JP6570512B2 - 新規なＳｔａｔ３阻害剤 - Google Patents

新規なＳｔａｔ３阻害剤 Download PDF

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Publication number
JP6570512B2
JP6570512B2 JP2016504370A JP2016504370A JP6570512B2 JP 6570512 B2 JP6570512 B2 JP 6570512B2 JP 2016504370 A JP2016504370 A JP 2016504370A JP 2016504370 A JP2016504370 A JP 2016504370A JP 6570512 B2 JP6570512 B2 JP 6570512B2
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JP
Japan
Prior art keywords
stat3
cancer
compound
pharmaceutically acceptable
cell
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Application number
JP2016504370A
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English (en)
Japanese (ja)
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JP2016517843A (ja
JP2016517843A5 (https=
Inventor
ジェイムズ タークソン，
ジェイムズ タークソン，
パトリック ガニング，
パトリック ガニング，
シーナ ハーフチェナリー，
シーナ ハーフチェナリー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii at Manoa
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University of Hawaii at Manoa
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Application filed by University of Hawaii at Manoa filed Critical University of Hawaii at Manoa
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2016504370A 2013-03-22 2014-03-21 新規なＳｔａｔ３阻害剤 Expired - Fee Related JP6570512B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361804613P 2013-03-22 2013-03-22
US61/804,613 2013-03-22
PCT/US2014/031412 WO2014153495A2 (en) 2013-03-22 2014-03-21 Novel stat3 inhibitors

Publications (3)

Publication Number Publication Date
JP2016517843A JP2016517843A (ja) 2016-06-20
JP2016517843A5 JP2016517843A5 (https=) 2017-03-16
JP6570512B2 true JP6570512B2 (ja) 2019-09-04

Family

ID=51581811

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016504370A Expired - Fee Related JP6570512B2 (ja) 2013-03-22 2014-03-21 新規なＳｔａｔ３阻害剤

Country Status (4)

Country Link
US (1) US9802888B2 (https=)
EP (1) EP2975936A4 (https=)
JP (1) JP6570512B2 (https=)
WO (1) WO2014153495A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2874057A1 (en) * 2012-05-25 2013-11-28 The Governing Council Of The University Of Toronto New salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
WO2015179956A1 (en) 2014-05-30 2015-12-03 The Governing Council Of The University Of Toronto Sulfonamide compounds and their use as stat5 inhibitors
KR102207381B1 (ko) * 2014-10-23 2021-01-27 싱 몰레큘러 메디신, 엘엘씨 세포내 항원에 대해 지향된 단일 도메인 항체
US20180072815A1 (en) 2014-10-23 2018-03-15 Singh Biotechnology, Llc Single Domain Antibodies Directed Against Intracellular Antigens
EP3570836A4 (en) * 2017-01-23 2020-08-19 The University of Hawaii 2-ARYLSULFONAMIDO-N-ARYLACETAMIDE STAT3 INHIBITORS
EP3501511A1 (en) 2017-12-22 2019-06-26 Fundación Centro Nacional De Investigaciones Oncológicas Carlos III Means for preventing and treating brain metastasis
CN110092743B (zh) * 2018-01-30 2022-03-15 中国医学科学院药物研究所 苯甲酰胺类化合物及其制备方法、用途和药物组合物
US20220168322A1 (en) * 2018-07-20 2022-06-02 Board Of Regents, The University Of Texas System Novel stat3 inhibitors identified by structure-based virtual screening incorporating sh2 domain flexibility
TWI875749B (zh) 2019-04-05 2025-03-11 美商凱麥拉醫療公司 Stat降解劑及其用途
CN113754541B (zh) * 2020-06-02 2025-01-03 深圳湾实验室 靶向eb病毒核抗原蛋白的小分子抑制剂、制备方法及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
JP3682584B2 (ja) * 2001-08-06 2005-08-10 ソニー株式会社 発光素子の実装方法及び画像表示装置の製造方法
HRP20110498T1 (hr) 2005-10-07 2011-08-31 Exelixis Azetidini kao inhibitori mek za liječenje proliferativnih bolesti
NZ567266A (en) 2005-10-13 2010-09-30 Orchid Res Lab Ltd Carbazole derivatives as pSTAT3/IL-6 inhibitors (carvedilol)
US20100197745A1 (en) 2008-02-04 2010-08-05 Hanigan Marie H Gamma-glutamyl transpeptidase inhibitors and methods of use
WO2010118309A2 (en) 2009-04-10 2010-10-14 Board Of Regents, The University Of Texas System Inhibitors of stat3 and uses thereof
US20110275577A1 (en) 2010-01-08 2011-11-10 Moleculin, Llc Methods of treating dermatologic, gynecologic, and genital disorders with caffeic acid analogs
EP2585464A2 (en) 2010-06-22 2013-05-01 University Of Central Florida Research Foundation, Inc. Substituted 2-(9h-purin-9-yl) acetic acid analogues as inhibitors of stat3
CA2874057A1 (en) * 2012-05-25 2013-11-28 The Governing Council Of The University Of Toronto New salicylic acid derivatives, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
DK2968346T3 (da) 2013-03-15 2024-05-06 Cancer Research Tech Llc Fremgangsmåder og sammensætninger til modulation af gamma-glutamylcyklus

Also Published As

Publication number Publication date
EP2975936A2 (en) 2016-01-27
WO2014153495A3 (en) 2015-02-19
EP2975936A4 (en) 2017-03-15
JP2016517843A (ja) 2016-06-20
US9802888B2 (en) 2017-10-31
WO2014153495A2 (en) 2014-09-25
US20160068478A1 (en) 2016-03-10
WO2014153495A9 (en) 2015-04-23

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