JP6543272B2 - 低減された毒性を有するアンホテリシンｂ誘導体 - Google Patents

低減された毒性を有するアンホテリシンｂ誘導体

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Publication number
JP6543272B2
JP6543272B2 JP2016567865A JP2016567865A JP6543272B2 JP 6543272 B2 JP6543272 B2 JP 6543272B2 JP 2016567865 A JP2016567865 A JP 2016567865A JP 2016567865 A JP2016567865 A JP 2016567865A JP 6543272 B2 JP6543272 B2 JP 6543272B2
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JP
Japan
Prior art keywords
epiamb
amb
mmol
solution
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2016567865A
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English (en)
Japanese (ja)
Other versions
JP2017518982A (ja
JP2017518982A5 (OSRAM
Inventor
ディー バーク，マーティン
ディー バーク，マーティン
イー ウノ，ブライス
イー ウノ，ブライス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois System
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Publication date
Application filed by University of Illinois System filed Critical University of Illinois System
Publication of JP2017518982A publication Critical patent/JP2017518982A/ja
Publication of JP2017518982A5 publication Critical patent/JP2017518982A5/ja
Application granted granted Critical
Publication of JP6543272B2 publication Critical patent/JP6543272B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2016567865A 2014-05-16 2015-05-15 低減された毒性を有するアンホテリシンｂ誘導体 Active JP6543272B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461994450P 2014-05-16 2014-05-16
US61/994,450 2014-05-16
US201462045907P 2014-09-04 2014-09-04
US62/045,907 2014-09-04
PCT/US2015/030965 WO2015175875A1 (en) 2014-05-16 2015-05-15 Amphotericin b derivative with reduced toxicity

Publications (3)

Publication Number Publication Date
JP2017518982A JP2017518982A (ja) 2017-07-13
JP2017518982A5 JP2017518982A5 (OSRAM) 2018-06-28
JP6543272B2 true JP6543272B2 (ja) 2019-07-10

Family

ID=54480735

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016567865A Active JP6543272B2 (ja) 2014-05-16 2015-05-15 低減された毒性を有するアンホテリシンｂ誘導体

Country Status (7)

Country Link
US (1) US9738677B2 (OSRAM)
EP (1) EP3142672B1 (OSRAM)
JP (1) JP6543272B2 (OSRAM)
CA (1) CA2981288C (OSRAM)
DK (1) DK3142672T3 (OSRAM)
ES (1) ES2749927T3 (OSRAM)
WO (1) WO2015175875A1 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10087206B2 (en) * 2014-10-17 2018-10-02 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B
WO2016168568A1 (en) 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
JP7477177B2 (ja) * 2018-09-07 2024-05-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
EP4009984A4 (en) * 2019-08-08 2023-09-06 The Board Of Trustees Of The University Of Illinois HYBRID AMPHOTERICIN B DERIVATIVES WITH REDUCED TOXICITY
AU2020329149A1 (en) * 2019-08-09 2022-03-03 The Board Of Trustees Of The University Of Illinois Combination treatment of systemic fungal infections
EP4192248B1 (en) * 2020-08-10 2025-12-03 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin b
CA3261962A1 (en) * 2022-07-08 2024-01-11 Univ Illinois TRANSFER OF C2 EPIMERIZED SUGARS TO AGLYCONIC AMPHOTEROCIBN B

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521418B2 (en) * 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
BRPI0512326A (pt) * 2004-06-21 2008-02-26 Nektar Therapeutics composições compreendendo anfotericina b, métodos e sistemas
US8513204B2 (en) * 2004-06-21 2013-08-20 Novartis Ag Compositions comprising amphotericin B, mehods and systems
WO2014059436A1 (en) * 2012-10-12 2014-04-17 The Board Of Trustees Of The University Of Illinois Electronic tuning of site selectivity
US10087206B2 (en) * 2014-10-17 2018-10-02 The Board Of Trustees Of The University Of Illinois Scalable synthesis of reduced toxicity derivative of amphotericin B

Also Published As

Publication number Publication date
CA2981288C (en) 2022-12-06
CA2981288A1 (en) 2015-11-19
DK3142672T3 (da) 2019-10-21
JP2017518982A (ja) 2017-07-13
US20170088572A1 (en) 2017-03-30
US9738677B2 (en) 2017-08-22
EP3142672A1 (en) 2017-03-22
EP3142672B1 (en) 2019-09-25
EP3142672A4 (en) 2017-11-15
WO2015175875A1 (en) 2015-11-19
ES2749927T3 (es) 2020-03-24

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