JP6513645B2 - 有機化合物におけるまたは関する改善 - Google Patents
有機化合物におけるまたは関する改善 Download PDFInfo
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- JP6513645B2 JP6513645B2 JP2016518972A JP2016518972A JP6513645B2 JP 6513645 B2 JP6513645 B2 JP 6513645B2 JP 2016518972 A JP2016518972 A JP 2016518972A JP 2016518972 A JP2016518972 A JP 2016518972A JP 6513645 B2 JP6513645 B2 JP 6513645B2
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- JP
- Japan
- Prior art keywords
- perfume
- hydroxy
- dimethyl
- compound
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002894 organic compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 claims description 146
- 239000002304 perfume Substances 0.000 claims description 79
- 150000001875 compounds Chemical class 0.000 claims description 67
- 239000004615 ingredient Substances 0.000 claims description 31
- 239000011541 reaction mixture Substances 0.000 claims description 28
- 239000002253 acid Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 239000003205 fragrance Substances 0.000 claims description 22
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 claims description 21
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 13
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 claims description 12
- LCRYKIFRBLQIAW-UHFFFAOYSA-N 3,7-dimethylocta-1,6-diene-1,3-diol Chemical compound CC(C)=CCCC(C)(O)C=CO LCRYKIFRBLQIAW-UHFFFAOYSA-N 0.000 claims description 11
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 11
- 150000001241 acetals Chemical class 0.000 claims description 11
- ZHOOOLQOWQVYOE-UHFFFAOYSA-N 2-cyclohexylidene-2-phenylacetonitrile Chemical compound C=1C=CC=CC=1C(C#N)=C1CCCCC1 ZHOOOLQOWQVYOE-UHFFFAOYSA-N 0.000 claims description 9
- 230000002378 acidificating effect Effects 0.000 claims description 7
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- YVSNOTITPICPTB-UHFFFAOYSA-N 4-methyl-2-(2-methylpropyl)oxan-4-ol Chemical compound CC(C)CC1CC(C)(O)CCO1 YVSNOTITPICPTB-UHFFFAOYSA-N 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
- 239000003054 catalyst Substances 0.000 claims description 5
- SAMJGBVVQUEMGC-UHFFFAOYSA-N 1-ethenoxy-2-(2-ethenoxyethoxy)ethane Chemical compound C=COCCOCCOC=C SAMJGBVVQUEMGC-UHFFFAOYSA-N 0.000 claims description 4
- 239000012298 atmosphere Substances 0.000 claims description 4
- 239000011261 inert gas Substances 0.000 claims description 4
