JP6501264B2 - エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 - Google Patents
エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用 Download PDFInfo
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- JP6501264B2 JP6501264B2 JP2015524425A JP2015524425A JP6501264B2 JP 6501264 B2 JP6501264 B2 JP 6501264B2 JP 2015524425 A JP2015524425 A JP 2015524425A JP 2015524425 A JP2015524425 A JP 2015524425A JP 6501264 B2 JP6501264 B2 JP 6501264B2
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- pirfenidone
- pyridone
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- lung
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Chemical & Material Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| HUE058753T2 (hu) | 2011-01-31 | 2022-09-28 | Avalyn Pharma Inc | Aeroszol formájú pirfenidon- és piridon-analóg vegyületek és alkalmazásaik |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| JP6799201B2 (ja) | 2013-07-31 | 2020-12-16 | アヴァリン ファーマ インク． | エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用 |
| AU2015204558B2 (en) | 2014-01-10 | 2020-04-30 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| CN110452216B (zh) | 2014-04-02 | 2022-08-26 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
| NZ747404A (en) * | 2016-03-28 | 2020-03-27 | Presage Biosciences Inc | Pharmaceutical combinations for the treatment of cancer |
| US10238821B2 (en) * | 2016-10-11 | 2019-03-26 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
| WO2018234527A1 (en) * | 2017-06-22 | 2018-12-27 | Softhale Nv | Aerosol delivery of pirfenidone |
| CN110869134B (zh) * | 2017-06-22 | 2023-12-22 | 索芙特海尔公司 | 用于吡非尼酮气雾剂的吸入装置、储存器以及递送方法 |
| GB201807050D0 (en) * | 2018-04-30 | 2018-06-13 | Cellprotect Nordic Pharmaceuticals Ab | Medical uses |
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| KR102847500B1 (ko) * | 2019-05-27 | 2025-08-20 | 디에스엠 아이피 어셋츠 비.브이. | 인 화합물 및 유기 황 화합물의 존재 하에서의 알킨의 알켄으로의 선택적 수소화 |
| WO2021215856A1 (ko) * | 2020-04-22 | 2021-10-28 | 영진약품 주식회사 | 안전성과 안정성이 개선된 피르페니돈을 포함하는 장용성 제제 및 이의 제조방법 |
| CN116600790A (zh) * | 2020-12-07 | 2023-08-15 | 满康德股份有限公司 | 治疗肺纤维化的方法和组合物 |
| WO2023184961A1 (en) * | 2022-03-30 | 2023-10-05 | The Chinese University Of Hong Kong | Pfd loaded microspheres and method for preparing injectable composite microsphere hydrogel solution from same |
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| US3826255A (en) | 1972-06-22 | 1974-07-30 | Hudson Oxygen Therapy Sales Co | Intermittent positive pressure breathing manifold |
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| ZA757570B (en) | 1974-12-09 | 1977-07-27 | Affiliated Med Res | A useful n-substituted pyridone |
| US4268460A (en) | 1977-12-12 | 1981-05-19 | Warner-Lambert Company | Nebulizer |
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| AU2013295800A1 (en) | 2015-03-19 |
| JP7120984B2 (ja) | 2022-08-17 |
| HUE063581T2 (hu) | 2024-01-28 |
| WO2014018668A2 (en) | 2014-01-30 |
| JP2024095678A (ja) | 2024-07-10 |
| EP2877164A2 (en) | 2015-06-03 |
| ES2959198T3 (es) | 2024-02-21 |
| EP2877164B1 (en) | 2023-07-05 |
| JP2022078126A (ja) | 2022-05-24 |
| EP2877164A4 (en) | 2016-01-13 |
| NZ705260A (en) | 2017-04-28 |
| WO2014018668A3 (en) | 2014-10-16 |
| AU2024267029A1 (en) | 2024-12-19 |
| JP2015523395A (ja) | 2015-08-13 |
| CA2880011C (en) | 2021-02-16 |
| AU2018206852A1 (en) | 2018-08-09 |
| JP2018172402A (ja) | 2018-11-08 |
| JP2020073494A (ja) | 2020-05-14 |
| CA2880011A1 (en) | 2014-01-30 |
| HK1210955A1 (en) | 2016-05-13 |
| AU2020201557A1 (en) | 2020-03-26 |
| AU2020201557B2 (en) | 2022-08-25 |
| AU2022271417A1 (en) | 2022-12-22 |
| EP2877164C0 (en) | 2023-07-05 |
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