JP6480588B2 - 標的とされた熱ショックタンパク質を刺激する及びタンパク質修復を促進するためのパルス状の電磁療法および超音波治療法 - Google Patents
標的とされた熱ショックタンパク質を刺激する及びタンパク質修復を促進するためのパルス状の電磁療法および超音波治療法 Download PDFInfo
- Publication number
- JP6480588B2 JP6480588B2 JP2017533207A JP2017533207A JP6480588B2 JP 6480588 B2 JP6480588 B2 JP 6480588B2 JP 2017533207 A JP2017533207 A JP 2017533207A JP 2017533207 A JP2017533207 A JP 2017533207A JP 6480588 B2 JP6480588 B2 JP 6480588B2
- Authority
- JP
- Japan
- Prior art keywords
- light
- tissue
- laser
- pulsed
- light beam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108010004889 Heat-Shock Proteins Proteins 0.000 title description 68
- 102000002812 Heat-Shock Proteins Human genes 0.000 title description 68
- 238000002604 ultrasonography Methods 0.000 title description 25
- 230000005451 protein repair Effects 0.000 title description 17
- 230000004936 stimulating effect Effects 0.000 title description 3
- 238000002560 therapeutic procedure Methods 0.000 title description 3
- 238000000940 electromagnetic therapy Methods 0.000 title 1
- 230000001737 promoting effect Effects 0.000 title 1
- 230000003287 optical effect Effects 0.000 claims description 27
- 230000000638 stimulation Effects 0.000 claims description 13
- 230000007246 mechanism Effects 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 9
- 210000001519 tissue Anatomy 0.000 description 108
- 238000011282 treatment Methods 0.000 description 35
- 230000004913 activation Effects 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 28
- 238000000034 method Methods 0.000 description 19
- 230000006378 damage Effects 0.000 description 15
- 230000000694 effects Effects 0.000 description 15
- 230000008901 benefit Effects 0.000 description 14
- 238000010521 absorption reaction Methods 0.000 description 13
- 230000005670 electromagnetic radiation Effects 0.000 description 13
- 230000005855 radiation Effects 0.000 description 13
- 210000000624 ear auricle Anatomy 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 12
- 230000002207 retinal effect Effects 0.000 description 12
- 239000000835 fiber Substances 0.000 description 10
- 230000008439 repair process Effects 0.000 description 10
- 238000009792 diffusion process Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 9
- 238000010438 heat treatment Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 230000007774 longterm Effects 0.000 description 7
- 210000001525 retina Anatomy 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 230000001413 cellular effect Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 239000013307 optical fiber Substances 0.000 description 5
- 239000006187 pill Substances 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 108090000695 Cytokines Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 206010012689 Diabetic retinopathy Diseases 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 208000017442 Retinal disease Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 206010064930 age-related macular degeneration Diseases 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 208000002780 macular degeneration Diseases 0.000 description 4
- 210000003928 nasal cavity Anatomy 0.000 description 4
- 210000000664 rectum Anatomy 0.000 description 4
- 230000000241 respiratory effect Effects 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 description 3
- 208000003569 Central serous chorioretinopathy Diseases 0.000 description 3
- 230000005856 abnormality Effects 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000003915 cell function Effects 0.000 description 3
- 208000014951 hematologic disease Diseases 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 230000000649 photocoagulation Effects 0.000 description 3
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 description 3
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 3
- 208000019838 Blood disease Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 206010038923 Retinopathy Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 210000000621 bronchi Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000029742 colonic neoplasm Diseases 0.000 description 2
- 238000002052 colonoscopy Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 208000018706 hematopoietic system disease Diseases 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 238000002647 laser therapy Methods 0.000 description 2
- 231100000518 lethal Toxicity 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000003818 metabolic dysfunction Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000001989 nasopharynx Anatomy 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 210000001533 respiratory mucosa Anatomy 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 description 1
- 101710154868 60 kDa heat shock protein, mitochondrial Proteins 0.000 description 1
