JP6601844B2 - 光安定性に優れたミルタザピン含有医薬製剤 - Google Patents
光安定性に優れたミルタザピン含有医薬製剤 Download PDFInfo
- Publication number
- JP6601844B2 JP6601844B2 JP2016235957A JP2016235957A JP6601844B2 JP 6601844 B2 JP6601844 B2 JP 6601844B2 JP 2016235957 A JP2016235957 A JP 2016235957A JP 2016235957 A JP2016235957 A JP 2016235957A JP 6601844 B2 JP6601844 B2 JP 6601844B2
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- Prior art keywords
- mirtazapine
- tablet
- preparation
- weight
- tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title claims description 47
- 229960001785 mirtazapine Drugs 0.000 title claims description 44
- 239000000825 pharmaceutical preparation Substances 0.000 title description 19
- 238000002360 preparation method Methods 0.000 claims description 41
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 33
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 29
- 239000006191 orally-disintegrating tablet Substances 0.000 claims description 27
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 19
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 claims description 19
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 12
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
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- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
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- 239000003826 tablet Substances 0.000 description 70
- 239000003795 chemical substances by application Substances 0.000 description 19
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 13
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016235957A JP6601844B2 (ja) | 2016-12-05 | 2016-12-05 | 光安定性に優れたミルタザピン含有医薬製剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016235957A JP6601844B2 (ja) | 2016-12-05 | 2016-12-05 | 光安定性に優れたミルタザピン含有医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018090541A JP2018090541A (ja) | 2018-06-14 |
| JP2018090541A5 JP2018090541A5 (enrdf_load_stackoverflow) | 2019-02-28 |
| JP6601844B2 true JP6601844B2 (ja) | 2019-11-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016235957A Expired - Fee Related JP6601844B2 (ja) | 2016-12-05 | 2016-12-05 | 光安定性に優れたミルタザピン含有医薬製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6601844B2 (enrdf_load_stackoverflow) |
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|---|---|---|---|---|
| JP7713140B2 (ja) * | 2021-02-04 | 2025-07-25 | トーアエイヨー株式会社 | タダラフィルを含有する錠剤及びその製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI256309B (en) * | 1999-10-13 | 2006-06-11 | Akzo Nobel Nv | New formulation of mirtazapine |
| CN1863517B (zh) * | 2003-10-07 | 2011-08-03 | 安壮奇制药公司 | 快速崩解制剂 |
| JP2012001460A (ja) * | 2010-06-15 | 2012-01-05 | Ohara Yakuhin Kogyo Kk | 光過敏性薬物の安定化法 |
| JP6243265B2 (ja) * | 2014-03-20 | 2017-12-06 | 日医工株式会社 | ロスバスタチン含有医薬製剤 |
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