HUE063581T2 - Aeroszol pirfenidon és piridon analóg vegyületek - Google Patents

Aeroszol pirfenidon és piridon analóg vegyületek

Info

Publication number
HUE063581T2
HUE063581T2 HUE13822166A HUE13822166A HUE063581T2 HU E063581 T2 HUE063581 T2 HU E063581T2 HU E13822166 A HUE13822166 A HU E13822166A HU E13822166 A HUE13822166 A HU E13822166A HU E063581 T2 HUE063581 T2 HU E063581T2
Authority
HU
Hungary
Prior art keywords
pyridone analog
analog compounds
aerosol pirfenidone
pirfenidone
aerosol
Prior art date
Application number
HUE13822166A
Other languages
English (en)
Hungarian (hu)
Inventor
Mark Surber
Original Assignee
Avalyn Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avalyn Pharma Inc filed Critical Avalyn Pharma Inc
Publication of HUE063581T2 publication Critical patent/HUE063581T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HUE13822166A 2012-07-24 2013-07-24 Aeroszol pirfenidon és piridon analóg vegyületek HUE063581T2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261675286P 2012-07-24 2012-07-24
US201361756983P 2013-01-25 2013-01-25
US201361824818P 2013-05-17 2013-05-17

Publications (1)

Publication Number Publication Date
HUE063581T2 true HUE063581T2 (hu) 2024-01-28

Family

ID=49997965

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13822166A HUE063581T2 (hu) 2012-07-24 2013-07-24 Aeroszol pirfenidon és piridon analóg vegyületek

Country Status (8)

Country Link
EP (1) EP2877164B1 (OSRAM)
JP (5) JP6501264B2 (OSRAM)
AU (5) AU2013295800A1 (OSRAM)
CA (1) CA2880011C (OSRAM)
ES (1) ES2959198T3 (OSRAM)
HU (1) HUE063581T2 (OSRAM)
NZ (1) NZ705260A (OSRAM)
WO (1) WO2014018668A2 (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
DK2670242T3 (da) 2011-01-31 2022-05-02 Avalyn Pharma Inc Aerosolpirfenidon- og pyridonanalogforbindelser og anvendelser deraf
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
AU2014296032A1 (en) 2013-07-31 2016-03-17 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
AU2015204558B2 (en) 2014-01-10 2020-04-30 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
RU2692485C2 (ru) 2014-04-02 2019-06-25 Интермьюн, Инк. Противофиброзные пиридиноны
NZ757763A (en) * 2016-03-28 2025-07-25 Presage Biosciences Inc Pharmaceutical combinations for the treatment of cancer
WO2018071427A1 (en) * 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
WO2018234527A1 (en) * 2017-06-22 2018-12-27 Softhale Nv Aerosol delivery of pirfenidone
CN117861026A (zh) * 2017-06-22 2024-04-12 索芙特海尔公司 用于吡非尼酮气雾剂的吸入装置、储存器以及递送方法
GB201807050D0 (en) * 2018-04-30 2018-06-13 Cellprotect Nordic Pharmaceuticals Ab Medical uses
US12497395B2 (en) 2019-04-24 2025-12-16 Convergene, Llc Small molecule bromodomain inhibitors and uses therof
US20220242807A1 (en) * 2019-05-27 2022-08-04 Dsm Ip Assets B.V. Selective hydrogenation of alkynes to alkenes in the presence of a phosphorus compound and an organic sulphur compound
KR102584268B1 (ko) * 2020-04-22 2023-10-05 영진약품 주식회사 안전성과 안정성이 개선된 피르페니돈을 포함하는 장용성 제제 및 이의 제조방법
IL303431A (en) * 2020-12-07 2023-08-01 Mannkind Corp Method and composition for the treatment of pulmonary fibrosis
EP4499095A1 (en) * 2022-03-30 2025-02-05 The Chinese University of Hong Kong Pfd loaded microspheres and method for preparing injectable composite microsphere hydrogel solution from same
CN115970069B (zh) * 2022-12-13 2024-09-24 南通大学附属医院 载吡非尼酮纳米粒子复合涂层输尿管支架管的制备方法
CN119548479A (zh) * 2024-12-31 2025-03-04 延边大学 一种吸入用吡非尼酮溶液及其使用方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826255A (en) 1972-06-22 1974-07-30 Hudson Oxygen Therapy Sales Co Intermittent positive pressure breathing manifold
YU41046B (en) 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
ZA757570B (en) 1974-12-09 1977-07-27 Affiliated Med Res A useful n-substituted pyridone
US4268460A (en) 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
US4253468A (en) 1978-08-14 1981-03-03 Steven Lehmbeck Nebulizer attachment
US4263907A (en) 1979-05-14 1981-04-28 Lindsey Joseph W Respirator nebulizer
US4510929A (en) 1982-04-30 1985-04-16 Bordoni Maurice E Disposable radioactive aerosol inhalation apparatus
US4649911A (en) 1983-09-08 1987-03-17 Baylor College Of Medicine Small particle aerosol generator for treatment of respiratory disease including the lungs
US4624251A (en) 1984-09-13 1986-11-25 Riker Laboratories, Inc. Apparatus for administering a nebulized substance
US5152456A (en) 1989-12-12 1992-10-06 Bespak, Plc Dispensing apparatus having a perforate outlet member and a vibrating device
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
DE59108798D1 (de) 1991-11-07 1997-08-28 Ritzau Pari Werk Gmbh Paul Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie
JP2849647B2 (ja) 1991-12-04 1999-01-20 ザ テクノロジー パートナーシップ ピーエルシー 流体の小水滴製造装置及びその方法
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5709202A (en) 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
EP0810853B1 (en) 1995-02-24 2004-08-25 Elan Pharma International Limited Aerosols containing nanoparticle dispersions
US6427682B1 (en) 1995-04-05 2002-08-06 Aerogen, Inc. Methods and apparatus for aerosolizing a substance
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US5823179A (en) 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
US6083922A (en) 1996-04-02 2000-07-04 Pathogenesis, Corp. Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
US5906202A (en) 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US6349719B2 (en) 1997-02-24 2002-02-26 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
DE19713636A1 (de) 1997-04-02 1998-10-08 Pari Gmbh Atemzugsimulator
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
EP1021172B1 (en) 1997-10-08 2002-04-10 Sepracor, Inc. Dosage form for aerosol administration
EP1129741B1 (en) 1997-11-19 2006-04-12 Microflow Engineering SA Spray device for an inhaler
US6192876B1 (en) 1997-12-12 2001-02-27 Astra Aktiebolag Inhalation apparatus and method
JP2002526447A (ja) 1998-09-18 2002-08-20 メファ・アクチェンゲゼルシャフト アルキルフェニルピリドンの局所製剤
GB2343122B (en) 1998-10-26 2003-01-08 Medic Aid Ltd Improvements in and relating to nebulisers
US6070575A (en) 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
US6584971B1 (en) 1999-01-04 2003-07-01 Medic-Aid Limited Drug delivery apparatus
US6338443B1 (en) 1999-06-18 2002-01-15 Mercury Enterprises, Inc. High efficiency medical nebulizer
US6962151B1 (en) 1999-11-05 2005-11-08 Pari GmbH Spezialisten für effektive Inhalation Inhalation nebulizer
WO2001076671A2 (en) 2000-04-11 2001-10-18 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
DE10102846B4 (de) 2001-01-23 2012-04-12 Pari Pharma Gmbh Aerosolgenerator
EP1304131B1 (de) 2001-10-18 2005-06-29 PARI GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung
EP1304130B1 (de) 2001-10-18 2004-06-23 PARI GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung
EP1438019A1 (en) 2001-10-24 2004-07-21 PARI GmbH Spezialisten für effektive Inhalation Kit for the preparation of a pharmaceutical composition
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
JP4542743B2 (ja) 2002-12-26 2010-09-15 Kdl株式会社 ピリドン誘導体の溶液状医薬組成物
US7838532B2 (en) 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
EP2173380A4 (en) * 2007-07-13 2011-08-31 Abbott Biotech Ltd METHOD AND COMPOSITIONS FOR PULMONARY ADMINISTRATION OF A TNFa HEMMER
AU2008345034A1 (en) * 2007-12-27 2009-07-09 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide - donating compounds and uses thereof
KR20110091510A (ko) * 2008-10-07 2011-08-11 엠펙스 파마슈티컬즈, 인코포레이티드 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
AU2010302420B2 (en) * 2009-10-02 2013-07-04 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
JP6239054B2 (ja) * 2010-11-26 2017-11-29 東芝メディカルシステムズ株式会社 磁気共鳴診断装置
DK2670242T3 (da) * 2011-01-31 2022-05-02 Avalyn Pharma Inc Aerosolpirfenidon- og pyridonanalogforbindelser og anvendelser deraf

Also Published As

Publication number Publication date
EP2877164A2 (en) 2015-06-03
NZ705260A (en) 2017-04-28
HK1210955A1 (en) 2016-05-13
ES2959198T3 (es) 2024-02-21
AU2020201557B2 (en) 2022-08-25
AU2024267029A1 (en) 2024-12-19
AU2022271417A1 (en) 2022-12-22
JP2024095678A (ja) 2024-07-10
EP2877164A4 (en) 2016-01-13
AU2020201557A1 (en) 2020-03-26
JP2020073494A (ja) 2020-05-14
WO2014018668A3 (en) 2014-10-16
AU2013295800A1 (en) 2015-03-19
AU2018206852A1 (en) 2018-08-09
JP7120984B2 (ja) 2022-08-17
JP2015523395A (ja) 2015-08-13
EP2877164B1 (en) 2023-07-05
EP2877164C0 (en) 2023-07-05
CA2880011A1 (en) 2014-01-30
JP2022078126A (ja) 2022-05-24
WO2014018668A2 (en) 2014-01-30
JP6501264B2 (ja) 2019-04-17
CA2880011C (en) 2021-02-16
JP2018172402A (ja) 2018-11-08

Similar Documents

Publication Publication Date Title
HUE063581T2 (hu) Aeroszol pirfenidon és piridon analóg vegyületek
IL274988A (en) Carbamoylpyridone-polycyclic compounds and their pharmaceutical use
HUE058753T2 (hu) Aeroszol formájú pirfenidon- és piridon-analóg vegyületek és alkalmazásaik
EP3091976A4 (en) Aerosol pirfenidone and pyridone analog compounds and uses thereof
IL236036A0 (en) Pyridinone and pyridizinone derivatives
CO7071126A2 (es) Derivados de piridona
DK2903991T3 (da) Anti-fibrotiske pyridinoner
EP2828258A4 (en) NOVEL PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE
HUE054178T2 (hu) Metil/fluor-piridinil-metoxi-szubsztituált piridinon-piridinil-vegyületek és fluor-pirimidinil-metoxi-szubsztituált piridinon-piridinil-vegyületek
GB201502602D0 (en) Aerosol actuators, devices and methods of making and using the same
IL229963A0 (en) Substituted quinolines and their use as medicaments
PL2842945T3 (pl) Pochodna sulfonamidowa i jej zastosowanie medyczne
IL251974A0 (en) Antifibrosis compounds and their uses
HUE036280T2 (hu) Vortioxetint és donepezilt tartalmazó készítmények
EP2931044A4 (en) PROCESSES FOR THE PREPARATION OF 4-AMINO-3-HALO-6- (SUBSTITUTED) PICOLINATES AND 4-AMINO-5-FLUORO-3-HALO-6 SUBSTITUTED-PICOLINATES
HUE038523T2 (hu) Piridon-származék és ezt tartalmazó gyógyszerkészítmény
DE112013005459A5 (de) Aerosol-Sprühsystem
TH1301004812B (th) ผลิตภัณฑ์ซึมซับและวิธีการผลิต
GB201220504D0 (en) Product and use thereof