JP2017149960A5 - - Google Patents
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- JP2017149960A5 JP2017149960A5 JP2017058554A JP2017058554A JP2017149960A5 JP 2017149960 A5 JP2017149960 A5 JP 2017149960A5 JP 2017058554 A JP2017058554 A JP 2017058554A JP 2017058554 A JP2017058554 A JP 2017058554A JP 2017149960 A5 JP2017149960 A5 JP 2017149960A5
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- JP
- Japan
- Prior art keywords
- group
- nanocarrier
- acid
- compound
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002539 nanocarrier Substances 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000004380 Cholic acid Substances 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 7
- 229960002471 cholic acid Drugs 0.000 claims 7
- 229920001223 polyethylene glycol Polymers 0.000 claims 7
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 4
- -1 2,3-dihydroxy-1-propoxy Chemical group 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims 4
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 4
- 235000019416 cholic acid Nutrition 0.000 claims 4
- 239000002872 contrast media Substances 0.000 claims 4
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000003716 cholic acid group Chemical group 0.000 claims 3
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 claims 2
- JJMDCOVWQOJGCB-UHFFFAOYSA-N 5-aminopentanoic acid Chemical compound [NH3+]CCCCC([O-])=O JJMDCOVWQOJGCB-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- YEYCQJVCAMFWCO-UHFFFAOYSA-N [10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] formate Chemical compound C1C=C2CC(OC=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 YEYCQJVCAMFWCO-UHFFFAOYSA-N 0.000 claims 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 2
- 238000010504 bond cleavage reaction Methods 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000002096 quantum dot Substances 0.000 claims 2
- KWNPRVWFJOSGMZ-UHFFFAOYSA-N 2-boronobenzoic acid Chemical compound OB(O)C1=CC=CC=C1C(O)=O KWNPRVWFJOSGMZ-UHFFFAOYSA-N 0.000 claims 1
- NSOQPFCRCLZMRT-UHFFFAOYSA-N 3-borono-2-nitrobenzoic acid Chemical compound OB(O)C1=CC=CC(C(O)=O)=C1[N+]([O-])=O NSOQPFCRCLZMRT-UHFFFAOYSA-N 0.000 claims 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 1
- 239000005153 Cholesterol Formate Substances 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 claims 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 1
- 229960002684 aminocaproic acid Drugs 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 229940127093 camptothecin Drugs 0.000 claims 1
- 229960005243 carmustine Drugs 0.000 claims 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 etoposide Drugs 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 230000005661 hydrophobic surface Effects 0.000 claims 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 claims 1
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 229940031182 nanoparticles iron oxide Drugs 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 108010094020 polyglycine Proteins 0.000 claims 1
- 229920000232 polyglycine polymer Polymers 0.000 claims 1
- 108010000222 polyserine Proteins 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960000235 temsirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 1
- 229960003048 vinblastine Drugs 0.000 claims 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485774P | 2011-05-13 | 2011-05-13 | |
| US61/485,774 | 2011-05-13 | ||
| US201161487953P | 2011-05-19 | 2011-05-19 | |
| US61/487,953 | 2011-05-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510540A Division JP6235460B6 (ja) | 2011-05-13 | 2012-05-14 | 可逆的に架橋されたミセルｓｙｓｔｅｍｓ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017149960A JP2017149960A (ja) | 2017-08-31 |
| JP2017149960A5 true JP2017149960A5 (enExample) | 2018-01-11 |
| JP6542827B2 JP6542827B2 (ja) | 2019-07-10 |
Family
ID=47177586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017058554A Active JP6542827B2 (ja) | 2011-05-13 | 2017-03-24 | 可逆的に架橋されたミセル系 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10106650B2 (enExample) |
| EP (1) | EP2707419B1 (enExample) |
| JP (1) | JP6542827B2 (enExample) |
| CN (1) | CN103748142B (enExample) |
| WO (1) | WO2012158622A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8557292B2 (en) | 2008-08-13 | 2013-10-15 | California Institute Of Technology | Carrier nanoparticles and related compositions, methods and systems |
| US10106650B2 (en) | 2011-05-13 | 2018-10-23 | The Regents Of The University Of California | Reversibly crosslinked micelle systems |
| EP2741778A1 (en) * | 2011-08-12 | 2014-06-18 | Ascendis Pharma A/S | Polymeric hyperbranched carrier-linked prodrugs |
| WO2013096388A1 (en) | 2011-12-21 | 2013-06-27 | The Regents Of The University Of California | Telodendrimers with enhanced drug delivery |
| US9642916B2 (en) * | 2012-12-12 | 2017-05-09 | The Regents Of The University Of California | Porphyrin modified telodendrimers |
| ES2737800T3 (es) * | 2013-03-01 | 2020-01-16 | California Inst Of Techn | Nanopartículas estabilizadas con composiciones de ácido nitrofenilborónico |
| EP2961395B1 (en) * | 2013-03-01 | 2024-06-19 | California Institute Of Technology | Targeted nanoparticles |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| WO2014185964A1 (en) * | 2013-05-14 | 2014-11-20 | California Institute Of Technology | Method of delivering therapeutics and imaging agents by nanoparticles that cross the blood brain barrier |
| CN104414973A (zh) * | 2013-08-21 | 2015-03-18 | 复旦大学 | 一种视黄酸和紫杉醇共递药的胶束给药系统及其制备方法 |
| US11406714B2 (en) | 2013-08-21 | 2022-08-09 | The Research Foundation For The State University Of New York | Telodendrimers and nanocarriers and methods of using same |
| CN105193732A (zh) * | 2014-06-05 | 2015-12-30 | 华东理工大学 | 雷帕霉素纳米缓释微球及其制备方法 |
| US11324827B2 (en) | 2014-10-01 | 2022-05-10 | Xiamen Sinopeg Biotech Co., Ltd. | Multifunctionalized polyethylene glycol derivative and preparation method therefor |
| CN104530417B (zh) * | 2014-10-01 | 2017-09-08 | 厦门赛诺邦格生物科技股份有限公司 | 一种多官能化h型聚乙二醇衍生物及其制备方法 |
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| WO2016050208A1 (zh) * | 2014-10-01 | 2016-04-07 | 厦门赛诺邦格生物科技有限公司 | 一种多官能化聚乙二醇衍生物修饰的生物相关物质 |
| EP3204048A4 (en) * | 2014-10-07 | 2018-06-27 | The Research Foundation for the State University of New York | Functional segregated telodendrimers and nanocarriers and methods of making and using same |
| ES2882255T3 (es) | 2015-07-01 | 2021-12-01 | California Inst Of Techn | Sistemas de administración basados en polímeros de ácido múcico catiónicos |
| ES2625024B1 (es) * | 2015-12-18 | 2018-05-10 | Consejo Superior De Investigaciones Cientificas | Material que comprende tectómeros de oligoglicina y nanohilos |
| WO2017149546A1 (en) * | 2016-03-03 | 2017-09-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Multi drug composite, preparation methods and uses thereof |
| US10517823B1 (en) * | 2016-08-10 | 2019-12-31 | Verily Life Sciences Llc | ROS—responsive liposomes for specific targeting |
| US10583083B1 (en) * | 2016-08-10 | 2020-03-10 | Verily Life Sciences Llc | ROS-responsive multilamellar liposomal vesicles for targeting inflammatory macrophages |
| WO2018053316A1 (en) * | 2016-09-15 | 2018-03-22 | The Regents Of The University Of California | Improved hybrid telodendrimers |
| US11369614B2 (en) | 2017-01-19 | 2022-06-28 | The Research Foundation For The State University Of New York | Telodendrimers with riboflavin moieties and nanocarriers and methods of making and using same |
| JP7525981B2 (ja) * | 2017-11-24 | 2024-07-31 | カリフォルニア インスティテュート オブ テクノロジー | ニトロフェニルボロン酸組成物によって安定化したナノ粒子 |
| JP2018070626A (ja) * | 2017-11-24 | 2018-05-10 | カリフォルニア インスティテュート オブ テクノロジー | 標的化ナノ粒子 |
| JP2018058868A (ja) * | 2017-11-24 | 2018-04-12 | カリフォルニア インスティテュート オブ テクノロジー | ニトロフェニルボロン酸組成物によって安定化したナノ粒子 |
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| CN111184874B (zh) * | 2018-11-14 | 2022-02-22 | 南京大学 | 疏水性纳米生物探针 |
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| JP2019108371A (ja) * | 2019-03-04 | 2019-07-04 | カリフォルニア インスティテュート オブ テクノロジー | 標的化ナノ粒子 |
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| CN115551917B (zh) * | 2019-12-17 | 2025-06-13 | 加利福尼亚大学董事会 | 用于治疗脑肿瘤的交联纳米治疗学的顺序靶向 |
| US20250011193A1 (en) * | 2021-11-09 | 2025-01-09 | Massachusetts Institute Of Technology | Particles containing pollutant-capturing micelles and related methods |
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| CN115531291B (zh) * | 2022-09-02 | 2025-02-14 | 南京医科大学 | 一种可载药的赖氨大黄酸自组装水凝胶及其制备方法与应用 |
| WO2024254448A2 (en) * | 2023-06-07 | 2024-12-12 | The Research Foundation For The State University Of New York | Boronate prodrug nanoformulations in disease treatments |
| CN121064464B (zh) * | 2025-11-06 | 2026-02-24 | 北京师范大学珠海校区 | 一种基于天然分子胆酸的抗菌牙科树脂材料 |
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| CN100444843C (zh) | 1998-08-10 | 2008-12-24 | 旭化成制药株式会社 | 法舒地尔盐酸盐缓释口服制剂 |
| JP4659937B2 (ja) | 1999-11-19 | 2011-03-30 | ナノキャリア株式会社 | コア−シェル構造のポリイオンコンプレックスミセル |
| AU2002953073A0 (en) | 2002-11-21 | 2003-01-16 | Access Pharmaceuticals Australia Pty Limited | Amplification of biotin-mediated targeting |
| US7846893B2 (en) * | 2005-02-16 | 2010-12-07 | Rutgers, The State University Of New Jersey | Drug-polymer conjugates coupled to a peptidic carrier |
| WO2008062909A1 (en) * | 2006-11-22 | 2008-05-29 | The University Of Tokyo | ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-BRIDGED POLYMERIC MICELLE |
| US9579400B2 (en) * | 2008-09-23 | 2017-02-28 | The Regents Of The University Of California | Nanocarriers for drug delivery |
| US9296988B2 (en) | 2009-06-19 | 2016-03-29 | The Regents Of The University Of California | Three-dimensional cell adhesion matrix |
| US10106650B2 (en) | 2011-05-13 | 2018-10-23 | The Regents Of The University Of California | Reversibly crosslinked micelle systems |
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