CN107076731B - 具有至少一个电致动流体流控制阀的流检测装置和相关方法 - Google Patents

具有至少一个电致动流体流控制阀的流检测装置和相关方法 Download PDF

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Publication number
CN107076731B
CN107076731B CN201580050709.5A CN201580050709A CN107076731B CN 107076731 B CN107076731 B CN 107076731B CN 201580050709 A CN201580050709 A CN 201580050709A CN 107076731 B CN107076731 B CN 107076731B
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China
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electrode
detection device
flow detection
layer
hydrophilic porous
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Expired - Fee Related
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CN107076731A (zh
Inventor
大卫·葛司培瑞诺
凯文·保罗·弗洛德·尼克尔斯
本杰明·K·威尔逊
奥祖尔·埃梅克·伊尔迪里姆
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Tuoqitai Co Ltd
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Tuoqitai Co Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrochemistry (AREA)
CN201580050709.5A 2014-09-19 2015-09-11 具有至少一个电致动流体流控制阀的流检测装置和相关方法 Expired - Fee Related CN107076731B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/490,956 US9638685B2 (en) 2014-09-19 2014-09-19 Flow assay with at least one electrically-actuated fluid flow control valve and related methods
US14/490,956 2014-09-19
PCT/US2015/049590 WO2016044080A1 (en) 2014-09-19 2015-09-11 Flow assay with at least one electrically-actuated fluid flow control valve and related methods

Publications (2)

Publication Number Publication Date
CN107076731A CN107076731A (zh) 2017-08-18
CN107076731B true CN107076731B (zh) 2019-09-20

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CN201580050709.5A Expired - Fee Related CN107076731B (zh) 2014-09-19 2015-09-11 具有至少一个电致动流体流控制阀的流检测装置和相关方法

Country Status (5)

Country Link
US (1) US9638685B2 (enExample)
EP (1) EP3194966B1 (enExample)
JP (1) JP6576439B2 (enExample)
CN (1) CN107076731B (enExample)
WO (1) WO2016044080A1 (enExample)

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US10549273B2 (en) 2014-09-19 2020-02-04 Tokitae Llc Flow assay with at least one electrically-actuated fluid flow control valve and related methods
WO2018187535A1 (en) * 2017-04-07 2018-10-11 Tokitae Llc Flow assay with at least one electrically-actuated fluid flow control valve and related methods
WO2020113127A1 (en) * 2018-11-28 2020-06-04 2Pi-Sigma Corp. Lateral flow assay with controlled conjugate and controlled flow time
US12385929B2 (en) 2018-12-02 2025-08-12 Polymer Technology Systems, Inc. Systems and methods for a combined strip detection and heating system in an electrochemical test strip
EP3887828B1 (en) * 2018-12-02 2024-01-31 Polymer Technology Systems, Inc. Systems and methods for a combined strip detection and heating system in an electrochemical test strip
CN113167760B (zh) * 2018-12-02 2023-11-03 聚合物技术系统公司 用于电化学测试条带中的电子门特征的系统和方法
US20210055284A1 (en) * 2019-08-20 2021-02-25 Zding Tech LLC Microchip immunoassay device having precise incubation time control and signal scaling and related methods
CN116408154A (zh) * 2021-12-29 2023-07-11 群创光电股份有限公司 电子装置

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CN1889905A (zh) * 2003-12-08 2007-01-03 屈德加薄膜产品股份有限公司 能量差复合材料及其制造方法
CN101166974A (zh) * 2005-04-29 2008-04-23 金伯利-克拉克环球有限公司 用于测定装置的流动控制技术
KR20100106280A (ko) * 2010-09-09 2010-10-01 아주대학교산학협력단 혈액 전처리가 가능한 측방 유동 검정 장치
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CN1190931A (zh) * 1995-07-10 1998-08-19 株式会社日本吸收体技术研究所 多孔性复合体片及其制造方法
CN1889905A (zh) * 2003-12-08 2007-01-03 屈德加薄膜产品股份有限公司 能量差复合材料及其制造方法
CN101166974A (zh) * 2005-04-29 2008-04-23 金伯利-克拉克环球有限公司 用于测定装置的流动控制技术
CN101896812A (zh) * 2007-12-14 2010-11-24 金伯利-克拉克环球有限公司 水合作用测试装置
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Also Published As

Publication number Publication date
EP3194966A4 (en) 2018-04-18
US20160084796A1 (en) 2016-03-24
WO2016044080A1 (en) 2016-03-24
EP3194966A1 (en) 2017-07-26
JP6576439B2 (ja) 2019-09-18
EP3194966B1 (en) 2019-09-04
JP2017527817A (ja) 2017-09-21
US9638685B2 (en) 2017-05-02
CN107076731A (zh) 2017-08-18

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