JP6576439B2 - 電気的駆動で流量を制御する少なくとも１つの弁を有するフローアッセイとその方法 - Google Patents
電気的駆動で流量を制御する少なくとも１つの弁を有するフローアッセイとその方法 Download PDFInfo
- Publication number
- JP6576439B2 JP6576439B2 JP2017514894A JP2017514894A JP6576439B2 JP 6576439 B2 JP6576439 B2 JP 6576439B2 JP 2017514894 A JP2017514894 A JP 2017514894A JP 2017514894 A JP2017514894 A JP 2017514894A JP 6576439 B2 JP6576439 B2 JP 6576439B2
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- flow assay
- hydrophobic layer
- layer
- gap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000003556 assay Methods 0.000 title claims description 170
- 238000000034 method Methods 0.000 title claims description 46
- 230000002209 hydrophobic effect Effects 0.000 claims description 198
- 239000012491 analyte Substances 0.000 claims description 96
- 239000000463 material Substances 0.000 claims description 59
- 238000006243 chemical reaction Methods 0.000 claims description 22
- 230000004913 activation Effects 0.000 claims description 17
- 239000011148 porous material Substances 0.000 claims description 16
- 230000004044 response Effects 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 239000007795 chemical reaction product Substances 0.000 claims description 9
- 230000008859 change Effects 0.000 claims description 7
- 238000006479 redox reaction Methods 0.000 claims description 3
- 239000000047 product Substances 0.000 claims 2
- 239000000523 sample Substances 0.000 description 117
- 230000015654 memory Effects 0.000 description 19
- 238000001994 activation Methods 0.000 description 12
- 238000010586 diagram Methods 0.000 description 12
- 230000009471 action Effects 0.000 description 11
- 230000006870 function Effects 0.000 description 11
- 238000009739 binding Methods 0.000 description 10
- 230000027455 binding Effects 0.000 description 10
- 230000000007 visual effect Effects 0.000 description 10
- 238000004891 communication Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 8
- 239000000020 Nitrocellulose Substances 0.000 description 6
- 238000004590 computer program Methods 0.000 description 6
- 229920001220 nitrocellulos Polymers 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000004809 Teflon Substances 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- -1 antibody Substances 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000007772 electrode material Substances 0.000 description 3
- 229910052737 gold Inorganic materials 0.000 description 3
- 239000010931 gold Substances 0.000 description 3
- AVXLXFZNRNUCRP-UHFFFAOYSA-N trichloro(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)silane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)[Si](Cl)(Cl)Cl AVXLXFZNRNUCRP-UHFFFAOYSA-N 0.000 description 3
- 229920002799 BoPET Polymers 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 244000043261 Hevea brasiliensis Species 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920003052 natural elastomer Polymers 0.000 description 2
- 229920001194 natural rubber Polymers 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- YIXADFSGAYLSOB-UHFFFAOYSA-N COC1(C(O1)(OC)OC)C(C(C(C(C(C(C(CCC(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F Chemical compound COC1(C(O1)(OC)OC)C(C(C(C(C(C(C(CCC(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F YIXADFSGAYLSOB-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 239000005041 Mylar™ Substances 0.000 description 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- GZGREZWGCWVAEE-UHFFFAOYSA-N chloro-dimethyl-octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[Si](C)(C)Cl GZGREZWGCWVAEE-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- LIKFHECYJZWXFJ-UHFFFAOYSA-N dimethyldichlorosilane Chemical compound C[Si](C)(Cl)Cl LIKFHECYJZWXFJ-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 238000011022 operating instruction Methods 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000009597 pregnancy test Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 150000004756 silanes Chemical class 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0427—Electrowetting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nanotechnology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Electrochemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/490,956 US9638685B2 (en) | 2014-09-19 | 2014-09-19 | Flow assay with at least one electrically-actuated fluid flow control valve and related methods |
| US14/490,956 | 2014-09-19 | ||
