JP6537050B2 - 血管内皮機能の改善剤 - Google Patents
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Description
[1] クローブ、コリアンダー、クミン、ニンニク、ショウガ、タマネギ、トウガラシ及びウコンを有効成分として含有する、血管内皮機能改善剤。
[2] 単回投与により、血管内皮機能の改善をもたらす、[1]の血管内皮機能改善剤。
[3] 食後における血管内皮機能の改善のための、[1]又は[2]の血管内皮機能改善剤。
本発明の血管内皮機能改善剤は、クローブ、コリアンダー、クミン、ニンニク、ショウガ、タマネギ、トウガラシ及びウコンを有効成分として含有する。なお、本明細書において、クローブは学名Syzygium aromaticumとする植物を指す。本発明に用いられるクローブの品種は限定されない。本発明においてクローブは、スパイスや漢方薬として一般的に用いられている開花前の花蕾部を少なくとも含んでいればよい。
クローブ:0.01〜3g、好ましくは0.5〜2g。
コリアンダー:0.01〜20g、好ましくは1〜5g。
クミン:0.01〜20g、好ましくは0.5〜5g。
ニンニク:0.01〜20g、好ましくは1〜5g。
ショウガ:0.01〜20g、好ましくは1〜5g。
トウガラシ:0.001〜2g、好ましくは0.05〜0.5g。
ウコン:0.01〜20g、好ましくは1〜10g。
タマネギ:0.01〜20g、好ましくは1〜10g。
本発明の血管内皮機能改善剤は、血管内皮機能を改善する能力を有する。血管内皮機能とは、上記したとおり、一酸化窒素(NO)、内皮由来過分極因子(EDHF)、プロスタグランジンI2といった種々の血管作動性物質を放出することで血管平滑筋緊張を調整するほか、細胞接着や血小板の粘着凝集を抑制するなど血管保護に関わる様々な機能を意味する。血管内皮機能は、手又は足の駆血後の血流依存性血管拡張反応(FMD(Flow−Mediated Dilation))による血管径の増大率(FMD値(%))に基づき評価することができる。FMD値の値が大きいほど血管内皮機能が高いことを示す。FMD値の測定は通常のFMD検査装置により行うことができる。
被験者と試験デザイン
14名の健常男性(45±9歳、BMI23.7±2.7kg/m2)を被験者とし、第1群(7名)及び第2群(7名)に無作為に振り分け、クロスオーバー試験を行った。なお、被験者は試験開始のおよそ12時間前から飲食が禁じられ(水のみ摂取可)、空腹状態にて試験に参加した。
クローブ0.9g、コリアンダー1.8g、クミン0.9g、ニンニク3.6g、ショウガ2.7g、タマネギ9g、トウガラシ0.09g、及びウコン4.5gを含むスパイスミックスをミートソース180g及び米飯200gと混合し、試験食を得た。クローブ、コリアンダー、クミン、ニンニク、ショウガ、トウガラシ、及びウコンは乾燥粉末の形態のものを用いた。タマネギは皮をむき、1/4カットしたものをソテーし、加熱処理したものを用いた。
コントロール食は、上記試験食よりスパイスミックスを除いたものを使用した。すなわち、ミートソース180g及び米飯200gとを混合し、コントロール食を得た。
FMD値の測定には(株)ユネクス社のFMD測定装置を用いた。測定方法は、既に報告されているFMD値測定のガイドラインに準じて行った(T Inoue, H et al Flow-mediated vasodilation as a diagnostic modality for vascular failure. Hypertens Res, 2008; 31(12): 2105-2113; 及び Mary C. et al Guidelines for the ultrasound assessment of endothelial-dependent flow - mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force. J. Am. Coll. Cardiol., 2002; 39(2): 257-265)。
結果を図2に示す。各結果は、測定されたFMD値の平均値を示す。
Claims (2)
- クローブ、コリアンダー、クミン、ニンニク、ショウガ、タマネギ、トウガラシ及びウコンを有効成分として含有する、食後の血糖上昇時の血管内皮機能を、空腹時の血管内皮機能よりも向上させるための、血管内皮機能増進剤。
- 単回投与により、血管内皮機能を向上させるための、請求項1に記載の血管内皮機能増進剤。
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TW202017586A (zh) | 2018-06-29 | 2020-05-16 | 日商好侍健康食品股份有限公司 | 血管內皮機能改善用或末梢血管之血流改善用組合物 |
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