JP6653706B2 - 血管腔サブ解像度セグメンテーション - Google Patents

血管腔サブ解像度セグメンテーション Download PDF

Info

Publication number
JP6653706B2
JP6653706B2 JP2017536972A JP2017536972A JP6653706B2 JP 6653706 B2 JP6653706 B2 JP 6653706B2 JP 2017536972 A JP2017536972 A JP 2017536972A JP 2017536972 A JP2017536972 A JP 2017536972A JP 6653706 B2 JP6653706 B2 JP 6653706B2
Authority
JP
Japan
Prior art keywords
intensity
lumen
voxel
diameter
centerline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017536972A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018501898A5 (enExample
JP2018501898A (ja
Inventor
ピンカス フレイマン，モーデカイ
ピンカス フレイマン，モーデカイ
ラマシュ，イェヒエル
ゴシェン，リラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Publication of JP2018501898A publication Critical patent/JP2018501898A/ja
Publication of JP2018501898A5 publication Critical patent/JP2018501898A5/ja
Application granted granted Critical
Publication of JP6653706B2 publication Critical patent/JP6653706B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/162—Segmentation; Edge detection involving graph-based methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/503—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/504—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/12—Edge-based segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G06T7/62—Analysis of geometric attributes of area, perimeter, diameter or volume
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10081—Computed x-ray tomography [CT]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10088—Magnetic resonance imaging [MRI]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10104—Positron emission tomography [PET]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10132—Ultrasound image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20081—Training; Learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20112—Image segmentation details
    • G06T2207/20168—Radial search
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30048—Heart; Cardiac
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30172—Centreline of tubular or elongated structure

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Quality & Reliability (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Geometry (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Image Analysis (AREA)
JP2017536972A 2015-01-16 2016-01-14 血管腔サブ解像度セグメンテーション Active JP6653706B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562104100P 2015-01-16 2015-01-16
US62/104,100 2015-01-16
PCT/IB2016/050156 WO2016113690A1 (en) 2015-01-16 2016-01-14 Vessel lumen sub-resolution segmentation

Publications (3)

Publication Number Publication Date
JP2018501898A JP2018501898A (ja) 2018-01-25
JP2018501898A5 JP2018501898A5 (enExample) 2020-01-09
JP6653706B2 true JP6653706B2 (ja) 2020-02-26

Family

ID=55273303

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017536972A Active JP6653706B2 (ja) 2015-01-16 2016-01-14 血管腔サブ解像度セグメンテーション

Country Status (5)

Country Link
US (1) US10580141B2 (enExample)
EP (1) EP3245632B1 (enExample)
JP (1) JP6653706B2 (enExample)
CN (1) CN107111876B (enExample)
WO (1) WO2016113690A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10210956B2 (en) 2012-10-24 2019-02-19 Cathworks Ltd. Diagnostically useful results in real time
WO2017199246A1 (en) 2016-05-16 2017-11-23 Cathworks Ltd. Vascular selection from images
EP3457930B1 (en) 2016-05-16 2023-11-15 Cathworks Ltd. System for vascular assessment
WO2018001099A1 (zh) * 2016-06-30 2018-01-04 上海联影医疗科技有限公司 一种血管提取方法与系统
WO2018208927A1 (en) 2017-05-09 2018-11-15 Heartflow, Inc. Systems and methods for anatomic structure segmentation in image analysis
US10885630B2 (en) 2018-03-01 2021-01-05 Intuitive Surgical Operations, Inc Systems and methods for segmentation of anatomical structures for image-guided surgery
AU2022213188A1 (en) * 2021-01-26 2023-08-10 Fluidda Respi Nv Method for dimensional measurement of a vessel
US12315076B1 (en) 2021-09-22 2025-05-27 Cathworks Ltd. Four-dimensional motion analysis of a patient's coronary arteries and myocardial wall
JP7876775B2 (ja) * 2021-10-14 2026-06-22 キヤノン株式会社 医用画像処理装置、医用画像処理方法及び医用画像処理プログラム
KR20240148399A (ko) 2022-02-10 2024-10-11 캐스웍스 엘티디. 기계 학습 기반 센서 분석 및 혈관 트리 분할을 위한 시스템 및 방법
EP4390845B1 (en) 2022-12-22 2025-07-30 Hemolens Diagnostics Spólka Z Ograniczona Odpowiedzialnoscia A computer-implemented method, computer program product and imaging system
KR20260052078A (ko) 2023-08-09 2026-04-17 캐스웍스 엘티디. 혈관 지수 측정을 위한 향상된 사용자 인터페이스 및 크로스토크 분석
IL326432A (en) 2023-08-09 2026-04-01 Cathworks Ltd Post-pci coronary analysis
JP7766752B2 (ja) * 2023-09-18 2025-11-10 オリンパスメディカルシステムズ株式会社 処置具
US12567489B2 (en) 2024-06-12 2026-03-03 Cathworks Ltd. Systems and methods for displaying distal fractional flow reserve values in vascular analysis