- 108091006112 ATPases Proteins 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010071155 Autoimmune arthritis Diseases 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 description 1
- 101100339887 Drosophila melanogaster Hsp27 gene Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 description 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 description 1
- 102000018932 HSP70 Heat-Shock Proteins Human genes 0.000 description 1
- 108010027992 HSP70 Heat-Shock Proteins Proteins 0.000 description 1
- 101150096895 HSPB1 gene Proteins 0.000 description 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 description 1
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- 208000001344 Macular Edema Diseases 0.000 description 1
- 206010025415 Macular oedema Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 102000005431 Molecular Chaperones Human genes 0.000 description 1
- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 208000034461 Progressive cone dystrophy Diseases 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 206010057430 Retinal injury Diseases 0.000 description 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 description 1
- 102000004389 Ribonucleoproteins Human genes 0.000 description 1
- 108010081734 Ribonucleoproteins Proteins 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000006472 autoimmune response Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000000746 body region Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000004637 cellular stress Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 201000008615 cone dystrophy Diseases 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 239000002619 cytotoxin Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 201000011190 diabetic macular edema Diseases 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000010230 macular retinal edema Diseases 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000001483 mobilizing effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000004845 protein aggregation Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008263 repair mechanism Effects 0.000 description 1
- 230000003938 response to stress Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 239000000790 retinal pigment Substances 0.000 description 1
- 210000001957 retinal vein Anatomy 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000037351 starvation Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0625—Warming the body, e.g. hyperthermia treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B2018/2065—Multiwave; Wavelength mixing, e.g. using four or more wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0642—Irradiating part of the body at a certain distance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0661—Radiation therapy using light characterised by the wavelength of light used ultraviolet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0043—Ultrasound therapy intra-cavitary
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Radiology & Medical Imaging (AREA)
- Diabetes (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Laser Surgery Devices (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/607,959 US9168174B2 (en) | 2012-05-25 | 2015-01-28 | Process for restoring responsiveness to medication in tissue of living organisms |
| US14/607,959 | 2015-01-28 | ||
| US201562153616P | 2015-04-28 | 2015-04-28 | |
| US62/153,616 | 2015-04-28 | ||
| US14/922,885 | 2015-10-26 | ||
| US14/922,885 US9427602B2 (en) | 2012-05-25 | 2015-10-26 | Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair |
| PCT/US2015/060893 WO2016122752A1 (fr) | 2015-01-28 | 2015-11-16 | Thérapie électromagnétique pulsée et par ultrasons pour stimuler des protéines de choc thermique ciblées et faciliter une réparation de protéine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019019121A Division JP6778772B2 (ja) | 2015-01-28 | 2019-02-05 | 標的とされた熱ショックタンパク質を刺激する及びタンパク質修復を促進するためのパルス状の電磁療法および超音波治療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018503434A JP2018503434A (ja) | 2018-02-08 |
| JP6480588B2 true JP6480588B2 (ja) | 2019-03-13 |
Family
ID=56544130
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533207A Active JP6480588B2 (ja) | 2015-01-28 | 2015-11-16 | 標的とされた熱ショックタンパク質を刺激する及びタンパク質修復を促進するためのパルス状の電磁療法および超音波治療法 |
| JP2019019121A Active JP6778772B2 (ja) | 2015-01-28 | 2019-02-05 | 標的とされた熱ショックタンパク質を刺激する及びタンパク質修復を促進するためのパルス状の電磁療法および超音波治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019019121A Active JP6778772B2 (ja) | 2015-01-28 | 2019-02-05 | 標的とされた熱ショックタンパク質を刺激する及びタンパク質修復を促進するためのパルス状の電磁療法および超音波治療法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP3250139A4 (fr) |
| JP (2) | JP6480588B2 (fr) |
| CN (1) | CN107205768B (fr) |
| AU (1) | AU2015380411B2 (fr) |
| BR (1) | BR112017016288A2 (fr) |
