JP6520348B2 - Blood purification circuit panel - Google Patents

Description

  The present invention relates to a blood purification circuit panel. More specifically, the present invention relates to a blood purification circuit panel provided with a panel formed of two resin sheets bonded together.

  Dialysis is a treatment to be performed for patients who can not excrete urine because the renal function is impaired and therefore the water adjustment etc. can not be made properly, for example, through the dialyzer which is a blood purifier. The blood is purified by contacting the blood.

  In the blood purification circuit including the dialyzer, various studies have been made up to now (see, for example, Patent Document 1 and Patent Document 2). The dialyzer incorporates a plurality of (e.g., 8000 to 20000, etc.) artificial capillaries, and blood from the blood inflow tube flows out of the blood outflow tube through these capillaries. Also, in the dialyzer, dialysate from the dialysate inflow tube flows out of the dialysate outflow tube after flowing outside of each capillary, whereby the substance between blood and dialysate through the membrane of the capillary tube Exchanges will be made, and unwanted material will be transferred to the dialysate and useful material will be transferred into the blood.

JP-A-8-38597 JP-A-9-313603

  Here, in order to cause the dialyzer to function as described above, a fluid such as a pump that causes blood to flow in and out of the dialyzer or a pump that causes dialysate to flow in and out of the dialyzer passes fluid around the dialyzer. Is attached via a tube.

  Also, for example, in the case where a dialyzer is fixed to a panel formed by bonding two resin sheets to constitute a blood purification circuit panel, a part of the panel is cut away or opened. A space is formed, and a pump tube for passing a fluid such as blood or dialysate is accommodated and disposed in the space.

  The pump tube is a component of the tube pump, and the drive of the tube pump can deliver the fluid in the pump tube in one direction, and the blood or dialysate delivered from the pump tube is connected to the dialyzer. It will be fed to the dialyzer through the blood inflow line and the dialysate inflow line. For example, the tube pump sequentially presses a part of the pump tube in the longitudinal direction to move the fluid in the pump tube in one direction, and the negative pressure generated in the pump tube causes the fluid in the pump tube to dialyser. It will be sent out.

  However, the complexity of the work of separately attaching the pump tube, which is a separate member to the panel, to the panel has been a problem since before, and the elimination of the pump tube leads to the reduction of the number of members and the cost. Was desired.

  The present invention has been made in view of the above problems, and is a pump for feeding a fluid into a dialyzer or the like when configuring a blood purification circuit panel including a panel formed of two resin sheets bonded together. An object of the present invention is to provide a blood purification circuit panel in which a tube is unnecessary.

  In order to solve the above problems, the blood purification circuit panel according to the present invention comprises a panel formed by bonding the inner surfaces of two resin sheets together, and a recessed groove in at least one of the inner surfaces of the resin sheet. And a hollow internal flow passage for passing the fluid, and by pressing a part of the internal flow passage, the fluid in the internal flow passage is fed in one direction, and the resin sheet is The resin sheet is composed mainly of a styrene-based elastomer and / or an olefin-based elastomer, the Duro A hardness according to JIS K6253 of the resin sheet is 30 to 80, and the compression set after being treated at 23 ° C. for 22 hours according to JIS K6262 is It is characterized by being 50% or less.

  The blood purification circuit panel according to the present invention is characterized in that, in the above-mentioned present invention, the resin sheet has a melt flow rate (MFR) at 230 ° C. of 0.1 to 5.0 g / 10 min.

  The blood purification circuit panel according to the present invention is characterized in that, in the above-mentioned present invention, the Duro A hardness is 50 to 70.

  In the blood purification circuit panel according to the present invention, in the above-described present invention, the blood purification circuit panel has a dialyzer fixed to the panel, and by pressing a part of the inner flow path, the fluid in the inner flow path is transferred to the dialyzer. It is characterized by being sent.

  In the blood purification circuit panel according to the present invention, in the above-described present invention, a reinforcing member is interposed between at least a part of the inner surface of the panel while being held between the two resin sheets. .

  The blood purification circuit panel according to the present invention is made of a predetermined resin material, and a resin sheet having a Duro A hardness and a compression set in a specific range is bonded to form a recessed groove on the inner surface of the panel. And a hollow internal flow passage for passing the fluid. Such an internal flow passage has appropriate hardness and restorability, etc., plays a role of a conventional pump tube, and by pressing a part of the internal flow passage, fluid can be delivered to a dialyzer or the like. In addition, since the arrangement of the internal flow passage eliminates the need for a pump tube for feeding the fluid to the dialyzer etc., it is possible to eliminate the complexity such as the work of attaching the pump tube to the panel and It becomes a blood purification circuit panel that can be reduced.

It is the schematic which showed the one aspect | mode of the blood purification circuit panel which concerns on this invention. It is the figure which took the cross section in the boundary (inner surface) of the resin sheet in FIG. It is the schematic which looked at the blood purification circuit panel shown in FIG. 1 from the back side. It is AA sectional drawing of FIG. It is BB sectional drawing of FIG. It is explanatory drawing which showed the longitudinal cross-section around a connection part. It is the schematic which showed the structure of the pump for pressing an internal flow path. It is explanatory drawing which showed the longitudinal cross-section around a connection part. It is explanatory drawing regarding the manufacturing process of a panel. It is explanatory drawing regarding the manufacturing process of a panel. It is explanatory drawing regarding the manufacturing process of a panel. It is explanatory drawing which showed the location to which the reinforcement member was applied. It is the schematic which showed an example of the reinforcement member for internal flow paths. It is explanatory drawing which showed the cross-sectional structure to which the reinforcement member for internal flow paths was applied. It is explanatory drawing which showed the cross-sectional structure to which the plate-shaped reinforcement member was applied.

  Hereinafter, one aspect of the blood purification circuit panel 1 according to the present invention will be described.

(1) Configuration of blood purification circuit panel 1:
FIG. 1 is a schematic view showing an embodiment of the blood purification circuit panel 1 according to the present invention, FIG. 2 is a cross-sectional view taken at the boundary (inner surface) of resin sheets 21 and 22 in FIG. FIG. 2 is a schematic view of the blood purification circuit panel 1 shown in FIG. 1 as viewed from the back side.

  The blood purification circuit panel 1 shown in FIG. 1 includes a plate-like panel 2 disposed orthogonal to the ground surface, and the panel 2 has a rectangular shape in the present embodiment, and the horizontal direction (in FIG. The width of the direction is slightly larger than the width of the orthogonal direction (vertical direction in FIG. 1 etc.). The panel 2 is formed by bonding two resin sheets 21 and 22 made of a predetermined resin material (described later), and the internal flow paths 4, 4a and hollows at the interface of the resin sheets 21 and 22. The flow paths 6, 71, 72 are formed, and the internal tube Ta or the like which is a separate member, the connecting portion R1 and the like are partially inserted and sandwiched, and the external tube T1 and the like are externally inserted. Further, as shown in FIG. 1 etc., in the present embodiment, the dialyzer which is a blood purifier from one surface of panel 2 (forward direction in FIG. 1 etc.) in the approximate center of panel 2. 3 is mounted from one side of the panel 2 (in the case of FIG. 1, etc., in the front direction).

(1-1) Dialer 3:
In the present embodiment, the dialyzer 3 has a cylindrical configuration, and is attached to the panel 2 with its longitudinal direction aligned in the vertical direction. In the present embodiment, the dialyzer 3 is attached such that its length is slightly larger than the vertical width of the panel 2 and that each end projects above the upper side of the panel 2 and below the lower side. Shows an aspect.

  Here, a schematic configuration of the dialyzer 3 will be described. Blood flows into the cylindrical dialyzer 3 whose both ends are sealed from the blood inflow pipe portion 31 on the upper end surface, and the purified blood flows out from the blood outflow pipe portion 32 on the lower end surface. It is supposed to be. Inside the dialyzer 3 are thin tubes 33 (see FIG. 4 and FIG. 5 described later) made of a plurality of (for example, but not limited to, 8000 to 20000) artificial membranes, of the dialyzer 3. The tubes 33 are arranged along the axial direction, and blood is to be introduced into these capillaries 33.

  Further, the dialysate flows into the dialyzer 3 from the dialysate inflow pipe portion 34 (flow pipe portion) on the side surface on the lower end side, and the dialysate outflow pipe portion 35 (distribution The dialysate is drained from the tube). The dialysate is allowed to flow outside the tubule 33 in the dialyzer 3, whereby material exchange is performed between the blood and the dialysate through the membrane of the tubule 33, and unnecessary substances are transferred to the dialysate. Useful substances are supposed to move into the blood.

  Although there is no restriction | limiting in particular in attachment to the dialyzer 3 with respect to the panel 2, For example, what is necessary is just to implement as follows. In addition, the attachment method demonstrated below is an example, and attachment of the dialyzer 3 with respect to the panel 2 can employ | adopt the arbitrary methods according to the shape of a panel 2, the dialyzer 3, and other members, a structure, etc. .

  FIG. 2 is a cross-sectional view taken at the boundary (inner surface) of the resin sheets 21 and 22 in FIG. 1, and shows the panel 2 in a state where the dialyzer 3 is not attached. As shown in FIG. 2, a mounting piece 23a extending vertically upward is formed substantially at the center of the upper side of the panel 2 according to the present embodiment, and the mounting piece 23a is formed from one of the vertical sides A notch 24 a cut in the horizontal direction is formed. The notch 24a has a semicircular arc shape on the inner peripheral portion on the depth side opposite to the opening side, and a pair of narrowed portions 25a so as to narrow the width of the notch 24a on the inner peripheral portions facing each other on the opening side. (For example, a convex portion) is provided. Similarly, at the center of the lower side of the panel 2, a vertically downward extending mounting piece 23b is formed. The mounting piece 23b is formed with a notch 24b cut out in the horizontal direction. In this case, the cut-out direction of the notch 24b of the mounting piece 23b is, for example, the same direction as the cut-out direction of the notch 24a of the mounting piece 23a described above. The formation of a pair of narrowed portions 25b in the notch 24b is also similar to the notch 24a.

  FIG. 3 is a schematic view of the blood purification circuit panel 1 shown in FIG. 1 as viewed from the back side. In FIG. 3, the flange portion 36a formed around the pipe of the dialysate outflow pipe portion 35 of the dialyzer 3, and the dialysis in the notch 24a of the attachment piece 23a of the panel 2 and the notch 24b of the attachment piece 23b respectively A flange portion 36 b formed around the pipe of the liquid inflow pipe portion 34 is fitted.

  The flange portion 36a formed on the dialysate outflow pipe portion 35 is formed of a circular plate material, and the maximum diameter thereof is formed to be slightly larger than the diameter of the notch 24a of the mounting piece 23a. The flange portion 36a has a certain thickness, and an annular groove 37a along the circumferential direction is formed at the central portion of the circumferential side surface. The inner peripheral portion of the notch 24a of the mounting piece 23a is fitted in the annular groove 37a. Such a configuration is also common to the notch 24b of the attachment piece 23b formed on the lower side of the panel 2 and the flange portion 36b and the annular groove 37b formed on the dialysis fluid inflow pipe portion 34 of the dialyzer 3.

  In such a configuration, the fixing of the dialyzer 3 to the panel 2 is performed in the annular grooves 37a and 37b of the flanges 36a and 36b of the dialyzer 3 and the insides of the notches 24a and 24b of the corresponding mounting pieces 23a and 23b of the panel 2. This is done by engaging the circumference and placing the constricted portions 25a, 25b and fitting them into the notches 24a, 24b. The flange portions 36a and 36b thus fitted into the notches 24a and 24b are configured so as not to be easily removed from the notches 24a and 24b by the narrowed portions 37a and 37b. In the flanges 36a and 36b, the inner peripheral portions of the notches 24a and 24b of the mounting pieces 23a and 23b are engaged with the annular grooves 37a and 37b, and the displacement in the axial direction is restricted. By the above, the dialyzer 3 can be disposed on the panel 2 simply and firmly.

(1-2) Internal channel 4, 4a:
Next, the internal flow paths 4, 4a for feeding a fluid such as blood or dialysate to the dialyzer 3 will be described.

  FIG. 4 is a cross-sectional view taken along the line A-A of FIG. 1, and FIG. 5 is a cross-sectional view taken along the line B-B of FIG. In the present embodiment, the internal flow path 4 formed at the right end of the panel 2 shown in FIG. 1 etc. extends from the upper side to the lower side of the panel 2 and, as shown in FIGS. In the panel 2 formed by the bonding of the sheets 21 and 22, the groove 41 and the area for forming the internal flow path 4 of one resin sheet 21 and the area for forming the internal flow path 4 of the other resin sheet 22 4 and the like show an embodiment in which two resin sheets 21 and 22 are overlapped to form a substantially circular cross section as concave grooves 41 and 42 having a substantially semicircular cross section. ing.

  Similarly, the internal flow path 4a formed on the other side (left side in FIG. 1 etc.) of the dialer 3 of the panel 2 shown in FIG. 1 etc. extends from the upper side to the lower side of the panel 2 As shown in FIG. 5 to FIG. 5, in the panel 2 formed by bonding two resin sheets 21 and 22, an area to form the internal flow path 4a of one resin sheet 21 and the inside of the other resin sheet 22. It is comprised by forming concave groove 41a, 42a about the field which forms channel 4a, and in the figure 4 grade etc., resin sheet 21,22 of two sheets is overlapped as concave groove 41a, 42a of a substantially semicircular cross section. The aspect which a cross section becomes substantially circular shape is shown together.

  The depth of the concave grooves 41, 41a, 42, 42a (hereinafter sometimes referred to simply as "the concave grooves 41, 42") in the internal flow channels 4, 4a is not particularly limited, but blood, dialysate, etc. In order to efficiently pass the fluid of the above, it is preferable to set it as approximately 2 to 50 mm. Further, as the shape of the concave grooves 41 and 42, in addition to the substantially circular shape in cross section, it is possible to adopt any shape in which the cross section can pass a fluid such as a triangular shape or a polygonal shape such as a square shape. Furthermore, although the concave grooves 41 and 42 may be formed on both of the two resin sheets 21 and 22 as shown in FIG. 4 etc., they are formed on both of the two resin sheets 21 and 22. It is not necessary, and it may be formed on at least one of the resin sheets 21 and 22 if fluid can pass therethrough.

  A connection portion R1 formed of a cylindrical member formed of a predetermined resin material or the like coaxially with the hollow flow passage 4 at each end of the internal flow passage 4 in the panel 2 in order to connect with the external attachment tube T1 or the like. The connecting portion R2 is disposed so as to be held by the sheet. The end face which is almost flush with the upper side and the lower side of the connecting portion R1 and the connecting portion R2 of the panel 2 has an inner diameter into which the external tubes T1 and T2 are inserted, and the external attaching tube T1 is inserted at the upper side of the panel The external tube T2 is inserted at the lower side of the panel.

  FIG. 6 is an explanatory view showing a longitudinal cross section around the connecting portion R1 (showing the side on which the resin sheet 21 appears). As shown in FIGS. 4 to 6, the connection portion R1 is formed on the side of the externally attached tube T1 so as to have an inner diameter into which the externally attached tube T1 can be inserted. The connecting portion R1 having such a shape is sandwiched between the resin sheets 21 and 22, and is positioned and disposed in the plane including the panel 2 with respect to the central axis, whereby the axial displacement can be restricted. The connecting portion R2 (and connecting portions R3 and R4 to be described later) is configured to be substantially in common with the connecting portion R1, and as described above, the external tube is attached to the end face of the lower side of the panel 2 of the connecting portion R2. T2 is to be inserted.

  Although the above contents have been described for the internal flow path 4 formed at the right end of the panel 2 in FIG. 1 etc., the same applies to the other side (left side in FIG. 1 etc.) of the panel 2 The internal flow path 4a of the structure which is set is formed. A connecting portion R3 and a connecting portion R4 exist in each of the narrow portions of the panel 2, the connecting portion R3 has substantially the same configuration as the connecting portion R1 and the connecting portion R2 has the same configuration as the connecting portion R4, and the panel 2 is configured The resin sheets 21 and 22 are held. The externally attached tube T3 is inserted in the end face on the upper side of the panel 2 of the connection portion R3, and the externally attached tube T4 is inserted in the end face on the lower side of the panel 2 of the connection portion R4.

  Here, since the resin sheets 21 and 22 are made of a predetermined resin material and the Duro A hardness and the compression set are in the specific ranges (described later in (2)), the internal flow paths 4 and 4a are described. By pressing a part of the fluid, the fluid in the internal flow channels 4, 4a is fed in one direction, and in the present embodiment, the fluid is fed to the dialyzer 3. The internal flow channels 4, 4a can, for example, discharge the fluid in the internal flow channels 4, 4a in one direction by driving the pump 5 separately disposed. The blood and the dialysate which are the fluid sent out from internal channel 4 will be sent into the inside of dialyzer 3 via blood inflow pipe part 31 or dialysate inflow pipe part 34 (refer to FIG. 1 etc.).

  FIG. 7 is a schematic view showing the configuration of the pump 5 for pressing the internal flow passage 4 (as well as the internal flow passage 4a). The pump 5 incorporates the rotating body 51, and in order to press the internal flow path 4, the rotating body 51 is disposed adjacent to the internal flow path 4. The rotating body 51 is provided with a plurality of (not shown in FIG. 7 four but not limited to) rollers 52 along its circumferential direction, and the rotating body 51 is rotated to rotate the rotating body 51. The roller 52 sequentially moves in one direction while pressing a part of the internal flow path 4 in the longitudinal direction. Therefore, the negative pressure generated in the internal flow passage 4 causes the fluid in the internal flow passage 4 to be delivered in one direction (the direction of the dialyzer 3). In addition, about the pump 5, not only the structure shown in FIG. 7 but the arbitrary structure which the fluid in the internal flow path 4 can send in one direction is employ | adopted by pressing a part of internal flow path 4 can do.

(1-3) Other channels (hollow channels 6, 7, 7a):
Next, other channels (hollow channels 6, 7, 7a) disposed in the blood purification circuit panel 1 according to the present invention will be described. As shown in FIG. 1 etc., in the region between the internal flow passage 4 of the panel 2 and the dialyzer 3, a hollow flow passage 6 extending from the upper side to the lower side of the panel 2 is formed. The hollow flow channel 6 is a region where the hollow flow channel 6 of one resin sheet 21 is formed in the panel 2 formed by bonding two resin sheets 21 and 22 in the same manner as the internal flow channel 4 described above, The other resin sheet 22 is configured by forming the concave grooves 61 and 62 in the region forming the hollow flow path 6, and in FIG. 4 etc., the concave grooves 61 and 62 having a substantially semicircular cross section (see also FIG. 5) In this embodiment, two resin sheets 21 and 22 are overlapped to form a substantially circular cross section.

  The hollow flow path 6 is formed with a hollow chamber 63 having a relatively large area in the middle of the path, and from the hollow chamber 63 to one side of the panel 2 (for example, the upper side in FIG. 1). Another hollow flow path (branch flow paths 64 and 65) is formed. Thus, the hollow flow channel 6 can be configured as branch flow channels 64 and 65 in addition to the hollow flow channel 6 which is the merging flow channel by changing the flow of the fluid.

  At each end of the hollow flow passage 6, a connection portion R5, a connection portion R6, and a connection portion R7, which are cylindrical members disposed coaxially with the hollow flow passage 6, are disposed so as to be held between the sheets. The end face substantially flush with the upper side and the lower side of the connecting portion R5, the connecting portion R6, and the connecting portion R7 has an inner diameter into which an external tube (not shown) is inserted. The connecting portions R5 and R6 have the same structure as the connecting portion R1 described above, and the connecting portion R7 has substantially the same configuration as the above-described R2.

  Further, hollow flow paths 7 and 7a extending from the upper side to the lower side of the panel 2 are juxtaposed in a region outside the internal flow path 4a of the panel 2 (left side in FIG. 1 etc.). The hollow flow paths 7 and 7a have a common configuration.

  The hollow flow passage 7 is a region where the hollow flow passage 7 of one resin sheet 21 is formed in the panel 2 formed by bonding two resin sheets 21 and 22 in the same manner as the internal flow passage 4 and the like described above And the other resin sheet 22 are formed by forming the concave grooves 71 and 72 in the region forming the hollow flow path 7, and in FIG. 5 and the like, two concave grooves 71 and 72 having a substantially semicircular cross section In this embodiment, the resin sheets 21 and 22 are superimposed to form a substantially circular cross section.

  Similarly, in the panel 2 formed by bonding the two resin sheets 21 and 22 in the hollow flow path 7a, a region of the one resin sheet 21 forming the hollow flow path 7a and the other resin sheet 22 It is comprised by forming concave groove 71a, 72b about the area | region which forms the hollow flow path 7a, and in FIG. 4 etc., the resin sheets 21 and 22 of 2 sheets are used as concave groove 71a, 72b of a substantially semicircular cross section. An embodiment is shown in which the cross sections are substantially circular in a superimposed manner.

  Here, the hollow flow channels 7, 7a are straight flow channels which are not branched or merged flow channels as compared with the hollow flow channel 6 described above, and connecting portions R8, R10 are provided on the upper side of the panel 2. On the lower side, connecting portions R9 and R11 are attached.

  FIG. 8 is an explanatory view showing a longitudinal cross section around the connecting portion R8 (showing the side on which the resin sheet 21 appears). The connecting portion R8 is shaped to have a constriction in the center, and the external tube T5 and the internal tube Ta are inserted. The connecting portions R9 to R11 also have a configuration substantially common to the connecting portion R8.

  As shown in FIG. 2, the connecting portion R8 and the connecting portion R9 are connected by a built-in tube Ta made of a resin material, and the connecting portion R10 and the connecting portion R11 are connected by a built-in tube Tb made of a resin material ing. The built-in tubes Ta and Tb are sandwiched by the resin sheets 21 and 22 together with the connection portions R8 to R11.

  Further, the externally attached tube T5 is inserted into the connecting portion R8, and the externally attached tube T6 is inserted into the connecting portion R9. Similarly, the externally attached tube T7 is inserted into the connecting portion R10, and the externally attached tube T8 is inserted into the connecting portion R11.

  The blood purification circuit panel 1 configured in this manner can configure (mount) the blood purification circuit panel 1 including the dialyzer 3, the pump 5 and the like on the panel 2 using an external tube. .

(2) Resin sheets 21 and 22 constituting panel 2:
The panel 2 is formed by bonding the inner surfaces of two resin sheets 21 and 22 together, but in the present invention, a styrene-based elastomer or an olefin-based elastomer is mainly used as a constituent material of the resin sheets 21 and 22 And use the resin. The styrene-based elastomer and the olefin-based elastomer may be used alone or in combination of two. In the present invention, the term "main component" refers to a component that occupies 50% or more of the entire resin material constituting the resin sheets 21 and 22.

  Examples of the styrene-based elastomer (styrene-based thermoplastic elastomer) include block copolymers having a soft segment consisting of a diene block (diene polymer part) and a hard segment consisting of a styrene block (styrene polymer part) or polystyrene etc. Specifically, for example, styrene-butadiene block copolymer (SB), styrene-butadiene-styrene block copolymer (SBS), styrene-isoprene block copolymer (SI) and styrene-isoprene-styrene block The hydrogenated substance of a copolymer (SIS) or those block copolymers is mentioned. Also, high impact polystyrene, ABS resin (acrylonitrile-butadiene-styrene copolymer) and the like can be used.

  Even if the above-mentioned hydrogen additive is a block copolymer in which all of the styrene block and the diene block are hydrogenated, the block copolymer in which only the diene block is hydrogenated or a part of the styrene block and the diene block is hydrogen It may be a partial hydrogen additive such as an added block copolymer. Specifically, for example, (hydrogenated) styrene-ethylene-butylene-styrene block copolymer (SEBS), (hydrogenated) styrene-ethylene-propylene-styrene block copolymer (SEPS), (hydrogenated) styrene -Ethylene-ethylene-propylene-styrene block copolymer (SEEPS), (hydrogenated) styrene-butadiene block copolymer (SEB), (hydrogenated) styrene-ethylene-propylene block copolymer (SEP) etc Be

  The olefin-based elastomer (olefin-based thermoplastic elastomer) is a blend of polyolefins such as polypropylene and polyethylene as hard segments and an olefin-based rubber as soft segments. Polyolefins as hard segments are crystalline polyolefins and include polypropylene, high density polyethylene (HDPE), low density polyethylene (LDPE) and the like. As an olefin rubber, ethylene propylene rubber (EPR, EPM), ethylene propylene diene rubber (EPDM) (crosslinking, partial crosslinking), acrylonitrile-butadiene rubber (NBR), hydrogenated NBR, ethylene-octene copolymer, ethylene- Butene-1 copolymer, linear low density polyethylene (LLDPE), ultra low density polyethylene (VLDPE), ethylene-ethyl acrylate copolymer (EEA), ethylene-vinyl acetate copolymer (EVA), isoprene rubber ( IR), butadiene rubber (BR) and the like. Those in which the hard segment polyolefin is composed of polyethylene are classified as polyethylene-based, and those composed of polypropylene are classified as polypropylene-based. Further, for example, a reactor type olefin elastomer (R-TPO) or the like in which polypropylene (polyethylene) is a hard segment and the soft segment is a copolymer containing propylene (ethylene) may be used.

  Moreover, as a constituent material of the resin sheets 21 and 22, only the above-mentioned styrene elastomer or olefin elastomer may be used as a constituent material, but such a styrene elastomer or olefin elastomer is used in combination with a polyolefin resin. It is also good. By using a polyolefin resin in combination, the hardness, the moldability and the like of the resin sheets 21 and 22 can be adjusted, and the cost can be reduced by using an inexpensive polyolefin resin. Examples of polyolefin resins include polypropylene resins such as polypropylene, polyethylene resins such as polyethylene, polybutene, poly-1-butene, and poly-4-methyl-1-pentene. Also, ethylene / α-olefin copolymer, ethylene / vinyl alcohol copolymer, ethylene / vinyl acetate copolymer, poly-4-methylpentene-1 resin, propylene / α-olefin copolymer And the like, and one of these may be used alone, or two or more may be used in combination. Among these, it is preferable to use a polypropylene-based resin, a propylene / α-olefin-based copolymer, and the like in that appropriate hardness can be imparted, low cost, versatility and the like. When using a styrene-based elastomer or an olefin-based elastomer, which is a main component, in combination with a polyolefin-based resin, the content of the polyolefin-based resin is such that physical properties such as Duro A hardness and compression set described later conform to the later described range. Although it may be adjusted appropriately, for example, the content of the polyolefin resin is less than 50.0% by mass with respect to the entire resin sheets 21 and 22 (the whole of the resin compositions constituting the resin sheets 21 and 22. The same applies hereinafter). The content is preferably more than 0% by mass and less than 50.0% by mass, and particularly preferably 1.0 to 40.0% by mass (the remaining portion is a styrene-based elastomer or an olefin-based elastomer).

  The melt flow rate (MFR) at 230 ° C. of the resin sheets 21 and 22 is preferably 0.1 to 5.0 g / 10 min. If the MFR is in such a range, good moldability and the like can be maintained. As MFR, a value measured according to JIS K 7210 (230 ° C., 2.16 kg) or the like may be used.

  In addition, in the range which does not impair the objective and effect of this invention in the constituent material of resin sheet 21 and 22 mentioned above, for example, resin material except having mentioned above, a plasticizer, an antistatic agent, antioxidant, an antifogging agent Various additives generally used in the field of resin materials may be added such as UV absorbers, heat stabilizers, boosters, mold release agents, coloring agents and neutralizing agents.

  Since the resin sheets 21 and 22 constituting the present invention form the internal flow path 4 to play the role of the conventional pump tube as a component of the panel 2, they need to have a predetermined hardness and restorability, etc. Do.

  In the present invention, Duro A hardness (referring to "type A durometer hardness" and also referred to as "Duro hardness A") according to JIS K6253 is set to 30 to 80. By setting the Duro A hardness in the above-mentioned range, it is possible to appropriately maintain a good restoring force, maintain the amount of liquid transfer, and suppress the load, wear, and the like of a pump or the like for pressing the internal flow path. On the other hand, if the Duro-A hardness of the sheet is less than 30, the wear will be severe, the restoration may be too good, and the liquid feed amount may decrease. If the Duro-A hardness is higher than 80, the sheet is too hard. The load to do so may be too high. The Duro A hardness of the resin sheets 21 and 22 is preferably 50 to 70.

  The compression set of the resin sheets 21 and 22 after treated at 23 ° C. for 22 hours according to JIS K6262 is 50% or less. The lower the compression set, the better the restorability (the smaller the number of sags due to repeated compression, etc.). However, if the compression set exceeds 50%, the formed sheet may be difficult to recover. .

  In order to make Duro A hardness and compression set (and MFR) of the resin sheets 21 and 22 into the above-mentioned range, for example, Duro A hardness and compression set of the resin material to be used conform to the above-mentioned range Such resin materials can be selected and used. In the case of using one kind of resin material, it is preferable to use a material that fits the above-mentioned range with respect to Duro-A hardness and compression set.

  In the case of using two or more kinds of resin materials in combination, it is preferable to use a material in which the resin material mixed and mixed conforms to the above-mentioned range with respect to Duro A hardness and compression set. For example, when using two materials (resin X and resin Y, the compounding ratio is X / Y = 1 / m) and the Duro A hardness of the resin X is P and the Duro A hardness of the resin Y is Q, Including the case of one kind of resin material described above, there are some fluctuations in molding conditions etc., but the value obtained by l · P + m · Q may be made to fit within the above-mentioned range. In addition, in order to increase the Duro-A hardness of the resin Z (styrene-based elastomer, olefin-based elastomer, etc.), which has a known Duro-A hardness, which is the main component, the content of the resin V (polyolefin-based resin) is It may be adjusted in combination in the range so as to fit in the above-mentioned range.

  Although the duro A hardness is described as an example, the same applies to compression set and MFR. Also, when three or more types of resin materials are used in combination, they may be considered in the same manner. For example, with regard to the Duro A hardness and compression set of the resin sheets 21 and 22, for the above-mentioned styrenic elastomers and olefin elastomers (elastomers), those having a Duro A hardness of 30 to 80 are selected, or 80 or less The polyolefin resin is mixed in the above-mentioned range of contents, and adjusted so as to fall within the above-mentioned range, including compression set (preferably using 50% or less of elastomer). Just do it.

  The thickness of the resin sheets 21 and 22 is not particularly limited, but is preferably 0.5 to 2.0 mm in consideration of smooth delivery of the fluid in the internal flow path 4. If the thickness is smaller than 0.5 mm, the resilience of the resin sheets 21 and 22 may be deteriorated, and if the thickness exceeds 2.0 mm, the load for pressing may be increased.

(3) An example of a method of manufacturing panel 2:
Hereinafter, an example of the method of manufacturing the panel 2 of the said structure is demonstrated using drawing. 9 to 11 are explanatory views related to the manufacturing process of the panel 2. The panel 2 can be manufactured simply by using a method such as that disclosed in, for example, Japanese Patent Application Laid-Open No. 2013-49186.

  First, as shown in FIG. 9, a pair of split molds 81, 82 (hereinafter referred to simply as "molds 81, 82") having an inner surface shape (cavities 88a, 88b etc.) corresponding to the shape of the panel 2 ), And place molten resin sheets (become parisons) 21 and 22 between the molds 81 and 82.

  The molten resin sheets 21 and 22 can be disposed between the molds 81 and 82, for example, as follows. As shown in FIG. 9, a predetermined amount of the melt-kneaded resin material is stored in an accumulator (not shown), and the molten resin is stored from extrusion slits 84a and 84b provided at T dies 83a and 83b at predetermined intervals. By intermittently extruding the material at a predetermined extrusion amount per unit time, the molten resin material can be extruded at a predetermined extrusion rate at a predetermined thickness so as to hang downward in a sheet shape.

  The sheet-like molten resin material is passed through the rollers 85a and 85c for the resin sheet 21 and the rollers 85b and 85d for the resin sheet 22 to adjust the thickness, and sent downward as the resin sheets 21 and 22. The resin sheets 21 and 22 having a uniform thickness in the extrusion direction are disposed between the split molds 81 and 82 disposed below the rollers 85a to 85d. The resin sheets 21 and 22 are positioned in such a manner as to protrude around the pinch off portions 89a and 89b.

  Next, as shown in FIG. 10, the molds 86a and 86b are moved toward the resin sheet 21 in the molten state with respect to the divided mold 81 until the molds 86a and 86b contact the outer surface of the resin sheet 21 facing the mold 81. Let Similarly, the molds 87 a and 87 b are moved toward the resin sheet 22 in the molten state with respect to the divided molds 82 until they contact the outer surface of the resin sheet 22 facing the molds 82.

  When the molds 86 and 87 are moved, the split mold 81 is moved to the resin sheet 21 side, the split mold 82 is moved to the resin sheet 22 side, and the molten resin sheets 21 and 22 from the split molds 81 and 82 side. By suctioning, the resin sheet 21 is brought into close contact with the split mold 81, and the resin sheet 22 is brought into close contact with the split mold 82, respectively.

  Specifically, a suction hole is formed from a vacuum suction chamber through a sealed space S1 formed by the cavity 88a of the split mold 81, the inner peripheral surfaces of the molds 86a and 86b, and the outer surface of the resin sheet 21 facing the split mold 81. By suctioning the resin sheet 21 via the same (not shown), the resin sheet 21 is pressed against the cavity 88a, and the resin sheet is shaped into a shape along the uneven surface of the cavity 88a. Similarly, a suction hole is drawn from a vacuum suction chamber through a sealed space S2 formed by the cavity 88b of the split mold 82, the inner peripheral surfaces of the molds 87a and 87b, and the outer surface of the resin sheet 22 facing the mold 82. The resin sheet 22 is pressed against the cavity 88b by suctioning the resin sheet 22 so as to shape the resin sheet 22 into a shape along the uneven surface of the cavity 88b. Thereby, the concave grooves 41 and 42 and the like are formed on the resin sheets 21 and 22 so as to protrude to the outer surface side, and the internal structure of the panel 2 is formed.

  Then, as shown in FIG. 11, the resin sheet 21 is held by suction while holding the mold 86 in contact with the outer surface of the resin sheet 21 as it is, and the mold is in contact with the outer surface of the resin sheet 22. The two molds 81 and 82 are moved toward each other until the respective annular pinch-off portions 89a and 89b abut each other while suction-holding the resin sheet 22 while holding 87 in the same position, and the resin sheet Weld 21 and 22 partially. When the pinch-off portions 89a and 89b are in contact with each other, flat portions of the outer surfaces of the two resin sheets 21 and 22 in which the concave grooves 41 and 42 are not formed are surface-welded. By closing 42 etc., the internal structure of the panel 2 such as the internal flow path 4 is formed. In FIG. 11, the burrs of the resin sheets 21 and 22 are not shown.

  Finally, the split molds 81 and 82 are opened, the panel 2 is taken out, and burrs and the like not shown are removed to form the panel 2. When the panel 2 is manufactured in this manner, the dialyzer 3 and the like are attached by the above-described means or the like to obtain the blood purification circuit panel 1 shown in FIG.

  In addition, other members (reinforcement members 9 etc. which are mentioned later as needed etc. are mentioned later), such as above-mentioned connection part R1 etc. and built-in tube Ta etc. which are incorporated in the panel 2, insert before dividing molds 81 and 82. And may be attached to the resin sheets 21 and 22. Specifically, for example, as shown in FIG. 10, another member (the connection portion R1, the built-in tube Ta, etc., a reinforcing member 9 described later, etc.) held by a suction disk of a manipulator not shown The resin sheets 21 and 22 are inserted from the side between the split molds 81 and 82 in a state of being shaped in a shape along the surface. Then, by moving the manipulator (not shown) in the horizontal direction toward the split mold 82, for example, another member is pressed against the resin sheet 22 adsorbed to the cavity 88b of the split mold 82 on the right side in FIG. The separate members may be attached to the resin sheet 22 by welding.

(4) Effects of the present invention:
The blood purification circuit panel 1 according to the present embodiment described above is made of a predetermined resin material, and the resin sheets 21 and 22 having Duro A hardness and compression set as specific ranges are bonded to form the panel 2. Grooves 41 and 42 are formed on the inner surface of the panel 2, and a hollow internal flow passage 4 for passing a fluid comprising the grooves 41 and 42 is disposed. Since the internal flow path 4 has appropriate hardness, restorability, etc., it plays the role of a conventional pump tube, and by pressing a part of the internal flow path 4, the fluid can be sent out to the dialyzer 3 or the like. In addition, the arrangement of the internal flow passage 4 eliminates the need for a pump tube for feeding the fluid to the dialyzer 3 and the like, thus eliminating the complexity of the work of attaching the pump tube to the panel 2 and the like And it becomes the blood purification circuit panel 1 which can aim at reduction of cost etc.

(5) Modification of the embodiment:
In addition, the aspect demonstrated above shows one aspect of this invention, Comprising: This invention is not limited to above-described embodiment, It comprises the structure of this invention and can achieve the objective and the effect. It goes without saying that modifications and improvements within the scope are included in the contents of the present invention. In addition, the specific structure, shape, and the like in practicing the present invention have no problem as other structures, shapes, and the like as long as the objects and effects of the present invention can be achieved. The present invention is not limited to the above-described embodiments, and modifications and improvements as long as the object of the present invention can be achieved are included in the present invention.

  As described above, according to the present invention, the concave grooves 41. 42 are formed on the inner surfaces of the resin sheets 21 and 22 having predetermined hardness and restorability, etc. Hereinafter, the internal flow path 4 will be described as an example) to feed a fluid such as blood to the dialyzer 3 or the like. On the other hand, by having predetermined hardness and restorability, etc., the internal flow path 4 can perform the function of delivering fluid by the function of a pump etc. If it is composed of only one, it may be suitable as a fluid flow path, but it may be slightly soft as a structural member (site that forms a structure), and if necessary, for example, in a partial portion of the internal flow path 4 It may be better to increase the rigidity, mechanical strength, etc. (hereinafter sometimes referred to simply as "rigidity etc.").

In addition, with respect to a portion other than the internal flow passage 4, for example, it is desirable to increase the rigidity and the like also in the plane portion of the panel 2 which is the structural portion. From the above, with respect to parts where rigidity and the like are required, in order to improve the rigidity and the like in each part of panel 2 (resin sheets 21 and 22), two reinforcing members 9 are provided on part of the inner surface of panel 2 A configuration in which the resin sheets 21 and 22 are sandwiched and interposed may be adopted.
In addition, the same code | symbol is attached | subjected to the structure and the same member as the above-mentioned content, and the detailed description is abbreviate | omitted or simplified.

  FIG. 12 is an explanatory view showing a portion to which the reinforcing member 9 is applied. In FIG. 12, a reinforcing member 9 (reinforcing member 9a for internal flow passage) having a shape shown in FIG. 13 described later so as to straddle the internal flow passage 4 (concave grooves 41 and 42) formed in the panel. And the aspect which applied the plate-shaped reinforcement member 9 (plate-like reinforcement member 9b) to the side edge of the panel 2 is shown. Thus, the reinforcing member 9 is applied to, for example, a portion straddling the internal flow passage 4 to enhance the rigidity and the like of the internal flow passage 4 and the periphery thereof, or to the side edge of the panel 2 which is a structural portion. It can be used as a means etc. which increase the rigidity of an application part and its periphery.

  FIG. 13 is a schematic view showing an example of the internal flow path reinforcing member 9a, and FIG. 14 is an explanatory view showing a cross-sectional configuration to which the internal flow path reinforcing member 9a is applied. The internal channel reinforcing member 9a for reinforcing the internal channel 4 and its periphery across the internal channel 4 is, as shown in FIG. 13, a hollow cylindrical channel portion 91 and both sides of the channel portion 91. The plate-like support part 92 formed in these is integrally molded. As a cross section is shown in FIG. 14, a channel portion 91 having a hollow cylindrical shape and having a hollow portion 93 through which a fluid can pass is fitted into the internal channel 4, and the plate-like support portion 92 is a panel 2 (resin sheet 21 and 22) are held in contact with the surface. Thus, the internal flow path reinforcing member 9a shown in FIGS. 13 and 14 is sandwiched between the two resin sheets 21 and 22 and interposed, and rigidity and mechanical strength of the internal flow path 4 and its periphery are obtained. Help to increase etc.

  Next, FIG. 15 is an explanatory view showing a cross-sectional configuration to which the plate-like reinforcing member 9b is applied. As shown in FIG. 15, the plate-like reinforcing member 9b applied to the side edge of the panel 2 which is a structural portion to reinforce the application portion and the periphery thereof is in surface contact with the application portion of the panel 2 (resin sheets 21 and 22). Will be held. Thus, the plate-like reinforcing member 9b is interposed between the two resin sheets 21 and 22 to be interposed, and serves to enhance the rigidity and mechanical strength of the application site and its periphery.

  In addition, since it is desirable that the rigidity etc. is high for the other parts, for example, the part to which the externally attached tube T1 is attached and the part to which the dialyzer 3 is attached, two reinforcing members 9 of a predetermined shape according to the parts The resin sheets 21 and 22 may be interposed and interposed. And the reinforcement member 9 can be applied not only to these site | parts but to arbitrary site | parts etc. where improvement of rigidity etc. is considered to be required.

  Here, the reinforcing member 9 is preferably formed of a material harder than the resin material or the like constituting the panel 2 described above, for example, polycarbonate (PC), polypropylene (PP), acrylonitrile-butadiene-styrene copolymer ( Engineering plastics, such as ABS resin) and polytetrafluoroethylene (PTFE), etc. can be used as a constituent material.

  Further, the reinforcing member 9 is inserted before clamping the split molds 81 and 82 in the same manner as the connecting portions R1 to R11 and the built-in tubes Ta, Tb and the like incorporated in the panel 2 described above. , 22 may be attached.

  Further, in the embodiment described above, as the configuration of the panel 2, the internal flow paths 4 and 4 a are disposed one by one on the left and right with the dialyzer 3 interposed therebetween, and the hollow flow path 6 is formed between the dialyzer 3 and the internal flow path 4 The configuration in which the hollow flow channels 7 and 7a are formed on the side of the internal flow channel 4a has been described with reference to FIGS. 1 to 3. On the other hand, the configuration of the panel 2 is not limited to this, and for the panel 2 formed by bonding the inner surfaces of the two resin sheets 21 and 22 to each other, the inner surface of at least one of the resin sheets 21 and 22 It is possible to adopt an arbitrary configuration in which hollow internal flow paths 4 and 4a for passing the fluid, which are composed of the concave grooves 41 and 42 (the concave grooves 41a and 42a), are disposed. Further, the number of internal channels 4, 4a is also arbitrary, and one or more required number of internal channels 4, 4a may be formed on the inner surface of the panel.

In the embodiment described above, when the externally attached tube T1 or the like is inserted into each flow path formed in the panel 2, the externally attached tube T1 or the like is inserted using the connecting portion R1 or the like. The external tube T1 etc. is directly formed on the panel without using the connecting part R1 etc. depending on the shape of the recessed It may be inserted into the end of the flow path.
In addition, the specific structure, shape, and the like at the time of implementation of the present invention may be other structures and the like as long as the object of the present invention can be achieved.

  Hereinafter, the present invention will be described in more detail based on Examples and Comparative Examples, but the present invention is not limited thereto.

[Examples 1 to 4 and Comparative Examples 1 and 2]
With the resin composition shown in Table 1 using the following resin materials, the blood purification circuit panel shown in FIG. 1 to FIG. 5 is subjected to the above-mentioned “an example of the manufacturing method of panel (2):”, It shape | molded according to 9-11. The depth of the recessed grooves was 2 to 50 mm, and the thickness of the resin sheet was 0.5 to 2.0 mm.

(A) Styrene elastomer:
Product name: Labaron (registered trademark) T331C (SEBS) (manufactured by Mitsubishi Chemical Corporation)
MFR: 0.7 g / 10 min Duro A hardness: 24
Compression set: 35%

(B) Olefin-based elastomer:
Product name: Tafmar (registered trademark) DF610 (polyethylene (PE) elastomer) (Mitsui Chemical Co., Ltd.)
MFR: 2.2 g / 10 minutes Duro A hardness: 57
Compression set: 45%

(C) styrenic elastomer:
Product name: Tuftec (registered trademark) H1062 (SEBS) (manufactured by Asahi Kasei Chemicals Corporation)
MFR: 4.5 g / 10 min Duro A hardness: 67
Compression set: 30%

(D) Polypolefin (PO) resin used in combination:
Product name: Prime Polypro (registered trademark) B 242 WC (manufactured by Prime Polymer Co., Ltd.) (Examples 1 and 2 and Comparative Example 2) The contents shown in Table 1 (the balance is (a) styrenic elastomer) did.)
MFR: 1.5 g / 10 minutes

  In addition, Duro A hardness (type A durometer hardness) of the above-mentioned and Table 1 has a value after processing for 22 hours at 23 ° C according to JIS K6252 and compression set according to JIS K6262, and melt flow rate (MFR) The value measured by JIS K 7210 (230 ° C., 2.16 kg) was used.

[Test Example 1]
With respect to Examples 1 to 4 and Comparative Examples 1 and 2 obtained as described above, “(1) Moldability” and “(2) Liquid transfer function” were evaluated under the following conditions. The results are shown in Table 1 including the constituent resins.

(1) Formability:
During molding, those with good appearance and no appearance defects such as crushing or thin portions were regarded as “○” (pass), and those with appearance defects such as crushing or thin portions as “X” (rejected) .

(2) Liquid transfer function:
As a molded product, for a hollow flow passage having an outer diameter of 7.0 mm and a thickness of 0.9 mm, a roller type tube pump having a configuration shown in FIG. 7 with a crushing amount of 1.7 mm and a rotational speed of 120 rpm for 5 hours ( Number of times of liquid delivery 36000 times) (The amount of liquid delivery under this condition is 5 L / hour), the thing of 4 L / hour or more of liquid delivery after 5 hours of liquid delivery is "○" (pass), The thing of less than 4 L / hour was made into "x" (fail).

(Consisting resin and result)

  As shown in Table 1, Examples 1 to 4 in which the Duro A hardness and the compression set of the resin sheet were in specific ranges, respectively, were good in moldability and excellent in liquid feeding function. there were.

  The present invention does not require a pump tube for feeding blood, dialysate and the like to the dialyzer, thereby reducing the number of members and eliminating the complexity of work, and as a blood purification circuit panel that can contribute to cost reduction, industrially The availability of is high.

1 ...... Blood purification circuit panel 2 ...... Panels 21, 22 ...... Resin sheets 23a, 23b ...... Mounting pieces 24a, 24b ...... Notches 25a, 25b ...... Stenotic portion 3 ...... Dialyzer 31 ...... Blood inflow tube portion 32 ...... blood outflow tube 33 ...... capillary 34 ...... dialysate inflow tube 35 ...... dialysate outflow tube 36a, 36b ...... flange 37a, 37b ...... annular groove 4, 4a ...... internal flow passage 41 , 41a, 42, 42a ...... groove 5 ...... pump 51 ...... rotator 52 ...... roller 6 ...... hollow channel 61, 62 ...... groove 63 ...... cavity 64,65 ...... branch channel 7 , 7a ...... Hollow flow channel 71, 71a, 72, 72a ...... Concave groove 81, 82 ...... Division mold 83a, 83b ...... T die 84a, 84b ...... Extrusion slit 85a to 85 ...... Rollers 86a, 86b, 87a, 87b ...... Formwork 88a, 88b ...... Cavities 89a, 89b ...... Pinch-off portion 9 ...... Reinforcement member 9a ...... Reinforcement member for internal flow passage 91 ...... Flow passage portion 92 ...... Support part 93 ...... Hollow part 9b ...... Plate-like reinforcing member R1 to R11 ...... Connection part S1, S2 ...... Sealed space T1 to T8 ...... External tube Ta, Tb ...... Internal tube

Claims (5)

A panel formed by laminating the inner surfaces of two resin sheets;
The inner surface of at least one sheet of the resin sheet is provided with a hollow internal flow passage formed of a recessed groove for passing a fluid,
By pressing a part of the internal flow path, the fluid in the internal flow path is fed in one direction,
The resin sheet is composed mainly of a styrene-based elastomer and / or an olefin-based elastomer,
A blood purification circuit panel characterized in that the Duro A hardness according to JIS K6253 of the resin sheet is 30 to 80, and the compression set after being treated at 23 ° C for 22 hours according to JIS K6262 is 50% or less.   The blood purification circuit panel according to claim 1, wherein the resin sheet has a melt flow rate (MFR) at 230 ° C of 0.1 to 5.0 g / 10 min.   The blood purification circuit panel according to claim 1 or 2, wherein the Duro A hardness is 50 to 70. Having a dialyzer fixed to the panel,
The blood purification circuit panel according to any one of claims 1 to 3, wherein the fluid in the internal flow path is fed to the dialyzer by pressing a part of the internal flow path.   The blood purification circuit according to any one of claims 1 to 4, wherein a reinforcing member is interposed between at least a part of the inner surface of the panel and the two resin sheets. panel.

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