JP6505325B2 - 慢性高眼圧非ヒト動物モデルの作製方法 - Google Patents
慢性高眼圧非ヒト動物モデルの作製方法 Download PDFInfo
- Publication number
- JP6505325B2 JP6505325B2 JP2018532502A JP2018532502A JP6505325B2 JP 6505325 B2 JP6505325 B2 JP 6505325B2 JP 2018532502 A JP2018532502 A JP 2018532502A JP 2018532502 A JP2018532502 A JP 2018532502A JP 6505325 B2 JP6505325 B2 JP 6505325B2
- Authority
- JP
- Japan
- Prior art keywords
- schlemm
- canal
- human animal
- catheter
- animal model
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000010171 animal model Methods 0.000 title claims description 30
- 230000001684 chronic effect Effects 0.000 title claims description 22
- 230000004410 intraocular pressure Effects 0.000 title claims description 22
- 238000000034 method Methods 0.000 title claims description 22
- 239000000835 fiber Substances 0.000 claims description 15
- 206010020772 Hypertension Diseases 0.000 claims description 14
- 230000001631 hypertensive effect Effects 0.000 claims description 14
- 210000002159 anterior chamber Anatomy 0.000 claims description 11
- 210000003786 sclera Anatomy 0.000 claims description 11
- 210000000795 conjunctiva Anatomy 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 210000001742 aqueous humor Anatomy 0.000 claims description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 6
- 229920002674 hyaluronan Polymers 0.000 claims description 6
- 229960003160 hyaluronic acid Drugs 0.000 claims description 6
- -1 polypropylene Polymers 0.000 claims description 6
- 206010002091 Anaesthesia Diseases 0.000 claims description 5
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 230000037005 anaesthesia Effects 0.000 claims description 5
- 230000008595 infiltration Effects 0.000 claims description 5
- 238000001764 infiltration Methods 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- 210000004087 cornea Anatomy 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 3
- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 3
- 239000003855 balanced salt solution Substances 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 229960004194 lidocaine Drugs 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 description 17
- 230000007246 mechanism Effects 0.000 description 10
- 210000001328 optic nerve Anatomy 0.000 description 6
- 208000020911 optic nerve disease Diseases 0.000 description 5
- 206010061323 Optic neuropathy Diseases 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 241000282693 Cercopithecidae Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 210000001585 trabecular meshwork Anatomy 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 206010030043 Ocular hypertension Diseases 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 210000003994 retinal ganglion cell Anatomy 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 241000452953 Bernardia myricifolia Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 210000004240 ciliary body Anatomy 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004406 elevated intraocular pressure Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000010363 gene targeting Methods 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 229940089982 healon Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 239000000076 hypertonic saline solution Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000649 photocoagulation Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 230000004243 retinal function Effects 0.000 description 1
- 210000001210 retinal vessel Anatomy 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610249471.5A CN105943186A (zh) | 2016-04-21 | 2016-04-21 | 一种慢性高眼压动物模型的建立方法 |
| CN201610249471.5 | 2016-04-21 | ||
| PCT/CN2017/078965 WO2017181835A1 (zh) | 2016-04-21 | 2017-03-31 | 一种慢性高眼压动物模型的建立方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018527147A JP2018527147A (ja) | 2018-09-20 |
| JP6505325B2 true JP6505325B2 (ja) | 2019-04-24 |
Family
ID=56917874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532502A Active JP6505325B2 (ja) | 2016-04-21 | 2017-03-31 | 慢性高眼圧非ヒト動物モデルの作製方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6505325B2 (zh) |
| CN (1) | CN105943186A (zh) |
| WO (1) | WO2017181835A1 (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943186A (zh) * | 2016-04-21 | 2016-09-21 | 温州眼视光发展有限公司 | 一种慢性高眼压动物模型的建立方法 |
| CN107981969B (zh) * | 2017-12-29 | 2023-07-14 | 苏州朗目医疗科技有限公司 | 一种青光眼内引流替代仿生支架 |
| CN109481071B (zh) * | 2019-01-16 | 2021-07-23 | 沈阳眼产业技术研究院有限公司 | 一种用于建立慢性高眼压动物模型的物品 |
| CN109907857B (zh) * | 2019-02-28 | 2023-10-31 | 中国人民解放军第四军医大学 | 一种小鼠眼球前方注射聚酯纤维微球的装置 |
| CN111053626B (zh) * | 2019-12-26 | 2021-08-20 | 中国人民解放军总医院 | 一种造模方法及动物模型及其应用 |
| CN111110441A (zh) * | 2020-01-08 | 2020-05-08 | 孙河 | 一种实验用大鼠巩膜静脉注射装置及方法 |
| CN113133431A (zh) * | 2021-02-25 | 2021-07-20 | 中南大学 | 慢性高眼压合并长眼轴动物模型的建立方法、模型及应用 |
| CN113273546A (zh) * | 2021-02-25 | 2021-08-20 | 中南大学 | 聚桂醇在制备慢性高眼压动物模型中的应用及动物模型 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5360399A (en) * | 1992-01-10 | 1994-11-01 | Robert Stegmann | Method and apparatus for maintaining the normal intraocular pressure |
| JP2002112664A (ja) * | 2000-10-04 | 2002-04-16 | Koken Co Ltd | 緑内障モデル動物の作成方法 |
| JP2003149236A (ja) * | 2001-08-30 | 2003-05-21 | Santen Pharmaceut Co Ltd | 緑内障治療薬のスクリーニング方法 |
| WO2004042001A2 (en) * | 2002-05-17 | 2004-05-21 | Emory University | Virus-like particles, methods of preparation, and immonogenic compositions |
| US8366653B2 (en) * | 2007-03-13 | 2013-02-05 | University Of Rochester | Intraocular pressure regulating device |
| US8951221B2 (en) * | 2009-08-20 | 2015-02-10 | Grieshaber Ophthalmic Research Foundation | Method and device for the treatment of glaucoma |
| WO2011046949A2 (en) * | 2009-10-12 | 2011-04-21 | The Regents Of The University Of Colorado, A Body Corporate | Implants for reducing intraocular pressure |
| US8434489B2 (en) * | 2009-10-23 | 2013-05-07 | Conceptus, Inc. | Contraceptive devices and methods |
| NL2004047C2 (en) * | 2010-01-04 | 2011-07-05 | D O R C Dutch Ophthalmic Res Ct International B V | An ophthalmic surgical device and a method of performing ophthalmic surgery. |
| EP2575715B1 (en) * | 2010-05-27 | 2014-10-29 | Ellex-iScience, Inc. | Device for placing circumferential implant in schlemm's canal |
| CN102824238B (zh) * | 2011-06-16 | 2014-07-09 | 王宁利 | 一种施莱姆氏管（Schlemm）扩张支架及其组合体 |
| CN202637223U (zh) * | 2012-04-24 | 2013-01-02 | 东华大学 | 一种不对输卵管组织产生损伤的阻塞型节育器 |
| CN203355084U (zh) * | 2013-07-10 | 2013-12-25 | 高广林 | 鼻胆引流管 |
| CN105943186A (zh) * | 2016-04-21 | 2016-09-21 | 温州眼视光发展有限公司 | 一种慢性高眼压动物模型的建立方法 |
-
2016
- 2016-04-21 CN CN201610249471.5A patent/CN105943186A/zh active Pending
-
2017
- 2017-03-31 JP JP2018532502A patent/JP6505325B2/ja active Active
- 2017-03-31 WO PCT/CN2017/078965 patent/WO2017181835A1/zh active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CN105943186A (zh) | 2016-09-21 |
| WO2017181835A1 (zh) | 2017-10-26 |
| JP2018527147A (ja) | 2018-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6505325B2 (ja) | 慢性高眼圧非ヒト動物モデルの作製方法 | |
| JP4082729B2 (ja) | 眼の眼内圧を低下させるための装置 | |
| CN103932841B (zh) | 一种施莱姆氏管(Schlemm)扩张支架及其组合体 | |
| US11707383B2 (en) | Inner drainage biomimetic stent for glaucoma and use thereof | |
| ES2797776T3 (es) | Un dispositivo quirúrgico oftálmico | |
| KR20040036912A (ko) | 녹내장을 처리하기 위한 개선된 분로 장치 및 방법 | |
| BR112016030196B1 (pt) | Dispositivo plano de uma só peça para drenagem temporal por pressão do humor aquoso do olho | |
| CN113288580A (zh) | 一种用于植入青光眼患者眼内的房水引流器 | |
| CN110037854B (zh) | 一种青光眼房水引流装置 | |
| CN201631477U (zh) | 青光眼微创房水引流植入物 | |
| CN108309555A (zh) | 一种青光眼术后瘢痕化抑制及滤过泡维护工具 | |
| RU2297815C1 (ru) | Способ хирургического лечения рефракторных глауком | |
| Van Der Veen et al. | The gonioseton, a surgical treatment for chronic glaucoma | |
| RU2533987C2 (ru) | Способ хирургического лечения глаукомы с малоинвазивным спонч-дренированием передней камеры | |
| US20180147088A1 (en) | Penetrating canaloplasty for treating angle-closure glaucoma | |
| RU2300352C1 (ru) | Способ одномоментного хирургического лечения катаракты, сочетанной с открыто- или узкоугольной глаукомой, с использованием единого операционного доступа и имплантацией интраокулярной линзы | |
| Cole et al. | Role of sphincterotomy in extracapsular cataract surgery. | |
| RU2548513C1 (ru) | Способ микроинвазивной непроникающей глубокой склерэктомии | |
| Yuen et al. | Combined phacoemulsification and nonpenetrating deep sclerectomy in the treatment of chronic angle-closure glaucoma with cataract | |
| RU2297816C1 (ru) | Способ хирургического лечения рефрактерных глауком | |
| Javed | Phacoemulsification under Topical Anesthesia Alone Versus Topical Anesthesia with Subconjunctival | |
| Sampaolesi et al. | Non-penetrating surgery for glaucoma | |
| Bylsma | Cataract surgical problem: Reply# 1 | |
| O'BRIEN | Surgical treatment of primary glaucoma | |
| RU2236203C2 (ru) | Способ профилактики повышения внутриглазного давления у больных с псевдоэксфолиативным синдромом и открытоугольной глаукомой при хирургии катаракты "малых разрезов" |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180309 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20181113 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190213 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190312 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190326 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6505325 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |