JP6530187B2 - Collagen peptide-containing composition - Google Patents

Description

  The present invention relates to a collagen peptide-containing composition. More particularly, the present invention relates to a composition containing collagen peptide, proteoglycan, ceramide, and pectin, and a method for suppressing the formation of aggregates or precipitates in a composition containing collagen peptide, proteoglycan, and ceramide.

  In recent years, beauty and skin aging prevention have attracted the interest of women. Collagen peptides have various functions such as skin-refining effects such as improving the moisture retention and elasticity of the skin, and effects of improving blood fluidity, and thus have been incorporated in many beverages, foods, cosmetics, etc. in recent years . In addition, proteoglycans have the ability to activate skin metabolism and have high moisturizing power, and thus are widely recognized as a skin care component by general consumers, and are blended in various products. Furthermore, ceramide is known to have an effect of protecting the skin and preventing rough skin.

  Thus, collagen peptides, proteoglycans and ceramides have cosmetic effects such as moisturizing and protective effects on the skin and improvement of sag. Therefore, these components are often blended in food and drink, medicines, cosmetics and the like.

  As a composition containing a functional component such as collagen peptide, many beverages are adopted. Beverages can be added at higher concentrations than ingredients such as capsules and tablets, and are easy to ingest, and the commercial value can be enhanced by selecting flavors, acidulants, sweeteners, etc. in accordance with consumer preferences. . However, in the case of compositions containing collagen peptides and the like, the formation of aggregates and precipitates may be problematic. Several methods have been reported as techniques for suppressing the formation of aggregates and precipitates in the composition (Patent Documents 1 and 2).

Patent No. 3416102 Patent No. 5021909

  In a composition containing a collagen peptide or the like, aggregates and precipitates may be formed to impair the appearance of the composition. Due to such appearance problems, a composition containing a collagen peptide or the like may cause a reduction in the product image or the reduction in the commercial value.

  An object of the present invention is to provide a composition in which the formation of aggregates and precipitates is suppressed.

  As a result of intensive studies to solve the above problems, the inventors of the present invention produced aggregates or precipitates in a composition containing collagen peptide, proteoglycan and ceramide, and the formation of aggregates or precipitates was pectin. It has been found that the addition can suppress.

That is, the present invention relates to the following, but is not limited thereto.
1). A composition comprising collagen peptide, proteoglycan, ceramide and pectin.
2). The composition according to 1), which is liquid.
3). The composition according to 1) or 2), wherein the content of proteoglycan is 0.0001 to 0.05 w / v%.
4). The composition according to any one of 1) to 3), wherein the content of pectin is 0.05 to 0.8 w / v%.
5). The composition according to any one of 1) to 4), wherein the ratio of the weight of proteoglycan to the weight of pectin (proteoglycan weight: pectin weight) is 1: 1 to 1: 800.
6). The composition in any one of 1) -5 whose content of a collagen peptide is 1.0-25 w / v%.
7). The composition in any one of 6) whose content of ceramide is 0.0001-0.1 w / v%.
8). The composition according to any one of 2) to 7), wherein the pH is 2.5 to 5.0.
9). The composition according to any one of 1) to 8), which is for oral use.
10). The composition according to any one of 1) to 9), which is for beautifying skin.
11). A method of suppressing the formation of aggregates or precipitates in compositions containing collagen peptides, proteoglycans and ceramides,
The above method, comprising the step of blending pectin with the composition.
12). The composition according to any one of claims 1 to 10, wherein the indication is attributable to the efficacy of collagen peptide, proteoglycan, ceramide or pectin.

  The present invention can suppress the formation of aggregates or precipitates by blending pectin with a composition containing a collagen peptide, proteoglycan and ceramide.

1. component
1-1. Collagen peptide The collagen peptide used in the present invention can be obtained by hydrolysis treatment of denatured collagen such as collagen or gelatin with an enzyme, acid, alkali or the like, but the origin and production method thereof are not particularly limited. .

  For example, collagen or gelatin as a raw material may be derived from bovine, porcine, chicken, fish or the like, and one or more of these may be used as a raw material.

  The enzyme used for collagen peptide preparation may be any enzyme capable of cleaving peptide bonds of collagen or gelatin, for example, collagenase, papain, bromelain, actinidin, ficin, cathepsin, pepsin, chymosin, trypsin, and the like. The enzyme preparation etc. which mixed the enzyme are mentioned.

  As the acid, for example, hydrochloric acid, sulfuric acid, nitric acid and the like can be used. As the alkali, for example, sodium hydroxide, calcium hydroxide or the like can be used.

  In the present invention, an aqueous solution of hydrolyzed collagen peptide may be used as it is, or a powder obtained by drying or the like may be used. Moreover, you may use what performed the refinement | purification process normally used to the said aqueous solution as forms, such as aqueous solution and powder. Even when any of these forms is used, the effect of the present invention is not affected at all.

  The average molecular weight of the collagen peptide is also not particularly limited. However, the larger the average molecular weight, the lower the body's absorbability of collagen peptide, or the more easily it solidifies at low temperature depending on the concentration. The smaller the average molecular weight, the more the body's absorbability increases, but the bitterness and bitterness peculiar to peptides occur. It will Taking these points into consideration, the average molecular weight of the collagen peptide used in the present invention is preferably 300 to 10,000, more preferably 500 to 9,000, and particularly preferably 500 to 6,000. Also, the average molecular weight may be 1,000 to 8,700. The average molecular weight of the collagen peptide in the present specification means the weight average molecular weight, and means the value measured by the Pagui method (gel filtration chromatography method).

  The collagen peptide may be a commercially available product, and a collagen peptide of a preferred molecular weight can be used. For example, commercially available "Nippipeptide PRA" (Nippi Co., Ltd.), "water-soluble collagen peptide SS" (Kyowa Fermentation Bio Co., Ltd.) "Collagen peptide SCP" (Nitta Gelatin Co., Ltd.), "HACP" (Gelese Co., Ltd.) Etc. can be used.

  In the present invention, one collagen peptide may be used alone, or two or more collagen peptides may be used in combination. The total content of collagen peptides in the composition of the present invention may vary depending on the application of the composition containing it, but typically it is 1.0 to 35 w / v%, preferably 1.0 to 25 w / V%, more preferably 2.0 to 20 w / v%.

1-2. Proteoglycan proteoglycan is a generic term for compounds in which glycosaminoglycans (mucopolysaccharides) such as chondroitin sulfate and dermatan sulfate are covalently bonded to a protein as a core. It is present in connective tissues such as animal cartilage and skin, and is a substance necessary to maintain the structure of these tissues. Examples of proteoglycans include aggrecan (Aggrecan), versican (Versican), neurocan (Neurocana), brevican (Brevican), decorin (Decorin), biglycan (Biglycan), testican (Testican), perlecan (Dholecan) Dystroglycan, Agrin, Claustrin etc. may be mentioned.

  There are no particular limitations on the type, origin and production method of proteoglycan used in the present invention. For example, any of the above proteoglycans may be used alone, or two or more types may be used in combination. Among them, aggrecan is preferred, and can be used alone or in combination with other proteoglycans. Moreover, the origin animal of proteoglycan is not limited, for example, it is derived from animals such as mammals (cow, pig etc.), birds (chicken etc.), fish (shark, salmon etc.), molluscs (squid, octopus etc) In addition, those derived from one or more animals can be used. Among these, salmon-derived, particularly salmon-derived nasal cartilage-derived ones are preferable, and can be used alone or in combination with other proteoglycans. The production method may be any known method such as an extraction method using a solvent such as water, acid (acetic acid etc.), alkali (sodium hydroxide, potassium hydroxide etc.), alcohol and the like. Although purification is not essential, known methods such as desalting and molecular weight fractionation may be used for purification. The molecular weight of proteoglycan is usually tens of thousands to tens of millions. The molecular weight of proteoglycan used in the present invention is also not particularly limited, but preferably 100,000 to 2,000,000.

  In the present invention, an aqueous solution containing proteoglycan may be used as it is, or a powder obtained by drying or the like may be used. Moreover, you may use what performed the refinement | purification process normally used to the said aqueous solution as forms, such as aqueous solution and powder. Even when any of these forms is used, the effect of the present invention is not affected at all.

  The total content of proteoglycans in the composition of the present invention may vary depending on the use of the composition containing it, but typically it is 0.0001 to 0.05 w / v%, preferably 0.001 to It is 0.05 w / v%, more preferably 0.002 to 0.02 w / v%.

  The method for measuring the content may be any known method, and for example, gel chromatography-molecular weight fractionation can be used. That is, molecular weight fractionation is performed using gel chromatography, and quantification with proteoglycan standard reagent (proteoglycan, salmon nasal cartilage origin (Wako Pure Chemical Industries)) is performed, or the molecular weight is 10,000 or more and the presence of acidic sugar and protein Measure the dry matter of the fraction for which it was confirmed. The presence of the acidic sugar can be confirmed by the carbazole sulfate method, and the presence of the protein can be confirmed by the measurement of absorbance at around 280 nm.

1-3. Ceramide Ceramide is a type of sphingolipid in which sphingosine and lipid form an amide bond. Various hydrophilic groups are bonded to this ceramide to form a major complex sphingolipid (sphingolipid containing phosphorus, sulfur, amino acid, sugar and the like in the molecule). For example, sphingomyelin in which phosphocholine is bound to ceramide is known as a major sphingophospholipid of animals. Further, a substance in which sugar is glycosidically bonded to ceramide is a glycosphingolipid. Glycosphingolipids are widely present in animals, plants, fungi and the like, and representative one is cerebroside in which monosaccharide is linked to ceramide. As cerebrosides, glucosylceramide in which glucose is linked to ceramide and galactosylceramide in which galactose is linked to ceramide are present in animals, and in plants and fungi, β-glucosylceramide in which glucose is linked to β-glycosidic linkage to ceramide is present.

  Ceramide plays an important role in the moisturizing function and barrier function of the skin in the horny layer which is the outermost layer of the skin. It is also known that ceramide exerts a moisturizing effect on the skin by constructing an intercellular lamellar structure in the stratum corneum after being produced and secreted in epidermal cells, and has an effect of protecting the skin and preventing roughening of the skin. It is done.

  The ceramide used in the present invention is not particularly limited as long as it is a compound having a sphing skeleton, and examples thereof include ceramides, sugar ceramides, sphingophospholipids, and glycosphingolipids, with sugar ceramides being particularly preferable. Examples of sugar ceramides include glucosyl ceramide, galactosyl ceramide and the like, and glucosyl ceramide is particularly preferable. As what is marketed, for example, commercially available Oryza ceramide WSP (Oriza Oilification Co., Ltd.), milk ceramide MC-5 SD30 (Snow Mark Meg Milk Co., Ltd.), etc. can be used.

  Raw materials of ceramide used in the present invention include, for example, epidermis of pig, cow, horse etc., brain, viscera or head of fish, mollusc or arthropod, chicken egg, milk etc. , Rye, rice, soybeans, corn, sweet potato, konnyaku, spinach, mushrooms (like maitake, tomogitake etc.), grapes, cherries, yuzu, olives, shiso, shikuwasa, prune, beets etc It is not a thing. Among these, those derived from rice are preferred. The ceramide used in the present invention may be a natural product or a synthetic product, and the method for extracting and purifying ceramide is not particularly limited. Moreover, although the animal and plant extract containing ceramide and the adjustment product which raised the content rate of ceramide with various methods can be used, the purity of ceramide is not specifically limited, either, The purity in which the refinement | purification process is given In addition to high ceramides, crude ceramides of low purity can also be used.

  In the present invention, an aqueous solution containing ceramide may be used as it is, or a powder obtained by drying or the like may be used. Moreover, you may use what performed the refinement | purification process normally used to the said aqueous solution as forms, such as aqueous solution and powder. Even when any of these forms is used, the effect of the present invention is not affected at all.

  The total content of ceramide in the aqueous liquid composition of the present invention may vary depending on the application of the composition containing it, but typically it is 0.0001 to 0.1 w / v%, preferably 0. It is 0005 to 0.05 w / v%, more preferably 0.001 to 0.005 w / v%.

1-4. Pectin Pectin is a high molecular weight carbohydrate, and is contained in plant leaves, stems and fruits, in particular, as a component of cells in the plant body and cells. This pectin is a polygalacturonic acid in which D-galacturonic acid is linearly linked by an α-1,4 bond, and is made of protopectin, pectinic acid, amidated pectin, pectic acid and the like. Since pectin can be used also for acidic foods, it is used as a gelling agent such as jam and jelly, and as a milk protein stabilizer such as yogurt drink.

  Pectins are generally classified roughly into HM pectins having an esterification degree of 50% or more and LM pectins having a degree of esterification of less than 50%, and the gelling conditions and gelling properties are different, but they are not particularly limited in the present invention.

  The pectin used in the present invention can be obtained by extraction from plant raw materials, but its origin and production method are not particularly limited. For example, citrus fruits (orange, grapefruit, yuzu, lime, lemon, etc.), apples, sugar beet etc. can be used as a raw material. Although the site | part containing a pectin varies in a leaf, a stem, a fruit, a peel, etc., the site | part used in this invention is not specifically limited, You may select and use a specific site | part even if it is whole fruit etc. Moreover, the kind is not particularly limited. In the present invention, pectin derived from citrus peel can be suitably used. As a commercially available product, for example, commercially available pectin P-27 (Nitta Gelatin Co., Ltd., Neosoft P (Sun Chemical Co., Ltd.), etc. can be used etc. The method for producing pectin used in the present invention is particularly limited. Alternatively, it can be produced from plant raw materials and the like through processes such as extraction, filtration, alcohol precipitation, drying, and grinding using a known method.

  In the present invention, an aqueous solution of pectin may be used as it is, or a powder obtained by drying or the like may be used. Moreover, you may use what performed the refinement | purification process normally used to the said aqueous solution as forms, such as aqueous solution and powder. Even when any of these forms is used, the effect of the present invention is not affected at all.

  The total content of pectin in the composition of the present invention may vary depending on the application of the composition containing it, but typically 0.05 to 0.8 w / v%, preferably 0.05 to 0 And more preferably 0.1 to 0.5 w / v%, and even more preferably 0.1 to 0.3 w / v%.

1-5. Proteoglycan Weight to Pectin Weight Ratio The present invention incorporates pectin to inhibit the formation of aggregates or precipitates derived from collagen peptides, proteoglycans, and ceramides in the composition. In the present invention, the ratio of proteoglycan weight to pectin weight is not particularly limited, but, for example, the ratio of proteoglycan weight to pectin weight in the composition (proteoglycan weight: pectin weight) is 1: 1 or more, preferably 1: 2 Or more, more preferably 1: 5 or more, still more preferably 1:10 or more, 1: 800 or less, preferably 1: 500 or less, more preferably 1: 100 or less, even more preferably 1:50 or less is there. Specifically, the ratio of proteoglycan weight to pectin weight (proteoglycan weight: pectin weight) in the composition is 1: 1 to 1: 800, preferably 1: 2 to 1: 500, more preferably 1: 5 to 1: 100, even more preferably 1:10 to 1:50.
2. Composition
2-1. pH
The formation of aggregates and precipitates from collagen peptides, proteoglycans and ceramides is often problematic at low pH. The composition containing the collagen peptide, proteoglycan, ceramide and pectin of the present invention can also suppress the formation of the above-mentioned aggregates and precipitates in a low pH range. The pH of the composition of the present invention is not particularly limited, but in view of the above-mentioned properties, a low pH is preferred. Such low pH range is typically pH 2.5 to pH 5.0, preferably pH 3.0 to pH 4.5, more preferably pH 3.3 to pH 4.0.
2-2. Composition The present invention relates to a composition comprising collagen peptide, proteoglycan, ceramide and pectin. In the present specification, the "composition" is not particularly limited. For example, a solid composition, a liquid composition, etc. are mentioned. Preferably, it is a liquid composition based on water, more preferably an aqueous liquid composition, and examples thereof include an aqueous solution, a suspension, and a dispersion. Generally, the collagen-containing aqueous solution may cause precipitation or separation during storage, but it is shaken at the time of use to disperse or dissolve the precipitate or separated matter. Thus, the compositions of the present invention also include those that produce such acceptable precipitation, separation, clouding, and the like. In addition, the composition may optionally contain a medium other than water, such as alcohol.

2-3. Plant Material The composition of the present invention may further contain a plant material, depending on the purpose. Such plant material is preferably one containing a cosmetically effective component, for example, pepper family plant extract (eg, hihatsu extract), flax lignan (secoilisalycinol diglycoside, matiresinol, pinoresinol, isolaricilesi) Nord, etc.) Linseed extract, cherry blossom extract, lotus cup extract, ginger extract, cinnamon extract, soy isoflavone, rose flower extract, plant origin (wheat, rice germ, straw, corn germ, pineapple) ceramide, lotus germ extract, Mulberry tea extract, firewood extract, pine bark extract, machiko extract, artichoke leaf extract, red seaweed extract, hyperglossia extract, sage extract, body oil extract, raspberry extract, donut oil extract, neem leaf extract, gotsukora extract, amla extract, mangosteen peel And Alnia extract, middle leaf extract, cottonseed extract, ginseng extract, fruit seed extract, purple brown rice extract, moon peach leaf extract, star fruit leaf extract, aloe extract, etc., and one or more of these may be used It can be used as a component of the composition of the invention.

  Hihatsu extract, linseed extract, cherry blossom extract, lotus cup extract, respectively, hijasu (long pepper, Piper longum), ear of flaxseed, linseed or flaxseed, cherry blossom, lotus cup of honeysuckle family (Lonicera caerulea L. ssp. Edus Hulten) It can be obtained by concentrating squeezed juice and extract obtained from fruits by methods such as pressing and solvent extraction. Other extracts or extracts can likewise be obtained from plant material. For the extraction, solvents such as water, methanol, ethanol and isopropanol can be used. Also, although not essential, purification may be performed.

2-4. Other Components The composition of the present invention may further contain additional components as long as the effects of the present invention are not adversely affected. Such components include, for example, vitamins, minerals, nutritional components, flavors, antioxidants, pigments, preservatives, seasonings, sweeteners, acidulants, pH adjusters, stabilizers, tonicity agents, Emulsifiers, buffers, fortifiers, preservatives.

2-5. Applications Since the composition of the present invention can be expected to have excellent skin-beautifying effects derived from components such as collagen peptides, it is used, for example, for preventing skin roughening, moisturizing skin, protecting skin, improving skin sag, etc. It can be provided by explicitly or implicitly indicating a certain effect, and is extremely useful for dry skin, rough skin, a subject of skin sagging, etc.

  The composition of the present invention can be provided in the form of food and drink, medicine, cosmetics and the like. When the composition of the present invention is provided as a food or drink, the form thereof may be provided in the form of health food such as functional food, supplement, drink (including solution and suspension), or soft drink. It is also possible to provide in the form of tea drink, lactic acid bacteria drink etc., but it is not limited thereto.

  The compositions of the present invention can be packaged. The form of the container is not limited in any way, and may be filled in a sealed container such as a bottle, a can, a paper pack, a plastic bottle, an aluminum pouch, a plastic pouch or a blow-shaped container.

  The container can be labeled. With respect to the contents of the indication, for example, an indication resulting from the efficacy of collagen peptide, proteoglycan, ceramide or pectin can be attached. For example, it is used for moisturizing, protecting the skin, preventing rough skin, and improving skin sagging. The indication may be attached to the composition itself, or may be attached to a container or package of the composition.