| PCT/US2015/049590 WO2016044080A1 (en) | 2014-09-19 | 2015-09-11 | Flow assay with at least one electrically-actuated fluid flow control valve and related methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527817A JP2017527817A (ja) | 2017-09-21 |
| JP2017527817A5 JP2017527817A5 (enExample) | 2018-10-18 |
| JP6576439B2 true JP6576439B2 (ja) | 2019-09-18 |
Family
ID=55525537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017514894A Expired - Fee Related JP6576439B2 (ja) | 2014-09-19 | 2015-09-11 | 電気的駆動で流量を制御する少なくとも１つの弁を有するフローアッセイとその方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9638685B2 (enExample) |
| EP (1) | EP3194966B1 (enExample) |
| JP (1) | JP6576439B2 (enExample) |
| CN (1) | CN107076731B (enExample) |
| WO (1) | WO2016044080A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2959768C (en) * | 2014-09-04 | 2020-06-09 | Siemens Healthcare Diagnostics Inc. | Diagnostic devices with modifiable hydrophobic surfaces |
| US10549273B2 (en) | 2014-09-19 | 2020-02-04 | Tokitae Llc | Flow assay with at least one electrically-actuated fluid flow control valve and related methods |
| WO2018187535A1 (en) * | 2017-04-07 | 2018-10-11 | Tokitae Llc | Flow assay with at least one electrically-actuated fluid flow control valve and related methods |
| WO2020113127A1 (en) * | 2018-11-28 | 2020-06-04 | 2Pi-Sigma Corp. | Lateral flow assay with controlled conjugate and controlled flow time |
| US12385929B2 (en) | 2018-12-02 | 2025-08-12 | Polymer Technology Systems, Inc. | Systems and methods for a combined strip detection and heating system in an electrochemical test strip |
| EP3887828B1 (en) * | 2018-12-02 | 2024-01-31 | Polymer Technology Systems, Inc. | Systems and methods for a combined strip detection and heating system in an electrochemical test strip |
| CN113167760B (zh) * | 2018-12-02 | 2023-11-03 | 聚合物技术系统公司 | 用于电化学测试条带中的电子门特征的系统和方法 |
| US20210055284A1 (en) * | 2019-08-20 | 2021-02-25 | Zding Tech LLC | Microchip immunoassay device having precise incubation time control and signal scaling and related methods |
| CN116408154A (zh) * | 2021-12-29 | 2023-07-11 | 群创光电股份有限公司 | 电子装置 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6258196B1 (en) * | 1995-07-10 | 2001-07-10 | Paragon Trade Brands, Inc. | Porous composite sheet and process for the production thereof |
| US7216660B2 (en) | 2000-11-02 | 2007-05-15 | Princeton University | Method and device for controlling liquid flow on the surface of a microfluidic chip |
| WO2002070118A2 (en) | 2001-02-09 | 2002-09-12 | Microchem Solutions | Apparatus and method for small-volume fluid manipulation and transportation |
| US7364647B2 (en) * | 2002-07-17 | 2008-04-29 | Eksigent Technologies Llc | Laminated flow device |
| US6939450B2 (en) * | 2002-10-08 | 2005-09-06 | Abbott Laboratories | Device having a flow channel |
| KR100474851B1 (ko) | 2003-01-15 | 2005-03-09 | 삼성전자주식회사 | 잉크 토출 방법 및 이를 채용한 잉크젯 프린트헤드 |
| EP1701679A4 (en) * | 2003-12-08 | 2008-07-16 | Tredegar Film Prod Corp | DIFFERENTIAL ENERGY COMPOSITES, CORRESPONDING PRODUCTION METHODS |
| US20050136550A1 (en) * | 2003-12-19 | 2005-06-23 | Kimberly-Clark Worldwide, Inc. | Flow control of electrochemical-based assay devices |
| US7807043B2 (en) * | 2004-02-23 | 2010-10-05 | Oakville Hong Kong Company Limited | Microfluidic test device |
| JP4185904B2 (ja) * | 2004-10-27 | 2008-11-26 | 株式会社日立ハイテクノロジーズ | 液体搬送基板、分析システム、分析方法 |
| US7858384B2 (en) * | 2005-04-29 | 2010-12-28 | Kimberly-Clark Worldwide, Inc. | Flow control technique for assay devices |
| AU2007310987B2 (en) * | 2006-10-18 | 2014-01-09 | President And Fellows Of Harvard College | Lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same |
| CN101578520B (zh) * | 2006-10-18 | 2015-09-16 | 哈佛学院院长等 | 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法 |
| US20080186801A1 (en) * | 2007-02-06 | 2008-08-07 | Qisda Corporation | Bubble micro-pump and two-way fluid-driving device, particle-sorting device, fluid-mixing device, ring-shaped fluid-mixing device and compound-type fluid-mixing device using the same |
| US8037903B2 (en) | 2007-04-04 | 2011-10-18 | Micropoint Bioscience, Inc. | Micromachined electrowetting microfluidic valve |
| JP5277372B2 (ja) * | 2007-09-10 | 2013-08-28 | 理想科学工業株式会社 | 送液装置及び送液制御方法 |
| US20090157024A1 (en) * | 2007-12-14 | 2009-06-18 | Kimberly-Clark Worldwide, Inc. | Hydration Test Devices |