- 230000003078 antioxidant effect Effects 0.000 claims description 3
- GLASPHLTTAHWPI-UHFFFAOYSA-N methyl 2-(2-hexyl-3-oxocyclopentyl)acetate Chemical compound CCCCCCC1C(CC(=O)OC)CCC1=O GLASPHLTTAHWPI-UHFFFAOYSA-N 0.000 claims description 3
- CYIGRWUIQAVBFG-UHFFFAOYSA-N 1,2-bis(2-ethenoxyethoxy)ethane Chemical compound C=COCCOCCOCCOC=C CYIGRWUIQAVBFG-UHFFFAOYSA-N 0.000 claims description 2
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 claims description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 2
- 230000003301 hydrolyzing effect Effects 0.000 claims description 2
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 239000000047 product Substances 0.000 description 52
- BKYXRISZNNAYRG-UHFFFAOYSA-N 9-hydroxy-5,9-dimethyldec-1-en-4-one Chemical compound CC(C(CC=C)=O)CCCC(C)(O)C BKYXRISZNNAYRG-UHFFFAOYSA-N 0.000 description 42
- 235000019645 odor Nutrition 0.000 description 34
- 238000009472 formulation Methods 0.000 description 23
- 239000003599 detergent Substances 0.000 description 22
- WTYGAUXICFETTC-UHFFFAOYSA-N cyclobarbital Chemical compound C=1CCCCC=1C1(CC)C(=O)NC(=O)NC1=O WTYGAUXICFETTC-UHFFFAOYSA-N 0.000 description 20
- 229960004138 cyclobarbital Drugs 0.000 description 20
- 239000002585 base Substances 0.000 description 19
- -1 double bonds Chemical group 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 12
- 239000002537 cosmetic Substances 0.000 description 12
- 238000004821 distillation Methods 0.000 description 12
- 239000002671 adjuvant Substances 0.000 description 10
- 239000010410 layer Substances 0.000 description 10
- 239000002243 precursor Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical group CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 8
- SRPFYGUVQUDURC-UHFFFAOYSA-N 2,6-Dimethyl-7-octene-2,6-diol Chemical compound CC(C)(O)CCCC(C)(O)C=C SRPFYGUVQUDURC-UHFFFAOYSA-N 0.000 description 7
- 150000001299 aldehydes Chemical class 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000003755 preservative agent Substances 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
- 239000002386 air freshener Substances 0.000 description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 6
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 239000002453 shampoo Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- JJRIKWAHJMMDSF-UHFFFAOYSA-N 2,6-dimethyloct-7-yne-2,6-diol Chemical compound CC(C)(O)CCCC(C)(O)C#C JJRIKWAHJMMDSF-UHFFFAOYSA-N 0.000 description 5