| CA (2) | CA3063889C (fr) |
| SG (1) | SG11201705677WA (fr) |
| WO (1) | WO2016122752A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019001348A2 (pt) * | 2016-08-09 | 2019-04-30 | Ojai Retinal Tech Llc | processo para fornecer terapia protetora a tecidos ou fluidos biológicos |
| CN110582238A (zh) * | 2017-05-01 | 2019-12-17 | 奥哈伊视网膜技术有限责任公司 | 用于治疗近视的系统及方法 |
| WO2019099068A1 (fr) * | 2017-11-15 | 2019-05-23 | Ojai Retinal Technology, Llc | Méthode et système permettant d'utiliser une énergie en vue de traiter un tissu biologique |
| CN112105417B (zh) * | 2018-04-24 | 2022-11-29 | 国家科学研究中心 | 用于使用微波引起的热曲线来影响生物组织和细胞的发生器 |
| CN112494135A (zh) * | 2020-11-20 | 2021-03-16 | 毕勇 | 一种支气管哮喘的激光热成形治疗装置 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5348002A (en) * | 1992-04-23 | 1994-09-20 | Sirraya, Inc. | Method and apparatus for material analysis |
| WO2000023147A1 (fr) * | 1998-10-20 | 2000-04-27 | Dornier Medtech Holding International Gmbh | Therapie thermique assortie d'une protection des tissus |
| JP2001104334A (ja) * | 1999-10-08 | 2001-04-17 | Olympus Optical Co Ltd | 医療用システム |
| GB0422525D0 (en) * | 2004-10-11 | 2004-11-10 | Luebcke Peter | Dermatological compositions and methods |
| JP2008109954A (ja) * | 2006-10-27 | 2008-05-15 | Matsushita Electric Works Ltd | カプセル型撮像装置 |
| EP2207595A4 (fr) * | 2007-10-19 | 2012-10-24 | Lockheed Corp | Système et procédé de conditionnement de tissu animal par rayon laser |
| JP2011508870A (ja) * | 2007-11-21 | 2011-03-17 | フォーカス サージェリー，インコーポレーテッド | 高密度集束超音波を用いた腫瘍の診断及び治療方法 |
| US8141557B2 (en) * | 2008-10-22 | 2012-03-27 | Peyman Gholam A | Method of oscillatory thermotherapy of biological tissue |
| US10219947B2 (en) * | 2012-05-25 | 2019-03-05 | Ojai Retinal Technology, Llc | System and process for retina phototherapy |
| WO2014040014A1 (fr) * | 2012-09-10 | 2014-03-13 | Dermal Photonics Corporation | Systèmes et procédés d'utilisation/réapprovisionnement |
| WO2014070699A1 (fr) * | 2012-11-01 | 2014-05-08 | Seminex Corporation | Traitements de la peau au laser à intensité variable |
-
2015
- 2015-11-16 JP JP2017533207A patent/JP6480588B2/ja active Active
- 2015-11-16 SG SG11201705677WA patent/SG11201705677WA/en unknown
- 2015-11-16 CA CA3063889A patent/CA3063889C/fr active Active
- 2015-11-16 CN CN201580074189.1A patent/CN107205768B/zh active Active
- 2015-11-16 BR BR112017016288-1A patent/BR112017016288A2/pt unknown
- 2015-11-16 CA CA2972416A patent/CA2972416C/fr active Active
- 2015-11-16 AU AU2015380411A patent/AU2015380411B2/en active Active
- 2015-11-16 WO PCT/US2015/060893 patent/WO2016122752A1/fr active Application Filing
- 2015-11-16 EP EP15880628.1A patent/EP3250139A4/fr active Pending
-
2019
- 2019-02-05 JP JP2019019121A patent/JP6778772B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3063889A1 (fr) | 2016-08-04 |
| EP3250139A1 (fr) | 2017-12-06 |
| JP6778772B2 (ja) | 2020-11-04 |
| WO2016122752A1 (fr) | 2016-08-04 |
| AU2015380411B2 (en) | 2019-03-14 |
| CA2972416A1 (fr) | 2016-08-04 |
| CA2972416C (fr) | 2020-01-14 |
| CN107205768B (zh) | 2020-06-16 |
| BR112017016288A2 (pt) | 2018-03-27 |
| JP2019108334A (ja) | 2019-07-04 |
| EP3250139A4 (fr) | 2018-06-27 |
| SG11201705677WA (en) | 2017-08-30 |
| JP2018503434A (ja) | 2018-02-08 |
| CN107205768A (zh) | 2017-09-26 |
| CA3063889C (fr) | 2023-03-14 |
| AU2015380411A1 (en) | 2017-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9427602B2 (en) | Pulsating electromagnetic and ultrasound therapy for stimulating targeted heat shock proteins and facilitating protein repair | |
| US10953241B2 (en) | Process for providing protective therapy for biological tissues or fluids | |
| US10531908B2 (en) | Method for heat treating biological tissues using pulsed energy sources | |
| JP6778772B2 (ja) | 標的とされた熱ショックタンパク質を刺激する及びタンパク質修復を促進するためのパルス状の電磁療法および超音波治療法 | |
| JP7353671B2 (ja) | レーザー光を利用し熱ショックタンパク質の活性化を刺激するように適応させたシステム | |
| US20170203132A1 (en) | System and process utilizing pulsed energy to treat biological tissue | |
| AU2017308587A1 (en) | Process for providing protective therapy for biological tissues or fluids | |
| JP7239990B2 (ja) | 生体組織を熱処置するためのパルスエネルギーを利用したプロセス | |
| WO2018169560A1 (fr) | Système et procédé utilisant une énergie pulsée pour traiter un tissu biologique |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170913 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20171120 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20180824 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180903 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20181128 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190110 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190207 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6480588 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |