JP6507102B2 - 薬物送達キャリアとしての生分解性でかつ臨床上適合性のナノ粒子 - Google Patents

薬物送達キャリアとしての生分解性でかつ臨床上適合性のナノ粒子 Download PDF

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JP6507102B2
JP6507102B2 JP2015556243A JP2015556243A JP6507102B2 JP 6507102 B2 JP6507102 B2 JP 6507102B2 JP 2015556243 A JP2015556243 A JP 2015556243A JP 2015556243 A JP2015556243 A JP 2015556243A JP 6507102 B2 JP6507102 B2 JP 6507102B2
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チャン ジェイ. リ,
チャン ジェイ. リ,
ヨウジー リ,
ヨウジー リ,
ケユル ガダ,
ケユル ガダ,
バイブハブ サクセナ,
バイブハブ サクセナ,
シャオシュー ダイ,
シャオシュー ダイ,
ジョセフ プラタ,
ジョセフ プラタ,
ナミタ ドドワドカル,
ナミタ ドドワドカル,
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1グローブ ヘルス インスティテュート エルエルシー
1グローブ ヘルス インスティテュート エルエルシー
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    • A61K9/513Organic macromolecular compounds; Dendrimers
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    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61K9/5107Excipients; Inactive ingredients
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    • A61K9/5169Proteins, e.g. albumin, gelatin
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2015556243A 2013-02-05 2014-02-05 薬物送達キャリアとしての生分解性でかつ臨床上適合性のナノ粒子 Active JP6507102B2 (ja)

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US201361761012P 2013-02-05 2013-02-05
US61/761,012 2013-02-05
PCT/US2014/014751 WO2014123935A1 (en) 2013-02-05 2014-02-05 Biodegradable and clinically-compatible nanop articles as drug delivery carriers

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JP2016513090A JP2016513090A (ja) 2016-05-12
JP2016513090A5 JP2016513090A5 (https=) 2017-03-02
JP6507102B2 true JP6507102B2 (ja) 2019-04-24

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US (2) US11001840B2 (https=)
EP (2) EP3845248A1 (https=)
JP (1) JP6507102B2 (https=)
KR (1) KR20150132131A (https=)
AU (2) AU2014215421A1 (https=)
CA (1) CA2899155A1 (https=)
ES (1) ES2873600T3 (https=)
IL (1) IL240148A0 (https=)
MX (1) MX2015010083A (https=)
RU (1) RU2015137815A (https=)
SG (2) SG10201706968UA (https=)
WO (1) WO2014123935A1 (https=)
ZA (1) ZA201506530B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3845248A1 (en) 2013-02-05 2021-07-07 1Globe Health Institute LLC Biodegradable and clinically-compatible nanoparticles as drug delivery carriers
CN105579582A (zh) 2013-07-25 2016-05-11 埃克西奎雷股份有限公司 用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体
AU2015269412B2 (en) 2014-06-04 2020-03-12 Exicure Operating Company Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
WO2016028940A1 (en) 2014-08-19 2016-02-25 Northwestern University Protein/oligonucleotide core-shell nanoparticle therapeutics
KR20170078843A (ko) 2014-11-21 2017-07-07 노오쓰웨스턴 유니버시티 구형 핵산 나노입자 접합체의 서열 특이적 세포 흡수
WO2016115320A1 (en) 2015-01-14 2016-07-21 Exicure, Inc. Nucleic acid nanostructructures with core motifs
EP3452598A4 (en) 2016-05-06 2020-04-29 Exicure, Inc. LIPOSOMAL SPHERICAL NUCLEIC ACID (ANS) CONSTRUCTS HAVING ANTISENSE OLIGONUCLEOTIDES (ASO) FOR THE SPECIFIC INACTIVATION OF INTERLEUKIN 17 RECEPTOR RNA
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
US10800817B2 (en) * 2016-12-19 2020-10-13 Morehouse School Of Medicine Compositions and methods for treating diseases by inhibiting exosome release
PL3568122T3 (pl) * 2017-01-10 2024-03-18 Dukebox Sp. Z O.O. Sposób wytwarzania zawiesiny nanocząsteczek soli potasowej albo soli magnezowej
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
KR102120482B1 (ko) * 2018-10-05 2020-06-08 씨제이제일제당 (주) 생분해성 고분자 나노입자를 포함하는 메모리 소자 및 이의 제조방법
WO2021011398A1 (en) * 2019-07-12 2021-01-21 The Board Of Trustees Of The Leland Stanford Junior University Functionalized nanoparticles and their use in treating bacterial infections
WO2021067952A1 (en) * 2019-10-04 2021-04-08 The University Of Chicago Targeted nanomedicine for treating vascular disorders
US20230070049A1 (en) * 2020-02-03 2023-03-09 Rutgers, The State University Of New Jersey Microrna-7 compositions for promoting functional recovery following spinal cord injury and methods of use thereof
US11998615B2 (en) 2021-04-14 2024-06-04 The Board Of Trustees Of The Leland Stanford Junior University Functionalized nanoparticles and their use in treating bacterial infections

