JP6532944B2 - 眼圧を下げる装置および方法 - Google Patents
眼圧を下げる装置および方法 Download PDFInfo
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- JP6532944B2 JP6532944B2 JP2017530965A JP2017530965A JP6532944B2 JP 6532944 B2 JP6532944 B2 JP 6532944B2 JP 2017530965 A JP2017530965 A JP 2017530965A JP 2017530965 A JP2017530965 A JP 2017530965A JP 6532944 B2 JP6532944 B2 JP 6532944B2
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- eye
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- discharge device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
- A61F2250/0024—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity made from both porous and non-porous parts, e.g. adjacent parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0051—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Description
眼球の前眼房に配置されるように構成された入口端と、出口端との間に延びるチューブであって、チューブが、入口端と出口端との間の流体流のための経路を画定する、チューブと、
内面および外面を有し、内面が眼球の外で結膜層を接触するように構成された出口部品であって、出口部品が、
チューブの出口端と流体連通するキャビティを画定し、外眼部表面の上への房水の放出を可能にするためキャビティへのアパーチャ開口部を有する筐体と、
チューブの出口端とアパーチャとの間の筐体のキャビティに配置された抵抗部であって、抵抗部が、眼球の前眼房から外眼部表面へチューブを通じて房水の流れを制御するために流れに対する抵抗を提供するよう構成されている、抵抗部と、
筐体と反対の方向で外側に突出する一対のタブであって、タブが、眼球に対して排出装置を固定するために結膜下に配置するよう適合されているタブと
を含む、出口部品と
を含む、装置。
眼から房水を排出する装置を提供するステップであって、排出装置が、
入口端と出口端との間に延びるチューブであって、チューブが、入口端と出口端との間に流体流のための経路を画定する、チューブと、
内面および外面を有する出口部品であって、出口部品が、
チューブの出口端と流体連通するキャビティを画定し、房水の放出を可能にするためキャビティにアパーチャ開口部を有する筐体と、
チューブの出口端とアパーチャとの間の筐体のキャビティに配置した抵抗部であって、抵抗部が、眼球の前眼房から外眼部表面にチューブを通じて房水の流れを制御するために流れに抵抗を提供するよう構成されている抵抗部と、
筐体から反対方向で外側に突出する一対のタブと
を含む出口部品と、
を含む、ステップと、
房水が眼の前眼房から外眼部表面にチューブを通じて流れるように眼に排出装置を埋め込むステップと、
結膜層の下にタブを固定するステップと
を含む、方法。
排出装置を埋め込むステップが、
結膜を切開することと、
結膜の下の切開の中にチューブの入口端を前進させることと、
眼の角膜縁の近くの切開部位に眼の組織を浸透させることと、
眼の前眼房の中の内側へ切開部位でチューブの入口端を通過させることと、
目蓋の下で結膜の外へ出口部品を配置することと、
チューブの入口端から外眼部表面へ、前眼房の房水を導くことと、
房水の流れを調節することと
を含む、先行または後述の実施形態のいずれかの方法、またはそれらの組み合わせ。
Claims (28)
- 眼圧を下げるため、眼から房水を排出する装置であって、前記眼が前眼房を有し、角膜と、前記角膜が強膜層および結膜層と連続している周辺角膜縁と、前記眼および目蓋の下の露出した眼の表面とを含み、前記排出装置が、
眼球の前眼房に配置されるように構成された入口端と、出口端との間に延びるチューブであって、前記チューブが、前記入口端と前記出口端との間の流体の流れのための経路を画定する、チューブと、
内面および外面を有し、前記内面が前記眼球の外で前記結膜層を接触するように構成された出口部品であって、前記出口部品が、
前記チューブの出口端と流体連通するキャビティを画定し、前記チューブから外眼部表面の上への流体の放出を可能にするために前記キャビティからの開口部を有する筐体と、
前記筐体のキャビティの少なくとも一部の中に配置されたフィルター要素と、
前記出口部品から取り外されるように構成された取り外し可能なカートリッジと、
を含む、出口部品と、
を含み、
前記流体が、前記フィルター要素および前記取り外し可能なカートリッジを通じて流れ、
前記取り外し可能なカートリッジが、前記眼球の前眼房から前記外眼部表面への前記流体の流れに対する所定の抵抗を提供し、かつ/または生体付着または詰まりを防止するよう構成されており、
前記取り外し可能なカートリッジが、前記フィルター要素が前記キャビティ内に留まっている間に前記出口部品から取り外されるように構成されている、排出装置。 - 前記チューブが、前眼房から前記目蓋の下の眼の外眼部表面へ延びるように十分な長さを有する、請求項1に記載の排出装置。
- 前記チューブの入口端が傾斜している、請求項1に記載の排出装置。
- 前記チューブが折りたたみ式である、請求項1に記載の排出装置。
- 前記筐体内の開口部が、前記開口部の反対側で所定の圧力差に応答して流体が前記筐体を出ることを可能にするための一方向弁を形成する、請求項1に記載の排出装置。
- 前記開口部が細長いスリットである、請求項5に記載の排出装置。