- 150000004808 allyl alcohols Chemical class 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 239000012467 final product Substances 0.000 description 5
- KVWWIYGFBYDJQC-UHFFFAOYSA-N methyl dihydrojasmonate Chemical compound CCCCCC1C(CC(=O)OC)CCC1=O KVWWIYGFBYDJQC-UHFFFAOYSA-N 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 4
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
- OHRBQTOZYGEWCJ-UHFFFAOYSA-N 3-(3-propan-2-ylphenyl)butanal Chemical compound CC(C)C1=CC=CC(C(C)CC=O)=C1 OHRBQTOZYGEWCJ-UHFFFAOYSA-N 0.000 description 4
- KZZASWGRLOTITL-UHFFFAOYSA-N 4-cyclohexyl-2-methylbutan-2-ol Chemical compound CC(C)(O)CCC1CCCCC1 KZZASWGRLOTITL-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 4
- 229940022663 acetate Drugs 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 239000006227 byproduct Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 229930007744 linalool Natural products 0.000 description 4
- GYHFUZHODSMOHU-UHFFFAOYSA-N nonanal Chemical compound CCCCCCCCC=O GYHFUZHODSMOHU-UHFFFAOYSA-N 0.000 description 4
- 239000012044 organic layer Substances 0.000 description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- ZJPKYCLAROITRY-UHFFFAOYSA-N 3-(1-ethoxyethoxy)-3,7-dimethylocta-1,6-diene Chemical compound CCOC(C)OC(C)(C=C)CCC=C(C)C ZJPKYCLAROITRY-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 3
- 238000005821 Claisen rearrangement reaction Methods 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 3
- NPFVOOAXDOBMCE-PLNGDYQASA-N cis-3-Hexenyl acetate Natural products CC\C=C/CCOC(C)=O NPFVOOAXDOBMCE-PLNGDYQASA-N 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- BOPPSUHPZARXTH-UHFFFAOYSA-N ocean propanal Chemical compound O=CC(C)CC1=CC=C2OCOC2=C1 BOPPSUHPZARXTH-UHFFFAOYSA-N 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- DTUQWGWMVIHBKE-UHFFFAOYSA-N phenylacetaldehyde Chemical compound O=CCC1=CC=CC=C1 DTUQWGWMVIHBKE-UHFFFAOYSA-N 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
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- 239000002562 thickening agent Substances 0.000 description 3
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- WBNJCBPWAMSDMR-YFVJMOTDSA-N (2e,6e)-3,7,11-trimethyldodeca-2,6-dienal Chemical compound CC(C)CCC\C(C)=C\CC\C(C)=C\C=O WBNJCBPWAMSDMR-YFVJMOTDSA-N 0.000 description 2
