JP6535679B2 - 拡張可能なサーマルサイクラーの提供及び熱電デバイスの隔離のための装置、システム、及び方法 - Google Patents

拡張可能なサーマルサイクラーの提供及び熱電デバイスの隔離のための装置、システム、及び方法 Download PDF

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Publication number
JP6535679B2
JP6535679B2 JP2016552634A JP2016552634A JP6535679B2 JP 6535679 B2 JP6535679 B2 JP 6535679B2 JP 2016552634 A JP2016552634 A JP 2016552634A JP 2016552634 A JP2016552634 A JP 2016552634A JP 6535679 B2 JP6535679 B2 JP 6535679B2
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thermal
thermoelectric device
heat sink
block
drip pan
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JP2017511697A (ja
JP2017511697A5 (enExample
Inventor
チー キオン リム，
チー キオン リム，
ウェイ スアン リー，
ウェイ スアン リー，
ウー ケン ロー，
ウー ケン ロー，
チー ウィ— チン，
チー ウィ― チン，
チン ヨン クー，
チン ヨン クー，
ス イン コー，
ス イン コー，
チョン ハン トー，
チョン ハン トー，
クアン ムーン ブー，
クアン ムーン ブー，
スー ヨン ラウ，
スー ヨン ラウ，
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ライフ テクノロジーズ コーポレーション
ライフ テクノロジーズ コーポレーション
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1883—Means for temperature control using thermal insulation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Hematology (AREA)
JP2016552634A 2014-02-18 2015-02-04 拡張可能なサーマルサイクラーの提供及び熱電デバイスの隔離のための装置、システム、及び方法 Active JP6535679B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461940981P 2014-02-18 2014-02-18
US61/940,981 2014-02-18
PCT/US2015/014357 WO2015126621A1 (en) 2014-02-18 2015-02-04 Apparatuses, systems and methods for providing scalable thermal cyclers and isolating thermoelectric devices

Publications (3)

Publication Number Publication Date
JP2017511697A JP2017511697A (ja) 2017-04-27
JP2017511697A5 JP2017511697A5 (enExample) 2018-03-01
JP6535679B2 true JP6535679B2 (ja) 2019-06-26

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JP2016552634A Active JP6535679B2 (ja) 2014-02-18 2015-02-04 拡張可能なサーマルサイクラーの提供及び熱電デバイスの隔離のための装置、システム、及び方法

Country Status (9)

Country Link
US (2) US10471431B2 (enExample)
EP (2) EP3401016A1 (enExample)
JP (1) JP6535679B2 (enExample)
KR (1) KR20160123356A (enExample)
CN (2) CN106102916B (enExample)
MX (1) MX2016010721A (enExample)
RU (1) RU2016134378A (enExample)
SG (1) SG11201606590UA (enExample)
WO (1) WO2015126621A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2922854A1 (en) 2013-09-16 2015-03-19 Life Technologies Corporation Apparatuses, systems and methods for providing thermocycler thermal uniformity
CN111016756B (zh) 2014-02-14 2023-08-08 金瑟姆股份公司 传导对流气候控制组件
US11639816B2 (en) 2014-11-14 2023-05-02 Gentherm Incorporated Heating and cooling technologies including temperature regulating pad wrap and technologies with liquid system
US11857004B2 (en) 2014-11-14 2024-01-02 Gentherm Incorporated Heating and cooling technologies
MX2018000785A (es) 2015-07-23 2018-08-29 Cepheid Dispositivo de control termico y metodos de uso.
JP6903638B2 (ja) * 2015-09-15 2021-07-14 ライフ テクノロジーズ コーポレーション 生物学的分析のためのシステム及び方法
US11583862B2 (en) 2015-09-15 2023-02-21 Life Technologies Corporation Systems and methods for biological analysis
SG11201805240PA (en) 2015-12-22 2018-07-30 Life Technologies Corp Thermal cycler systems and adaptor
USD774206S1 (en) 2016-01-22 2016-12-13 Life Technologies Corporation Thermal cycler housing
US20210291190A1 (en) * 2018-07-13 2021-09-23 Deepdivebio, Inc. Thermocycler reaction control
US10991869B2 (en) 2018-07-30 2021-04-27 Gentherm Incorporated Thermoelectric device having a plurality of sealing materials
JP7608337B2 (ja) 2018-11-30 2025-01-06 ジェンサーム インコーポレイテッド 熱電調整システム及び方法
CN113287208B (zh) * 2019-01-14 2025-08-26 生物辐射实验室股份有限公司 热泵设备和组件
US11152557B2 (en) * 2019-02-20 2021-10-19 Gentherm Incorporated Thermoelectric module with integrated printed circuit board
KR102578721B1 (ko) * 2020-10-05 2023-09-15 (주)바이오니아 핵산증폭검사장치 및 이를 구비하는 시료자동분석시스템
US12478969B2 (en) * 2022-09-29 2025-11-25 Seegene, Inc. Device for heating sample
WO2024162515A2 (ko) * 2023-02-01 2024-08-08 구상호 온도 조절 모듈의 인출입이 가능하고 가열 및 냉각 기능을 갖는 핵산 추출 장치

