JP6638096B2 - 用量測定システム及び方法 - Google Patents

用量測定システム及び方法 Download PDF

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Publication number
JP6638096B2
JP6638096B2 JP2018567096A JP2018567096A JP6638096B2 JP 6638096 B2 JP6638096 B2 JP 6638096B2 JP 2018567096 A JP2018567096 A JP 2018567096A JP 2018567096 A JP2018567096 A JP 2018567096A JP 6638096 B2 JP6638096 B2 JP 6638096B2
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Prior art keywords
electromagnetic radiation
light guide
sensors
delivery device
drug delivery
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Japanese (ja)
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JP2019527818A (ja
Inventor
ホエーリー,リチャード
シフラニック,ケビン
ルグラン,マシュー
ホワイト,ジェームス
カロザース,ジェフリー
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コモン センシング インコーポレイテッド
コモン センシング インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31535Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
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    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
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    • A61M5/16886Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body for measuring fluid flow rate, i.e. flowmeters
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    • GPHYSICS
    • G01MEASURING; TESTING
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    • G01F11/021Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/025Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01FMEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F17/00Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01FMEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
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    • G01F23/22Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
    • G01F23/28Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
    • G01F23/284Electromagnetic waves
    • G01F23/2845Electromagnetic waves for discrete levels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01FMEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/22Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
    • G01F23/28Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
    • G01F23/284Electromagnetic waves
    • G01F23/292Light, e.g. infrared or ultraviolet
    • G01F23/2921Light, e.g. infrared or ultraviolet for discrete levels
    • G01F23/2922Light, e.g. infrared or ultraviolet for discrete levels with light-conducting sensing elements, e.g. prisms
    • G01F23/2925Light, e.g. infrared or ultraviolet for discrete levels with light-conducting sensing elements, e.g. prisms using electrical detecting means
    • G01F23/2927Light, e.g. infrared or ultraviolet for discrete levels with light-conducting sensing elements, e.g. prisms using electrical detecting means for several discrete levels, e.g. with more than one light-conducting sensing element
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    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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    • GPHYSICS
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    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Thermal Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
JP2018567096A 2016-07-15 2017-07-13 用量測定システム及び方法 Active JP6638096B2 (ja)

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US201662362946P 2016-07-15 2016-07-15
US62/362,946 2016-07-15
PCT/US2017/041982 WO2018013843A1 (en) 2016-07-15 2017-07-13 Dose measurement systems and methods

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EP (2) EP4361580A3 (enExample)
JP (2) JP6638096B2 (enExample)
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DK (1) DK3485237T3 (enExample)
