JP6468633B2 - Three-layer structure seamless capsule - Google Patents
Three-layer structure seamless capsule Download PDFInfo
- Publication number
- JP6468633B2 JP6468633B2 JP2014204883A JP2014204883A JP6468633B2 JP 6468633 B2 JP6468633 B2 JP 6468633B2 JP 2014204883 A JP2014204883 A JP 2014204883A JP 2014204883 A JP2014204883 A JP 2014204883A JP 6468633 B2 JP6468633 B2 JP 6468633B2
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- JP
- Japan
- Prior art keywords
- core
- layer structure
- water
- seamless capsule
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- ZDHXKXAHOVTTAH-UHFFFAOYSA-N trichlorosilane Chemical compound Cl[SiH](Cl)Cl ZDHXKXAHOVTTAH-UHFFFAOYSA-N 0.000 description 1
- 239000005052 trichlorosilane Substances 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicinal Preparation (AREA)
Description
本発明は、三層構造シームレスカプセルに関し、より詳しくは、コアと、前記コアを被包する保護層と、前記保護層を被包する水溶性ゲル化剤を含む皮膜層とを備えた三層構造カプセルであって、前記コアは水と配合禁忌の関係にある物質と第一油性物質と多孔性微粒子粉末とを含有し、前記保護層は第二油性物質を含有することを特徴とする三層構造シームレスカプセルに関する。 The present invention relates to a three-layer structure seamless capsule, and more specifically, a three-layer structure including a core, a protective layer encapsulating the core, and a film layer containing a water-soluble gelling agent encapsulating the protective layer. It is a structural capsule, wherein the core contains a substance incompatible with water, a first oily substance, and a porous fine particle powder, and the protective layer contains a second oily substance. It relates to a layered seamless capsule.
従来から、様々な有効成分をコアに含有させたカプセルが種々報告されている。これらのカプセルにおける皮膜の材料としては、ゼラチンや、寒天及び水溶性高分子の混合物などが広く用いられている。 Conventionally, various capsules containing various active ingredients in the core have been reported. As a film material for these capsules, gelatin, agar and a mixture of water-soluble polymers are widely used.
ゼラチンや、寒天及び水溶性高分子の混合物を材料とする皮膜には水を含有しているため、水と配合禁忌の関係にある物質をコアに含有させる場合には、皮膜とコアを隔離しなければならない。 Since the film made of gelatin or a mixture of agar and water-soluble polymer contains water, when the core contains a substance incompatible with water, separate the film from the core. There must be.
皮膜とコアに含有される成分とを隔離したカプセルとして、例えば、内包されている腸内有用細菌が、常温において非流動性の疎水性物質を介して、カプセル皮膜から隔離されてなる腸内有用細菌含有カプセル(特許文献1参照)や、ビフィズス菌粉末に保護剤を添加し、融点30〜45℃、融点幅3℃以下の硬化油に懸濁してカプセル核液とし、ゼラチンを用いて皮膜を形成することを特徴とするビフィズス菌含有ソフトカプセル(特許文献2参照)や、内容物と該内容物を被覆する皮膜よりなるシームレスカプセルにおいて、該内容物が親水性物質であり、該内容物と皮膜との間にショ糖の低級脂肪酸エステルが介在することを特徴とする親水性物質を内容物とするシームレスカプセル(特許文献3参照)が提案されている。しかしながら、かかるカプセルでは皮膜とコアに含有される成分との隔離が不十分であり、コアに含有される成分が直接カプセル皮膜に接触することを一時的に防ぐことが可能であるにすぎず、皮膜や硬化油やその他の物質に含まれている水が経時的にコアに含有される成分と接するという問題があった。 For example, a capsule in which the coating and the components contained in the core are separated, for example, the useful gut bacteria contained in the gut are isolated from the capsule coating through a non-flowable hydrophobic substance at room temperature. A protective agent is added to a bacteria-containing capsule (see Patent Document 1) and bifidobacteria powder, suspended in a hardened oil having a melting point of 30 to 45 ° C. and a melting point width of 3 ° C. or less to form a capsule core solution, and a coating film is formed using gelatin. A bifidobacteria-containing soft capsule (see Patent Document 2) characterized in that it is formed, or a seamless capsule comprising a content and a film covering the content, wherein the content is a hydrophilic substance, and the content and the film There has been proposed a seamless capsule (see Patent Document 3) containing a hydrophilic substance characterized in that a lower fatty acid ester of sucrose is interposed therebetween. However, in such capsules, the separation between the film and the components contained in the core is insufficient, and it is only possible to temporarily prevent the components contained in the core from directly contacting the capsule film, There was a problem that water contained in the film, hydrogenated oil and other substances contacted with the components contained in the core over time.
また、酸、水分または熱に弱い内容物質を常温で非流動性である疎水性物質に懸濁し、これをカプセル化した後に常温通風乾燥し、ついでこの乾燥カプセルをさらに真空乾燥または真空凍結乾燥させることを特徴とする酸、水分または熱に弱い内容物質を包含するカプセル(特許文献4参照)が提案されている。かかるカプセルによって、水分に弱い内容物を保護することが可能となるが、真空乾燥や真空凍結という複雑な工程が必要であると共にコストもかかるという問題があった。 Also, a substance that is sensitive to acid, moisture, or heat is suspended in a hydrophobic substance that is non-flowable at room temperature, encapsulated and then air-dried at room temperature, and then the dried capsule is further vacuum dried or vacuum freeze dried. A capsule (see Patent Document 4) including a substance that is sensitive to acid, moisture, or heat is proposed. Such capsules can protect moisture-sensitive contents, but there is a problem that a complicated process such as vacuum drying and vacuum freezing is necessary and cost is high.