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3036893A (en) 1960-03-14 1962-05-29 Scientific Industries Automatic chemical analyzer
US3260413A (en) 1964-08-31 1966-07-12 Scientific Industries Automatic chemical analyzer
US3216804A (en) 1962-01-31 1965-11-09 Scientific Industries Automatic chemical analyzer and sample dispenser
US3128239A (en) 1962-06-29 1964-04-07 Robert Z Page Biological detection equipment
US3261668A (en) 1962-08-14 1966-07-19 Scientific Industries Chemical analyzer tape
US3271112A (en) 1962-12-12 1966-09-06 Donald L Williams Apparatus for laboratory testing
US3368872A (en) 1964-08-31 1968-02-13 Scientific Industries Automatic chemical analyzer
EP0089383B1 (de) 1982-03-18 1985-08-28 Turgut Koruk Quantisierte (digitale) Heizplatte
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5038852A (en) 1986-02-25 1991-08-13 Cetus Corporation Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
CA1339653C (en) 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
EP0342155A3 (de) 1988-05-13 1990-06-27 Agrogen-Stiftung Laboratoriumsgerät zum wahlweisen Heizen und Kühlen
GB8814962D0 (en) 1988-06-23 1988-07-27 Lep Scient Ltd Biochemical reaction machine
US4865986A (en) 1988-10-06 1989-09-12 Coy Corporation Temperature control apparatus
DE8814398U1 (de) 1988-11-17 1989-02-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV, 3400 Göttingen Thermostatiergerät
US4950608A (en) 1989-04-25 1990-08-21 Scinics Co., Ltd. Temperature regulating container
US5504007A (en) 1989-05-19 1996-04-02 Becton, Dickinson And Company Rapid thermal cycle apparatus
DE4029004C1 (enExample) 1990-09-13 1992-04-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften Ev, 3400 Goettingen, De
US6703236B2 (en) 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
FI915731A0 (fi) 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
DE4234086A1 (de) 1992-02-05 1993-08-12 Diagen Inst Molekularbio Verfahren zur bestimmung von in vitro amplifizierten nukleinsaeuresequenzen
US5601141A (en) 1992-10-13 1997-02-11 Intelligent Automation Systems, Inc. High throughput thermal cycler
US5441576A (en) 1993-02-01 1995-08-15 Bierschenk; James L. Thermoelectric cooler
CA2130517C (en) 1993-09-10 1999-10-05 Walter Fassbind Array of reaction containers for an apparatus for automatic performance of temperature cycles
CA2130013C (en) * 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
US5525300A (en) * 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
DE4435107C1 (de) 1994-09-30 1996-04-04 Biometra Biomedizinische Analy Miniaturisierter Fluß-Thermocycler
US20020068357A1 (en) 1995-09-28 2002-06-06 Mathies Richard A. Miniaturized integrated nucleic acid processing and analysis device and method
US6825047B1 (en) 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
WO1998005060A1 (en) 1996-07-31 1998-02-05 The Board Of Trustees Of The Leland Stanford Junior University Multizone bake/chill thermal cycling module
DE19646115C2 (de) 1996-11-08 2000-05-25 Eppendorf Geraetebau Netheler Verwendung von Temperiereinrichtungen zur Temperierung eines Temperierblockes