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Publication number Priority date Publication date Assignee Title
US8817258B2 (en) 2012-05-21 2014-08-26 Common Sensing Inc. Dose measurement system and method
US9255830B2 (en) 2012-05-21 2016-02-09 Common Sensing Inc. Dose measurement system and method
CA2952167C (en) 2014-06-13 2023-06-13 Aterica Inc. System and device for management of medication delivery devices
WO2016019375A1 (en) 2014-08-01 2016-02-04 Common Sensing Inc. Liquid measurement systems, apparatus, and methods optimized with temperature sensing
EP3407940A4 (en) 2016-01-29 2019-09-04 Companion Medical, Inc. PURPOSES OF AUTOMATIC DRUG DISPOSAL
DK3485237T3 (da) 2016-07-15 2024-02-26 Bigfoot Biomedical Inc Dosismålesystemer
CN106291507B (zh) * 2016-07-21 2018-10-30 京东方科技集团股份有限公司 检测光测距装置及测距方法
JP6790950B2 (ja) * 2017-03-22 2020-11-25 Tdk株式会社 状態検出装置
GB201718859D0 (en) * 2017-11-15 2017-12-27 Smith & Nephew Sensor positioning for sensor enabled wound therapy dressings and systems
US11464459B2 (en) 2017-12-12 2022-10-11 Bigfoot Biomedical, Inc. User interface for diabetes management systems including flash glucose monitor
US11083852B2 (en) 2017-12-12 2021-08-10 Bigfoot Biomedical, Inc. Insulin injection assistance systems, methods, and devices
US11077243B2 (en) 2017-12-12 2021-08-03 Bigfoot Biomedical, Inc. Devices, systems, and methods for estimating active medication from injections
WO2019118531A2 (en) 2017-12-12 2019-06-20 Bigfoot Biomedical, Inc. Therapy assist information and/or tracking device and related methods and systems
US11197964B2 (en) 2017-12-12 2021-12-14 Bigfoot Biomedical, Inc. Pen cap for medication injection pen having temperature sensor
US10987464B2 (en) 2017-12-12 2021-04-27 Bigfoot Biomedical, Inc. Pen cap for insulin injection pens and associated methods and systems
US11116899B2 (en) 2017-12-12 2021-09-14 Bigfoot Biomedical, Inc. User interface for diabetes management systems and devices
EP3545991A1 (en) 2018-03-29 2019-10-02 Tecpharma Licensing AG Power supply for drug delivery systems
EP3545992A1 (en) 2018-03-29 2019-10-02 Tecpharma Licensing AG State estimation for drug delivery systems
EP3545993A1 (en) * 2018-03-29 2019-10-02 Tecpharma Licensing AG Status indicator for drug delivery systems
ES2978417T3 (es) * 2018-04-19 2024-09-12 Lilly Co Eli Sistema detector de estado para dispositivo de inyección
EP3793646A1 (en) 2018-05-18 2021-03-24 Novo Nordisk A/S Drug delivery assembly with information capture
AU2019281223A1 (en) * 2018-06-07 2021-01-28 St Andrews Pharmaceutical Technology Ltd Apparatus and a method for the use of pulsed electromagnetic field to change the condition of a product and/or the generation of said product
NL2021179B1 (en) 2018-06-26 2020-01-06 Eriks N V Fill level detection in plunger fluid containers
CN109115300B (zh) * 2018-08-06 2020-04-07 重庆恒中能源装备有限公司 一种抗震远程液位计u型管
CH715259A1 (de) * 2018-08-16 2020-02-28 Wilco Ag Verfahren und Vorrichtung zur Inspektion eines Zustands einer auf einer Spritze aufgesetzten Kanüle.
WO2020061100A1 (en) * 2018-09-17 2020-03-26 Rx Bandz, Llc Miniaturized wearable medication administration device
US12205699B1 (en) 2018-10-30 2025-01-21 Bigfoot Biomedical, Inc. Method of pairing therapy devices using shared secrets, and related systems, methods and devices
US20200240826A1 (en) * 2019-01-28 2020-07-30 Battelle Memorial Institute Fluid end of life sensors
US11948671B2 (en) 2019-04-11 2024-04-02 Medtronic Minimed, Inc. Intelligent accessories for medicine dispensing device
TWI701057B (zh) * 2019-07-12 2020-08-11 廣達電腦股份有限公司 注射裝置的記錄裝置
CN114728123B (zh) * 2019-09-25 2025-02-14 杨森制药公司 被配置成确定药物给药方案的药物施用系统
EP4072632A1 (en) * 2019-12-11 2022-10-19 Sanofi Modular system for a drug delivery device with electronic and corresponding modules and method
KR20220144835A (ko) * 2020-02-25 2022-10-27 베링거 인겔하임 인터내셔날 게엠베하 주사 디바이스 및 이를 위한 재사용 가능 부품
EP3928815A1 (en) * 2020-06-22 2021-12-29 Becton Dickinson France Sensor assembly and system
AU2021318491B2 (en) * 2020-07-28 2024-12-19 Eli Lilly And Company Methods and apparatus for aspects of a dose detection system module for a medication delivery device
EP4085946A1 (en) * 2021-05-03 2022-11-09 medmix Switzerland AG Method for identifying a drug delivery device, set of a drug delivery device and an electronic device for identifying a drug delivery device
JP7705548B2 (ja) * 2021-07-30 2025-07-09 イーライ リリー アンド カンパニー 用量関連データを伴う医療デバイスからの無線ブロードキャストパケットを処理するための技法
GB2623937A (en) * 2022-08-24 2024-05-08 Pa Knowledge Ltd System and method
CN116764034A (zh) * 2023-07-12 2023-09-19 江苏德尔福医疗器械有限公司 注射器用的控制系统、注射器及其注射方法
CN119302046A (zh) * 2023-12-29 2025-01-10 深圳木芯科技有限公司 检测仪和灭菌系统

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2807527C3 (de) 1978-02-22 1980-09-11 Goetze Ag, 5093 Burscheid Verfahren zum Impfen oder Veredeln von Metallschmelzen
US4623248A (en) * 1983-02-16 1986-11-18 Abbott Laboratories Apparatus and method for determining oxygen saturation levels with increased accuracy
JPS60259935A (ja) * 1984-06-07 1985-12-23 Komatsugawa Kakoki Kk 濁度計
US4857738A (en) 1987-12-18 1989-08-15 General Signal Corporation Absorption measurements of materials
US4904878A (en) 1988-08-12 1990-02-27 Caterpillar Inc. Multi-point refractive liquid level sensor
US4952055A (en) 1988-10-03 1990-08-28 Wyatt Technology Corporation Differential refractometer
EP0393144A4 (en) 1988-10-20 1992-08-12 Conax Buffalo Corporation Optical liquid level sensors
US5402241A (en) * 1989-03-30 1995-03-28 The Foxboro Company Optical probe for fluid light transmission properties
US5303585A (en) 1991-10-31 1994-04-19 Jtl Medical Corporation Fluid volume sensor
US5184510A (en) 1991-12-23 1993-02-09 Ford Motor Company Liquid level sensor
US5569212A (en) 1994-07-22 1996-10-29 Raya Systems, Inc. Apparatus for electrically determining injection doses in syringes
US5782814A (en) 1994-07-22 1998-07-21 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical inductance
US6068615A (en) 1994-07-22 2000-05-30 Health Hero Network, Inc. Inductance-based dose measurement in syringes
US5452076A (en) 1993-09-29 1995-09-19 Optiguard, Inc. Fluid detection system
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
US5606125A (en) 1994-06-28 1997-02-25 Lyons; Kevin Material level-interface control system
US5792117A (en) 1994-07-22 1998-08-11 Raya Systems, Inc. Apparatus for optically determining and electronically recording injection doses in syringes
US6110148A (en) 1994-07-22 2000-08-29 Health Hero Network, Inc. Capacitance-based dose measurements in syringes
US5720733A (en) 1994-07-22 1998-02-24 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical capacitance measurements
US5556002A (en) 1995-02-03 1996-09-17 Abc Techcorp Measured liquid dispensing system
AU696439B2 (en) 1995-03-07 1998-09-10 Eli Lilly And Company Recyclable medication dispensing device
JPH08297036A (ja) * 1995-04-25 1996-11-12 Hayashi Telempu Co Ltd 輝光型表示指針
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
US5748091A (en) 1996-10-04 1998-05-05 Mcdonnell Douglas Corporation Fiber optic ice detector
US6270455B1 (en) 1997-03-28 2001-08-07 Health Hero Network, Inc. Networked system for interactive communications and remote monitoring of drug delivery
US6090473A (en) * 1997-06-24 2000-07-18 Bridgestone Corporation Electromagnetic-wave shielding and light transmitting plate
GB9807020D0 (en) 1998-04-02 1998-06-03 Bamford Excavators Ltd A method of marking a mechanical element, an encoding scheme, a reading means for said marking and an apparatus for determining the position of said element
EP1956365B1 (en) 1998-08-26 2013-01-23 Sensors for Medicine and Science, Inc. Optical-based sensing devices
JP2000279515A (ja) 1999-03-29 2000-10-10 Oi Shoji Kk 点滴状況監視装置
AU2001249105A1 (en) 2000-03-07 2001-09-17 Honeywell International, Inc. Apparatus and method for measuring the level of a fluid
EP1265659A4 (en) 2000-03-22 2006-12-13 Docusys Inc DRUG DELIVERY AND MONITORING SYSTEM
CN1471980A (zh) * 2002-06-06 2004-02-04 西门子公司 注射系统
EP1382946A1 (en) 2002-07-15 2004-01-21 Product Innovation Limited Level sensors
EP1526885B1 (en) 2002-07-24 2006-12-06 Deka Products Limited Partnership Optical displacement sensor for infusion devices
WO2004024217A1 (de) 2002-08-31 2004-03-25 Disetronic Licensing Ag Verabreichungsvorrichtung mit temperatursensor
AU2004286716B2 (en) 2003-11-06 2010-03-25 Lifescan, Inc. Drug delivery pen with event notification means
EP1692498B1 (en) 2003-11-26 2017-12-27 Separation Technology, Inc. Method and apparatus for ultrasonic determination of hematocrit and hemoglobin concentration
US7408632B2 (en) 2004-02-20 2008-08-05 Transform Pharmaceuticals, Inc. Miscibility determination of a combination of liquids
US7049622B1 (en) * 2004-04-09 2006-05-23 Sandia Corporation Optical position sensor for determining the interface between a clear and an opaque fluid
US20070109640A1 (en) 2004-10-05 2007-05-17 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Refractive boundary elements, devices, and materials
US8221356B2 (en) 2004-10-21 2012-07-17 Novo Nordisk A/S Medication delivery system with a detector for providing a signal indicative of an amount of a set and/or ejected dose of drug
US7604985B2 (en) 2004-11-10 2009-10-20 Becton, Dickinson And Company System and method for determining fill volume in a container
WO2006051847A1 (ja) 2004-11-12 2006-05-18 The New Industry Research Organization Hiv等のウイルス感染の有無、又はプリオン感染の有無を近赤外線分光法により検査・判定する方法、及び同方法に使用する装置
US7181361B2 (en) 2005-01-14 2007-02-20 Flying J, Inc. Collecting and communicating temperature and volume data directly from a dispenser
US7499581B2 (en) 2005-02-10 2009-03-03 Forhealth Technologies, Inc. Vision system to calculate a fluid volume in a container
FR2885071B1 (fr) 2005-04-28 2010-02-12 Becton Dickinson France Procede d'identification d'un contenant et/ou d'un article fini obtenu a partir dudit contenant, en particulier a usage medical
DE602006019712D1 (enExample) 2005-05-10 2011-03-03 Novo Nordisk As
US8034296B2 (en) 2005-07-01 2011-10-11 Honeywell International Inc. Microfluidic card for RBC analysis
US7212953B1 (en) 2005-12-09 2007-05-01 Dresser, Inc. Portable diagnostic analysis of gas meter and electronic corrector
US7772008B2 (en) 2006-01-06 2010-08-10 Artel, Inc. Method and apparatus for determining liquid volume
DE102006047537B4 (de) 2006-10-07 2024-05-16 Sanofi-Aventis Deutschland Gmbh Verfahren und Vorrichtung zur Bestimmung der Position eines Stopfens einer Ampulle für ein Arzneimittel in einem medizinischen Gerät sowie deren Verwendung, ein entsprechendes medizinisches Gerät sowie Herstellung eines medizinischen Geräts
US9022970B2 (en) 2006-10-16 2015-05-05 Alcon Research, Ltd. Ophthalmic injection device including dosage control device
EP1920793A1 (de) 2006-11-10 2008-05-14 F.Hoffmann-La Roche Ag Optische Postitionserkennung des Stopfens einer Ampulle
US8079245B1 (en) 2007-01-19 2011-12-20 EnerTrac, Inc. Fuel oil and propane monitoring, delivery and sale system and method
EP2125083B1 (en) 2007-03-21 2013-08-21 Novo Nordisk A/S A medical delivery system having container recognition and container for use with the medical delivery system
US8582107B2 (en) 2007-06-02 2013-11-12 Allan Bruce Shang Method and system for detecting the level of anesthesia agent in an anesthesia vaporizer
CN102170929B (zh) * 2008-10-01 2014-03-26 诺沃—诺迪斯克有限公司 具有监测设备的医疗组件
US8983677B2 (en) 2008-10-01 2015-03-17 Honeywell International Inc. Acoustic fingerprinting of mechanical devices
JP5562969B2 (ja) 2008-11-06 2014-07-30 ノボ・ノルデイスク・エー/エス 電子的に支援された薬剤送達装置
US20100134303A1 (en) 2008-12-02 2010-06-03 Perkins James T Fluid level detector for an infusion fluid container
US8463083B2 (en) 2009-01-30 2013-06-11 Claudio Oliveira Egalon Side illuminated multi point multi parameter optical fiber sensor
US8136966B2 (en) 2009-02-26 2012-03-20 Cssn Inc. Light mixing chamber
CA2753139C (en) 2009-02-27 2017-10-24 Lifescan, Inc. Drug delivery management systems and methods
KR101749480B1 (ko) * 2009-03-31 2017-06-20 주식회사 쿠라레 발광체
WO2011004319A1 (en) * 2009-07-08 2011-01-13 Koninklijke Philips Electronics N.V. Apparatuses and methods for managing liquid volume in a container
US8773660B2 (en) 2009-09-18 2014-07-08 Sanofi—Aventis Deutschland GmbH Arrangement for determining a longitudinal position of a stopper
WO2011084713A1 (en) 2009-12-17 2011-07-14 Glumetrics, Inc. Glucose sensor and controller with user selectable output
EP2526986B1 (en) 2010-03-01 2016-11-30 Panasonic Healthcare Holdings Co., Ltd. Medicine administering device
US8269977B2 (en) 2010-05-26 2012-09-18 Gerard A Alphonse Discrete spectrum broadband optical source
DE102010045212A1 (de) 2010-09-13 2012-03-15 Audi Ag Messeinrichtung und Verfahren zum Ermitteln eines Flüssigkeitsfüllstands in einem Kraftstofftank
WO2012062843A1 (en) 2010-11-12 2012-05-18 Sanofi-Aventis Deutschland Gmbh Drug delivery device and method for a drug delivery device
KR102162031B1 (ko) 2011-01-05 2020-10-07 노엠 레빈 유량계
EP2688607A1 (en) 2011-03-22 2014-01-29 Sanofi-Aventis Deutschland GmbH Service and maintenance station for handheld drug delivery device
NL2007149C2 (nl) 2011-07-20 2013-01-22 Lely Patent Nv Sensorsysteem, sensorinrichting daarmee, en melkdierbehandelingsinrichting daarmee.
US9033923B2 (en) 2011-07-25 2015-05-19 Nestec S.A. Infrared reflective air-in-line sensor system
US8618485B1 (en) 2011-09-23 2013-12-31 The United States Of America As Represented By The Secretary Of The Navy Detection of discontinuity densities in composite materials
CN103889488B (zh) * 2011-10-28 2017-03-01 皇家飞利浦有限公司 对气溶胶流的分析与控制
WO2013073650A1 (ja) 2011-11-20 2013-05-23 日本ケミカルリサーチ株式会社 温度測定部付き注射装置
CN102645253B (zh) 2012-04-26 2014-06-18 宝力马(苏州)传感技术有限公司 一种光电式连续液位测量方法及装置
US9255830B2 (en) 2012-05-21 2016-02-09 Common Sensing Inc. Dose measurement system and method
US8817258B2 (en) * 2012-05-21 2014-08-26 Common Sensing Inc. Dose measurement system and method
EP2911717B1 (en) * 2012-10-23 2019-05-22 Insuline Medical Ltd. Drug dispensing-tracking device, system and method
FR3004252B1 (fr) 2013-04-04 2015-11-06 Areva Np Procede d'etalonnage d'un capteur de niveau
WO2015143058A1 (en) * 2014-03-21 2015-09-24 Osprey Medical, Inc. Syringe with optical system for monitoring the position of the plunger rod
US20150362350A1 (en) 2014-05-09 2015-12-17 Marqmetrix, Inc. External Sensing Device for Machine Fluid Status and Machine Operation Status
WO2016019375A1 (en) 2014-08-01 2016-02-04 Common Sensing Inc. Liquid measurement systems, apparatus, and methods optimized with temperature sensing
KR20170036066A (ko) 2014-09-02 2017-03-31 일라이 릴리 앤드 캄파니 의료용 유체 용기 내의 피스톤을 검출하기 위한 감지 시스템
DE102014118854A1 (de) * 2014-12-17 2016-06-23 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung zur Bestimmung einer die Flüssigkeitsmenge repräsentierenden Größe sowie deren Verwendung
CA3020577C (en) * 2016-05-19 2023-08-01 Trudell Medical International Smart valved holding chamber
DK3485237T3 (da) 2016-07-15 2024-02-26 Bigfoot Biomedical Inc Dosismålesystemer
US10371559B2 (en) * 2017-04-17 2019-08-06 The Boeing Company Differential spectral liquid level sensor

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