  The beverage of the present invention is not particularly limited as long as it is produced using a composition containing collagen peptide, proteoglycan, ceramide, and pectin, and can be produced according to a conventional method. That is, a composition containing a collagen peptide, proteoglycan, ceramide, and pectin is used as a raw material, and the composition is prepared through steps such as preparation of an acidulant, a sweetener and the like, sterilization and filling, and the like. The sterilization conditions may be any as long as the conditions specified in the Food Sanitation Law are satisfied, and various sterilization machines such as a plate heat exchanger, a pipe heat exchanger, and a Pastelizer can be used. Also, the filling method is not particularly limited, and hot pack filling, aseptic filling and the like can be employed.

3. The present invention also relates to a method of suppressing the formation of aggregates or precipitates in compositions containing collagen peptides, proteoglycans and ceramides. The method is characterized by blending pectin with the composition. The total content of pectin in the composition is not particularly limited, but typically 0.05 to 0.8 w / v%, preferably 0.05 to 0.5 w / v%, more preferably Is 0.1 to 0.5 w / v%, still more preferably 0.1 to 0.3 w / v%. Also, the ratio of proteoglycan weight to pectin weight (proteoglycan weight: pectin weight) in the composition is not particularly limited, but typically it is 1: 1 or more, preferably 1: 2 or more, more preferably Is 1: 5 or more, still more preferably 1:10 or more, 1: 800 or less, preferably 1: 500 or less, more preferably 1: 100 or less, even more preferably 1:50 or less. Specifically, the ratio of proteoglycan weight to pectin weight (proteoglycan weight: pectin weight) in the composition is 1: 1 to 1: 800, preferably 1: 2 to 1: 500, more preferably 1: The ratio is 5: 1 to 100, and still more preferably 1:10 to 1:50, but is not limited thereto.

  There is no particular limitation on the method and timing of blending pectin into the composition, as long as pectin is finally included in the composition. For example, other components may be added or mixed into the composition containing pectin, or pectin may be added or mixed into the composition containing other components.

  Hereinafter, the present invention will be more specifically described by way of examples, but the present invention is not limited thereto.

Example 1
In the composition containing collagen peptide, proteoglycan, ceramide, and pectin, two kinds of beverages were manufactured with the composition shown in Table 1 in order to evaluate the flavor and the aggregation inhibiting effect of the precipitate and the precipitate generated over time .

  Specifically, raw materials other than the acidulant were added to water and dissolved, and after adjusting the pH to be 3.50 ± 0.20 with the acidulant, measurement was performed. Table 1 shows the final blending amount of the acidulant required for pH adjustment and the like. The resulting solution was sterilized with a plate-type heat exchanger, and 50 mL of each was dispensed into a brown bottle and sealed up to obtain beverages (1) and (2). The collagen peptide used is one having an average molecular weight of 3,000, the proteoglycan is one having a molecular weight of about 450,000 derived from salmon nasal cartilage, the ceramide is glucosylceramide derived from rice, and the plant extract is Hihatsu extract Pectin is HM pectin derived from citrus peel.

  These beverages were stored at 5 ° C. for 4 months, and the amount of precipitate and the nature and flavor of the precipitate were evaluated visually and in a sensory test by three expert panelists.

  The evaluation results are shown in Table 1 together with the formulations. The evaluation criteria are shown in Table 2.

  In the beverage (1) to which pectin was not added, the amount of precipitation was large, and the cohesiveness of the precipitate was strong and difficult to disperse. On the other hand, it was shown that in the case of (2) in which pectin was added, the amount of precipitation was suppressed while maintaining a good flavor, and the flocculation of the precipitate was weak and easy to be dispersed.

(Example 2)
In a composition containing collagen peptide, proteoglycan, ceramide, and a thickening stabilizer, a beverage is manufactured with the composition shown in Table 3 in order to evaluate the effect on flavor and precipitation that occurs over time and aggregation of the precipitate. did.

