JP6542827B2 - 可逆的に架橋されたミセル系 - Google Patents
可逆的に架橋されたミセル系 Download PDFInfo
- Publication number
- JP6542827B2 JP6542827B2 JP2017058554A JP2017058554A JP6542827B2 JP 6542827 B2 JP6542827 B2 JP 6542827B2 JP 2017058554 A JP2017058554 A JP 2017058554A JP 2017058554 A JP2017058554 A JP 2017058554A JP 6542827 B2 JP6542827 B2 JP 6542827B2
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- JP
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- Prior art keywords
- peg
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- ptx
- nanocarrier
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
- C08G65/3348—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing nitrogen in addition to sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
- C08G83/003—Dendrimers
- C08G83/004—After treatment of dendrimers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485774P | 2011-05-13 | 2011-05-13 | |
| US61/485,774 | 2011-05-13 | ||
| US201161487953P | 2011-05-19 | 2011-05-19 | |
| US61/487,953 | 2011-05-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510540A Division JP6235460B6 (ja) | 2011-05-13 | 2012-05-14 | 可逆的に架橋されたミセルsystems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017149960A JP2017149960A (ja) | 2017-08-31 |
| JP2017149960A5 JP2017149960A5 (enExample) | 2018-01-11 |
| JP6542827B2 true JP6542827B2 (ja) | 2019-07-10 |
Family
ID=47177586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017058554A Active JP6542827B2 (ja) | 2011-05-13 | 2017-03-24 | 可逆的に架橋されたミセル系 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10106650B2 (enExample) |
| EP (1) | EP2707419B1 (enExample) |
| JP (1) | JP6542827B2 (enExample) |
| CN (1) | CN103748142B (enExample) |
| WO (1) | WO2012158622A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010019718A2 (en) | 2008-08-13 | 2010-02-18 | California Institute Of Technology | Carrier nanoparticles and related compositions, methods and systems |
| WO2012158622A2 (en) | 2011-05-13 | 2012-11-22 | The Regents Of The University Of California | Reversibly crosslinked micelle systems |
| AU2012296950B2 (en) * | 2011-08-12 | 2016-09-22 | Ascendis Pharma A/S | Polymeric hyperbranched carrier-linked prodrugs |
| EP2793953B1 (en) * | 2011-12-21 | 2019-12-04 | The Regents of The University of California | Telodendrimers with enhanced drug delivery |
| US9642916B2 (en) * | 2012-12-12 | 2017-05-09 | The Regents Of The University Of California | Porphyrin modified telodendrimers |
| JP6251295B2 (ja) * | 2013-03-01 | 2017-12-20 | カリフォルニア インスティテュート オブ テクノロジー | ニトロフェニルボロン酸組成物によって安定化したナノ粒子 |
| EP2961395B1 (en) * | 2013-03-01 | 2024-06-19 | California Institute Of Technology | Targeted nanoparticles |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| EP2997070A4 (en) * | 2013-05-14 | 2016-12-14 | California Inst Of Techn | METHOD FOR THE DELIVERY OF THERAPEUTIC AND CONTRASTANTS THROUGH NANOPARTICLES THAT GO THROUGH THE BLOOD-BRAIN-BARRIER |
| US11406714B2 (en) | 2013-08-21 | 2022-08-09 | The Research Foundation For The State University Of New York | Telodendrimers and nanocarriers and methods of using same |
| CN104414973A (zh) * | 2013-08-21 | 2015-03-18 | 复旦大学 | 一种视黄酸和紫杉醇共递药的胶束给药系统及其制备方法 |
| CN105193732A (zh) * | 2014-06-05 | 2015-12-30 | 华东理工大学 | 雷帕霉素纳米缓释微球及其制备方法 |
| WO2016050208A1 (zh) * | 2014-10-01 | 2016-04-07 | 厦门赛诺邦格生物科技有限公司 | 一种多官能化聚乙二醇衍生物修饰的生物相关物质 |
| CN104530417B (zh) * | 2014-10-01 | 2017-09-08 | 厦门赛诺邦格生物科技股份有限公司 | 一种多官能化h型聚乙二醇衍生物及其制备方法 |
| WO2016050210A1 (zh) * | 2014-10-01 | 2016-04-07 | 厦门赛诺邦格生物科技有限公司 | 一种多官能化聚乙二醇衍生物及其制备方法 |
| CN104530413B (zh) * | 2014-10-01 | 2017-08-25 | 厦门赛诺邦格生物科技股份有限公司 | 一种多官能化h型聚乙二醇衍生物修饰的生物相关物质 |
| EP3204048A4 (en) | 2014-10-07 | 2018-06-27 | The Research Foundation for the State University of New York | Functional segregated telodendrimers and nanocarriers and methods of making and using same |
| ES2980216T3 (es) | 2015-07-01 | 2024-09-30 | California Inst Of Techn | Sistemas de administración basados en polímeros de ácido múcico catiónicos |
| ES2625024B1 (es) * | 2015-12-18 | 2018-05-10 | Consejo Superior De Investigaciones Cientificas | Material que comprende tectómeros de oligoglicina y nanohilos |
| CN109562078A (zh) * | 2016-03-03 | 2019-04-02 | 特瑞奥纳米有限公司 | 多药物复合物、其制备方法及用途 |
| US10517823B1 (en) * | 2016-08-10 | 2019-12-31 | Verily Life Sciences Llc | ROS—responsive liposomes for specific targeting |
| US10583083B1 (en) * | 2016-08-10 | 2020-03-10 | Verily Life Sciences Llc | ROS-responsive multilamellar liposomal vesicles for targeting inflammatory macrophages |
| JP7102005B2 (ja) * | 2016-09-15 | 2022-07-19 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 改善されたハイブリッドテロデンドリマー |
| WO2018136778A1 (en) | 2017-01-19 | 2018-07-26 | The Research Foundation For The State University Of New York | Telodendrimers with riboflavin moieties and nanocarriers and methods of making and using same |
| JP2018058868A (ja) * | 2017-11-24 | 2018-04-12 | カリフォルニア インスティテュート オブ テクノロジー | ニトロフェニルボロン酸組成物によって安定化したナノ粒子 |
| JP2018070626A (ja) * | 2017-11-24 | 2018-05-10 | カリフォルニア インスティテュート オブ テクノロジー | 標的化ナノ粒子 |
| JP7525981B2 (ja) * | 2017-11-24 | 2024-07-31 | カリフォルニア インスティテュート オブ テクノロジー | ニトロフェニルボロン酸組成物によって安定化したナノ粒子 |
| US20190381188A1 (en) | 2018-06-13 | 2019-12-19 | California Institute Of Technology | Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same |
| WO2020036529A1 (en) | 2018-08-13 | 2020-02-20 | Polymer Factory Sweden Ab | Dendritic nanogel carriers and method of production |
| CN111184874B (zh) * | 2018-11-14 | 2022-02-22 | 南京大学 | 疏水性纳米生物探针 |
| US11179475B2 (en) | 2018-11-28 | 2021-11-23 | International Business Machines Corporation | Biodegradable functional polycarbonate nanoparticle carries for delivering molecular cargo |
| JP2019108371A (ja) * | 2019-03-04 | 2019-07-04 | カリフォルニア インスティテュート オブ テクノロジー | 標的化ナノ粒子 |
| CN111904932B (zh) * | 2019-05-08 | 2023-06-20 | 北京德立福瑞医药科技有限公司 | 一种含有糖皮质激素的胶束制剂及其制备方法 |
| CA3158694A1 (en) | 2019-12-04 | 2021-06-10 | Dantari, Inc. | Methods and compositions for synthesis of therapeutic nanoparticles |
| US20230076792A1 (en) * | 2019-12-17 | 2023-03-09 | The Regents Of The University Of California | Sequential targeting in crosslinking nano-theranostics for treating brain tumors |
| EP4429798A1 (en) * | 2021-11-09 | 2024-09-18 | Massachusetts Institute of Technology | Particles containing pollutant-capturing micelles and related methods |
| CN115531291B (zh) * | 2022-09-02 | 2025-02-14 | 南京医科大学 | 一种可载药的赖氨大黄酸自组装水凝胶及其制备方法与应用 |
| WO2024254448A2 (en) * | 2023-06-07 | 2024-12-12 | The Research Foundation For The State University Of New York | Boronate prodrug nanoformulations in disease treatments |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100396171B1 (ko) | 1998-08-10 | 2003-08-27 | 아사히 가세이 가부시키가이샤 | 염산 파수딜의 경구 서방성 제제 |
| JP4659937B2 (ja) | 1999-11-19 | 2011-03-30 | ナノキャリア株式会社 | コア−シェル構造のポリイオンコンプレックスミセル |
| AU2002953073A0 (en) * | 2002-11-21 | 2003-01-16 | Access Pharmaceuticals Australia Pty Limited | Amplification of biotin-mediated targeting |
| US7846893B2 (en) | 2005-02-16 | 2010-12-07 | Rutgers, The State University Of New Jersey | Drug-polymer conjugates coupled to a peptidic carrier |
| EP2087912B1 (en) | 2006-11-22 | 2017-05-10 | The University of Tokyo | Sirna carrier using disulfide-bridged polymeric micelle |
| US9579400B2 (en) | 2008-09-23 | 2017-02-28 | The Regents Of The University Of California | Nanocarriers for drug delivery |
| US9296988B2 (en) | 2009-06-19 | 2016-03-29 | The Regents Of The University Of California | Three-dimensional cell adhesion matrix |
| WO2012158622A2 (en) | 2011-05-13 | 2012-11-22 | The Regents Of The University Of California | Reversibly crosslinked micelle systems |
-
2012
- 2012-05-14 WO PCT/US2012/037794 patent/WO2012158622A2/en not_active Ceased
- 2012-05-14 EP EP12786464.3A patent/EP2707419B1/en active Active
- 2012-05-14 US US14/117,570 patent/US10106650B2/en active Active
- 2012-05-14 CN CN201280032611.3A patent/CN103748142B/zh active Active
-
2017
- 2017-03-24 JP JP2017058554A patent/JP6542827B2/ja active Active
-
2018
- 2018-09-14 US US16/131,644 patent/US11192978B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012158622A2 (en) | 2012-11-22 |
| CN103748142B (zh) | 2016-04-27 |
| WO2012158622A3 (en) | 2013-03-28 |
| JP2017149960A (ja) | 2017-08-31 |
| CN103748142A (zh) | 2014-04-23 |
| US20150045419A1 (en) | 2015-02-12 |
| EP2707419A4 (en) | 2014-11-26 |
| US20190112423A1 (en) | 2019-04-18 |
| JP2014514431A (ja) | 2014-06-19 |
| US10106650B2 (en) | 2018-10-23 |
| JP6235460B2 (ja) | 2017-11-22 |
| EP2707419A2 (en) | 2014-03-19 |
| US11192978B2 (en) | 2021-12-07 |
| EP2707419B1 (en) | 2019-08-14 |
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| JP6542827B2 (ja) | 可逆的に架橋されたミセル系 | |
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| JP5539993B2 (ja) | 薬物送達のためのナノ担体 | |
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