JP6530141B2 - 音響コータを用いたエアロゾル粒子のコーティング - Google Patents
音響コータを用いたエアロゾル粒子のコーティング Download PDFInfo
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- JP6530141B2 JP6530141B2 JP2018529499A JP2018529499A JP6530141B2 JP 6530141 B2 JP6530141 B2 JP 6530141B2 JP 2018529499 A JP2018529499 A JP 2018529499A JP 2018529499 A JP2018529499 A JP 2018529499A JP 6530141 B2 JP6530141 B2 JP 6530141B2
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Description
本開示は、第1のエアロゾルを形成するためにコーティング材料をエアロゾル化するステップと、第2のエアロゾルを形成するために検体粒子を含むエアロゾルを提供するステップと、第1のエアロゾルおよび第2のエアロゾルを受け取る音響コータを提供するステップと、 第1のエアロゾルを第2のエアロゾルの粒子に衝突させて、第2のエアロゾルの粒子上に第1のエアロゾルのコーティングを形成するように、音響コータに音響場を提供するステップとを有する方法を実現する。コーティング材料は、固体粒子および固体粒子の混合物の少なくとも1つを有する。固体粒子は、1マイクロメートル未満の粒子サイズの金属粉末を有する。この混合物は、金属粉末および非金属粉末を有する。金属粉末は、コバルト粉末を有する。
図面中のすべての参照番号、指示記号および引き出しは、本明細書に完全に記載されているかのように、この参照により本明細書に組み込まれる。図の要素に番号を付け忘れたことは、権利の放棄を意図したものではない。番号の付いていない参照は、図および附属書においてアルファベット文字によって識別することもできる。
本発明者らはさらに、粒子が音響コータの長さに沿って円運動して移動する際に過剰なMALDIマトリックス材料を空気流から凝縮させ、かなりの割合のコーティングされた検体粒子が当該音響コータ中の空気流に残るようにするために、音響場を、90度位相をずらして、印加できると考えている。
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Claims (15)
- サンプリングされたエアロゾル粒子をコーティングする方法であって、
コーティング材料をエアロゾル化して、液体粒子を有する第1のエアロゾルを形成するステップと、
検体粒子を有するサンプリングされたエアロゾルを提供して第2のエアロゾルを形成するステップと、
上記第1のエアロゾルおよび上記第2のエアロゾルを受け取るための音響コータを提供するステップと、
上記第2のエアロゾル粒子上に、第1のエアロゾルのコーティングを有する、コーティングされたエアロゾル粒子を形成するために、上記第1のエアロゾルを上記第2のエアロゾルの粒子にオンザフライで衝突させるように上記音響コータに音響場を提供するステップとを有することを特徴とする、上記方法。 - 上記コーティング材料がMALDIマトリックス溶液を有する、請求項1に記載の方法。
- 上記MALDIマトリックス溶液が、上記検体粒子を染色するための染色剤を有する、請求項2に記載の方法。
- 上記MALDIマトリックス溶液が、2,5−ジヒドロキシ安息香酸、α−シアノ−4−ヒドロキシ桂皮酸、3,5−ジメトキシ−4−ヒドロキシ桂皮酸、2−メルカプト−4,5−ジヒドロキシ安息香酸、1,8−ジヒドロキシアントラセン−9(10H)−オン、3−メトキシ−4−ヒドロキシ桂皮酸、2,4,6−トリヒドロキシアセトフェノン、2−(4−ヒドロキシフェニルアゾ)−安息香酸、トランス−3−インドールアクリル酸、4−ヒドロキシ−3−メトキシ安息香酸、6−アザ−2−チオチミン、2−アミノ−4−メチル−5−ニトロピリジン、4−ニトロアニリン、1,5−ジアミノナフタレン、5−フルオロサリチル酸、5−クロロサリチル酸、5−ブロモサリチル酸、5−ヨードサリチル酸、5−メチルサリチル酸、5−アミノサリチル酸、および1,8−ジアミノナフタレンのうちの少なくとも1つを有する、請求項2に記載の方法。
- 上記MALDIマトリックス溶液が、アセトニトリル、水、エタノール、メタノール、プロパノール、アセトン、クロロホルム、イソプロピルアルコール、テトラヒドロフラン、トルエン、塩酸、トリフルオロ酢酸、ギ酸、および酢酸のうちの少なくとも1つを有する、請求項2に記載の方法。
- 上記音響コータに入る前に、上記第1のエアロゾルが上記第2のエアロゾルと混合される混合ステップをさらに有する、請求項1に記載の方法。
- エアロゾルの堆積を低減または排除するために、混合ステップ中にシース流体を付加する、請求項6に記載の方法。
- 上記被覆された第2のエアロゾル粒子を乾燥させる乾燥ステップをさらに有する、請求項1に記載の方法。
- 上記サンプリングされたエアロゾルが、呼気粒子、および、周囲空気から収集されるエアロゾルの少なくとも1つを有する、請求項1に記載の方法。
- 検体粒子を含有するサンプリングされたエアロゾルをMALDIマトリックス溶液でコーティングするためのデバイスであって、
液体粒子の第1のエアロゾルを形成するためにMALDIマトリックス溶液をエアロゾル化するための噴霧器と、
上記噴霧器と流体連通し、上記第1のエアロゾルおよび検体粒子を含有するサンプリングされたエアロゾルを受け取るように構成された音響コータとを有し、
上記音響コータに音響場を印加して、上記第1のエアロゾルが、上記サンプリングされたエアロゾル中の上記検体粒子に衝突して、上記検体粒子上に、上記第1のエアロゾルのコーティングを有する、コーティングされたエアロゾル粒子を形成することを特徴とする、上記デバイス。 - 混合チャンバをさらに有し、上記第1のエアロゾルは、上記音響コータに入る前に上記検体粒子を含有するサンプリングされたエアロゾルと混合される請求項10に記載のデバイス。
- サンプルされたエアロゾル粒子をコーティング材料でコーティングする方法であって、
個体粒子および個体粒子の混合物の少なくとも一方を有するコーティング材料をエアロゾル化して第1のエアロゾルを形成するステップと、
検体粒子を含有するサンプリングされたエアロゾルを提供して第2のエアロゾルを形成するステップと、
上記第1のエアロゾルおよび上記第2のエアロゾルを受け取るための音響コータを提供するステップと、
上記第1のエアロゾルを上記第2のエアロゾルの粒子に衝突させて上記第2のエアロゾルの粒子上に、上記第1のエアロゾルのコーティングを有する、コーティングされたエアロゾル粒子を形成するように上記音響コータに音響場を提供するステップとを有することを特徴とする、上記方法。 - 上記固体粒子が、1マイクロメートル未満の粒子サイズの金属粉末を有する、請求項12に記載の方法。
- 液体試料中の検体粒子をコーティングするための方法であって、
コーティング材料をエアロゾル化して、液体粒子を有する第1のエアロゾルを形成するステップと、
液体サンプルをエアロゾル化して検体粒子を有する第2のエアロゾルを形成するステップと、
上記第1のエアロゾルおよび上記第2のエアロゾルを受け取るための音響コータを提供するステップと、
上記第1のエアロゾルを上記第2のエアロゾルの粒子にオンザフライで衝突させて上記検体粒子上に、第1のエアロゾルのコーティングを有する、コーティングされたエアロゾル粒子を形成するように上記音響コータに音響場を提供するステップとを有することを特徴とする、上記方法。 - 上記コーティング材料がMALDIマトリックス溶液を有する、請求項14に記載の方法。
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