  Specifically, materials other than the acidulant were added to water and dissolved, and the pH was adjusted to 3.50 ± 0.20 with the acidulant, and then the volume was adjusted to 1,000 ml. Table 3 shows the final blending amount of the acidulant required for pH adjustment and the like. 50 mL each of the obtained solution was dispensed into a brown bottle and sealed up, and then immersion sterilization was performed to obtain beverages (3) and (16). The collagen peptide, proteoglycan, ceramide, plant extract and pectin used are the same as in Example 1. These beverages were stored at 5 ° C. for 4 days, and the amount of precipitation and the nature of the precipitate, and the flavor and texture were evaluated visually and in a sensory test by three expert panelists.

  The evaluation results are shown in Table 4. The evaluation criteria are as described in Table 2.

  In the beverages (4) and (5) to which pectin was added, the formation of precipitates was significantly suppressed, the flocculation of the precipitates was weak and easy to disperse, and the flavor and texture were also excellent.

(Example 3)
Formulations shown in Table 5 in the same manner as in Example 2 for the purpose of evaluating the influence of the addition amount of proteoglycan and pectin on the flavor and texture and the precipitation and precipitate aggregation generated over time (17) A beverage was produced in (26).

  These beverages were stored at 5 ° C. for 8 days, and the amount of precipitation and the nature and flavor of the precipitate were evaluated on the 4th and 8th days visually and in a sensory test by 3 expert panelists.

  The evaluation results are shown in Table 6. The evaluation criteria are as described in Table 2.

  When proteoglycan was added at a concentration of 0.001 w / v%, the addition of pectin at a concentration of 0.05 w / v% significantly suppressed the formation of precipitate. In addition, when proteoglycan was added at a concentration of 0.01 w / v%, suppression of precipitation was observed at an added concentration of pectin of 0.05 w / v%, and formed at an added concentration of 1.0 w / v%. Was significantly suppressed. Furthermore, when proteoglycan was added at a concentration of 0.05 w / v%, it was found that the formation of a precipitate tended to be suppressed as the concentration of pectin added was increased. With regard to flavor and texture, when pectin was added at a concentration of 1.0 w / v%, the viscosity increased, flavor release was lacking, and a heavy texture was obtained.

  In the present invention, the formation of an aggregate or a precipitate can be suppressed by blending pectin with a composition containing a collagen peptide, proteoglycan and ceramide. Since pectin is a naturally derived component, it is highly safe. Therefore, in the present invention, since the appearance of the collagen peptide-containing composition can be maintained in a good state by a simple and safe method, the industrial applicability is high.

Claims (11)

Collagen, proteoglycans, a liquid composition containing ceramides, and pectin, the ratio of the weight of proteoglycan weight and pectin (proteoglycan Weight: pectin weight) 1: 1 to 1: 800, the liquid composition object. The liquid composition according to claim 1 , wherein the content of proteoglycan is 0.0001 to 0.05 w / v%. The liquid composition according to claim 1 or 2 , wherein the content of pectin is 0.05 to 0.8 w / v%. The liquid composition according to any one of claims 1 to 3 , wherein the ratio of proteoglycan weight to pectin weight (proteoglycan weight: pectin weight) is 1: 5 to 1: 100. The liquid composition according to any one of claims 1 to 4 , wherein the content of collagen peptide is 1.0 to 35 w / v%. The liquid composition according to any one of claims 1 to 5, wherein the content of ceramide is 0.0001 to 0.1 w / v%. The liquid composition according to any one of claims 1 to 6 , which has a pH of 2.5 to 5.0. The liquid composition according to any one of claims 1 to 7 , which is for oral use. The liquid composition according to any one of claims 1 to 8 , which is for beautifying skin. A method of suppressing the formation of aggregates or precipitates in compositions containing collagen peptides, proteoglycans and ceramides,
The method, which comprises the step of combining pectin with the composition such that the ratio of proteoglycan weight to pectin weight (proteoglycan weight: pectin weight) is 1: 1 to 1: 800. The liquid composition according to any one of claims 1 to 9 , which is labeled according to the efficacy of collagen peptide, proteoglycan, ceramide or pectin.