015/051877 WO2015198072A1 (en) | 2014-06-27 | 2015-06-26 | Modified latency associated protein construct |
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| JP2017526625A JP2017526625A (ja) | 2017-09-14 |
| JP2017526625A5 JP2017526625A5 (enExample) | 2018-06-28 |
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| GB202004679D0 (en) | 2020-03-31 | 2020-05-13 | Stealthyx Therapeutics Ltd | Modified latercy associated protein construct |
| CN115667523A (zh) * | 2020-04-10 | 2023-01-31 | 西托姆克斯治疗公司 | 可活化细胞因子构建体和相关组合物以及方法 |
| WO2022011434A1 (en) * | 2020-07-17 | 2022-01-20 | The University Of Western Australia | Compositions and methods for the treatment of cancer |
| KR20230157448A (ko) | 2021-03-16 | 2023-11-16 | 싸이톰스 테라퓨틱스, 인크. | 마스킹된 활성화 가능한 사이토카인 작제물 및 관련 조성물 및 방법 |
| CN120603603A (zh) * | 2023-01-12 | 2025-09-05 | 瑞泽恩制药公司 | 用于靶向递送TGFβ的组合物和方法 |
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| US5284763A (en) | 1985-03-22 | 1994-02-08 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
| US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| US6942853B2 (en) * | 2001-01-09 | 2005-09-13 | Queen Mary And Westfield College | Latent fusion protein |
| AU2002243679A1 (en) * | 2001-01-24 | 2002-08-06 | Zymogenetics, Inc. | Cub domain protein zcub3 and materials and methods for making it |
| AU2006302587A1 (en) * | 2005-10-04 | 2007-04-19 | Greenville Hospital System | Latent procytotoxins and uses thereof |
| GB0724556D0 (en) | 2007-12-17 | 2008-01-30 | Queen Mary & Westfield College | LAtency associated protein construct with aggrecanase sensitive cleavage site |
| EP2377888A1 (en) * | 2010-04-07 | 2011-10-19 | Corimmun GmbH | Fusion protein |
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| EP3160992A1 (en) | 2017-05-03 |
| GB201411506D0 (en) | 2014-08-13 |
| JP2017526625A (ja) | 2017-09-14 |
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