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2708166A1 (fr) * 1993-07-22 1995-01-27 Philips Laboratoire Electroniq Procédé de traitement d'images numérisées pour la détection automatique de sténoses.
JPH0765154A (ja) * 1993-08-31 1995-03-10 Toshiba Corp 血管像の定量解析装置及びその定量解析方法
WO1997013457A1 (en) * 1995-10-06 1997-04-17 Philips Electronics N.V. Determining a dimension from a density distribution
JP4421203B2 (ja) * 2003-03-20 2010-02-24 株式会社東芝 管腔状構造体の解析処理装置
CN1976629A (zh) * 2004-04-26 2007-06-06 D·F·杨克洛维茨 用于准确测定定向瘤变化的医学影像系统
US20060079746A1 (en) * 2004-10-11 2006-04-13 Perret Florence M Apparatus and method for analysis of tissue classes along tubular structures
US7711165B2 (en) 2005-07-28 2010-05-04 Siemens Medical Solutions Usa, Inc. System and method for coronary artery segmentation of cardiac CT volumes
DE102006002259A1 (de) * 2006-01-17 2007-07-19 Siemens Ag Verfahren zur Untersuchung von Gefäßen eines Patienten auf der Grundlage von innerhalb eines Untersuchungsbereichs mit einem Tomographiegerät erfassten Bilddaten
US7990379B2 (en) 2006-10-25 2011-08-02 Siemens Aktiengesellschaft System and method for coronary segmentation and visualization
US8077939B2 (en) * 2006-11-22 2011-12-13 General Electric Company Methods and systems for enhanced plaque visualization
EP2104453B1 (en) * 2006-11-30 2019-07-17 Koninklijke Philips N.V. Visualizing a vascular structure
US20090012382A1 (en) * 2007-07-02 2009-01-08 General Electric Company Method and system for detection of obstructions in vasculature
JP5523681B2 (ja) * 2007-07-05 2014-06-18 株式会社東芝 医用画像処理装置
EP2219520B1 (en) 2007-10-31 2012-12-12 Cabra Technology A/S Method for calculating pressures in a fluid stream through a tube section, especially a blood vessel with atherosclerotic plaque
US8126232B2 (en) 2008-03-05 2012-02-28 Siemens Aktiengesellschaft System and method for 3D vessel segmentation with minimal cuts
JP2010000306A (ja) * 2008-06-23 2010-01-07 Toshiba Corp 医用画像診断装置、画像処理装置、及びプログラム
US9171353B2 (en) * 2008-07-16 2015-10-27 Siemens Medical Solutions Usa, Inc. Multimodal image reconstruction with zonal smoothing
US8077954B2 (en) * 2008-08-04 2011-12-13 Siemens Aktiengesellschaft System and method for image processing
DE102009023504A1 (de) 2009-06-02 2010-12-09 Siemens Aktiengesellschaft Verfahren zur Bestimmung eines Abmessungswerts und Abmessungsbestimmungseinrichtung
US12426789B2 (en) * 2009-09-23 2025-09-30 Lightlab Imaging, Inc. Blood vessel lumen morphology and minimum lumen area measurements data collection by intravascular imaging systems for stenosis or stent planning
US8675941B2 (en) * 2010-09-30 2014-03-18 Siemens Aktiengesellschaft Method for visualization of airway anatomical changes
EP2665406B1 (en) * 2011-01-20 2021-03-10 University of Iowa Research Foundation Automated determination of arteriovenous ratio in images of blood vessels
US10186056B2 (en) * 2011-03-21 2019-01-22 General Electric Company System and method for estimating vascular flow using CT imaging
US8600132B2 (en) * 2011-05-03 2013-12-03 General Electric Company Method and apparatus for motion correcting medical images
US9814531B2 (en) * 2011-08-26 2017-11-14 EBM Corporation System for diagnosing bloodflow characteristics, method thereof, and computer software program
US9595079B2 (en) 2012-02-14 2017-03-14 Koninklijke Philips N.V. High resolution volumetric image generation based on super resolution post-processing and point spread function
JP6101048B2 (ja) * 2012-02-20 2017-03-22 キヤノン株式会社 画像処理装置及び画像処理方法
US9943233B2 (en) * 2012-10-24 2018-04-17 Cathworks Ltd. Automated measurement system and method for coronary artery disease scoring
US9858387B2 (en) * 2013-01-15 2018-01-02 CathWorks, LTD. Vascular flow assessment
BR112015010012A2 (pt) 2012-11-06 2017-07-11 Koninklijke Philips Nv método; e sistema
US9351698B2 (en) * 2013-03-12 2016-05-31 Lightlab Imaging, Inc. Vascular data processing and image registration systems, methods, and apparatuses
US9196037B2 (en) * 2013-03-15 2015-11-24 Wake Forest University Health Sciences Vascular territory segmentation using mutual clustering information from image space and label space
US10165955B2 (en) * 2014-02-06 2019-01-01 Reuven Gladshtein Obtaining cardiovascular parameters using arterioles related transient time
US9943277B2 (en) * 2014-04-02 2018-04-17 International Business Machines Corporation Detecting coronary stenosis through spatio-temporal tracking
SG11201707951WA (en) * 2015-03-31 2017-10-30 Agency Science Tech & Res Method and apparatus for assessing blood vessel stenosis
GB201506842D0 (en) * 2015-04-22 2015-06-03 Ucl Business Plc And Schooling Steven Locally rigid vessel based registration for laparoscopic liver surgery
JP6516597B2 (ja) * 2015-07-07 2019-05-22 キヤノン株式会社 画像処理装置及び画像処理方法
JP5890055B1 (ja) * 2015-07-09 2016-03-22 株式会社アルム 血管画像処理装置、血管画像処理プログラム、および血管画像処理方法
EP4162870B1 (en) * 2016-03-16 2024-01-31 HeartFlow, Inc. System and method for estimating a healthy lumen diameter and stenosis quantification in coronary arteries