DE29623597U1 (de) 1996-11-08 1999-01-07 Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg Temperierblock mit Temperiereinrichtungen
JP2001521379A (ja) 1997-03-28 2001-11-06 ザ パーキン−エルマー コーポレーション Ｐｃｒのための熱サイクラの改良
US6106784A (en) 1997-09-26 2000-08-22 Applied Chemical & Engineering Systems, Inc. Thawing station
US6558947B1 (en) 1997-09-26 2003-05-06 Applied Chemical & Engineering Systems, Inc. Thermal cycler
WO1999019067A1 (en) 1997-10-10 1999-04-22 Biosepra, Inc. Aligned multiwell multiplate stack and method for processing biological/chemical samples using the same
US7188001B2 (en) 1998-03-23 2007-03-06 Cepheid System and method for temperature control
US6093370A (en) 1998-06-11 2000-07-25 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
JP2000102376A (ja) 1998-09-30 2000-04-11 Sanyo Electric Co Ltd インキュベータの温度制御装置
US6337435B1 (en) 1999-07-30 2002-01-08 Bio-Rad Laboratories, Inc. Temperature control for multi-vessel reaction apparatus
US6633785B1 (en) 1999-08-31 2003-10-14 Kabushiki Kaisha Toshiba Thermal cycler and DNA amplifier method
DE29917313U1 (de) 1999-10-01 2001-02-15 MWG-BIOTECH AG, 85560 Ebersberg Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen
US7169355B1 (en) * 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
JP4457331B2 (ja) 2000-03-31 2010-04-28 エイブル株式会社 振とう培養機及び培養液の計測または制御方法
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
GB2366628B (en) 2000-09-11 2002-09-18 Bookham Technology Plc Method and apparatus for temperature control
US7727479B2 (en) 2000-09-29 2010-06-01 Applied Biosystems, Llc Device for the carrying out of chemical or biological reactions
JP2002355038A (ja) 2001-03-29 2002-12-10 Japan Science & Technology Corp 遺伝子解析方法およびその解析装置
JP2004534386A (ja) * 2001-04-09 2004-11-11 リサーチ・トライアングル・インスティチュート Ｄｎａゲノムチップ、プロテオームチップ、熱光スイッチング回路および赤外線タグ用薄膜熱電加熱冷却装置
DE10221763A1 (de) 2002-05-15 2003-12-04 Eppendorf Ag Thermocycler mit in Cyclen angesteuertem Temperierblock
JP3980966B2 (ja) 2002-08-21 2007-09-26 シャープ株式会社 プレゼンテーション用表示装置
US6730883B2 (en) * 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
US8676383B2 (en) * 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
US20070184548A1 (en) * 2002-12-23 2007-08-09 Lim Hi Tan Device for carrying out chemical or biological reactions
AU2004243070B2 (en) * 2003-05-23 2010-04-15 Bio-Rad Laboratories, Inc. Localized temperature control for spatial arrays of reaction media
US20040241048A1 (en) 2003-05-30 2004-12-02 Applera Corporation Thermal cycling apparatus and method for providing thermal uniformity
US7122799B2 (en) 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
US7694694B2 (en) 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
WO2006002403A1 (en) 2004-06-23 2006-01-05 Applera Corporation Thermal cycler
US7585663B2 (en) 2004-08-26 2009-09-08 Applied Biosystems, Llc Thermal device, system, and method, for fluid processing device
US7051536B1 (en) * 2004-11-12 2006-05-30 Bio-Rad Laboratories, Inc. Thermal cycler with protection from atmospheric moisture
EP1710017B1 (en) * 2005-04-04 2012-12-19 Roche Diagnostics GmbH Thermocycling of a block comprising multiple samples
