JP6487949B2 - 局所用コルチコステロイド組成物 - Google Patents

局所用コルチコステロイド組成物 Download PDF

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Publication number
JP6487949B2
JP6487949B2 JP2016575611A JP2016575611A JP6487949B2 JP 6487949 B2 JP6487949 B2 JP 6487949B2 JP 2016575611 A JP2016575611 A JP 2016575611A JP 2016575611 A JP2016575611 A JP 2016575611A JP 6487949 B2 JP6487949 B2 JP 6487949B2
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JP
Japan
Prior art keywords
composition
skin
betamethasone
alcohol
spray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016575611A
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English (en)
Japanese (ja)
Other versions
JP2017508802A5 (enExample
JP2017508802A (ja
Inventor
カンダヴィッリ,サティーシュ
サフカー,プリヤダーシャニ
オクム,フランクリン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promius Pharma LLC
Original Assignee
Promius Pharma LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promius Pharma LLC filed Critical Promius Pharma LLC
Publication of JP2017508802A publication Critical patent/JP2017508802A/ja
Publication of JP2017508802A5 publication Critical patent/JP2017508802A5/ja
Application granted granted Critical
Publication of JP6487949B2 publication Critical patent/JP6487949B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2016575611A 2014-03-11 2015-03-11 局所用コルチコステロイド組成物 Expired - Fee Related JP6487949B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461951165P 2014-03-11 2014-03-11
US61/951,165 2014-03-11
PCT/US2015/020031 WO2015138650A1 (en) 2014-03-11 2015-03-11 Topical corticosteroid compositions

Publications (3)

Publication Number Publication Date
JP2017508802A JP2017508802A (ja) 2017-03-30
JP2017508802A5 JP2017508802A5 (enExample) 2017-06-29
JP6487949B2 true JP6487949B2 (ja) 2019-03-20

Family

ID=52727460

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016575611A Expired - Fee Related JP6487949B2 (ja) 2014-03-11 2015-03-11 局所用コルチコステロイド組成物
JP2017516360A Expired - Fee Related JP6535735B2 (ja) 2014-03-11 2015-09-09 局所用コルチコステロイド組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017516360A Expired - Fee Related JP6535735B2 (ja) 2014-03-11 2015-09-09 局所用コルチコステロイド組成物

Country Status (13)

Country Link
US (4) US20150258119A1 (enExample)
EP (2) EP3116473B1 (enExample)
JP (2) JP6487949B2 (enExample)
KR (2) KR101930244B1 (enExample)
CN (1) CN106659682B (enExample)
AU (2) AU2015229403B2 (enExample)
BR (1) BR112016021023A2 (enExample)
CA (2) CA2945943C (enExample)
EA (2) EA201691808A8 (enExample)
ES (1) ES2857602T3 (enExample)
MX (2) MX381164B (enExample)
WO (2) WO2015138650A1 (enExample)
ZA (1) ZA201606704B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011026076A2 (en) 2009-08-31 2011-03-03 Dr. Reddy's Laboratories Ltd. Topical formulations comprising a steroid
US20160184431A1 (en) 2014-03-11 2016-06-30 Promius Pharma Llc Topical compositions comprising a corticosteroid
WO2017091168A1 (en) * 2015-11-28 2017-06-01 Pharmacti̇ve İlaç San. Ve Ti̇c. A.Ş. A topical spray comprising isoconazole nitrate and difluocortolone valerate
AU2017207806B2 (en) * 2016-01-12 2022-08-04 Acasti Pharma U.S., Inc. Betamethasone oral spray formulation and method of use to treat ataxia
GB201604316D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
WO2018020385A1 (en) * 2016-07-27 2018-02-01 Sun Pharmaceutical Industries Limited Touch-free topical spray of halobetasol
CA3037582A1 (en) 2016-09-21 2018-03-29 Avexxin As Pharmaceutical composition
US10543177B2 (en) * 2017-04-11 2020-01-28 Kevin Mrohs Composition and method for treating skin conditions
US11620886B2 (en) 2018-02-19 2023-04-04 Invue Security Products Inc. Merchandise security system with inductive charging
WO2020069448A1 (en) * 2018-09-28 2020-04-02 Joel Studin Transpore delivery of steroids and large molecules
JP7412292B2 (ja) * 2019-07-10 2024-01-12 積水化学工業株式会社 製剤
WO2021080527A1 (en) * 2019-10-24 2021-04-29 Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. Topical pharmaceutical compositions containing difluocortolone and isoconazole
CN115103666A (zh) * 2020-02-11 2022-09-23 塔罗制药工业有限公司 包含去羟米松和他扎罗汀的组合物
US11382863B2 (en) * 2020-03-04 2022-07-12 Somerset Therapeutics Llc Injectable suspension comprising an insoluble corticosteroid and a soluble corticosteroid
CN113092601B (zh) * 2021-03-02 2022-12-20 苏州市药品检验检测研究中心 一种化妆品中倍他米松17-丙酸酯及倍他米松21-丙酸酯的检测方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892856A (en) 1974-04-10 1975-07-01 Squibb & Sons Inc Topical steroid formulation
US3934013A (en) 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition
US4343798A (en) 1981-06-23 1982-08-10 The Procter & Gamble Company Topical antimicrobial anti-inflammatory compositions
US4552872A (en) * 1983-06-21 1985-11-12 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing corticosteroids
US5422361A (en) * 1989-12-20 1995-06-06 Schering Corporation Stable cream and lotion bases for lipophilic drug compositions
IT1247529B (it) 1991-04-24 1994-12-17 Poli Ind Chimica Spa Composizioni farmaceutiche in forma di schiuma per somministrazione intravaginale, cutanea e orale
ES2180599T3 (es) 1994-09-30 2003-02-16 Mika Pharma Ges Fur Die Entwic Composicion farmaceutica.
GB9504265D0 (en) 1995-03-03 1995-04-19 Medeva Plc Corticosteroid-containing pharmaceutical composition
IL152486A0 (en) * 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US7820145B2 (en) * 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US20080206161A1 (en) * 2002-10-25 2008-08-28 Dov Tamarkin Quiescent foamable compositions, steroids, kits and uses thereof
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
CN101267804A (zh) * 2003-12-16 2008-09-17 弗米克斯有限公司 含油的药物和化妆品泡沫
CN101048136B (zh) * 2004-08-31 2011-06-22 施蒂福研究澳大利亚股份有限公司 微乳化和亚微米乳化方法和组合物
RU2381023C2 (ru) * 2004-08-31 2010-02-10 Стифель Ресёрч Австралия Пти Лтд Способ получения микроэмульсий и субмикронных эмульсий и композиции на их основе
US20060246098A1 (en) * 2005-03-16 2006-11-02 Srinivasa Rao Stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same
ES2539634T3 (es) 2005-04-25 2015-07-02 Dow Pharmaceutical Sciences Uso de una formulación de clobetasol en forma de pulverización para tratar la psoriasis
GB2443162B (en) 2006-10-28 2011-02-09 Nupharm Lab Ltd Betamethasone spray
WO2011026076A2 (en) * 2009-08-31 2011-03-03 Dr. Reddy's Laboratories Ltd. Topical formulations comprising a steroid
WO2011039637A2 (en) * 2009-10-02 2011-04-07 Foamix Ltd. Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
NL2004437C2 (en) * 2010-03-19 2011-09-20 Forte Iq B V Spray-pumpable comprising composition suitable for topical skin application.
WO2011156030A2 (en) * 2010-06-11 2011-12-15 Precision Dermatology, Inc. High oil-content emollient aerosol foam compositions
IN2015DN01009A (enExample) * 2012-08-10 2015-06-12 Asahi Glass Co Ltd
AU2014233362A1 (en) * 2013-03-15 2015-10-01 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment
US10111956B2 (en) * 2013-06-03 2018-10-30 Tolmar, Inc. Corticosteroid compositions

Also Published As

Publication number Publication date
WO2016144381A1 (en) 2016-09-15
EP3197432A4 (en) 2018-10-10
MX2016011841A (es) 2017-02-02
CA2945943C (en) 2020-10-27
AU2015385750B2 (en) 2019-01-31
KR20160144377A (ko) 2016-12-16
US20180250312A1 (en) 2018-09-06
EP3197432A1 (en) 2017-08-02
EA201692334A1 (ru) 2018-02-28
ES2857602T3 (es) 2021-09-29
JP2017530974A (ja) 2017-10-19
EA201691808A1 (ru) 2017-02-28
EP3116473B1 (en) 2020-12-30
US20200230155A1 (en) 2020-07-23
CN106659682B (zh) 2020-12-29
CA2945943A1 (en) 2015-09-17
CA2946201A1 (en) 2016-09-15
AU2015229403B2 (en) 2019-05-02
KR101930246B1 (ko) 2018-12-18
CN106659682A (zh) 2017-05-10
WO2015138650A1 (en) 2015-09-17
JP2017508802A (ja) 2017-03-30
EA201691808A8 (ru) 2017-04-28
ZA201606704B (en) 2019-07-31
MX2016011842A (es) 2017-02-02
AU2015385750A1 (en) 2016-10-27
MX381164B (es) 2025-03-12
KR101930244B1 (ko) 2018-12-18
JP6535735B2 (ja) 2019-06-26
KR20170023791A (ko) 2017-03-06
AU2015229403A1 (en) 2016-10-27
CA2946201C (en) 2020-10-27
BR112016021023A8 (pt) 2018-01-30
US20150258119A1 (en) 2015-09-17
EP3116473A1 (en) 2017-01-18
BR112016021023A2 (pt) 2021-09-14
US20160030450A1 (en) 2016-02-04

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