Also Published As

Publication number Publication date
WO2016113690A1 (en) 2016-07-21
US10580141B2 (en) 2020-03-03
US20180276828A1 (en) 2018-09-27
EP3245632A1 (en) 2017-11-22
EP3245632B1 (en) 2020-07-15
CN107111876B (zh) 2021-01-05
JP2018501898A (ja) 2018-01-25
CN107111876A (zh) 2017-08-29

Similar Documents

Publication Publication Date Title
US10580141B2 (en) Vessel lumen sub-resolution segmentation
JP7191038B2 (ja) スペクトルイメージングｆｆｒ
CN105830123B (zh) 谱图像数据处理
CN104508710B (zh) 对图像数据中的选择性组织的视觉抑制
JP6484760B2 (ja) 非侵襲的血流予備量比（ｆｆｒ）に対する側副血流モデル化
US9600877B2 (en) Quantitative imaging
CN107077731B (zh) 成像不确定性的可视化
JP6645831B2 (ja) かん流撮像
JP7346418B2 (ja) 肺画像を評価するためのシステム及び方法
US10993688B2 (en) Method of data processing for computed tomography
EP3146505B1 (en) Visualization of tissue of interest in contrast-enhanced image data
Manohar et al. Regional dynamics of fractal dimension of the left ventricular endocardium from cine computed tomography images
Metz et al. GPU accelerated alignment of 3-D CTA with 2-D X-ray data for improved guidance in coronary interventions
Öksüz et al. A hybrid method for coronary artery stenoses detection and quantification in CTA images
Hachaj et al. Segmentation and visualization of tubular structures in computed tomography angiography
Giordano et al. Classification of hemodynamically significant stenoses from dynamic CT perfusion and CTA myocardial territories
Freiman et al. Automatic coronary lumen segmentation with partial volume modeling improves lesions' hemodynamic significance assessment
US10898150B2 (en) Vessel cross-sectional area measurement using CT angiography
WO2023078816A1 (en) Image processing device, medical imaging system and computer program element
CN103109308B (zh) 管状结构的管腔特性的量化
Boskamp et al. infoRAD 287

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170719

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190111

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191125

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20191125

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20191220

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20191225

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200107

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200128

R150 Certificate of patent or registration of utility model

Ref document number: 6653706

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250