US7303450B2 (en) * 2005-09-06 2007-12-04 Lear Corporation Electrical terminal assembly
WO2008070198A2 (en) 2006-05-17 2008-06-12 California Institute Of Technology Thermal cycling system
WO2007146443A2 (en) 2006-06-14 2007-12-21 Oldenburg Kevin R Ph D Thermal-cycling devices and methods of using the same
US20080038163A1 (en) * 2006-06-23 2008-02-14 Applera Corporation Systems and Methods for Cooling in Biological Analysis Instruments
US20080087316A1 (en) 2006-10-12 2008-04-17 Masa Inaba Thermoelectric device with internal sensor
DE102007003754A1 (de) 2007-01-19 2008-07-24 Eppendorf Ag Temperiervorrichtung mit Kalibrierungseinrichtung
US20080176292A1 (en) 2007-01-23 2008-07-24 Texas A&M University System Portable buoyancy driven pcr thermocycler
WO2008116184A1 (en) * 2007-03-21 2008-09-25 Applera Corporation Adaptive thermal block temperature control method and system
US9170060B2 (en) 2008-01-22 2015-10-27 Lawrence Livermore National Security, Llc Rapid microfluidic thermal cycler for nucleic acid amplification
EP2153901A1 (de) 2008-08-01 2010-02-17 Eppendorf Ag Temperierungsvorrichtung mit Testmöglichkeit und Verfahren zum Testen einer Temperierungsvorrichtung
US20100081191A1 (en) * 2008-09-26 2010-04-01 Marlow Industries, Inc. Anisotropic heat spreader for use with a thermoelectric device
US20100124766A1 (en) * 2008-11-14 2010-05-20 Life Technologies Corporation Apparatus and Method for Segmented Thermal Cycler
KR20110111449A (ko) 2008-12-31 2011-10-11 인터젠엑스 인크. 미세유체 칩을 갖는 기구
EP2473893B1 (en) 2009-09-01 2021-07-28 Life Technologies Corporation Thermal block assemblies and instruments providing low thermal non-uniformity for rapid thermal cycling
GB201005704D0 (en) * 2010-04-06 2010-05-19 It Is Internat Ltd Improvements in systems for chemical and/or biochemical reactions
CN103003448B (zh) 2010-04-09 2015-06-17 生命技术公司 使用动态控制改进热循环仪的热均匀性
JP5867668B2 (ja) 2010-12-01 2016-02-24 セイコーエプソン株式会社 熱サイクル装置及び熱サイクル方法
CN106268992A (zh) 2010-12-17 2017-01-04 Bjs Ip有限公司 用于快速pcr加热的方法及系统
JP5687514B2 (ja) 2011-02-17 2015-03-18 株式会社日立ハイテクノロジーズ 核酸配列解析装置
US20130157376A1 (en) 2011-12-20 2013-06-20 Idaho Technology, Inc. Thermal Cycler Calibration Device and Related Methods
EP2825865B1 (en) 2012-03-09 2020-07-22 Ubiquitome Limited Portable device for detecting molecule(s)
CA2922854A1 (en) 2013-09-16 2015-03-19 Life Technologies Corporation Apparatuses, systems and methods for providing thermocycler thermal uniformity

Also Published As

Publication number Publication date
JP2017511697A (ja) 2017-04-27
RU2016134378A3 (enExample) 2018-05-29
US10471431B2 (en) 2019-11-12
EP3107658B1 (en) 2018-07-04
US20200101461A1 (en) 2020-04-02
US20150231636A1 (en) 2015-08-20
EP3107658A1 (en) 2016-12-28
CN204874536U (zh) 2015-12-16
WO2015126621A1 (en) 2015-08-27
CN106102916B (zh) 2019-04-23
RU2016134378A (ru) 2018-03-22
EP3401016A1 (en) 2018-11-14
CN106102916A (zh) 2016-11-09
KR20160123356A (ko) 2016-10-25
MX2016010721A (es) 2016-11-23
SG11201606590UA (en) 2016-09-29

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