一方、カプセルの作製において、気相法シリカなどの多孔性微粒子粉末は、アグロメレート化調合物において、活性化合物の放出速度を調整するための充填剤(特許文献5参照)や、ソフトカプセルの親油性媒体中におけるコートされた有用物質の顆粒の沈降抑制剤や、特許文献6参照)や、ソフトカプセルにおける皮膜の付着性又は滑走性の改善剤(特許文献7参照)として用いることが提案されている。 On the other hand, in the preparation of capsules, porous fine particle powders such as gas phase process silica are used in fillers for adjusting the release rate of active compounds in agglomerated preparations (see Patent Document 5) and lipophilic media for soft capsules. It has been proposed to be used as a sedimentation inhibitor for granules of coated useful substances in the inside, and as an agent for improving the adhesion or sliding property of a film in a soft capsule (see Patent Document 6).
本発明の課題は、コアと皮膜層とが隔離され、コアに含有される水と配合禁忌の関係にある物質と水との接触が防止され、水と配合禁忌の関係にある物質を安定に維持することが可能な三層構造シームレスカプセルを提供することにある。 The problem of the present invention is that the core and the film layer are isolated, the contact between the water contained in the core and the substance incompatible with the water and the contact with water is prevented, and the water incompatible with the water is stabilized. It is to provide a three-layer structure seamless capsule that can be maintained.
本発明者らは、コアに硬化油を含有するカプセルを作製する過程で、後述する参考例に記載のように、硬化油にアエロジル(登録商標)を分散させ、かかる硬化油を融点以上に加温した状態で、冷却した中鎖脂肪酸トリグリセライド(MCT)中に滴下したところ、硬化油とMCTの間に界面が生じて硬化油がMCT中に溶解することがなく球状となり、かつ、球状を保ったまま硬化油の融点以下に冷却されて固化することを見いだした。そこで、かかる現象を応用し、ビフィズス菌と硬化油とアエロジルとを含有するコア、前記コアを被包する硬化油を含有する保護層、前記保護層を被包するゼラチンを含む皮膜層とを備えた三層構造シームレスカプセルを作製したところ、コアと皮膜層が隔離され、ビフィズス菌が安定的に維持されていることを見いだし、本発明を完成した。 In the process of producing a capsule containing a hardened oil in the core, the inventors disperse Aerosil (registered trademark) in the hardened oil and add the hardened oil to the melting point or higher as described in Reference Examples described later. When dropped in a cooled medium chain fatty acid triglyceride (MCT) in a warmed state, an interface is formed between the hardened oil and MCT, and the hardened oil does not dissolve in the MCT and becomes spherical and keeps the spherical shape. It has been found that it is cooled to below the melting point of the hardened oil and solidifies. Therefore, by applying such a phenomenon, it comprises a core containing bifidobacteria, hardened oil and aerosil, a protective layer containing hardened oil encapsulating the core, and a coating layer containing gelatin encapsulating the protective layer As a result, a core and a coating layer were isolated from each other, and it was found that bifidobacteria were stably maintained, thereby completing the present invention.
すなわち、本発明は、以下に開示されるとおりのものである。
(1)コアと、前記コアを被包する保護層と、前記保護層を被包する水溶性ゲル化剤を含む皮膜層とを備えた三層構造カプセルであって、前記コアは水と配合禁忌の関係にある物質と第一油性物質と多孔性微粒子粉末とを含有し、前記保護層は第二油性物質を含有することを特徴とする三層構造シームレスカプセル。
(2)コアにおいて、第一油性物質100質量部に対して多孔性微粒子粉末を0.1〜20質量部含有することを特徴とする上記(1)記載の三層構造シームレスカプセル。
(3)多孔性微粒子粉末が気相法シリカであることを特徴とする上記(1)又は(2)記載の三層構造シームレスカプセル。
(4)気相法シリカがアエロジルであることを特徴とする上記(1)〜(3)のいずれか記載の三層構造シームレスカプセル。
(5)コアに含有されている第一油性物質が硬化油であることを特徴とする上記(1)〜(4)のいずれか記載の三層構造シームレスカプセル。
(6)融点が30〜60℃の硬化油であることを特徴とする上記(5)記載の三層構造シームレスカプセル。
(7)保護層が、第一油性物質に対して融点差が2℃以上の第二油性物質を含有することを特徴とする上記(1)〜(6)のいずれか記載の三層構造シームレスカプセル。
(8)保護層が、第一油性物質より融点が2℃以上高い第二油性物質を含有することを特徴とする上記(7)記載の三層構造シームレスカプセル。
(9)水溶性ゲル化剤がゼラチンであることを特徴とする上記(1)〜(8)のいずれか記載の三層構造シームレスカプセル。
(10)水溶性ゲル化剤がゼラチン及びペクチンであることを特徴とする上記(1)〜(8)のいずれか記載の三層構造シームレスカプセル。
(11)水と配合禁忌の関係にある物質が、ビフィズス菌、乳酸菌、ビタミンB1、ビタミンB2、ビタミンB12、又はビタミンCであることを特徴とする上記(1)〜(10)のいずれか記載の三層構造シームレスカプセル。
(12)コアと、前記コアを被包する保護層と、前記保護層を被包する皮膜層とを備えた三層構造シームレスカプセルの作製方法であって、以下の工程(a)〜(d)を備えたことを特徴とする作製方法。
(a)水と配合禁忌の関係にある物質と第一油性物質と多孔性微粒子粉末とを含有するコア液を調製する工程;
(b)第二油性物質を含有する保護液を調製する工程;
(c)水溶性ゲル化剤と水とを含有する皮膜液を調製する工程;
(d)同心三重ノズルを用い、外側ノズルからは前記皮膜液を、内側ノズルからは前記コア液を、中間ノズルからは前記保護液を吐出させて三層液滴とし、かかる三層液滴を硬化液と接触させて皮膜液を硬化させる工程;
That is, the present invention is as disclosed below.
