JP4016049B2 - Medical multi-chamber container - Google Patents

Description

  In the present invention, two or more kinds of medical solutions are stored in separate storage chambers separated by an adhesive portion, and when used, the medical solutions are suitable for mixing the plurality of pharmaceutical solutions in a sealed state by peeling the adhesive portions. It relates to a multi-chamber container.

  In the medical field, it is very common to administer a plurality of drug components in a living body in a mixed state, but depending on the combination of drug components to be mixed, the following method is adopted. For example, in the case of infusion, liquids containing amino acids and glucose are likely to be altered by the Maillard reaction, so each component is stored in a separate closed system and often mixed immediately before administration to a patient. At this time, in order to perform the mixing operation aseptically (with a closed system) and easily, a container partitioned into a plurality of storage chambers is used to store different infusion components in each of the storage chambers. In addition, a method has been put to practical use in which the storage chamber partitioned immediately before use is communicated and mixed in the closed system by some means.

It is important that the container infusion can be stably isolated until immediately before use, and can be easily communicated during use (during mixing), and various forms have been devised and proposed for this purpose. ing. Typical ones are: [1] Narrowing between storage chambers from outside (Japanese Patent Laid-Open Nos. 53-38189, 61-103823, 1-160558, etc.), [2] Connecting the storage chambers with a tube exposed outside the container, and clamping the tube with a clamp (Japanese Utility Model Publication No. 57-76636, etc.), [3] Having a communication tool that can communicate between the storage chambers during use (4) Japanese Patent Publication No. 57-52455, etc., [4] The adhesive part separating the storage chambers is made of a seal having a sealing strength that is relatively stable and can be easily peeled off during mixing. JP, 63-309263, JP 1-240469, JP 2-4671, JP 2-57584, JP 2-241457, JP 2-255418, JP 4-242647. No. No. -31153, a JP-like No. 5-68702). Among these, what has a lot of operability and practicality is the so-called easy-peeling multi-chamber container of [4], and is attracting the most attention. The technical point of this type is that the peelable adhesive part between the storage chambers is relatively stable and difficult to peel off during manufacturing or transportation, and is easily peeled off by hand or instrument during use (during mixing). It has sufficient seal strength to obtain, and the seal strength of the peripheral portion connected to the outside world (atmosphere) is sufficient. Accordingly, the selection of the material forming the inner wall of the container (that is, forming the adhesive portion) is the most important, but generally the material forming the micro-layer separation structure, for example, a mixture of polyethylene and polypropylene, polyethylene and A mixture with a cross-linked polyethylene or the like (these are types in which a peelable adhesive portion causes so-called cohesive peeling at the time of peeling) is used. However, the problem is that these materials satisfy the requirements for materials for infusion containers, that is, safety, flexibility, transparency, heat resistance (high-pressure steam sterilization resistance), etc. is there. For example, a mixture of polyethylene and polypropylene is not sufficiently transparent, and a mixture of polyethylene and cross-linked polyethylene is liable to generate gels and fish eyes and is inferior in productivity.
JP 53-38189 A JP 61-103823 A JP-A-1-160558 Japanese Utility Model Publication No. 57-76636 JP-A-57-52455 Japanese Patent Publication No. 6-26563 JP-A 63-309263 JP-A-1-240469 JP-A-2-4671 Japanese Patent Laid-Open No. 2-57584 JP-A-2-241457 JP-A-2-255418 JP-A-4-242647 Japanese Patent Laid-Open No. 5-31153 Japanese Patent Laid-Open No. 5-68702

  An object of the present invention is to solve problems such as material safety, flexibility, transparency, and heat resistance (high-pressure steam sterilization resistance) associated with easily peelable medical multi-chamber containers.

What brings about the solution of the said subject is the medical multi-chamber container of the following (1)- (11) .

(1) A medical multi-chamber container in which opposing inner wall surfaces are partitioned by a peelable adhesive portion and partitioned into a plurality of storage chambers, wherein the inner wall surfaces are crystalline polypropylene-based polymer and styrene-based thermoplastic made from the polymer composition of an elastomer, and the weight ratio of the crystalline polypropylene-based polymer and the styrene-based thermoplastic elastomer, 75: 25-65: 35 der is, further, the polymer composition A medical multi-chamber container comprising 5 to 20% by weight of an ethylene butene copolymer which is an olefinic elastomer .

  (2) The styrenic thermoplastic elastomer comprises a block (polystyrene-ethylenebutylene copolymer-polystyrene), a block (polystyrene-ethylenepropylene copolymer-polystyrene), a block (polystyrene-ethylenebutylene copolymer-polyethylene) and a block (polystyrene-ethylenepropylene). The medical multi-chamber container according to (1) above, which is at least one block copolymer selected from the group of copolymer-polyethylene).

(3) The medical multi-chamber container according to (1) or (2), wherein the medical multi-chamber container is composed of a single sheet in a polymer composition of the crystalline polypropylene polymer and the styrene thermoplastic elastomer. Medical multi-chamber container.
(4) the polymer composition, wherein the crystalline polypropylene-based polymer, wherein the weight ratio of the styrene-based thermoplastic elastomer and the ethylene butene copolymers is a multi-chamber medical according to (1) is 60:30:10 container.
( 5 ) The medical multi-chamber container according to any one of (1) to ( 4 ), wherein the crystalline polypropylene-based polymer is a crystalline polypropylene random copolymer.
( 6 ) The medical multi-chamber container stores two or more kinds of pharmaceutical liquids in separate storage chambers separated by the adhesive part, and the plurality of pharmaceutical liquids are sealed by peeling the adhesive part during use. The medical multi-chamber container according to any one of the above (1) to ( 5 ), which is mixed in a state.
( 7 ) The styrenic thermoplastic elastomer is a block (polystyrene-ethylenebutylene copolymer-polystyrene) copolymer, and the total of polystyrene parts at both ends occupies 5 to 40% by weight in the block copolymer, And any of said (1) thru | or ( 6 ) whose ratio of the butylene part in an ethylene butylene copolymer part occupies 20 to 90 weight%, and also MFR of this block copolymer is 0.5-20. A multi-chamber container for medical use according to crab.
( 8 ) The styrenic thermoplastic elastomer is a block (polystyrene-ethylenepropylene copolymer-polystyrene) copolymer, and the total of polystyrene parts at both ends occupies 5 to 40% by weight in the block copolymer, The medical multi-chamber container according to any one of (1) to ( 6 ), wherein the block copolymer has an MFR of 0.5 to 20.
( 9 ) The styrenic thermoplastic elastomer is a block (polystyrene-ethylene butylene copolymer-polyethylene) copolymer, and the weight ratio of the polystyrene part, the ethylene butylene copolymer part and the polyethylene part in the block copolymer is 3 to 30 weights. %: 40 to 80% by weight: 10 to 40% by weight, the proportion of the butylene part in the ethylene butylene copolymer part is 30 to 90% by weight, and the MFR of the block copolymer is 0.5 to 20 (1) thru | or the medical multi-chamber container in any one of ( 6 ).
( 10 ) The styrenic thermoplastic elastomer is a block (polystyrene-ethylenepropylene copolymer-polyethylene) copolymer, and the weight ratio of the polystyrene part, the ethylenepropylene copolymer part and the polyethylene part in the block copolymer is 3 to 30 weights. %: 40-80% by weight: 10-40% by weight, and the MFR of the block copolymer is 0.5-20, The medical multi-chamber container according to any one of (1) to ( 6 ) above .

  The medical multi-chamber container of the present invention is excellent because it contains a polymer composition that exhibits the maximum compatibility of polypropylene-based polymer (PP) and styrene-based thermoplastic elastomer (SBC) as the inner wall surface. Transparency and flexibility. In addition, since the adhesive part can be peeled but has an appropriate sealing strength, the pharmaceutical solution isolated in the plurality of storage chambers is not mixed during transportation, but can be easily mixed during use. Furthermore, it has good moldability, productivity, and heat resistance, and satisfies the Japanese Pharmacopoeia standards for heavy metals and eluates, so it is useful as a medical multi-chamber container. When SBC is one of SEBS, SEPS, SEBE, and SEPE, and when the content of SBC in the polymer composition of PP and SBC is 10 to 50% by weight, the above characteristics are remarkably exhibited. The

  Although the form of the medical multi-chamber container of this invention is not specifically limited, It demonstrates with reference to FIG. 1, FIG. 2 as one Example of a form. FIG. 1 is a front view of a medical multi-chamber container, and FIG. 2 is a cross-sectional view taken along line AA of FIG. The medical multi-chamber container 1 is a container having a discharge port 2 on one side and two storage chambers. The peripheral edge portion 3 is heat-sealed to release both ends of the inflation sheet, and the adhesive portion 4 is sealed to such an extent that it can be peeled off. At the time of use (mixing), the adhesive chamber 4 is peeled off by pressing the storage chamber 5 with a hand or an instrument, etc., and the two storage chambers 5 communicate with each other, so that the isolated drug solution can be easily removed. Can be mixed. The medical multi-chamber container 1 of the present invention has an appropriate sealing strength, is excellent in properties such as safety, flexibility, transparency and heat resistance, and is easy to produce.

  Although there is room for elucidation as to whether the polymer composition of polypropylene and polystyrene-based thermoplastic elastomer in the present invention forms a micro-layer separation structure or a completely compatible system, polypropylene and polystyrene-based thermoplastic elastomer It is considered that the moderate ten-minute interaction is closely related to the degree of seal strength.

In the present invention, a polypropylene-based polymer (hereinafter referred to as PP) means a polypropylene having a normal stereoregular structure, that is, an isotactic or syndiotactic crystalline homopolymer, or a crystalline copolymer based on these. However, a copolymer, particularly a random copolymer, is advantageous in terms of transparency and flexibility (low flexural modulus). The comonomer may be an α having 2 to 12 carbon atoms such as ethylene, butene-1, pentene-1, hexene-1, heptene-1, octene-1, decene-1, dodecene-1, 4-methylpentene-1. -Olefin is good, and the amount of comonomer is preferably about 2 to 30 mol%, more preferably about 3 to 25 mol%. Here, the flexural modulus of elasticity (JIS K7203) of PP is preferably 12000 Kg / cm ² or less, more preferably 10,000 Kg / cm ² . When the flexural modulus exceeds 12000 Kg / cm ² , the rigidity of the polymer composition with the styrenic thermoplastic elastomer is inevitably high (the styrenic thermoplastic elastomer also shows a function as a softener of PP, but a large amount This is because the self-drainage property (property that can be drained without an aeration needle at the time of infusion) is easily impaired. From the viewpoint of heat resistance, PP preferably has a Vicat softening point (JIS K7206) of 100 ° C. or higher. In consideration of moldability and mechanical properties of the molded product (container sheet), MFR (melt flow rate, JIS K7210) at a temperature of 230 ° C. and a load of 2160 g is preferably 0.3 to 15, more preferably 0.5. It is good that it is -10.

  Next, typical examples of the styrenic thermoplastic elastomer (hereinafter referred to as SBC) in the present invention are listed below. These can be produced by a generally known method. MFR is a measured value at a temperature of 230 ° C. and a load of 2160 g according to JIS standard K7210.

