JP6648033B2 - 試薬保存システム及び方法 - Google Patents
試薬保存システム及び方法 Download PDFInfo
- Publication number
- JP6648033B2 JP6648033B2 JP2016561076A JP2016561076A JP6648033B2 JP 6648033 B2 JP6648033 B2 JP 6648033B2 JP 2016561076 A JP2016561076 A JP 2016561076A JP 2016561076 A JP2016561076 A JP 2016561076A JP 6648033 B2 JP6648033 B2 JP 6648033B2
- Authority
- JP
- Japan
- Prior art keywords
- storage compartment
- reagent storage
- reagent
- valve
- reaction chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 226
- 238000003860 storage Methods 0.000 title claims description 127
- 238000000034 method Methods 0.000 title claims description 75
- 238000006243 chemical reaction Methods 0.000 claims description 105
- 238000007789 sealing Methods 0.000 claims description 44
- 230000007246 mechanism Effects 0.000 claims description 40
- 238000004519 manufacturing process Methods 0.000 claims description 26
- 239000000758 substrate Substances 0.000 claims description 23
- 239000012528 membrane Substances 0.000 claims description 22
- 238000000576 coating method Methods 0.000 claims description 15
- 239000011248 coating agent Substances 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 12
- 238000002603 single-photon emission computed tomography Methods 0.000 claims description 10
- 238000009792 diffusion process Methods 0.000 claims description 6
- 239000000700 radioactive tracer Substances 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 description 58
- 229940121896 radiopharmaceutical Drugs 0.000 description 58
- 230000002799 radiopharmaceutical effect Effects 0.000 description 58
- 239000000463 material Substances 0.000 description 34
- 239000002904 solvent Substances 0.000 description 20
- 230000015572 biosynthetic process Effects 0.000 description 13
- 238000003786 synthesis reaction Methods 0.000 description 12
- 238000012546 transfer Methods 0.000 description 11
- 238000002600 positron emission tomography Methods 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 9
- 238000003384 imaging method Methods 0.000 description 9
- 238000002955 isolation Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 238000012545 processing Methods 0.000 description 9
- 239000007789 gas Substances 0.000 description 7
- 230000002285 radioactive effect Effects 0.000 description 7
- 230000004888 barrier function Effects 0.000 description 5
- 239000011521 glass Chemical group 0.000 description 5
- 238000012879 PET imaging Methods 0.000 description 4
- 238000013019 agitation Methods 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 238000007667 floating Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000035882 stress Effects 0.000 description 4
- 239000002699 waste material Substances 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000005304 joining Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 229920002799 BoPET Polymers 0.000 description 2
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 2