(1) A three-layer capsule comprising a core, a protective layer encapsulating the core, and a coating layer containing a water-soluble gelling agent encapsulating the protective layer, wherein the core is blended with water A three-layer structure seamless capsule comprising a contraindicated substance, a first oily substance, and a porous fine particle powder, wherein the protective layer contains a second oily substance.
(2) The three-layer structure seamless capsule according to the above (1), wherein the core contains 0.1 to 20 parts by mass of porous fine particle powder with respect to 100 parts by mass of the first oily substance.
(3) The three-layer structure seamless capsule according to the above (1) or (2), wherein the porous fine particle powder is vapor phase silica.
(4) The three-layer structure seamless capsule according to any one of (1) to (3) above, wherein the vapor phase method silica is Aerosil.
(5) The three-layer structure seamless capsule according to any one of (1) to (4), wherein the first oily substance contained in the core is a hardened oil.
(6) The three-layer structure seamless capsule according to the above (5), which is a hardened oil having a melting point of 30 to 60 ° C.
(7) The three-layer seamless structure according to any one of (1) to (6) above, wherein the protective layer contains a second oily substance having a melting point difference of 2 ° C. or more with respect to the first oily substance. capsule.
(8) The three-layer structure seamless capsule according to the above (7), wherein the protective layer contains a second oily substance having a melting point of 2 ° C. or more higher than that of the first oily substance.
(9) The three-layer structure seamless capsule according to any one of (1) to (8) above, wherein the water-soluble gelling agent is gelatin.
(10) The three-layer structure seamless capsule according to any one of (1) to (8) above, wherein the water-soluble gelling agent is gelatin and pectin.
(11) Any one of (1) to (10) above, wherein the substance incompatible with water is bifidobacteria, lactic acid bacteria, vitamin B1, vitamin B2, vitamin B12, or vitamin C Three-layer seamless capsule.
(12) A method for producing a three-layer structure seamless capsule comprising a core, a protective layer encapsulating the core, and a coating layer encapsulating the protective layer, the following steps (a) to (d) And a manufacturing method characterized by comprising:
(A) a step of preparing a core liquid containing a substance incompatible with water, a first oily substance, and a porous fine particle powder;
(B) preparing a protective liquid containing the second oily substance;
(C) a step of preparing a coating liquid containing a water-soluble gelling agent and water;
(D) Using a concentric triple nozzle, the coating liquid is discharged from the outer nozzle, the core liquid is discharged from the inner nozzle, and the protective liquid is discharged from the intermediate nozzle to form a three-layer liquid droplet. A step of curing the coating liquid by contacting with the curing liquid;
本発明の三層構造シームレスカプセルによれば、コアと皮膜層とが隔離され、コアに含有される水と配合禁忌の関係にある物質と水との接触が防止され、水と配合禁忌の関係にある物質を安定に維持することが可能となる。 According to the three-layer structure seamless capsule of the present invention, the core and the coating layer are isolated, the contact between the water contained in the core and the substance incompatible with the compound and water is prevented, and the relationship between water and the compounded contraindication This makes it possible to maintain a stable substance.
本発明の三層構造シームレスカプセルとしては、コアと、前記コアを被包する保護層と、前記保護層を被包する水溶性ゲル化剤を含む皮膜層とを備えた三層構造カプセルであって、前記コアは水と配合禁忌の関係にある物質と第一油性物質と多孔性微粒子粉末とを含有し、前記保護層は第二油性物質を含有することを特徴とする三層構造シームレスカプセルであれば特に制限されず、水と配合禁忌の関係にある物質を安定的に維持することが可能なシームレスカプセルである。 The three-layer structure seamless capsule of the present invention is a three-layer structure capsule comprising a core, a protective layer encapsulating the core, and a film layer containing a water-soluble gelling agent encapsulating the protective layer. The core comprises a substance incompatible with water, a first oily substance and a porous fine particle powder, and the protective layer contains a second oily substance. If it is, it will not restrict | limit in particular, It is a seamless capsule which can maintain stably the substance which has the relation of water and a combination contraindication.
また、本発明の三層構造シームレスカプセルの作製方法としては、コアと、前記コアを被包する保護層と、前記保護層を被包する皮膜層とを備えた三層構造シームレスカプセルの作製方法であって、
(a)水と配合禁忌の関係にある物質と第一油性物質と多孔性微粒子粉末とを含有するコア液を調製する工程;
(b)第二油性物質を含有する保護液を調製する工程;
(c)水溶性ゲル化剤と水とを含有する皮膜液を調製する工程;
(d)同心三重ノズルを用い、外側ノズルからは前記皮膜液を、内側ノズルからは前記コア液を、中間ノズルからは前記保護液を吐出させて三層液滴とし、かかる三層液滴を硬化液と接触させて皮膜液を硬化させる工程;
の工程(a)〜(d)を備えたことを特徴とする作製方法であれば特に制限されず、かかる作製方法により、水と配合禁忌の関係にある物質を安定的に維持することが可能な上記本発明の三層構造シームレスカプセルを作製することが可能となる。
Further, as a method for producing a three-layer structure seamless capsule of the present invention, a method for producing a three-layer seamless capsule comprising a core, a protective layer encapsulating the core, and a coating layer encapsulating the protective layer Because
(A) a step of preparing a core liquid containing a substance incompatible with water, a first oily substance, and a porous fine particle powder;
(B) preparing a protective liquid containing the second oily substance;
(C) a step of preparing a coating liquid containing a water-soluble gelling agent and water;
(D) Using a concentric triple nozzle, the coating liquid is discharged from the outer nozzle, the core liquid is discharged from the inner nozzle, and the protective liquid is discharged from the intermediate nozzle to form a three-layer liquid droplet. A step of curing the coating liquid by contacting with the curing liquid;
There is no particular limitation as long as it is a production method characterized by comprising the steps (a) to (d), and by this production method, it is possible to stably maintain a substance having a contraindicated relationship with water. Thus, it is possible to produce a three-layer structure seamless capsule of the present invention.
本発明の三層構造シームレスカプセルや、本発明の三層構造シームレスカプセルの作製方法(以下、総称して「本件発明」ともいう。)において、コアとしては、水と配合禁忌の関係にある物質と第一油性物質と多孔性微粒子粉末とを含有していれば特に制限されず、保護層によって被包されることによって皮膜層と隔離される。 In the three-layer structure seamless capsule of the present invention and the method for producing the three-layer structure seamless capsule of the present invention (hereinafter collectively referred to as “the present invention”), the core is a substance incompatible with water. And the first oily substance and the porous fine particle powder are not particularly limited, and are separated from the coating layer by being encapsulated by the protective layer.
上記水と配合禁忌の関係にある物質としては、水との接触により不安定となる物質であれば特に制限されないが、ビフィドバクテリアム・ロンガム、ビフィドバクテリアム・ビフィダムなどのビフィズス菌、スプレプトコックス・フェシウム、ラクトコックス・ラクチス亜種・ラクチス、ラクトバチルス・ヘルベティクス、ラクトバチルス・アシドフィルス、ラクトバチルス・カゼイなどの乳酸菌に例示される、水との接触により生育能力が低下する腸内細菌や、ビタミンB1、ビタミンB2、ビタミンB12、又はビタミンCなどの、水との接触により分解が生じるビタミンを挙げることができ、ビフィズス菌又は乳酸菌を好適に挙げることができる。 Substances that are incompatible with the above water are not particularly limited as long as they are unstable when contacted with water, but bifidobacteria such as Bifidobacterium longum and Bifidobacterium bifidum, spray Enterobacteria whose growth ability is reduced by contact with water, exemplified by lactic acid bacteria such as Ptocox fesium, Lactococcus lactis subspecies and lactis, Lactobacillus helvetics, Lactobacillus acidophilus, Lactobacillus casei In addition, vitamins such as vitamin B1, vitamin B2, vitamin B12, or vitamin C that are decomposed by contact with water can be mentioned, and bifidobacteria or lactic acid bacteria can be preferably mentioned.
本件発明において、多孔性微粒子粉末としては、粒子内部に多数の細孔を有するものであれば特に制限されず、気相法シリカや湿式法シリカなどの非晶質合成シリカ、アルミナ、アルミナ水和物、炭酸カルシウム、炭酸マグネシウム、二酸化チタンなどの公知の微粒子粉末を挙げることができるが、空隙率が高い観点から、好ましくは気相法シリカや湿式法シリカなどの非晶質合成シリカ、アルミナ又はアルミナ水和物、より好ましくは気相法シリカや湿式法シリカなどの非晶質合成シリカ、さらに好ましくは気相法シリカを挙げることができる。 In the present invention, the porous fine particle powder is not particularly limited as long as it has a large number of pores inside the particle, and amorphous synthetic silica such as vapor phase method silica and wet method silica, alumina, hydrated alumina From the viewpoint of high porosity, preferably amorphous synthetic silica such as gas phase method silica or wet method silica, alumina or Alumina hydrate, more preferably amorphous synthetic silica such as gas phase method silica and wet method silica, and more preferably gas phase method silica can be used.
非晶質合成シリカは、製造方法によって気相法シリカと湿式法シリカとその他のシリカに分類され、湿式法シリカは、更に製造方法によって沈降法シリカ、ゲル法シリカ、ゾル法シリカに分類される。 Amorphous synthetic silica is classified into vapor phase silica, wet method silica and other silicas according to the production method, and wet method silica is further classified into precipitation method silica, gel method silica and sol method silica according to the production method. .
気相法シリカは、湿式法に対して乾式法とも呼ばれ、一般的には火炎加水分解法によって作られる。具体的には四塩化ケイ素を水素及び酸素とともに燃焼して作る方法が一般的に知られているが、四塩化ケイ素の代わりにメチルトリクロロシランやトリクロロシランなどのシラン類も、単独又は四塩化ケイ素と混合した状態で使用することができる。気相法シリカとしてはアエロジル(登録商標)(日本アエロジル社製)や、レオロシール(登録商標)(トクヤマ社製)などの市販品を用いることができる。 Vapor phase silica is also called a dry method as opposed to a wet method, and is generally made by a flame hydrolysis method. Specifically, a method of making silicon tetrachloride by burning with hydrogen and oxygen is generally known, but silanes such as methyltrichlorosilane and trichlorosilane can be used alone or silicon tetrachloride instead of silicon tetrachloride. Can be used in a mixed state. Commercially available products such as Aerosil (registered trademark) (manufactured by Nippon Aerosil Co., Ltd.) and Leolosil (registered trademark) (manufactured by Tokuyama Corp.) can be used as the vapor phase silica.
沈降法シリカは、ケイ酸ソーダと硫酸をアルカリ条件で反応させて製造され、粒子成長したシリカ粒子が凝集・沈降し、その後濾過、水洗、乾燥、粉砕・分級の行程を経て製造される。沈降法シリカとしては、ニップシール(登録商標)(東ソー・シリカ社製)などの市販品を用いることができる。 Precipitated silica is produced by reacting sodium silicate and sulfuric acid under alkaline conditions, and the silica particles that have grown are agglomerated and settled, followed by filtration, washing with water, drying, pulverization and classification. Commercially available products such as NIPSEAL (registered trademark) (manufactured by Tosoh Silica Co., Ltd.) can be used as the precipitated silica.
ゲル法シリカは、ケイ酸ソーダと硫酸を酸性条件下で反応させて製造される。熟成中に微小粒子は溶解し、他の一次粒子同士を結合するように再析出するため、明確な一次粒子は消失し、内部空隙構造を有する比較的硬い凝集粒子を形成する。ゲル法シリカとしては、ニップジェル(登録商標)(東ソー・シリカ社製)やサイロイド(登録商標)、サイロジェット(登録商標)(グレースジャパン社製)などの市販品を用いることができる。 Gel silica is produced by reacting sodium silicate and sulfuric acid under acidic conditions. During the ripening, the fine particles dissolve and reprecipitate so as to bind other primary particles, so that the distinct primary particles disappear and form relatively hard aggregated particles having an internal void structure. Commercially available products such as Nipgel (registered trademark) (manufactured by Tosoh Silica), Cyloid (registered trademark), and Silojet (registered trademark) (produced by Grace Japan) can be used as the gel method silica.
ゾル法シリカは、コロイダルシリカとも呼ばれ、ケイ酸ソーダの酸などによる複分解やイオン交換樹脂層を通して得られるシリカゾルを加熱熟成して得られる。ゾル法シリカとしては、スノーテックス(登録商標)(日産化学工業社製)などの市販品を用いることができる。 The sol method silica is also called colloidal silica, and is obtained by heating and aging a silica sol obtained through metathesis of sodium silicate acid or the like through an ion exchange resin layer. Commercially available products such as Snowtex (registered trademark) (manufactured by Nissan Chemical Industries, Ltd.) can be used as the sol silica.
多孔性微粒子粉末の比表面積は40m2/g以上、好ましくは100〜500m2/gを挙げることができる。 The specific surface area of the porous fine particle powder is 40 m 2 / g or more, preferably 100 to 500 m 2 / g.
本件発明において、多孔性微粒子粉末を2種以上併用することもできる。例えば、粉砕した気相法シリカと湿式法シリカとの併用や、微粉砕した湿式法シリカとアルミナあるいはアルミナ水和物との併用や、気相法シリカとアルミナあるいはアルミナ水和物との併用が挙げられる。 In the present invention, two or more kinds of porous fine particle powders can be used in combination. For example, combined use of pulverized gas phase method silica and wet method silica, combination use of finely pulverized wet method silica and alumina or alumina hydrate, and combination use of gas phase method silica and alumina or alumina hydrate. Can be mentioned.
コアにおいて、第一油性物質100質量部に対して多孔性微粒子粉末を0.1〜20質量部、好ましくは1〜10質量部、より好ましくは2〜8質量部、さらに好ましくは3〜6質量部含有していることが好ましい。 In the core, 0.1 to 20 parts by mass, preferably 1 to 10 parts by mass, more preferably 2 to 8 parts by mass, and further preferably 3 to 6 parts by mass of the porous fine particle powder with respect to 100 parts by mass of the first oily substance. It is preferable to contain a part.
本件発明において、第一油性物質や第二油性物質における油性物質としては、硬化油、部分硬化油、サフラワー油、亜麻仁油、ゴマ油、オリーブ油、大豆油、からし油、ナタネ油、コーン油、ヒマシ油、月見草油、パーム核油、ホホバ油、綿実油、ヤシ油、落花生油、カカオ脂、ラード、ヘッド、EPA、DHA、サメ肝油、タラ肝油などの動植物油や、中鎖脂肪酸トリグリセリド(MCT)や、グリセリン脂肪酸エステルや、脂肪酸アシルエステルや、流動パラフィンなどから選択される1種又は2種以上を用いることができ、上記硬化油としては、硬化ヒマシ油、硬化大豆油、硬化菜種油、硬化ヤシ油、カカオ脂、硬化パーム核油、牛脂硬化油、豚脂硬化油を挙げることができる。 In the present invention, as the oily substance in the first oily substance or the second oily substance, hardened oil, partially hardened oil, safflower oil, linseed oil, sesame oil, olive oil, soybean oil, mustard oil, rapeseed oil, corn oil, Castor oil, evening primrose oil, palm kernel oil, jojoba oil, cottonseed oil, coconut oil, peanut oil, cacao butter, lard, head, EPA, DHA, shark liver oil, cod liver oil and other animal and vegetable oils and medium chain fatty acid triglycerides (MCT) Alternatively, one or more selected from glycerin fatty acid ester, fatty acid acyl ester, liquid paraffin, and the like can be used. As the hardened oil, hardened castor oil, hardened soybean oil, hardened rapeseed oil, hardened palm Examples thereof include oil, cacao butter, hydrogenated palm kernel oil, beef tallow hardened oil, and pork tallow hardened oil.
第一油性物質における油性物質と第二油性物質は同じ油性物質でも異なる油性物質でもよいが、第二油性物質は、第一油性物質に対して融点差が2℃以上であることや、第一油性物質より融点が2℃以上高いことが好ましい。第二油性物質として、第一油性物質に対して融点差が2℃以上である油性物質や、第一油性物質より融点が2℃以上高い油性物質を用いることで、一方の油性物質が他の油性物質よりも早く凝固し、第一油性物質と第二油性物質とが互いに溶け込むことをより防ぐことが可能となる。なお、硬化油などのように融点が一定の規格幅の温度である油性物質においては、一定の規格幅の温度における上限と下限の和の2分の1(中間)の温度を融点として採用する。 The oily substance and the second oily substance in the first oily substance may be the same oily substance or different oily substances, but the second oily substance has a melting point difference of 2 ° C. or more with respect to the first oily substance, It is preferable that the melting point is 2 ° C. or higher than the oily substance. As the second oily substance, an oily substance having a melting point difference of 2 ° C. or higher with respect to the first oily substance or an oily substance having a melting point of 2 ° C. higher than that of the first oily substance is used. It is possible to solidify faster than the oily substance and to prevent the first oily substance and the second oily substance from being dissolved into each other. In the case of an oily substance having a specified temperature range with a constant melting point, such as hardened oil, a temperature that is half the sum of the upper limit and the lower limit of the temperature with a specified range is used as the melting point. .
第一油性物質としては、硬化油を用いることが好ましく、融点が30〜60℃、好ましくは33〜37℃の硬化油を用いることがより好ましい。 As the first oily substance, it is preferable to use a hardened oil, and it is more preferable to use a hardened oil having a melting point of 30 to 60 ° C., preferably 33 to 37 ° C.
本件発明における上記コアやコア液、及び/又は上記保護層や保護液には、レシチンや各種界面活性剤、アルコール類などの界面活性を調整できる添加剤や、ショ糖酢酸イソ酪酸エステル(SAIB)などの比重調整剤や、ビタミンE、BHT、BHAに代表される抗酸化剤などを含有してもよい。 In the core and core liquid and / or the protective layer and protective liquid in the present invention, additives capable of adjusting the surface activity such as lecithin, various surfactants, alcohols, sucrose acetate isobutyrate (SAIB) Specific gravity adjusting agents such as vitamin E, BHT, and antioxidants typified by BHA may be contained.
本件発明において、水溶性ゲル化剤としては、ゼラチン、カラギーナン、寒天、ジェランガム、ファーセレラン、ユーケマ藻類、ペクチン、アルギン酸塩類、プルラン、グルコマンナン、アラビアゴム、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、ポリビニルピロリドン、ポリビニルアルコール、デンプン類などの親水性高分子から選択される1種又は2種以上を挙げることができ、ゼラチン、カラギーナン、寒天、ジェランガム、ファーセレラン、ユーケマ藻類といった、冷却によってゲル化する水溶性ゲル化剤を好適に挙げることができる。また、腸溶性カプセルとするためには、水溶性ゲル化剤としてゼラチン、ペクチン及びアルギン酸塩類から選ばれる二種以上を用いることができ、好ましくはゼラチン及びペクチンを用いることができる。 In the present invention, examples of the water-soluble gelling agent include gelatin, carrageenan, agar, gellan gum, fur celeran, aquatic algae, pectin, alginate, pullulan, glucomannan, gum arabic, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone, polyvinyl Water-soluble gelling agents that can be selected from hydrophilic polymers such as alcohols and starches, and gelatinize by cooling, such as gelatin, carrageenan, agar, gellan gum, farseleran, and yukema algae Can be preferably mentioned. In order to obtain an enteric capsule, two or more kinds selected from gelatin, pectin and alginates can be used as a water-soluble gelling agent, and gelatin and pectin can be preferably used.
さらに、本件発明における上記皮膜層や皮膜液には、グリセリンなどの可塑剤、リン酸ナトリウムなどのpH調整剤、クエン酸三ナトリウム、メタリン酸ナトリウムなどのキレート剤、乳酸カルシウム、塩化カリウムなどのゲル化促進剤、ポリグリセリン脂肪酸エステル、レシチンなどの界面活性剤、甘味料、香料、防腐剤、着色剤などを含有してもよい。なお、水溶性ゲル化剤と水とを含有する皮膜液を用いてシームレスカプセルを作製した場合の皮膜層には水が含まれる。 Further, the coating layer and the coating liquid in the present invention include plasticizers such as glycerin, pH adjusters such as sodium phosphate, chelating agents such as trisodium citrate and sodium metaphosphate, gels such as calcium lactate and potassium chloride. A surface active agent such as a crystallization accelerator, polyglycerin fatty acid ester, lecithin, sweetener, fragrance, preservative, colorant and the like may be contained. In addition, water is contained in the membrane | film | coat layer at the time of producing a seamless capsule using the membrane | film | coat liquid containing a water-soluble gelatinizer and water.
本発明の三層構造シームレスカプセルの作製方法において、水と配合禁忌の関係にある物質と第一油性物質と多孔性微粒子粉末とを含有するコア液を調製する方法としては、第一油性物質に水と配合禁忌の関係にある物質と多孔性微粒子粉末を加えて分散させる方法を挙げることができ、分散方法としては、人の手による撹拌に加え、プロペラ撹拌、タービン型撹拌、ホモミキサー型撹拌など、従来公知の方法を用いることができる。 In the method for producing a three-layer structure seamless capsule of the present invention, a method for preparing a core liquid containing a substance incompatible with water, a first oily substance, and a porous fine particle powder includes the first oily substance. Examples include a method of adding and dispersing a substance having a contraindicated relationship with water and a porous fine particle powder. As a dispersion method, in addition to stirring by human hands, propeller stirring, turbine stirring, homomixer stirring For example, a conventionally known method can be used.
本発明の三層構造シームレスカプセルの作製方法における硬化液としては、水溶性ゲル化剤と水とを含有する皮膜液に触れることで水溶性ゲル化剤と水とを含有する皮膜液を硬化させる液であれば特に制限されず、例えば冷却によってゲル化する水溶性ゲル化剤を用いる場合には、皮膜液との界面張力を生ずるMCT、流動パラフィン、大豆油、オリーブ油、サフラワー油などの植物油を含有する疎水性液体を挙げることができる。なお、例えばペクチンやアルギン酸塩など、カルシウムイオンと反応してゲル化するゲル化剤を採用する場合には、カプセル形成後に、カルシウム水溶液などのゲル化助剤に浸漬することで水溶性ゲル化剤のゲル化を強化することも可能である。 As the hardening liquid in the method for producing a three-layer structure seamless capsule of the present invention, the film liquid containing the water-soluble gelling agent and water is cured by touching the film liquid containing the water-soluble gelling agent and water. If it uses a water-soluble gelling agent that gels by cooling, for example, vegetable oils such as MCT, liquid paraffin, soybean oil, olive oil, safflower oil that produce interfacial tension with the coating liquid are used. Can be mentioned. In addition, when adopting a gelling agent that reacts with calcium ions and gels, such as pectin and alginate, for example, a water-soluble gelling agent is formed by immersing in a gelling aid such as a calcium aqueous solution after capsule formation. It is also possible to reinforce the gelation.
(三層構造シームレスカプセルの作製)
同心三重ノズル(富士カプセル社製)を用い、最も外側のノズルからは表1に示す組成からなる皮膜液を、最も内側のノズルからは表2に示す組成からなるコア液を、中間のノズルからは表3に示す組成からなる保護液を吐出させて三層液滴とし、かかる三層液滴をMCTからなる硬化液と接触させて皮膜液を硬化させることにより、コアと、前記コアを被包する保護層と、前記保護層を被包する皮膜層とを備えた三層構造シームレスカプセル(実施品)を作製した。得られた三層構造シームレスカプセル(実施品)の構造を図1に示す。比較例として、表2に代わって表4に示す組成(アエロジルなし)からなるコア液を用いたカプセル(比較品)を上記と同様に作製した。なお、比較品については核と皮膜層との間に界面が生じず、三層構造とならなかった。
(Production of three-layer structure seamless capsule)
Using a concentric triple nozzle (manufactured by Fuji Capsule Co., Ltd.), from the outermost nozzle, the coating liquid having the composition shown in Table 1, and from the innermost nozzle, the core liquid having the composition shown in Table 2 is passed from the intermediate nozzle. Is a three-layer droplet by discharging a protective liquid having the composition shown in Table 3, and the coating liquid is cured by bringing the three-layer droplet into contact with a curable liquid composed of MCT. A three-layer structure seamless capsule (implemented product) comprising a protective layer to be wrapped and a film layer to encapsulate the protective layer was produced. The structure of the obtained three-layer structure seamless capsule (implemented product) is shown in FIG. As a comparative example, a capsule (comparative product) using a core liquid having a composition (without aerosil) shown in Table 4 instead of Table 2 was prepared in the same manner as described above. The comparative product did not have an interface between the core and the coating layer, and did not have a three-layer structure.
(ビフィズス菌の生存率)
ビフィズス菌は水との接触により生育能力が低下することや、死滅することが知られている。そこで、作製したカプセルに含まれるビフィズス菌の生菌数を測定し、コアと皮膜層が保護層によって隔離され、ビフィズス菌と水との接触が抑制されているかを調べた。
(Bifidobacteria survival rate)
It is known that bifidobacteria are reduced in growth ability or killed by contact with water. Therefore, the viable count of bifidobacteria contained in the prepared capsule was measured, and it was examined whether the core and the coating layer were isolated by the protective layer, and contact between the bifidobacteria and water was suppressed.
上記の方法で作製した実施品及び比較品において、カプセル作製直後(初期値)、35℃で4週間、及び35℃で8週間保存後にビフィズス菌の生菌数を測定し、35℃で4週間、35℃で8週間保存後のビフィズス菌の生菌数を三層構造シームレスカプセル作製直後の生菌数(初期値)で割った値の百分率を表5に示す。生菌数の測定は、はっ酵乳・乳酸菌飲料中のビフィズス菌の菌数測定法(社団法人全国はっ酵乳乳酸菌飲料協会冊子(2000))に記載の方法に準じて行った。 In the manufactured product and the comparative product prepared by the above method, immediately after capsule production (initial value), the viable count of bifidobacteria was measured after storage at 35 ° C. for 4 weeks and at 35 ° C. for 8 weeks, and at 35 ° C. for 4 weeks. Table 5 shows the percentage of the value obtained by dividing the viable count of bifidobacteria after storage at 35 ° C. for 8 weeks by the viable count (initial value) immediately after preparation of the three-layer structure seamless capsule. The number of viable bacteria was measured according to the method described in the method for measuring the number of bifidobacteria in fermented milk and lactic acid bacteria beverages (National Fermented Milk Lactic Acid Beverage Association Booklet (2000)).
表5に示すように、実施品(アエロジルあり)では35℃で8週間保存しても生菌数が82%と高かったが、比較品(アエロジルなし)では、35℃4週間保存で26%、35℃8週間ではわずか5%であった。したがって、本発明の三層構造シームレスカプセルは、コアと皮膜層が保護層によって隔離され、ビフィズス菌と水との接触が抑制されることにより、ビフィズス菌を安定的に維持可能であることが明らかとなった。 As shown in Table 5, the viable cell count was as high as 82% even when stored for 8 weeks at 35 ° C. in the product (with Aerosil), but it was 26% when stored for 4 weeks at 35 ° C. in the comparative product (without Aerosil). It was only 5% at 35 ° C for 8 weeks. Therefore, it is clear that the three-layer structure seamless capsule of the present invention can stably maintain bifidobacteria by separating the core and the coating layer by the protective layer and suppressing the contact between bifidobacteria and water. It became.
(三層構造シームレスカプセルの三次元表示画像)
上記の方法で作製した三層構造シームレスカプセル(実施品)を35℃で4週間保存後に、モリブデンターゲットによるラング法(透過法)による観察を行い、三次元表示画像を高分解能3DX線顕微鏡「NANO3DX」(リガク社製)によって得た。得られた三次元表示画像を図2に示す。
(Three-dimensional display image of three-layer structure seamless capsule)
After the three-layer structure seamless capsule (product) produced by the above method is stored at 35 ° C. for 4 weeks, it is observed by a Lange method (transmission method) using a molybdenum target, and a three-dimensional display image is displayed on a high-resolution 3DX-ray microscope “NANO3DX”. (Obtained by Rigaku Corporation). The obtained three-dimensional display image is shown in FIG.
図2に示すように、作製した三層構造シームレスカプセルにおいて、コアと保護層、保護層と皮膜層とが混ざることなくきれいに凝固し、保護層によってコアと皮膜層が完全に隔離されていることが明らかとなった。 As shown in FIG. 2, in the prepared three-layer structure seamless capsule, the core and the protective layer, the protective layer and the coating layer are solidified without mixing, and the core and the coating layer are completely separated by the protective layer. Became clear.
また、三次元表示画像に用いた三層構造シームレスカプセル(実施品:N=10)の核、保護層、皮膜層、総カプセルの平均質量はそれぞれ67、46、25、138mgであり、カプセル粒径は6.5mmであった。 In addition, the average mass of the core, protective layer, coating layer, and total capsule of the three-layer structure seamless capsule (practical product: N = 10) used for the three-dimensional display image is 67, 46, 25, and 138 mg, respectively. The diameter was 6.5 mm.
(三層構造シームレスカプセルの崩壊試験)
上記の方法で作製した実施品の崩壊試験を文献(第16改正日本薬局方解説書 東京広川書店刊行 B589(2011))に記載の方法に準じて行った。崩壊試験第一液を用いた試験、崩壊試験第二液を用いた試験をそれぞれ18個の三層構造シームレスカプセルについて行った。
(Disintegration test of three-layer structure seamless capsule)
The disintegration test of the implementation goods produced by said method was done according to the method as described in literature (The 16th revision Japanese Pharmacopoeia explanation book Tokyo Hirokawa Shoten publication B589 (2011)). A test using the first liquid for the disintegration test and a test using the second liquid for the disintegration test were performed on each of the 18 three-layer seamless capsules.
崩壊試験第一液を用いた試験により、120分後にも18個の三層構造シームレスカプセル全てにおいて崩壊はみられなかった。一方、崩壊試験第二液を用いた試験により、20分後には18個の三層構造シームレスカプセルがすべて崩壊した。したがって、上記記載のゼラチンとペクチンを用いた本発明の三層構造シームレスカプセルは、腸溶性を有するカプセルであることが明らかとなった。 According to the test using the first disintegration test, no disintegration was observed in all the 18 three-layer seamless capsules even after 120 minutes. On the other hand, in the test using the second liquid for the disintegration test, all of the 18 three-layer seamless capsules disintegrated after 20 minutes. Therefore, it was revealed that the three-layer structure seamless capsule of the present invention using the gelatin and pectin described above is an enteric capsule.
(参考例)
10℃に冷却した融点−5℃以下のMCTに、40℃以上に加温した融点が35℃の硬化油を滴下した。その結果、硬化油とMCTとの間に界面が生じず、硬化油が瞬時にMCT中に溶け込んだ(図示なし)。
(Reference example)
A hardened oil having a melting point of 35 ° C. heated to 40 ° C. or higher was added dropwise to MCT having a melting point of −5 ° C. or lower cooled to 10 ° C. As a result, no interface was formed between the hardened oil and MCT, and the hardened oil instantly dissolved in MCT (not shown).
一方、上記硬化油にアエロジルを分散したものを、40℃以上に加温した状態で、10℃に冷却した上記MCTに滴下したところ、図3に示すように硬化油がMCT中に溶解することなく球状を保ち、図4に示すように融点以下に硬化油が冷却されることによって球状を保ったまま固化した。なお、図3において、滴下した直後の硬化油は透明であるため、硬化油の位置を矢印で示した。したがって、アエロジルを分散した硬化油とMCTは界面を生ずることが確認された。 On the other hand, when the oil hardened in the above-mentioned hardened oil is added to the MCT cooled to 10 ° C. while being heated to 40 ° C. or higher, the hardened oil dissolves in the MCT as shown in FIG. As shown in FIG. 4, the hardened oil was cooled below the melting point and solidified while keeping the spherical shape. In addition, in FIG. 3, since the hardened oil immediately after dripping is transparent, the position of the hardened oil was shown by the arrow. Therefore, it was confirmed that the hardened oil in which Aerosil was dispersed and MCT formed an interface.
本発明の三層構造シームレスカプセルは、医薬、医薬部外品、食品などの分野において、水と配合禁忌の関係にある物質を安定に保持できるカプセル製剤として利用可能である。 The three-layer structure seamless capsule of the present invention can be used as a capsule preparation that can stably hold a substance incompatible with water in the fields of pharmaceuticals, quasi drugs, foods and the like.
Claims (11)
(a)ビフィズス菌、乳酸菌、ビタミンB1、ビタミンB2、ビタミンB12、又はビタミンCから選ばれる水と配合禁忌の関係にある物質と第一油性物質と多孔性微粒子粉末とを含有するコア液を調製する工程;
(b)第二油性物質を含有する保護液を調製する工程;
(c)水溶性ゲル化剤と水とを含有する皮膜液を調製する工程;
(d)同心三重ノズルを用い、外側ノズルからは前記皮膜液を、内側ノズルからは前記コア液を、中間ノズルからは前記保護液を吐出させて三層液滴とし、かかる三層液滴を硬化液と接触させて皮膜液を硬化させる工程;
A method for producing a three-layer structure seamless capsule comprising a core, a protective layer encapsulating the core, and a coating layer encapsulating the protective layer, comprising the following steps (a) to (d): A manufacturing method characterized by the above.
(A) A core liquid containing a substance selected from bifidobacteria, lactic acid bacteria, vitamin B1, vitamin B2, vitamin B12, or vitamin C , a substance having a contraindicated relationship with the water, a first oily substance, and a porous fine particle powder is prepared. The step of:
(B) preparing a protective liquid containing the second oily substance;
(C) a step of preparing a coating liquid containing a water-soluble gelling agent and water;
(D) Using a concentric triple nozzle, the coating liquid is discharged from the outer nozzle, the core liquid is discharged from the inner nozzle, and the protective liquid is discharged from the intermediate nozzle to form a three-layer liquid droplet. A step of curing the coating liquid by contacting with the curing liquid;
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WO2019111398A1 (en) * | 2017-12-08 | 2019-06-13 | 森下仁丹株式会社 | Trilayer-structure capsule comprising non-hydrogenated fat and oil, and manufacturing method therefor |
KR102280148B1 (en) * | 2018-12-04 | 2021-07-21 | 주식회사 케이티앤지 | Triple capsule and Method and Apparatus for manufacturing thereof |
CA3139731A1 (en) * | 2019-06-14 | 2020-12-17 | Takehiro Nishikawa | Delayed disintegration-type capsule and method for producing same |
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