[1] SEBS: block (polystyrene-ethylenebutylene copolymer-polystyrene)
SEBS is a block copolymer obtained by hydrogenation of a polystyrene-polybutadiene (block copolymer of 1,2-conjugate and 1,4-conjugate) -triblock copolymer (SBS) having a polystyrene structure. . In consideration of compression set, moldability, other mechanical properties, etc., the total of polystyrene parts (S part) at both ends preferably occupies 5 to 40% by weight in SEBS, more preferably 7 to 30% by weight. % Is good. Further, the ethylene butylene copolymer part (EB part) preferably occupies 20 to 90% by weight of the butylene part, more preferably 30 to 80% by weight. SEBS preferably has a MFR of 0.5 to 20, more preferably 1 to 15.

[2] SEPS: Block (polystyrene-ethylenepropylene copolymer-polystyrene)
In much the same way as SEBS, SEPS is obtained by hydrogenation of a polystyrene-polyisoprene-polystyrene type triblock copolymer (SIS). In consideration of the same matter as SEBS, the total of polystyrene parts (S part) at both ends preferably occupies 5 to 40% by weight in SEPS, more preferably 7 to 30% by weight, and MFR is preferably The thing of 0.5-20 is preferable, More preferably, the thing of 1-15 is good.

[3] SEBE: Block (polystyrene-ethylene butylene copolymer-polyethylene)
SEBE is obtained by hydrogenating a triblock copolymer having a structure of polyethylene-polybutadiene (copolymer of 1,2-bond and 1,4-bond) -poly-1,4-butadiene. Considering the same matter as in the case of SEBS, the weight ratio of polystyrene part (S part), ethylene butylene copolymer part (EB part) and polyethylene part (E part) is preferably 3 to 30% by weight: 40 to 80% by weight. %: 10 to 40% by weight, more preferably 5 to 25% by weight: 45 to 75% by weight: 12 to 35% by weight. The amount of butylene in the EB part is preferably 30 to 90% by weight. Further, the MFR is preferably the same as that of SEBS.

[4] SEPE: Block (polystyrene-ethylenepropylene copolymer-polyethylene)
SEPE is obtained by hydrogenating a triblock copolymer having a polystyrene-poly-1,4-isoprene-poly-1,4-butadiene structure. Considering the same matter as in the case of SEBS, the weight ratio of polystyrene part (S part), ethylene propylene copolymer part (EP part) and polyethylene part (E part) is preferably 3 to 30% by weight: 40 to 80% by weight. %: 10 to 40% by weight, more preferably 5 to 25% by weight: 45 to 75% by weight, and 12 to 35% by weight, and the MFR is preferably the same as that of SEBS.

  In addition to the above [1] to [4], a block (polystyrene-poly-1,2-isoprene-polystyrene) or a hydrogenated product thereof is also one of SBCs preferably used.

The inner wall surface of the medical multi-chamber container of the present invention is a polymer composition of PP and SBC as shown at the beginning. Generally, the polymer composition has a heat sealing property. , flexibility, transparency, in consideration of heat resistance, the weight ratio of PP and the SBC, preferably 90: 10 to 50: a 50, more preferably 85: 15 to 60: and even better 40 . It should be noted that if the PP is too much, the rigidity becomes high and the flexibility of the container tends to be lowered, and if the SBC is too much, the sheet forming ability tends to be low.

  In the medical multi-chamber container of the present invention, the inner wall surface is a polymer composition of PP and SBC, and (1) the case is made of a sheet of the polymer composition of PP and SBC, and (2) There may be a multilayer sheet having a polymer composition of PP and SBC as an inner layer (inner wall surface of the container) and another polymer (or polymer composition) as an outer layer or an intermediate layer. In (2), it is combined with other polymers (or other polymer compositions) depending on the required performance such as barrier properties, transparency, flexibility, heat resistance, strength, etc. of the container gas (water vapor, oxygen, etc.) However, typical examples of other polymers (or other polymer compositions) that are specifically preferred are shown below.

(A) Density of 0.910 to 0.930 g / with α-olefins such as butene-1, pentene-1, hexene-1, heptene-1, octene-1, and 4-methylpentene-1 as copolymerization components linear low density polyethylene cm ³ (LLDPE).

  (B) Crystalline polypropylene or a crystalline polypropylene copolymer containing the same as a main component. However, since it has high rigidity, it is preferable to use it as a thin layer.

  (C) A polymer composition of (b) and amorphous polypropylene (atactic polypropylene).

  (D) Ethylene vinyl alcohol copolymer. Used for the purpose of imparting gas barrier properties to the container.

  Further, the thickness of the sheet forming the medical multi-chamber container of the present invention is preferably 0.2 to 0.6 mm as a whole, more preferably 0.25 to 0.45 mm. In the case of a layer (in the case of (2) above), the polymer composition layer of PP and SBC is preferably 0.01 mm or more, more preferably 0.02 mm or more.

The medical multi-chamber container of the present invention can be produced by a generally known method. That is, it is extruded through a single-layer or multi-layer T die or a circular die (melting temperature is preferably 160 to 230 ° C., more preferably 170 to 200 ° C.), and the obtained flat sheet or tube-shaped sheet The parison and the like may be processed into a predetermined shape and form by appropriately utilizing techniques such as thermoforming, blowing, stretching (non-stretching is better considering heat sealing properties), cutting, and fusion. The most important point in the production of a medical multi-chamber container is the heat sealing process. That is, [1] The peelable adhesive section partitioned into a plurality of storage spaces is unlikely to peel off during manufacturing or transportation, and when used (mixed), the storage chamber is pressed with a hand or instrument. The seal strength is such that it can be easily peeled off (generally 180 ° peel strength is about 0.3 to 1.2 kg / 15 mm), and [2] the peripheral portion that is in contact with the outside world cannot be easily peeled off. Since it is required to have a sealing strength (180 ° peel strength is preferably 1.5 kg / 15 mm or more, more preferably 2 kg / 15 mm or more), it is important to control the sealing conditions of the adhesive portion and the peripheral portion. is there. In the case of the medical multi-chamber container of the present invention, the seal of the adhesive portion is a temperature of 110 to 150 ° C., a pressure of 1 to 4 Kg / cm ² , a time of 0.2 to 5 seconds, a seal width of ^{2 to} 10 mm, Is usually performed at a temperature of 130 to 200 ° C., a pressure of ^{2 to} 5 kg / cm ² , a time of 0.2 to 10 seconds, and a seal width of 5 mm or more. The number of storage chambers is generally 2-4.

  Further, the polymer composition of PP and SBC can be adjusted by using a commonly known uniaxial or biaxial melt mixing extruder or static melt mixer. The melting temperature during mixing is preferably in the range of 160 to 220 ° C.

  It should be noted that another olefin-based elastomer (for example, ethylene propylene copolymer or ethylene butene copolymer) may be added to the polymer composition of PP and SBC within a range not impairing the gist of the present invention. There is no problem. Moreover, in order to prevent blocking between sheets, the inner surface and outer surface of a container may be roughened, and an antiblocking agent and a slip agent may be added.

  The medical multi-chamber container of the present invention is effective for a combination of drugs that easily change in quality, such as a combination of an amino acid solution and a glucose solution, and can be applied not only to infusion but also to the blood field.

  Hereinafter, the medical multi-chamber container of the present invention will be described in more detail with reference to specific examples.

[Experimental materials and methods]
Examples 1-6, Comparative Example 1
(1) Preparation of raw material polymer: The raw material polymer (in pellet form) used is shown in Table 1.

（２）重合体組成物の調整：表１のＰＰ（Ａ１、Ａ２）、ＳＢＣ（Ｂ１〜Ｂ４）、アモルファスポリプロピレン（Ｃ）および低密度ポリエチレン（Ｄ）を原料とし、φ４５ｍｍの２軸溶融混練押出機を用いて、所定の割合で１８０〜２００℃の温度範囲で混練し、押出されたストランドを水冷、カッティング、乾燥して表２に示すペレット状の重合体組成物を得た。

(2) Preparation of polymer composition: PP45 (A1, A2), SBC (B1 to B4), amorphous polypropylene (C) and low density polyethylene (D) in Table 1 as raw materials, φ45 mm biaxial melt kneading extrusion A pelletized polymer composition shown in Table 2 was obtained by kneading at a predetermined ratio in a temperature range of 180 to 200 ° C. using a machine and water-cooling, cutting and drying the extruded strand.

（３）シートの作製：表１および／または表２のポリマーまたは重合体組成物を単層用または多層用のサーキュラーダイ（インフレダイ）に供給し、１８０〜２００℃でチューブ状のシートを押出し、水冷リングで冷却後、厚さ０．３３ｍｍ、折径２００ｍｍのシートを５ｍ／分の速度で巻き取った。

(3) Production of sheet: The polymer or polymer composition of Table 1 and / or Table 2 is supplied to a single-layer or multi-layer circular die (inflation die), and a tubular sheet is extruded at 180 to 200 ° C. After cooling with a water cooling ring, a sheet having a thickness of 0.33 mm and a folding diameter of 200 mm was wound up at a speed of 5 m / min.

(4) Fabrication of a medical multi-chamber container: The sheet obtained in (3) is cut into a length of 300 mm, and a width of 7 mm at the center is heat sealed under conditions of a temperature of 120 ° C., a pressure of 2 kg / cm ² and a time of 5 seconds. After forming the adhesion part, 400 ml each of 3 wt / v% amino acid aqueous solution in one chamber and 15 wt / v% glucose aqueous solution in the other chamber, the peripheral part (both ends) width 10 mm, temperature 160 ° C., pressure Heat-sealing was performed under the conditions of 4 kg / cm ² and a time of 5 seconds, and the storage chamber 5 shown in FIG.

(5) High-pressure steam sterilization: The container of (4) is placed in a high-pressure steam sterilizer, sterilized in a nitrogen atmosphere at a temperature of 110 ° C., a gauge pressure of 1.8 kg / cm ² for 30 minutes, and cooled to room temperature. did.

  (6) Evaluation of the transparency of the container: After leaving the container of (5) in a nitrogen atmosphere for 48 hours, a part of the sheet of the container is cut off, and the transmittance in water at a wavelength of 450 mm is measured by the Shimadzu double beam self-recording spectrophotometer. It was measured with a total of UV-300 and used as a measure of transparency.

  (7) Evaluation of the flexibility of the container: The sheet of the container of (5) was cut into a dumbbell shape, and the tensile elastic modulus was measured according to JIS K7113 to obtain a measure of flexibility.

  (8) Measurement of seal strength: The adhesion part and the peripheral part of the container of (5) were cut out, and the 180 ° peel strength was measured at a speed of 300 mm / min (the peel strength in Table 3 is a value converted to a width of 15 mm). Is).

  (9) Evaluation of peelability (communication) of the adhesion part of the container: Whether or not the adhesion part is peeled to such an extent that the container of (5) is placed on a desk and one container is pressed by hand. (Tested 5 times for each case).

  (10) Heavy metal and eluate test: The sheet obtained in (3) was tested according to the Japanese Pharmacopoeia general test method "Plastic test method for infusion".

[Experimental result]
[1] Adjustment of the polymer composition and extrusion of the sheet were smooth, and no foreign matter, foaming, etc. were observed, and polymer composition pellets and sheets with high uniformity were obtained in all cases.

  [2] In any composition, it was confirmed that heavy metals and eluates are compatible with the Japanese Pharmacopoeia.

  [3] Table 3 shows the structure of the sheet and the transparency (water permeability), flexibility (tensile modulus) and seal strength after high-pressure steam sterilization. It can be seen that the containers (Examples 1 to 6) using the polymer composition in the present invention are excellent in transparency and flexibility. On the other hand, it is apparent that the combination of polyethylene and polyethylene (Comparative Example 1) is inferior in transparency and flexibility.

  [4] The peelability (communication) of the adhesion part of the container was good (including the comparative example) and could be easily communicated (the sealing strength in Table 3 also supports this).

It is a front view which shows one Example of the medical multiple chamber container of this invention. It is AA sectional view taken on the line of the Example.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical multi-chamber container 2 Outlet 3 Peripheral part 4 Adhesion part 5 Storage chamber

Claims (10)

A medical multi-chamber container in which opposing inner wall surfaces are partitioned by a peelable adhesive portion and partitioned into a plurality of storage chambers, wherein the inner wall surface is made of a crystalline polypropylene polymer and a styrene thermoplastic elastomer. made from the polymer composition and the weight ratio of the crystalline polypropylene-based polymer and the styrene-based thermoplastic elastomer, 75: 25-65: 35 der is, further, the polymer composition, olefin A medical multi-chamber container comprising 5 to 20% by weight of an ethylene butene copolymer which is an elastomer . The styrenic thermoplastic elastomer is composed of a block (polystyrene-ethylenebutylene copolymer-polystyrene), a block (polystyrene-ethylenepropylene copolymer-polystyrene), a block (polystyrene-ethylenebutylene copolymer-polyethylene) and a block (polystyrene-ethylenepropylene copolymer-polyethylene). 2) The medical multi-chamber container according to claim 1, which is at least one block copolymer selected from the group of (1). The medical multi-chamber container according to claim 1 or 2, wherein the medical multi-chamber container is composed of a single sheet in a polymer composition of the crystalline polypropylene polymer and the styrene thermoplastic elastomer. The medical multi-chamber container according to claim 1 , wherein the polymer composition has a weight ratio of the crystalline polypropylene polymer, the styrene thermoplastic elastomer, and the ethylene butene copolymer of 60:30:10. The medical multi-chamber container according to any one of claims 1 to 4 , wherein the crystalline polypropylene-based polymer is a crystalline polypropylene random copolymer. The medical multi-chamber container stores two or more kinds of pharmaceutical liquids in separate storage chambers separated by the adhesive part, and the plurality of pharmaceutical liquids are mixed in a sealed state by peeling the adhesive part during use. The medical multi-chamber container according to any one of claims 1 to 5 . The styrenic thermoplastic elastomer is a block (polystyrene-ethylene butylene copolymer-polystyrene) copolymer, and the total of polystyrene parts at both ends occupies 5 to 40% by weight of the block copolymer, and ethylene The medical use according to any one of claims 1 to 6 , wherein the proportion of the butylene portion in the butylene copolymer portion occupies 20 to 90% by weight, and the MFR of the block copolymer is 0.5 to 20. Multi-chamber container. The styrenic thermoplastic elastomer is a block (polystyrene-ethylenepropylene copolymer-polystyrene) copolymer, and the total of polystyrene parts at both ends occupies 5 to 40% by weight of the block copolymer. The medical multi-chamber container according to any one of claims 1 to 6 , wherein the block copolymer has an MFR of 0.5 to 20. The styrenic thermoplastic elastomer is a block (polystyrene-ethylene butylene copolymer-polyethylene) copolymer, and the weight ratio of the polystyrene part, the ethylene butylene copolymer part and the polyethylene part in the block copolymer is 3 to 30% by weight: 40 -80 wt%: 10 to 40 wt%, the proportion of butylene in the ethylene butylene copolymer portion is 30 to 90 wt%, and the MFR of the block copolymer is 0.5 to 20 The medical multi-chamber container according to any one of 6 . The styrenic thermoplastic elastomer is a block (polystyrene-ethylenepropylene copolymer-polyethylene) copolymer, and the weight ratio of polystyrene part, ethylenepropylene copolymer part and polyethylene part in the block copolymer is 3 to 30% by weight: 40 The medical multi-chamber container according to any one of claims 1 to 6 , wherein -80 wt%: 10 to 40 wt%, and the MFR of the block copolymer is 0.5 to 20.

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