| US9080993B2 (en) | 2008-07-29 | 2015-07-14 | Sharp Kabushiki Kaisha | Microdevice, microchip apparatus and analysis method utilizing the same |
| US20100159599A1 (en) | 2008-12-18 | 2010-06-24 | Xuedong Song | Lateral-flow porous membrane assay with flow rate control |
| PL2403645T3 (pl) * | 2009-03-06 | 2017-05-31 | President And Fellows Of Harvard College | Mikroprzepływowe, elektrochemiczne urządzenia |
| EP2419216A1 (en) * | 2009-04-15 | 2012-02-22 | Koninklijke Philips Electronics N.V. | Microfluidic device comprising sensor |
| JP2011220808A (ja) * | 2010-04-08 | 2011-11-04 | Sharp Corp | 送液装置 |
| KR101190142B1 (ko) * | 2010-09-09 | 2012-10-12 | 아주대학교산학협력단 | 혈액 전처리가 가능한 측방 유동 검정 장치 |
| US8973613B2 (en) | 2011-04-27 | 2015-03-10 | Google Inc. | Electrorheological valve |
| US20130087459A1 (en) | 2011-10-06 | 2013-04-11 | Kyungpook National University Industry-Academic Cooperation | Device for varying wetting properties of droplet and device for separating particles using the same |
| CA2818332C (en) | 2012-06-12 | 2021-07-20 | Ortho-Clinical Diagnostics, Inc. | Lateral flow assay devices for use in clinical diagnostic apparatus and configuration of clinical diagnostic apparatus for same |
| EP2703817A1 (en) | 2012-09-03 | 2014-03-05 | Celoxio AB | On chip control of fluids using electrodes |
-
2014
- 2014-09-19 US US14/490,956 patent/US9638685B2/en not_active Expired - Fee Related
-
2015
- 2015-09-11 EP EP15841137.1A patent/EP3194966B1/en not_active Not-in-force
- 2015-09-11 JP JP2017514894A patent/JP6576439B2/ja not_active Expired - Fee Related
- 2015-09-11 WO PCT/US2015/049590 patent/WO2016044080A1/en not_active Ceased
- 2015-09-11 CN CN201580050709.5A patent/CN107076731B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP3194966A4 (en) | 2018-04-18 |
| CN107076731B (zh) | 2019-09-20 |
| US20160084796A1 (en) | 2016-03-24 |
| WO2016044080A1 (en) | 2016-03-24 |
| EP3194966A1 (en) | 2017-07-26 |
| EP3194966B1 (en) | 2019-09-04 |
| JP2017527817A (ja) | 2017-09-21 |
| US9638685B2 (en) | 2017-05-02 |
| CN107076731A (zh) | 2017-08-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017527817A (ja) | 電気的駆動で流量を制御する少なくとも１つの弁を有するフローアッセイとその方法 | |
| US12275007B2 (en) | Handheld impedance-based diagnostic test system for detecting analytes | |
| Byrne et al. | Chemo/bio-sensor networks | |
| US7939021B2 (en) | Droplet actuator analyzer with cartridge | |
| CN101500694B (zh) | 液滴操纵系统 | |
| CA3121035C (en) | Lateral flow assay with controlled conjugate and controlled flow time | |
| CN103282122A (zh) | 用于样本分析的多流体筒罐和它们的使用方法 | |
| JP2012523550A5 (enExample) | ||
| EP3669178B1 (en) | Systems for performing optical and electrochemical assays | |
| EP3669179B1 (en) | Systems for performing optical and electrochemical assays | |
| WO2004039489A2 (en) | Computer programs,workstations, systems and methods for microfluidic substrates in cell | |
| EP2703817A1 (en) | On chip control of fluids using electrodes | |
| US11060994B2 (en) | Techniques for performing optical and electrochemical assays with universal circuitry | |
| SG174649A1 (en) | Assay | |
| WO2014159615A2 (en) | Thermal control system for controlling the temperature of a fluid | |
| US20070161926A1 (en) | Body fluid sampling device | |
| Chauhan et al. | Barrier-free microfluidic paper analytical devices for multiplex colorimetric detection of analytes | |
| Mamaril et al. | Identifying hypocalcemia in dairy cattle by combining 3D printing and paper diagnostics | |
| CN103329081A (zh) | 用于流体样本分析的微流控装置 | |
| JP5519012B2 (ja) | 変換器補強要素を備えた分析装置 | |
| US10549273B2 (en) | Flow assay with at least one electrically-actuated fluid flow control valve and related methods | |
| CN112384796B (zh) | 包含电导率传感器的流体通道中血细胞比容的测量方法 | |
| HK1243170A1 (en) | Flow assay with at least one electrically-actuated fluid flow control valve and related methods | |
| HK1243170B (zh) | 具有至少一个电致动流体流控制阀的流检测装置和相关方法 | |
| OA18187A (en) | Flow assay with at least one electricallyactuated fluid flow control valve and related methods |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180906 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180906 |
|
| TRDD | Decision of grant or rejection written | ||
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20190724 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190730 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190820 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6576439 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |