JP6542827B2 - 可逆的に架橋されたミセル系 - Google Patents

可逆的に架橋されたミセル系 Download PDF

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Publication number
JP6542827B2
JP6542827B2 JP2017058554A JP2017058554A JP6542827B2 JP 6542827 B2 JP6542827 B2 JP 6542827B2 JP 2017058554 A JP2017058554 A JP 2017058554A JP 2017058554 A JP2017058554 A JP 2017058554A JP 6542827 B2 JP6542827 B2 JP 6542827B2
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peg
acid
ptx
nanocarrier
group
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Japanese (ja)
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JP2017149960A5 (enExample
JP2017149960A (ja
Inventor
エス.ラム キット
エス.ラム キット
ユアンペイ リ
ユアンペイ リ
チュンタオ ルオ
チュンタオ ルオ
カイ シャオ
カイ シャオ
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University of California
University of California Berkeley
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University of California San Diego UCSD
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3348Polymers modified by chemical after-treatment with organic compounds containing sulfur containing nitrogen in addition to sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002Dendritic macromolecules
    • C08G83/003Dendrimers
    • C08G83/004After treatment of dendrimers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02Polyalkylene oxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
JP2017058554A 2011-05-13 2017-03-24 可逆的に架橋されたミセル系 Active JP6542827B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161485774P 2011-05-13 2011-05-13
US61/485,774 2011-05-13
US201161487953P 2011-05-19 2011-05-19
US61/487,953 2011-05-19

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2014510540A Division JP6235460B6 (ja) 2011-05-13 2012-05-14 可逆的に架橋されたミセルsystems

Publications (3)

Publication Number Publication Date
JP2017149960A JP2017149960A (ja) 2017-08-31
JP2017149960A5 JP2017149960A5 (enExample) 2018-01-11
JP6542827B2 true JP6542827B2 (ja) 2019-07-10

Family

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JP2017058554A Active JP6542827B2 (ja) 2011-05-13 2017-03-24 可逆的に架橋されたミセル系

Country Status (5)

Country Link
US (2) US10106650B2 (enExample)
EP (1) EP2707419B1 (enExample)
JP (1) JP6542827B2 (enExample)
CN (1) CN103748142B (enExample)
WO (1) WO2012158622A2 (enExample)

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WO2010019718A2 (en) 2008-08-13 2010-02-18 California Institute Of Technology Carrier nanoparticles and related compositions, methods and systems
WO2012158622A2 (en) 2011-05-13 2012-11-22 The Regents Of The University Of California Reversibly crosslinked micelle systems
AU2012296950B2 (en) * 2011-08-12 2016-09-22 Ascendis Pharma A/S Polymeric hyperbranched carrier-linked prodrugs
EP2793953B1 (en) * 2011-12-21 2019-12-04 The Regents of The University of California Telodendrimers with enhanced drug delivery
US9642916B2 (en) * 2012-12-12 2017-05-09 The Regents Of The University Of California Porphyrin modified telodendrimers
JP6251295B2 (ja) * 2013-03-01 2017-12-20 カリフォルニア インスティテュート オブ テクノロジー ニトロフェニルボロン酸組成物によって安定化したナノ粒子
EP2961395B1 (en) * 2013-03-01 2024-06-19 California Institute Of Technology Targeted nanoparticles
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
EP2997070A4 (en) * 2013-05-14 2016-12-14 California Inst Of Techn METHOD FOR THE DELIVERY OF THERAPEUTIC AND CONTRASTANTS THROUGH NANOPARTICLES THAT GO THROUGH THE BLOOD-BRAIN-BARRIER
US11406714B2 (en) 2013-08-21 2022-08-09 The Research Foundation For The State University Of New York Telodendrimers and nanocarriers and methods of using same
CN104414973A (zh) * 2013-08-21 2015-03-18 复旦大学 一种视黄酸和紫杉醇共递药的胶束给药系统及其制备方法
CN105193732A (zh) * 2014-06-05 2015-12-30 华东理工大学 雷帕霉素纳米缓释微球及其制备方法
WO2016050208A1 (zh) * 2014-10-01 2016-04-07 厦门赛诺邦格生物科技有限公司 一种多官能化聚乙二醇衍生物修饰的生物相关物质
CN104530417B (zh) * 2014-10-01 2017-09-08 厦门赛诺邦格生物科技股份有限公司 一种多官能化h型聚乙二醇衍生物及其制备方法
WO2016050210A1 (zh) * 2014-10-01 2016-04-07 厦门赛诺邦格生物科技有限公司 一种多官能化聚乙二醇衍生物及其制备方法
CN104530413B (zh) * 2014-10-01 2017-08-25 厦门赛诺邦格生物科技股份有限公司 一种多官能化h型聚乙二醇衍生物修饰的生物相关物质
EP3204048A4 (en) 2014-10-07 2018-06-27 The Research Foundation for the State University of New York Functional segregated telodendrimers and nanocarriers and methods of making and using same
ES2980216T3 (es) 2015-07-01 2024-09-30 California Inst Of Techn Sistemas de administración basados en polímeros de ácido múcico catiónicos
ES2625024B1 (es) * 2015-12-18 2018-05-10 Consejo Superior De Investigaciones Cientificas Material que comprende tectómeros de oligoglicina y nanohilos
CN109562078A (zh) * 2016-03-03 2019-04-02 特瑞奥纳米有限公司 多药物复合物、其制备方法及用途
US10517823B1 (en) * 2016-08-10 2019-12-31 Verily Life Sciences Llc ROS—responsive liposomes for specific targeting
US10583083B1 (en) * 2016-08-10 2020-03-10 Verily Life Sciences Llc ROS-responsive multilamellar liposomal vesicles for targeting inflammatory macrophages
JP7102005B2 (ja) * 2016-09-15 2022-07-19 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 改善されたハイブリッドテロデンドリマー
WO2018136778A1 (en) 2017-01-19 2018-07-26 The Research Foundation For The State University Of New York Telodendrimers with riboflavin moieties and nanocarriers and methods of making and using same
JP2018058868A (ja) * 2017-11-24 2018-04-12 カリフォルニア インスティテュート オブ テクノロジー ニトロフェニルボロン酸組成物によって安定化したナノ粒子
JP2018070626A (ja) * 2017-11-24 2018-05-10 カリフォルニア インスティテュート オブ テクノロジー 標的化ナノ粒子
JP7525981B2 (ja) * 2017-11-24 2024-07-31 カリフォルニア インスティテュート オブ テクノロジー ニトロフェニルボロン酸組成物によって安定化したナノ粒子
US20190381188A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same
WO2020036529A1 (en) 2018-08-13 2020-02-20 Polymer Factory Sweden Ab Dendritic nanogel carriers and method of production
CN111184874B (zh) * 2018-11-14 2022-02-22 南京大学 疏水性纳米生物探针
US11179475B2 (en) 2018-11-28 2021-11-23 International Business Machines Corporation Biodegradable functional polycarbonate nanoparticle carries for delivering molecular cargo
JP2019108371A (ja) * 2019-03-04 2019-07-04 カリフォルニア インスティテュート オブ テクノロジー 標的化ナノ粒子
CN111904932B (zh) * 2019-05-08 2023-06-20 北京德立福瑞医药科技有限公司 一种含有糖皮质激素的胶束制剂及其制备方法
CA3158694A1 (en) 2019-12-04 2021-06-10 Dantari, Inc. Methods and compositions for synthesis of therapeutic nanoparticles
US20230076792A1 (en) * 2019-12-17 2023-03-09 The Regents Of The University Of California Sequential targeting in crosslinking nano-theranostics for treating brain tumors
EP4429798A1 (en) * 2021-11-09 2024-09-18 Massachusetts Institute of Technology Particles containing pollutant-capturing micelles and related methods
CN115531291B (zh) * 2022-09-02 2025-02-14 南京医科大学 一种可载药的赖氨大黄酸自组装水凝胶及其制备方法与应用
WO2024254448A2 (en) * 2023-06-07 2024-12-12 The Research Foundation For The State University Of New York Boronate prodrug nanoformulations in disease treatments

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JP4659937B2 (ja) 1999-11-19 2011-03-30 ナノキャリア株式会社 コア−シェル構造のポリイオンコンプレックスミセル
AU2002953073A0 (en) * 2002-11-21 2003-01-16 Access Pharmaceuticals Australia Pty Limited Amplification of biotin-mediated targeting
US7846893B2 (en) 2005-02-16 2010-12-07 Rutgers, The State University Of New Jersey Drug-polymer conjugates coupled to a peptidic carrier
EP2087912B1 (en) 2006-11-22 2017-05-10 The University of Tokyo Sirna carrier using disulfide-bridged polymeric micelle
US9579400B2 (en) 2008-09-23 2017-02-28 The Regents Of The University Of California Nanocarriers for drug delivery
US9296988B2 (en) 2009-06-19 2016-03-29 The Regents Of The University Of California Three-dimensional cell adhesion matrix
WO2012158622A2 (en) 2011-05-13 2012-11-22 The Regents Of The University Of California Reversibly crosslinked micelle systems

Also Published As

Publication number Publication date
WO2012158622A2 (en) 2012-11-22
CN103748142B (zh) 2016-04-27
WO2012158622A3 (en) 2013-03-28
JP2017149960A (ja) 2017-08-31
CN103748142A (zh) 2014-04-23
US20150045419A1 (en) 2015-02-12
EP2707419A4 (en) 2014-11-26
US20190112423A1 (en) 2019-04-18
JP2014514431A (ja) 2014-06-19
US10106650B2 (en) 2018-10-23
JP6235460B2 (ja) 2017-11-22
EP2707419A2 (en) 2014-03-19
US11192978B2 (en) 2021-12-07
EP2707419B1 (en) 2019-08-14

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