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219577A (en) 1990-06-22 1993-06-15 The Regents Of The University Of California Biologically active composition having a nanocrystalline core
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5879715A (en) * 1997-09-02 1999-03-09 Ceramem Corporation Process and system for production of inorganic nanoparticles
DE19856432A1 (de) * 1998-12-08 2000-06-15 Basf Ag Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen
DE19912502A1 (de) 1999-03-19 2000-09-21 Inst Neue Mat Gemein Gmbh Nanoskalige Teilchen, Komplexe mit Polynukleotiden und deren Verwendung
AU2002214854A1 (en) 2000-10-25 2002-05-06 Inex Pharmaceuticals Corporation Lipid formulations for target delivery
IN192520B (https=) * 2001-08-01 2004-04-24 Univ Delhi
ES2559828T3 (es) 2003-07-16 2016-02-16 Protiva Biotherapeutics Inc. ARN de interferencia encapsulado en lípidos
JP5103022B2 (ja) 2004-02-13 2012-12-19 ノッド ファーマシューティカルズ, インコーポレイテッド リン酸カルシウムナノ粒子のコア、生体分子および胆汁酸を含む粒子、ならびにそれらの製造方法および治療用途
US7611690B2 (en) 2005-01-04 2009-11-03 Gp Medical, Inc. Nanoparticles for protein drug delivery
US20110081410A1 (en) 2005-06-28 2011-04-07 St. Marianna University, School Ofmedicine Therapeutic agent for local inflammation
CN100435784C (zh) 2005-07-25 2008-11-26 管晓虹 含有和包封中药成分的无机盐纳米粒子的制备方法
US20080248108A1 (en) * 2006-10-06 2008-10-09 Jain Krotz Multilayered polyelectrolyte-based capsules for cell encapsulation and delivery of therapeutic compositions
CN101686939B (zh) 2007-04-17 2013-03-27 巴克斯特国际公司 用于肺部投送的核酸微粒
WO2009012303A2 (en) * 2007-07-16 2009-01-22 Northeastern University Therapeutic stable nanoparticles
JP2010537640A (ja) * 2007-08-27 2010-12-09 ボストン バイオメディカル, インコーポレイテッド マイクロrna模倣剤または阻害剤としての非対称性rna二重鎖の組成物
WO2009042625A1 (en) 2007-09-25 2009-04-02 Idexx Laboratories, Inc. Pharmaceutical compositions for administering oligonucleotides
CA2707010A1 (en) 2007-12-14 2009-06-25 Kazuhisa Sugimoto .alpha.-lipoic acid nanoparticles and methods for preparing thereof
CA2710983A1 (en) 2007-12-27 2009-10-01 The Ohio State University Research Foundation Lipid nanoparticle compositions and methods of making and using the same
WO2009140421A2 (en) 2008-05-13 2009-11-19 University Of Washington Polymeric carrier
JP2012509904A (ja) 2008-11-26 2012-04-26 ユニバーシティ・オブ・カンザス 核酸送達組成物および核酸送達法
EP2198885B1 (en) 2008-12-19 2012-02-08 Biolitec AG Calcium phosphate nanoparticles as dye carrier for photodynamic therapy
US9937128B2 (en) * 2009-08-03 2018-04-10 The University Of North Carolina At Chapel Hill Liposomes comprising a calcium phosphate-containing precipitate
US20120220647A1 (en) * 2009-09-14 2012-08-30 Jin-Ho Choy Nano-hybrid of targetable sirna-layered inorganic hydroxide, manufacturing method thereof, and pharmaceutical composition for treating tumor comprising the nano-hybrid
JP5491119B2 (ja) * 2009-10-02 2014-05-14 日東電工株式会社 薬物含有微粒子を含む医薬組成物およびその製造方法
US20130236396A1 (en) * 2010-05-03 2013-09-12 University Of Utah Research Foundation Nanoparticles produced from recombinant polymers and methods of making and using the same
WO2013040295A2 (en) 2011-09-14 2013-03-21 University Of South Florida Divalent-metal coated nanoparticles for delivery of compositions into the central nervous system by nasal insufflation
CA2853685C (en) 2011-11-04 2019-09-03 Nitto Denko Corporation Single use system for sterilely producing lipid-nucleic acid particles
US20130243699A1 (en) 2011-12-07 2013-09-19 Regents Of The University Of Minnesota Biodegradable Magnetic Nanoparticles and Related Methods
ITRM20120480A1 (it) 2012-10-09 2014-04-10 Uni Degli Studi Camerino Nanoparticelle lipidiche multicomponenti e procedimenti per la loro preparazione.
EP3845248A1 (en) 2013-02-05 2021-07-07 1Globe Health Institute LLC Biodegradable and clinically-compatible nanoparticles as drug delivery carriers

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US20160046936A1 (en) 2016-02-18
AU2014215421A1 (en) 2015-08-13
EP2953646A4 (en) 2017-02-15
IL240148A0 (en) 2015-09-24
AU2018200903A1 (en) 2018-02-22
ES2873600T3 (es) 2021-11-03
EP2953646A1 (en) 2015-12-16
EP2953646B1 (en) 2021-03-10
US20210230595A1 (en) 2021-07-29
SG11201506116XA (en) 2015-09-29
HK1217906A1 (en) 2017-01-27
WO2014123935A9 (en) 2014-10-23
CA2899155A1 (en) 2014-08-14
EP3845248A1 (en) 2021-07-07
MX2015010083A (es) 2016-04-26
KR20150132131A (ko) 2015-11-25
RU2015137815A (ru) 2017-03-13
WO2014123935A1 (en) 2014-08-14
ZA201506530B (en) 2018-11-28
SG10201706968UA (en) 2017-09-28
US11001840B2 (en) 2021-05-11
JP2016513090A (ja) 2016-05-12

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