- 前記筐体と反対の方向で外側に突出する一対のタブであって、前記タブが、前記眼球に対して前記排出装置を固定するために結膜下に配置されるように適合されている、タブ
をさらに含む、請求項1に記載の排出装置。 - 前記タブがそれぞれ縫合を通過する開口部を画定する、請求項7に記載の排出装置。
- 前記チューブの外面に配置されたアンカー部材であって、前記チューブが前記眼に埋め込まれる場合に前記眼球の組織を係合するように構成されたアンカー部材をさらに含む、請求項1に記載の排出装置。
- 前記アンカー部材が前記チューブの入口端に隣接している、請求項9に記載の排出装置。
- 前記アンカー部材が、前記チューブの外面から外側に延びる少なくとも1つの略三角形のフランジを含む、請求項9に記載の排出装置。
- 前記少なくとも1つの略三角形のフランジが、前記チューブの外面に沿って長手方向に離間した複数のフランジを含む、請求項11に記載の排出装置。
- 前記複数のフランジが、前記チューブの遠位端に沿って配置されている、請求項12に記載の排出装置。
- 前記アンカー部材が、前記チューブの外面に形成されており、前記出口端に向けて外側へ半径方向に傾斜している複数の軸方向に離間した突起を含む、請求項9に記載の排出装置。
- 前記突起が、前記チューブの外側に沿って一体となり形成されている、請求項14に記載の排出装置。
- 前記アンカー部材が、前記チューブの外面に形成された少なくとも1つの周辺の溝を含む、請求項9に記載の排出装置。
- 前記チューブの外面に配置された縫合バーをさらに含み、前記縫合バーが、前記眼に縫合で前記チューブを固定するために前記眼の表面に隣接するよう構成されている、請求項1に記載の排出装置。
- 前記取り外し可能なカートリッジが、前記ハウジングのキャビティ内に前記取り外し可能なカートリッジを封入する拡大可能な材料から形成されている、請求項1に記載の排出装置。
- 前記フィルター要素が、複数の各々の孔径を有する複数の孔を含む、請求項1に記載の排出装置。
- 前記フィルター要素が、前記フィルター要素の長さに沿ってある勾配の孔径を有する、請求項19に記載の排出装置。
- 前記出口部品が、前記出口部品の外面に一体となり形成されている、外側に突出するリッジ部材を含む、請求項1に記載の排出装置。
- 前記結膜層の内殖を促進するために、前記チューブまたは前記出口部品の外面の少なくとも一部に配置されている、増殖を刺激する多孔性の細胞内殖材料の層をさらに含む、請求項1に記載の排出装置。
- 前記増殖を刺激する材料の層が、ヒドロキシアパタイトまたは多孔性ポリエチレンを含む、請求項22に記載の排出装置。
- 前記取り外し可能なカートリッジが、前記筐体の開口部を介して前記出口部品から取り外し可能であるように構成されている、請求項1に記載の排出装置。
- 前記フィルター要素が、前記取り外し可能なカートリッジの上流に配置されており、それにより、前記流体が前記チューブから前記フィルター要素へ流れ、その後前記フィルター要素から前記取り外し可能なカートリッジへ流れる、請求項1に記載の排出装置。
- 前記取り外し可能なカートリッジが、前記生体付着または詰まりを防止する薬剤を含む、請求項1に記載の排出装置。
- 前記筐体のキャビティが入口を含み、前記フィルター要素が前記キャビティの入口を閉鎖する、請求項1に記載の排出装置。
- 前記筐体がフランジを含み、前記フィルター要素が、前記キャビティの入口を閉鎖するように前記フランジに対して封入されている、請求項27に記載の排出装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US14/473,228 | 2014-08-29 | ||
US14/473,228 US10201451B2 (en) | 2014-08-29 | 2014-08-29 | Device and method for reducing intraocular pressure |
PCT/US2015/047080 WO2016033270A1 (en) | 2014-08-29 | 2015-08-27 | Device and method for reducing intraocular pressure |
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JP2019095760A Division JP2019150653A (ja) | 2014-08-29 | 2019-05-22 | 眼圧を下げる装置および方法 |
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JP2017526504A JP2017526504A (ja) | 2017-09-14 |
JP6532944B2 true JP6532944B2 (ja) | 2019-06-19 |
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JP2017530965A Active JP6532944B2 (ja) | 2014-08-29 | 2015-08-27 | 眼圧を下げる装置および方法 |
JP2019095760A Pending JP2019150653A (ja) | 2014-08-29 | 2019-05-22 | 眼圧を下げる装置および方法 |
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EP (1) | EP3185824A1 (ja) |
JP (2) | JP6532944B2 (ja) |
CA (1) | CA2959520C (ja) |
WO (1) | WO2016033270A1 (ja) |
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JP2017526504A (ja) | 2017-09-14 |
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EP3185824A1 (en) | 2017-07-05 |
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