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- AOYNUTHNTBLRMT-MXWOLSILSA-N 2-Deoxy-2(F-18)fluoro-2-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H]([18F])C=O AOYNUTHNTBLRMT-MXWOLSILSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000109 continuous material Substances 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229920005570 flexible polymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000009517 secondary packaging Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0015—Diaphragm or membrane valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/003—Valves for single use only
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00873—Heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
- B01J2219/00894—More than two inlets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
- B01J2219/00954—Measured properties
- B01J2219/00961—Temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
- B01J2219/00954—Measured properties
- B01J2219/00963—Pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
- B01J2219/00954—Measured properties
- B01J2219/00966—Measured properties pH
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00986—Microprocessor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
- B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Mechanical Engineering (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micromachines (AREA)
Description
Claims (13)
- 試薬を保存するためのマイクロ流体デバイスであって、
試薬を保持するように構成された試薬保存コンパートメントを含むマイクロ流体デバイスの第1の部分と、
生成物を形成するための反応プロセスに際して試薬を受け入れ、試薬を担持するように構成された反応チャンバーを含むマイクロ流体デバイスの第2の部分と、
試薬保存コンパートメントを反応チャンバーから選択的に隔離する手段であって、
前記試薬保存コンパートメントを反応チャンバーから選択的に隔離する手段が、膜を備える弁であり、
前記弁は、試薬保存コンパートメントと反応チャンバーとの間に延在する流路に対して、試薬保存コンパートメントの下流であって、反応チャンバーの上流に位置し、前記弁が、前記弁が閉じた状態の場合に試薬保存コンパートメントを反応チャンバーから隔離するように構成された、
試薬保存コンパートメントを反応チャンバーから選択的に隔離する手段と;
前記弁の上に配置された封止機構であって、
前記封止機構が、支持構造と、前記膜に接するように形成され、かつ前記膜を押し下げて弁を閉じた状態にする、支持構造から延在するクランプとを備え、
前記封止機構が、支持構造から延在してクランプの脇に位置する複数のアームを備え、
前記封止機構が前記弁の上に配置されることにより、前記支持構造がデバイスの第1の表面の近傍にあり、前記支持構造から延在する複数のアームが、デバイス中に延び、前記複数のアームの複数の端部上の突起を介して、前記弁の下の位置においてデバイスの第2の表面に係合するように構成され、弁を閉じた状態で保持する、
封止機構と;
を備える単一ユニットを含む、マイクロ流体デバイス。 - マイクロ流体デバイスが、反応プロセスの開始前に一定期間、周囲環境から、生成物を形成するために反応プロセスで利用される全ての試薬を保存し、隔離するように構成されている、請求項1に記載のマイクロ流体デバイス。
- 封止機構が、封止機構の少なくとも一部が壊れている場合にだけ、弁を開放状態にすることできるように構成されている、請求項1または2に記載のマイクロ流体デバイス。
- 第1の部分及び第2の部分が連結されて単一ユニットを形成する、請求項1乃至請求項3のいずれか1項に記載のマイクロ流体デバイス。
- 第1の部分が、第2の部分を取り外し可能に受け入れるように構成された穴を含む、請求項1乃至請求項4のいずれか1項に記載のマイクロ流体デバイス。
- 試薬保存コンパートメントからの試薬の拡散を低減するように構成された皮膜が、試薬保存コンパートメント内に配設されている、請求項1乃至請求項5のいずれか1項に記載のマイクロ流体デバイス。
- 第1の部分が、各々が異なる試薬を保存する2以上の試薬保存コンパートメントを含む、請求項1乃至請求項6のいずれか1項に記載のマイクロ流体デバイス。
- 試薬がPET又はSPECTトレーサーを生成するように構成された試薬を、試薬保存コンパートメント内に含む、請求項1乃至請求項7のいずれか1項に記載のマイクロ流体デバイス。
- 試薬を保存するためのシステムであって、
基板を形成する1以上の層と、
試薬を保存するように構成され、基板内に配置される試薬保存コンパートメントと、
試薬保存コンパートメントと反応チャンバーとの間に延在する流路を介して試薬保存コンパートメントと流体結合されている反応チャンバーであって、反応チャンバーが反応プロセスに際して試薬を保持するように構成された、反応チャンバーと、
流路を横切って試薬保存コンパートメントの下流であって、反応チャンバーの上流に配置された、試薬保存コンパートメントを反応チャンバーから選択的に隔離する手段であって、
前記試薬保存コンパートメントを反応チャンバーから選択的に隔離する手段が、膜を備える弁であり、
前記弁が閉じた状態の場合に反応チャンバーから試薬保存コンパートメントを隔離するように構成された、試薬保存コンパートメントを反応チャンバーから選択的に隔離する手段と、
前記弁の上に配置された封止機構であって、
前記封止機構が、支持構造と、前記膜に接するように形成され、かつ前記膜を押し下げて弁を閉じた状態にする、支持構造から延在するクランプとを備え、
前記封止機構が、支持構造から延在してクランプの脇に位置する複数のアームを備え、
前記封止機構が前記弁の上に配置されることにより、前記支持構造がデバイスの第1の表面の近傍にあり、前記支持構造から延在する複数のアームが、デバイス中に延び、前記複数のアームの複数の端部上の突起を介して、前記弁の下の位置においてデバイスの第2の表面に係合するように構成され、弁を閉じた状態で保持する、
封止機構と、
を含む、マイクロ流体デバイスと;
試薬保存コンパートメントから反応チャンバーへの試薬の動きを開始させるためにデバイスを操作するように構成されたインターフェースシステムと
を含む、試薬を保存するためのシステム。 - 請求項1乃至請求項8のいずれか1項に記載の試薬を保存するためのマイクロ流体デバイスを製造する方法であって、
1以上の層を有する基板を形成する工程と、
試薬保存コンパートメントを基板の内部に作製する工程であって、試薬保存コンパートメントが、入口と、試薬保存コンパートメントから試薬を輸送するように構成された流路とを有する、工程と、
入口を介して試薬を試薬保存コンパートメントに挿入する工程と、
試薬保存コンパートメントを反応チャンバーから選択的に隔離する手段を適用する工程と、
流路を封止し、試薬を試薬保存コンパートメント内に収容するために、封止機構を膜の上方に、かつ弁体を通して配置する工程と
を含む、方法。 - その中に形成された反応チャンバーを有する1以上の追加の層を流路と結び付けることを含む、請求項10に記載の方法。
- 試薬保存コンパートメントの内部の少なくとも一部に皮膜を塗工することを含み、皮膜が、試薬保存コンパートメントからの試薬の拡散を低減するように構成されている、請求項10又は請求項11に記載の方法。
- 封止機構が、入口を封止するために弁体の表面と係合する1以上の層を貫いて延びる1以上のアームを備える、請求項10乃至請求項12のいずれか1項に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/144,047 | 2013-12-30 | ||
US14/144,047 US10076751B2 (en) | 2013-12-30 | 2013-12-30 | Systems and methods for reagent storage |
PCT/EP2014/078996 WO2015101539A1 (en) | 2013-12-30 | 2014-12-22 | Systems and methods for reagent storage |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017512645A JP2017512645A (ja) | 2017-05-25 |
JP2017512645A5 JP2017512645A5 (ja) | 2017-12-28 |
JP6648033B2 true JP6648033B2 (ja) | 2020-02-14 |
Family
ID=52278640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016561076A Active JP6648033B2 (ja) | 2013-12-30 | 2014-12-22 | 試薬保存システム及び方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US10076751B2 (ja) |
EP (1) | EP3089821B1 (ja) |
JP (1) | JP6648033B2 (ja) |
CN (1) | CN106061608B (ja) |
WO (1) | WO2015101539A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9399216B2 (en) * | 2013-12-30 | 2016-07-26 | General Electric Company | Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure |
US10473668B2 (en) * | 2014-06-06 | 2019-11-12 | The Regents Of The University Of California | Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette |
WO2016130964A1 (en) | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Decapping and capping apparatus, systems and methods for use in diagnostic analyzers |
CN107129930B (zh) * | 2017-06-09 | 2019-11-26 | 北京百康芯生物科技有限公司 | 一种全集成核酸检测微流控芯片及其使用方法 |
FR3072301B1 (fr) * | 2017-10-18 | 2022-01-07 | P M B | Cassette microfluidique de synthese d'un radio-traceur et procede de synthese d'un radio-traceur avec une telle cassette |
GB201819415D0 (en) * | 2018-11-29 | 2019-01-16 | Quantumdx Group Ltd | Microfluidic apparatus and method |
US20220335240A1 (en) * | 2021-04-15 | 2022-10-20 | Microsoft Technology Licensing, Llc | Inferring Structure Information from Table Images |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3568735A (en) | 1968-06-26 | 1971-03-09 | Cooke Eng Co | Laboratory microtitration dispensing apparatus |
DE2632970A1 (de) | 1976-07-22 | 1978-01-26 | Merck Patent Gmbh | Geraet zur wiederholten reproduzierbaren abgabe von bestimmten variierbaren volumenmengen |
US4388411A (en) | 1981-04-29 | 1983-06-14 | Hewlett-Packard Company | Apparatus and method for detecting fluid |
WO1988004638A1 (en) | 1986-12-17 | 1988-06-30 | Microvol Limited | Pressurised metering dispenser |
US4925444A (en) | 1987-08-07 | 1990-05-15 | Baxter Travenol Laboratories, Inc. | Closed multi-fluid delivery system and method |
US5039863A (en) | 1988-11-15 | 1991-08-13 | Ube Industries, Ltd. | Automatic radioisotope filling apparatus |
RU2041263C1 (ru) | 1993-08-11 | 1995-08-09 | Геннадий Моисеевич Ершов | Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления |
JP3212216B2 (ja) | 1994-03-22 | 2001-09-25 | 三菱電機株式会社 | 直流電動モータ式操舵装置 |
US5632876A (en) | 1995-06-06 | 1997-05-27 | David Sarnoff Research Center, Inc. | Apparatus and methods for controlling fluid flow in microchannels |
US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US5776103A (en) | 1995-10-11 | 1998-07-07 | Science Incorporated | Fluid delivery device with bolus injection site |
US6068751A (en) | 1995-12-18 | 2000-05-30 | Neukermans; Armand P. | Microfluidic valve and integrated microfluidic system |
FI102642B1 (fi) | 1996-06-19 | 1999-01-15 | Orion Yhtymae Oyj | Reaktioastian tai vastaavan tulppa |
US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
JP3469585B2 (ja) * | 1997-05-23 | 2003-11-25 | ガメラ バイオサイエンス コーポレイション | ミクロ流体工学システムでの流動運動を駆動するために向心的加速を使用するための装置および方法 |
CA2291854A1 (en) | 1997-06-09 | 1998-12-17 | Steven A. Sundberg | Apparatus and methods for correcting for variable velocity in microfluidic systems |
US5988435A (en) | 1997-07-09 | 1999-11-23 | Barnstead/Thermolyne Corporation | Fluid dispensing system |
US5961492A (en) | 1997-08-27 | 1999-10-05 | Science Incorporated | Fluid delivery device with temperature controlled energy source |
US6120733A (en) | 1997-11-12 | 2000-09-19 | Goodman; David B. P. | Self-contained assay device |
US5957167A (en) | 1997-12-18 | 1999-09-28 | Pharmacopeia, Inc. | Article for dispensing small volumes of liquid |
US6173073B1 (en) | 1998-01-05 | 2001-01-09 | Canon Kabushiki Kaisha | System for analyzing table images |
US6318970B1 (en) | 1998-03-12 | 2001-11-20 | Micralyne Inc. | Fluidic devices |
DE19835833A1 (de) | 1998-08-07 | 2000-02-17 | Max Planck Gesellschaft | Dosierkopf zur parallelen Bearbeitung einer Vielzahl von Fluidproben |
JP3545269B2 (ja) | 1998-09-04 | 2004-07-21 | 日本碍子株式会社 | 質量センサ及び質量検出方法 |
US6794981B2 (en) | 1998-12-07 | 2004-09-21 | Honeywell International Inc. | Integratable-fluid flow and property microsensor assembly |
US6406605B1 (en) | 1999-06-01 | 2002-06-18 | Ysi Incorporated | Electroosmotic flow controlled microfluidic devices |
US6395232B1 (en) | 1999-07-09 | 2002-05-28 | Orchid Biosciences, Inc. | Fluid delivery system for a microfluidic device using a pressure pulse |
US6355024B1 (en) | 1999-07-14 | 2002-03-12 | Mallinckrodt Inc. | Medical fluid delivery system |
US6524456B1 (en) | 1999-08-12 | 2003-02-25 | Ut-Battelle, Llc | Microfluidic devices for the controlled manipulation of small volumes |
DE19949912C2 (de) | 1999-10-16 | 2003-02-27 | Karlsruhe Forschzent | Vorrichtung für eine Kraftübersetzung, Verfahren zu deren Herstellung und deren Verwendung |
US7040144B2 (en) | 2000-02-23 | 2006-05-09 | Caliper Life Sciences, Inc. | Microfluidic viscometer |
US6706538B1 (en) | 2000-02-29 | 2004-03-16 | Boston Innovation Inc. | Microvolume liquid dispensing array |
DE10022398B4 (de) | 2000-04-28 | 2011-03-17 | Eppendorf Ag | Gaspolster-Mikrodosiersystem |
DE10116674C2 (de) | 2001-04-04 | 2003-08-14 | Eppendorf Ag | Vorrichtung zur Detektion von Fluiden in einem mikrofluidischen Bauteil |
US6805841B2 (en) | 2001-05-09 | 2004-10-19 | The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Liquid pumping system |
DE10123259A1 (de) | 2001-05-12 | 2002-11-21 | Eppendorf Ag | Mikrofluidisches Speicher- und/oder Dosierbauteil |
US6880576B2 (en) * | 2001-06-07 | 2005-04-19 | Nanostream, Inc. | Microfluidic devices for methods development |
US6919058B2 (en) | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
US6631648B2 (en) | 2001-08-28 | 2003-10-14 | Wisconsin Alumni Research Foundation | Microfluidic flow sensing method and apparatus |
US7459127B2 (en) | 2002-02-26 | 2008-12-02 | Siemens Healthcare Diagnostics Inc. | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
US6877528B2 (en) | 2002-04-17 | 2005-04-12 | Cytonome, Inc. | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
US7459128B2 (en) | 2002-08-13 | 2008-12-02 | Molecular Bioproducts, Inc. | Microfluidic mixing and dispensing |
US7122153B2 (en) | 2003-01-08 | 2006-10-17 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
JP3768486B2 (ja) * | 2003-03-20 | 2006-04-19 | 株式会社エンプラス | 微小流体取扱装置 |
DE10319045A1 (de) | 2003-04-25 | 2004-12-09 | november Aktiengesellschaft Gesellschaft für Molekulare Medizin | Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten |
EP1618060A4 (en) | 2003-04-30 | 2007-03-21 | Aurora Discovery Inc | METHOD AND SYSTEM FOR ACCURATE DISTRIBUTION OF A LIQUID |
FR2855076B1 (fr) | 2003-05-21 | 2006-09-08 | Inst Curie | Dispositif microfluidique |
US7435381B2 (en) * | 2003-05-29 | 2008-10-14 | Siemens Healthcare Diagnostics Inc. | Packaging of microfluidic devices |
US7874432B2 (en) | 2004-03-23 | 2011-01-25 | Velocys | Protected alloy surfaces in microchannel apparatus and catalysts, alumina supported catalysts, catalyst intermediates, and methods of forming catalysts and microchannel apparatus |
EP1600209A1 (en) | 2004-05-29 | 2005-11-30 | Haldor Topsoe A/S | Heat exchange process and reactor |
US7305850B2 (en) * | 2004-07-23 | 2007-12-11 | Velocys, Inc. | Distillation process using microchannel technology |
US7213473B2 (en) | 2004-12-15 | 2007-05-08 | Sandia National Laboratories | Sample preparation system for microfluidic applications |
EP1707267A1 (en) | 2005-03-30 | 2006-10-04 | F. Hoffman-la Roche AG | Device having a self sealing fluid port |
CN101146607A (zh) * | 2005-03-31 | 2008-03-19 | 柯尼卡美能达医疗印刷器材株式会社 | 逆流防止结构、使用该结构的检查用微型芯片以及检查装置 |
DE102005045393B4 (de) | 2005-09-23 | 2017-01-05 | Drägerwerk AG & Co. KGaA | Verfahren zum Dosieren von Lösungen |
CA2624243C (en) | 2005-09-29 | 2013-12-31 | Siemens Medical Solutions Usa, Inc. | Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography |
KR101306214B1 (ko) | 2005-10-24 | 2013-09-09 | 미쓰이 가가쿠 가부시키가이샤 | 마이크로칩 디바이스 |
TWI272374B (en) | 2005-11-29 | 2007-02-01 | Ind Tech Res Inst | Flow measurement device and manufacture method thereof |