- 229940098795 (3z)- 3-hexenyl acetate Drugs 0.000 description 2
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- SSNZFFBDIMUILS-ZHACJKMWSA-N (E)-dodec-2-enal Chemical compound CCCCCCCCC\C=C\C=O SSNZFFBDIMUILS-ZHACJKMWSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 2
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- XVOKPNRYHDZDMX-UHFFFAOYSA-N 1-(4-ethyl-2-bicyclo[2.2.1]heptanyl)cyclohexan-1-ol Chemical compound C1C(CC)(C2)CCC1C2C1(O)CCCCC1 XVOKPNRYHDZDMX-UHFFFAOYSA-N 0.000 description 2
- NEHPIUGJDUWSRR-UHFFFAOYSA-N 1-(4-propan-2-ylcyclohexyl)ethanol Chemical compound CC(C)C1CCC(C(C)O)CC1 NEHPIUGJDUWSRR-UHFFFAOYSA-N 0.000 description 2
- FYMOBFDUZIDKMI-UHFFFAOYSA-N 2,2-dimethyl-3-(3-methylphenyl)propan-1-ol Chemical compound CC1=CC=CC(CC(C)(C)CO)=C1 FYMOBFDUZIDKMI-UHFFFAOYSA-N 0.000 description 2
- UEGBWDUVDAKUGA-UHFFFAOYSA-N 2,6,10-trimethylundec-9-enal Chemical compound CC(C)=CCCC(C)CCCC(C)C=O UEGBWDUVDAKUGA-UHFFFAOYSA-N 0.000 description 2
- DNRJTBAOUJJKDY-UHFFFAOYSA-N 2-Acetyl-3,5,5,6,8,8-hexamethyl-5,6,7,8- tetrahydronaphthalene Chemical compound CC(=O)C1=C(C)C=C2C(C)(C)C(C)CC(C)(C)C2=C1 DNRJTBAOUJJKDY-UHFFFAOYSA-N 0.000 description 2
- RIWRBSMFKVOJMN-UHFFFAOYSA-N 2-methyl-1-phenylpropan-2-ol Chemical compound CC(C)(O)CC1=CC=CC=C1 RIWRBSMFKVOJMN-UHFFFAOYSA-N 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- ZGIGZINMAOQWLX-NCZFFCEISA-N 3,7,11-Trimethyl-2,6,10-dodecatrienyl acetate Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\COC(C)=O ZGIGZINMAOQWLX-NCZFFCEISA-N 0.000 description 2
- JFTSYAALCNQOKO-UHFFFAOYSA-N 3-(4-ethylphenyl)-2,2-dimethylpropanal Chemical compound CCC1=CC=C(CC(C)(C)C=O)C=C1 JFTSYAALCNQOKO-UHFFFAOYSA-N 0.000 description 2
- JTVKFAPEIBMMHX-UHFFFAOYSA-N 3-(4-methylcyclohex-3-en-1-yl)butan-1-ol Chemical compound OCCC(C)C1CCC(C)=CC1 JTVKFAPEIBMMHX-UHFFFAOYSA-N 0.000 description 2
- OXYRENDGHPGWKV-UHFFFAOYSA-N 3-methyl-5-phenylpentan-1-ol Chemical compound OCCC(C)CCC1=CC=CC=C1 OXYRENDGHPGWKV-UHFFFAOYSA-N 0.000 description 2
- YXVSKJDFNJFXAJ-UHFFFAOYSA-N 4-cyclohexyl-2-methylbutan-2-ol Chemical compound CC(C)(O)CCC1=CC=CC=C1 YXVSKJDFNJFXAJ-UHFFFAOYSA-N 0.000 description 2
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- 241000207199 Citrus Species 0.000 description 2
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- GUUHFMWKWLOQMM-NTCAYCPXSA-N alpha-hexylcinnamaldehyde Chemical compound CCCCCC\C(C=O)=C/C1=CC=CC=C1 GUUHFMWKWLOQMM-NTCAYCPXSA-N 0.000 description 2
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 2
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- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 238000005690 transetherification reaction Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07C47/26—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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Description
よって、本発明の他の側面において、実質的にいかなる酸も塩基もない形態の反応混合物を提示し、反応混合物から混合物5,9−ジメチル−9−ヒドロキシ−デセン−4−アールを蒸留するステップを含む、反応混合物から5,9−ジメチル−9−ヒドロキシ−デセン−4−アール(I)を調製する方法が提供される。
酸は、酢酸などのC−1〜C4のカルボン酸、クエン酸などのポリカルボン酸および弱い鉱酸からなる群から選択されてもよい。
反応混合物は、洗浄後であるとき、実質的に酸も塩基もないものと考えられ、洗浄用リカーは、約6.5〜約7.5の間のpHを有する。
を有する。
任意に、反応は、不活性雰囲気下で、例えば窒素雰囲気下で、行われる。
いったん転移反応が完了すると、反応混合物は、反応の経過中に形成されたあらゆるアセタールをも加水分解するために、酸で処置され得る。
I) 酸中、不活性ガス雰囲気下、1〜100barで、より具体的には5〜20barおよびセ氏(−)10〜200℃の温度で、より具体的にはセ氏140〜190℃で、ヒドロキシリナロオール(3)とエチルビニルエーテルとを反応させることで、アセタールを含む反応混合物を形成すること;
II) 冷却された反応混合物を、セ氏(−)20〜40℃および大気圧で、酸性化することで、前記アセタールを加水分解すること;
III) 反応混合物のpHをわずかに酸性のpH4〜6に調整する前に、反応混合物を塩基で中和することで、5,9−ジメチル−9−ヒドロキシ−デセン−4−アール(I)を産出すること;ならびに、
IV) 反応混合物を蒸留することで、純粋な5,9−ジメチル−9−ヒドロキシ−デセン−4−アール(I)を単離すること
を含む。
本発明の特定の態様において、とりわけ所望される嗅覚的な印象は、50〜70wt%の5,9−ジメチル−9−ヒドロキシ−デセン−4−アールが、E体で存在し、および、30〜50wt%がZ体であるとき、得られる。
よって、本発明の他の側面において、式(I)で表される化合物の、単独での、または、シクロヘキサールの代わりとしての化合物(II)との混合物での、使用が提供される。
本発明のさらに他の側面において、任意に式(II)で表される化合物との混合物において、式(I)で表される化合物で香りを付けられた、ファインフレグランスまたはパーソナルケアまたは家庭用の製品などの、香りを付けられた物品が提供される。
本発明の他の特定の態様において、香料組成物は、2−シクロヘキシリデン−2−フェニルアセトニトリルおよび4−メチル−2−(2−メチルプロピル)テトラヒドロ−2H−ピラン−4−オールを含む。
本発明に従う香料組成物において、2−シクロヘキシリデン−2−フェニルアセトニトリル、例えばペオニル(商標)は、5,9−ジメチル−9−ヒドロキシ−デセン−4−アール1重量部あたり0.001〜10重量部で用いられてもよい。
本発明に従う香料組成物において、4−(オクタヒドロ−4,7−メタノ−5H−インデン−5−イリデン)ブタナール、例えばデュピカル(商標)は、5,9−ジメチル−9−ヒドロキシ−デセン−4−アール1重量部あたり0.0001〜0.5重量部で用いられてもよい。
香料組成物において、式(I)で表される化合物は、任意に化合物(II)との組み合わせにおいて、前記香料組成物の総重量に基づき、約1〜30重量%、より詳細には5〜20重量%の量で用いられてもよい。
アイリス、ミモザ、イラン(Ylang)、ベルガモット、ジャスミンおよびバラなどから選択される、天然の成分;
シクラメンアルデヒド(103-95-7)、ヒドロキシシトロネラール(107-75-5)、ヒドロキシシトロネラールジエチルアセタール(7779-94-4)、リリアール(80-54-6)、シクロヘキサール(31906-04-4)、シルビアール(Silvial)(6658-48-6)、ボージュナール(Bourgeonal)(18127-01-0)、フロルヒドラル(Florhydral)(125109-85-5)およびサイクルマックス(Cyclemax)(7775-00-0)などの、合成ミュゲフレグランス成分;
リナロオール(78-70-6)、ロシトール(Rossitol)(215231-33-7)およびコロナール(Coranol)(83926-73-2)などの、フリージアタイプの調和したフローラル成分;
Alc.桂皮アルコール(104-54-1)、プロピルフェニルアルコール(122-97-4)およびテルピネオール(8000-41-7)などの、ライラックタイプの調和したフローラル成分;
スーパーミュゲ(Super Muguet)(26330-65-4)、ヒドロキシシトロネラールジメチルアセタート(141-92-4)、マグノール(Magnol)(92046-49-6)、ムゲタノール(63767-86-2)、ムゲシア(Mugesia)(56836-93-2)、インドール(120-72-9)およびインドレン(Indolene)(67860-00-8)などの、ミュゲタイプの調和したフローラル成分;
フィクソリド(Fixolide)(21145-77-7)、チベトリド(Thibetolide)(106-02-5)、ヘリオトロピン(Heliotropine)(120-57-0)およびバニリン(121-33-5)などの、調和した粉状の成分;ならびに、
フィキシア(Phixia)(107-75-5)、ファルネサール(19317-11-4)、酢酸ファルネシル(29548-30-9)、酢酸ロジニル(141-11-7)、シクロメチレンシトロネロール(15760-18-6)、マイヨール(5502-75-0)、酢酸ミラルジル(Myraldyl acetate)(72403-67-9)およびメロニア(Melonia)(3613-30-7)などの、多様な調和したフローラルな成分
を含み、ここで、分子のCAS番号は、括弧内に提供される。
本明細書に記載の、式(I)で表される化合物、香料混合物または香料組成物は、特徴的な匂いを、ファインフレグランス、パーソナルケアおよび家庭用の組成物などのあらゆる種類の物品へ加えるために用いられてもよい。
トイレ用洗剤または化粧室用洗剤、言い換えれば、洗面ボウルおよび便器を洗浄するための製品であって、これらの製品は、好ましくは、粉末、ブロック、錠剤または液体、好ましくはゲルの形態で供給される。界面活性剤などの他の典型的な成分の他に、それらは一般に、水垢または尿による垢(urine scale)を除去するために、例えばクエン酸および/または乳酸などの有機酸、あるいは、硫酸水素ナトリウム、アミド硫酸またはリン酸を含む;
を含む。
塗料保存剤、塗料艶出し剤、塗料洗剤、洗浄保存剤、洗車用シャンプー、自動車洗浄およびワックス製品、トリム金属用艶出し剤、トリム金属用保護フィルム、プラスチック洗剤、タール除去剤、スクリーン洗剤、エンジン洗剤等
を含む。
(a)化粧用スキンケア製品、特に、浴室用製品、肌洗浄およびクレンジング製品、スキンケア製品、アイメイク、リップケア製品、ネイルケア製品、デリケートゾーンケア製品、フットケア製品;
(b)具体的な効果を有する化粧品、特に、日焼け止め剤、日焼け製品、脱色素製品、デオドラント、制汗剤、脱毛剤、シェービング製品、香料;
(c)化粧用デンタルケア製品、特に、デンタルおよびオーラルケア製品、トゥースケア製品、義歯用洗浄剤、義歯用接着剤;ならびに、
(d)化粧用ヘアケア製品、特に、ヘアシャンプー、ヘアケア製品、ヘアセッティング製品、整髪料およびヘアカラー製品
を含む。
例えば液体または固体の形態の、浄化剤または衣類用コンディショナー
を含む。
有利には、極めて少量であっても不快な匂いを隠すことができる、揮発性の、および、通常心地良い匂いのする化合物を好ましくは含有する製品を含む。生活圏のためのエアフレッシュナーは、特に、松葉油、シトラス油、ユーカリ油、ラベンダー油等の天然および合成のエッセンシャルオイルを、例えば最大50重量%までの量で含有する。エアロゾルとしては、それらは、より少量のかかるエッセンシャルオイルを、例として5重量%未満または2重量%未満で含有する傾向があるが、加えて、アセトアルデヒド(特に<0.5重量%)、イソプロピルアルコール(特に<5重量%)、鉱油(特に<5重量%)および噴射剤などの化合物も含む。他の提示形態は、スティックおよびブロックを含む。
を含む。
ここから、本発明をさらに説明するのに役立つ一連の例が続く。
(E/Z)−5,9−ジメチル−9−ヒドロキシ−デセン−4−アール(I)
a)2,6−ジメチルオクタ−7−イン−2,6−ジオール(2)
反応器に水(1593ml)を入れ、硫酸(875g、8.7mol)を加えた。溶液を20℃まで冷却した。3,7−ジメチルオクタ−6−エン−1−イン−3−オール(1、2.45kg、16.1mol)を加え、混合物を25℃で48時間撹拌した。
曝気撹拌機を備えた反応器に、2,6−ジメチルオクタ−7−イン−2,6−ジオール(2、2.4kg、14.1mol)およびトルエン(1.8l)を入れた。鉛で被毒された活性炭上のパラジウム(リンドラー触媒、25g)を加え、反応器を、先ずは不活性ガスで、次いで水素で、フラッシュした。混合物を、理論量の水素が消費されるまで、0.1〜0.2barで7.5時間水素化した。反応の間中、温度を、水浴により34〜40℃に保った。反応終了時のGCによる分析から、6%超の副生成物が水素化されていることがわかった。触媒を濾過によって除去し、(3)のトルエン溶液を、さらなる処置をせずに次の合成ステップのために使用した。(3)のサンプルを、分光分析のため、ヘキサンから再結晶化した。m.p.46〜47℃。
撹拌機を有する圧力容器(Buechi、5000ml)に、以前の水素化反応からのトルエン中2,6−ジメチルオクタ−7−エン−2,6−ジオールの混合物(3、2.25l、7mol)、エチルビニルエーテル(1.26kg、17mol)およびフェニルホスホン酸(13g、82mmol)を加えた。オートクレーブをフラッシュし、窒素により予め2barまで加圧し、150℃まで(圧力4〜6bar)30分間加熱した。次いで温度を175℃まで上げ(圧力8〜10bar)、50分間維持した。反応混合物を冷却し、10lのジャケット付(jacketed)反応器へ移した。水(3l)およびHCl(2M、300ml)を加え、GC分析から混合物中の(I)で表されるアセタールが完全に加水分解されたことがわかるまで、混合物を50℃で撹拌した。混合物を飽和水性KHCO3溶液で中和し、層を分離した。水層をMtBEで抽出し、有機層を合わせ、酢酸(10%、500ml)で洗浄し、MgSO4上で乾燥させ、真空濃縮した。粗生成物を、一掃フィルム蒸留(150℃、0.06mbar)を行うことで、淡オレンジ色液体として(I)が得られた(1077g、78%収率)。
本例は、GB 981,702の例27の手法に従い、生成物を単離し特徴付けした。
撹拌機、濃縮機および滴下漏斗が装着された1000mLの多頚フラスコへ、180gトルエン中180gヒドロキシリナロオール;0.9gリン酸(85%);および0.3gトリエタノールアミンの溶液を入れる。フラスコを、撹拌しながら125℃まで加熱し、150gジエチレングリコールジビニルエーテルを2時間にわたって加え、混合物を、この温度を維持しながら撹拌する。添加後、10gのトルエンをフラスコへ加え、混合物を、同じ温度でさらに2.5時間撹拌する。その後、反応混合物を、120g水中10g塩化ナトリウムの溶液により70℃で3回洗浄する。重炭酸ナトリウムおよび水の10%水溶液で洗浄後、トルエンを分留し、残渣を真空下で分画することで、無色〜浅黄色の油として(E&Z)−9−ヒドロキシ−5,9−ジメチルデカ−4−エナールが得られる。
メタ重亜硫酸ナトリウム(9.59g)を水に溶解し、9−ヒドロキシ−5,9−ジメチルデカ−4−エナール(10g)をそこへ加えた。エタノール(10ml)を溶液へ加えた。混合物が不透明になった。混合物を室温で30分間撹拌した。有機材料のGC分析から、ほぼ全てのアルデヒドが、そのスルホナート付加体の形態で水相に存在することがわかった。混合物をさらに30分間撹拌した後、50mlのMtBEを加えた。層を分離し、水層を、10mlのMtBEでもう2回抽出した。水相のpHは4.4であった。一部を取り、凍結乾燥させ、分析に供した:
2種のファインフレグランス、シクロヘキサールを含有する男性タイプ1つおよび女性タイプ1つを、比較製剤として使用した。
男性タイプおよび女性タイプの両方のフレグランスを、シクロヘキサールを除去し、それを上表に記載の等量のフレグランス組成物と置き換えることによって、改変することで、3種の改変された男性タイプの香水と3種の改変された女性タイプの香水とを提供した。
改変された全てのフレグランスが、比較製剤の匂いの特色と酷似していると査定された。これは、表に記載の香料の処方が、ファイン香粧品の設定においてシクロヘキサールの代替物として好適であることを実証している。
香りを付けられていない衣類用柔軟剤の基剤に、シクロヘキサールで香りを付けて比較製剤を形成し、および、類似の量の上表に記載の各香料組成物で香りを付けて試験製剤を製造した。香りを付けられた衣類用柔軟剤組成物を水中に希釈し、これらの希釈された組成物の匂いの特色を、熟練されたパフューマーらのパネルが査定した。
香りを付けられていないシャワー用ゲルの基剤に、シクロヘキサールで香りを付けて比較製剤を形成し、および、類似の量の上表に記載の各香料組成物で香りを付けて試験製剤を製造した。香りを付けられたシャワー用ゲル組成物を水中に希釈し、これらの希釈された組成物の匂いの特色を、熟練されたパフューマーらのパネルが査定した。
香りを付けられていないシャンプーの基剤に、シクロヘキサールで香りを付けて比較製剤を形成し、および、類似の量の上表に記載の各香料組成物で香りを付けて試験製剤を製造した。このように香りを付けられたシャンプー組成物を水中に希釈し、これらの希釈された組成物の匂いの特色を、熟練されたパフューマーらのパネルが査定した。
以下の香料製剤において、5,9−ジメチル−9−ヒドロキシ−デセン−4−アールまたは例5に記載の混合物と、シクロヘキサール(Lyral(商標))とは代替可能な成分である。5,9−ジメチル−9−ヒドロキシ−デセン−4−アールが、シクロヘキサールのように、フレグランス組成物の本体、拡散性およびラジアンス(radiance)へ加わる。
以下の香料製剤において、5,9−ジメチル−9−ヒドロキシ−デセン−4−アールまたは例5に記載の混合物と、シクロヘキサール(Lyral(商標))とは代替可能な成分である。5,9−ジメチル−9−ヒドロキシ−デセン−4−アールが、シクロヘキサールのように、フレグランス組成物の本体、拡散性およびラジアンスへ加わる。
Claims (14)
- 式(I)
- 50〜70wt%がE体であり、および、30〜50wt%がZ体である、請求項1に記載の化合物。
- 請求項1または2に記載の式(I)で表される化合物と、式(II)
- 請求項1または2に記載の化合物を含む、香料組成物。
- 請求項1または2に記載の化合物または請求項3に記載の香料混合物と、2−シクロヘキシリデン−2−フェニルアセトニトリル、4−(オクタヒドロ−4,7−メタノ−5H−インデン−5−イリデン)ブタナール、4−メチル−2−(2−メチルプロピル)テトラヒドロ−2H−ピラン−4−オール、およびメチル2−(2−ヘキシル−3−オキソシクロペンチル)アセタートからなる群から選択される1種または2種以上の化合物とを含む、香料組成物。
- 少なくとも1種の追加の香料成分を含む、請求項4または5に記載の香料組成物。
- 請求項1または2に記載の化合物、請求項3に記載の香料混合物あるいは請求項4〜6のいずれか一項に記載の香料組成物を含む、パーソナルケアのまたは家庭用の組成物あるいはファインフレグランス組成物。
- 抗酸化剤を含む、請求項1または2に記載の化合物を含む組成物、請求項3に記載の香料混合物、請求項4〜6のいずれか一項に記載の香料組成物、あるいは請求項7に記載のパーソナルケアのまたは家庭用の製品あるいはファインフレグランス。
- 香料組成物またはパーソナルケアのもしくは家庭用の製品またはファインフレグランスに、ミュゲの匂いのノートを与える方法であって、前記方法が、請求項1または2に記載の化合物あるいは請求項3に記載の香料混合物をそれらへ加えるステップを含む、前記方法。
- いかなる酸も塩基もない形態の反応混合物を提供し、および、反応混合物から混合物5,9−ジメチル−9−ヒドロキシ−4−デセナールを蒸留するステップを含む、反応混合物から5,9−ジメチル−9−ヒドロキシ−4−デセナール(I)
反応混合物が、式
式中、
- 5,9−ジメチル−9−ヒドロキシ−4−デセナールを調製する方法であって、以下のステップ:
I) 酸中、不活性ガス雰囲気下、1〜100barで、および−10〜200℃の温度で、ヒドロキシリナロオールとエチルビニルエーテルとを反応させることで、アセタールを含む反応混合物を形成すること;
II) 冷却された反応混合物を、−20〜40℃および大気圧で、酸性化することで、前記アセタールを加水分解すること;
III) 反応混合物のpHを酸性のpH4〜6に調整する前に、反応混合物を塩基で中和することで、5,9−ジメチル−9−ヒドロキシ−4−デセナールを産出すること;ならびに、任意に、
IV) 反応混合物を蒸留することで、純粋な5,9−ジメチル−9−ヒドロキシ−4−デセナールを単離すること
を含む、前記方法。 - 請求項1または2に記載の式(I)で表される化合物あるいは請求項3に記載の香料混合物の、シクロヘキサールの代わりとしての使用。
- 請求項1または2に記載の式(I)で表される化合物あるいは請求項3に記載の香料混合物を含む香料組成物であって、シクロヘキサールを含まない、前記香料組成物。
- 香りを付けられた物品であって、請求項1または2に記載の式(I)で表される化合物あるいは請求項3に記載の香料混合物で香りを付けられた、前記物品。
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BR112015030088A2 (pt) | 2017-07-25 |
JP2016521739A (ja) | 2016-07-25 |
MX2015015906A (es) | 2016-03-09 |
RU2015149954A3 (ja) | 2018-03-29 |
US20150307432A1 (en) | 2015-10-29 |
US9469590B2 (en) | 2016-10-18 |
PH12015502665B1 (en) | 2016-03-07 |
RU2667901C2 (ru) | 2018-09-25 |
PH12015502665A1 (en) | 2016-03-07 |
AU2014280241B2 (en) | 2017-12-21 |
WO2014198709A1 (en) | 2014-12-18 |
ES2623787T3 (es) | 2017-07-12 |
CN105283435A (zh) | 2016-01-27 |
IL242437B (en) | 2018-05-31 |
CN112661622A (zh) | 2021-04-16 |
RU2015149954A (ru) | 2017-07-20 |
AU2014280241A1 (en) | 2015-11-26 |
KR102321134B1 (ko) | 2021-11-03 |
GB2515128A (en) | 2014-12-17 |
BR112015030088B1 (pt) | 2020-12-29 |
PL2920139T3 (pl) | 2017-08-31 |
EP2920139A1 (en) | 2015-09-23 |
ZA201508404B (en) | 2020-01-29 |
EP2920139B1 (en) | 2017-02-01 |
GB2515128B (en) | 2015-05-27 |
US10315976B2 (en) | 2019-06-11 |
KR20160019441A (ko) | 2016-02-19 |
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