JP6521967B2 - 疾患の治療のためのｋｄｍ１ａ阻害剤 - Google Patents

疾患の治療のためのｋｄｍ１ａ阻害剤 Download PDF

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JP6521967B2
JP6521967B2 JP2016533392A JP2016533392A JP6521967B2 JP 6521967 B2 JP6521967 B2 JP 6521967B2 JP 2016533392 A JP2016533392 A JP 2016533392A JP 2016533392 A JP2016533392 A JP 2016533392A JP 6521967 B2 JP6521967 B2 JP 6521967B2
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alkyl
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optionally substituted
amino
nitrogen
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JP2016531121A5 (enExample
JP2016531121A (ja
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ジョン エム． マッコール
ジョン エム． マッコール
ジュニア ヒュー ヤング ラインホフ
ジュニア ヒュー ヤング ラインホフ
マイケル クレア
マイケル クレア
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イマーゴ バイオサイエンシーズ インコーポレイテッド
イマーゴ バイオサイエンシーズ インコーポレイテッド
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07C2601/00—Systems containing only non-condensed rings
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
JP2016533392A 2013-08-06 2014-08-06 疾患の治療のためのｋｄｍ１ａ阻害剤 Active JP6521967B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361862759P 2013-08-06 2013-08-06
US61/862,759 2013-08-06
US201461954276P 2014-03-17 2014-03-17
US61/954,276 2014-03-17
PCT/US2014/049906 WO2015021128A1 (en) 2013-08-06 2014-08-06 Kdm1a inhibitors for the treatment of disease

Publications (3)

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JP2016531121A JP2016531121A (ja) 2016-10-06
JP2016531121A5 JP2016531121A5 (enExample) 2017-09-14
JP6521967B2 true JP6521967B2 (ja) 2019-05-29

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US (4) US9790195B2 (enExample)
EP (1) EP3030323B1 (enExample)
JP (1) JP6521967B2 (enExample)
KR (1) KR102255778B1 (enExample)
CN (1) CN105592888A (enExample)
AU (1) AU2014306149B2 (enExample)
BR (1) BR112016002496B1 (enExample)
CA (1) CA2920257C (enExample)
DK (1) DK3030323T3 (enExample)
ES (1) ES2734209T3 (enExample)
IL (1) IL243976B (enExample)
MX (1) MX383590B (enExample)
WO (1) WO2015021128A1 (enExample)
ZA (1) ZA201600901B (enExample)

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ES2973286T3 (es) 2014-11-26 2024-06-19 St Europeo Di Oncologia S R L Modelos de trastornos del desarrollo neurológico basados en la reprogramación y usos de los mismos
PL3256218T3 (pl) 2015-02-12 2025-03-31 Imago Biosciences Inc. Inhibitor kdm1a i jego zastosowanie w terapii
WO2016198649A1 (en) 2015-06-12 2016-12-15 Oryzon Genomics, S.A. Biomarkers associated with lsd1 inhibitors and uses thereof
WO2017013061A1 (en) 2015-07-17 2017-01-26 Oryzon Genomics, S.A. Biomarkers associated with lsd1 inhibitors and uses thereof
KR102710120B1 (ko) 2015-08-12 2024-09-27 인사이트 홀딩스 코포레이션 Lsd1 저해제의 염
RU2726622C2 (ru) 2015-11-27 2020-07-15 Тайхо Фармасьютикал Ко., Лтд. Новое соединение бифенила или его соль
US20190091256A1 (en) * 2016-03-02 2019-03-28 Beth Israel Deaconess Medical Center Therapeutic targets for lin-28-expressing cancers
AU2017233898B2 (en) 2016-03-15 2022-12-15 Oryzon Genomics, S.A. Combinations of LSD1 inhibitors for use in the treatment of solid tumors
ES3042059T3 (en) 2016-03-16 2025-11-18 Oryzon Genomics Sa Methods to determine kdm1a target engagement and chemoprobes useful therefor
EP4585270A3 (en) * 2016-06-07 2025-09-24 The J. David Gladstone Institutes Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same
CN111194306B (zh) * 2016-08-16 2023-05-16 伊美格生物科学公司 用于制备kdm1a抑制剂的方法和过程
EP3535420A1 (en) 2016-11-03 2019-09-11 Oryzon Genomics, S.A. Biomarkers for determining responsiveness to lsd1 inhibitors
US20190256929A1 (en) 2016-11-03 2019-08-22 Oryzon Genomics, S.A. Pharmacodynamic biomarkers for personalized cancer care using epigenetic modifying agents
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WO2018216800A1 (ja) 2017-05-26 2018-11-29 大鵬薬品工業株式会社 新規なビフェニル化合物又はその塩
WO2018221555A1 (ja) * 2017-05-31 2018-12-06 大鵬薬品工業株式会社 Ｉｎｓｍ１の発現に基づくｌｓｄ１阻害剤の治療効果の予測方法
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JP7450559B2 (ja) * 2018-05-11 2024-03-15 イマーゴ バイオサイエンシーズ インコーポレイテッド 疾患の処置のためのｋｄｍ１ａ阻害剤
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