WO2008002462A2 (en) * | 2006-06-23 | 2008-01-03 | Micronics, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
DE102006001881A1 (de) | 2006-01-13 | 2007-07-19 | Roche Diagnostics Gmbh | Verpackungskassette für Reagenzienträger |
US7862000B2 (en) | 2006-02-03 | 2011-01-04 | California Institute Of Technology | Microfluidic method and structure with an elastomeric gas-permeable gasket |
DE102006006706A1 (de) | 2006-02-13 | 2007-08-23 | Rheinisch-Westfälische Technische Hochschule Aachen | Mikroventil |
US7741121B2 (en) | 2006-08-24 | 2010-06-22 | Siemens Medical Solutions Usa, Inc. | System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices |
US7790118B2 (en) * | 2006-10-18 | 2010-09-07 | California Institute Of Technology | Microfluidic devices and related methods and systems |
WO2008076395A2 (en) | 2006-12-14 | 2008-06-26 | The Trustees Of The University Of Pennsylvania | Mechanically actuated diagnostic device |
US8728413B2 (en) | 2007-02-08 | 2014-05-20 | Biokit, S.A. | Reagent container pack |
US7628082B2 (en) | 2007-06-25 | 2009-12-08 | Integrated Sensing Systems, Inc. | Microfluidic device and microtube therefor |
DE102008002675B4 (de) | 2008-06-26 | 2014-11-06 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Abdichteinrichtung zur Verwendung in einem Probeaufbereitungschip sowie Verfahren zu deren Herstellung |
DK2376226T3 (en) | 2008-12-18 | 2018-10-15 | Opko Diagnostics Llc | IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES |
US8435454B2 (en) | 2009-07-09 | 2013-05-07 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
GB0913903D0 (en) | 2009-08-10 | 2009-09-16 | Forensic Science Service Ltd | Improvements in and relating to sample handling |
WO2011044474A1 (en) * | 2009-10-08 | 2011-04-14 | Ge Healthcare Limited | Chromatography components |
EP2488293A4 (en) * | 2009-10-15 | 2018-05-23 | The Regents of The University of California | Digital microfluidic platform for radiochemistry |
GB2474888A (en) | 2009-10-30 | 2011-05-04 | Univ Dublin City | Microfluidic devices with degassing driven fluid flow |
WO2011082276A1 (en) | 2009-12-31 | 2011-07-07 | General Electric Company | Microvalve |
DE102010003223B4 (de) | 2010-03-24 | 2014-09-18 | Albert-Ludwigs-Universität Freiburg | Vorrichtung zum Einsetzen in einen Rotor einer Zentrifuge, Zentrifuge und Verfahren zum fluidischen Koppeln von Kavitäten |
US8911689B2 (en) | 2010-07-27 | 2014-12-16 | General Electric Company | Interfacing caps for microfluidic devices and methods of making and using the same |
US8961906B2 (en) | 2010-07-27 | 2015-02-24 | General Electric Company | Fluid connector devices and methods of making and using the same |
EP2613880B1 (en) | 2010-09-09 | 2014-09-17 | Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. | Microfluidic device, microfluidic dosing system and method for microfluidic dosing |
US20130000758A1 (en) * | 2011-06-30 | 2013-01-03 | Agilent Technologies, Inc. | Microfluidic device and external piezoelectric actuator |
US20130000759A1 (en) * | 2011-06-30 | 2013-01-03 | Agilent Technologies, Inc. | Microfluidic device and external piezoelectric actuator |
US9492990B2 (en) | 2011-11-08 | 2016-11-15 | Picosys Incorporated | Room temperature glass-to-glass, glass-to-plastic and glass-to-ceramic/semiconductor bonding |
US9475025B2 (en) | 2011-12-29 | 2016-10-25 | General Electric Company | Microfluidic handling system |
EP2802417B1 (en) * | 2012-01-09 | 2019-05-15 | Micronics, Inc. | Microfluidic reactor system |
-
2013
- 2013-12-30 US US14/144,047 patent/US10076751B2/en active Active
-
2014
- 2014-12-22 EP EP14821641.9A patent/EP3089821B1/en active Active
- 2014-12-22 WO PCT/EP2014/078996 patent/WO2015101539A1/en active Application Filing
- 2014-12-22 CN CN201480076549.7A patent/CN106061608B/zh active Active
- 2014-12-22 JP JP2016561076A patent/JP6648033B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
WO2015101539A1 (en) | 2015-07-09 |
CN106061608A (zh) | 2016-10-26 |
EP3089821A1 (en) | 2016-11-09 |
EP3089821B1 (en) | 2021-08-25 |
US20150182963A1 (en) | 2015-07-02 |
JP2017512645A (ja) | 2017-05-25 |
US10076751B2 (en) | 2018-09-18 |
CN106061608B (zh) | 2019-09-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6648033B2 (ja) | 試薬保存システム及び方法 | |
KR101321658B1 (ko) | 폐쇄 용기에서 샘플을 처리하기 위한 시스템 및 방법, 및관련 소자 | |
CN106414348A (zh) | 具有多个传感器的单次使用的生物反应器端口 | |
TWI447393B (zh) | 反應晶片及其製造方法 | |
ES2629289T3 (es) | Placa de reacción | |
CN102686316A (zh) | 用于样本分析的集成铰链匣壳体 | |
JP6216451B2 (ja) | 生化学用試薬類保存デバイス、及び生化学用分析装置 | |
US20160001246A1 (en) | Modular cassette synthesis unit | |
CN104427929A (zh) | 包括仪器以及料盒的临床诊断系统 | |
JP5912582B2 (ja) | 包材入り液体試薬内蔵型マイクロチップおよびその使用方法 | |
JP2014503426A (ja) | ブリスタ包装材に液体を充填する方法及び液体を充填するためのキャビティを備えたブリスタ包装材 | |
WO2018012429A1 (ja) | 流体デバイス、流体デバイスの製造方法、及び流体デバイス用のバルブ | |
US11236298B2 (en) | System for use in bioprocessing | |
JP6850794B2 (ja) | メソ流体および/またはマイクロ流体プロセス用のデバイスおよび方法 | |
JP5702976B2 (ja) | 検体検出装置 | |
JP2010094540A (ja) | 医療用薬液封入物の製造方法及びそのための容器 | |
US20150064071A1 (en) | Disposable Module For Device For Synthesizing Radioisotopes And Process For Manufacturing Said Module | |
JP2015507602A (ja) | 区画反応器 | |
US20200049288A1 (en) | Functionalized Unitary Molded Manifolds For Closed Fluid Handling Systems | |
US20080305556A1 (en) | Chemical reaction cartridge and method of using the same | |
JP4552548B2 (ja) | 逐次移送式反応槽、逐次移送式反応槽の製造方法及び逐次移送式反応槽を用いた試験方法 | |
CN110234577A (zh) | 集成流体模块和测试装置 | |
JP2024059629A (ja) | 流体デバイス | |
JP2022515474A (ja) | 滅菌監視のための多層テストパック | |
He et al. | Controlled release of drugs with nanostructured capsules in microdroplets |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171120 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20171120 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20181225 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190108 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190315 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20190607 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190708 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20191217 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200115 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6648033 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |