JP6420314B2 - Ｍｅｔａｐ２阻害剤及び肥満症の治療方法 - Google Patents

Ｍｅｔａｐ２阻害剤及び肥満症の治療方法 Download PDF

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JP6420314B2
JP6420314B2 JP2016507631A JP2016507631A JP6420314B2 JP 6420314 B2 JP6420314 B2 JP 6420314B2 JP 2016507631 A JP2016507631 A JP 2016507631A JP 2016507631 A JP2016507631 A JP 2016507631A JP 6420314 B2 JP6420314 B2 JP 6420314B2
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glycine
pharmaceutical composition
compound
certain embodiments
obesity
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JP2016519106A5 (enExample
JP2016519106A (ja
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エス．ピーターソン ジョン
エス．ピーターソン ジョン
シャナハン ジェイムズ
シャナハン ジェイムズ
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シンデブルックス，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016507631A 2013-04-10 2014-04-09 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法 Active JP6420314B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361810468P 2013-04-10 2013-04-10
US61/810,468 2013-04-10
US201461925918P 2014-01-10 2014-01-10
US61/925,918 2014-01-10
PCT/US2014/033476 WO2014169026A1 (en) 2013-04-10 2014-04-09 Metap2 inhibitors and methods of treating obesity

Related Child Applications (1)

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JP2018192578A Division JP2019023219A (ja) 2013-04-10 2018-10-11 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法

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JP2016519106A JP2016519106A (ja) 2016-06-30
JP2016519106A5 JP2016519106A5 (enExample) 2017-04-13
JP6420314B2 true JP6420314B2 (ja) 2018-11-07

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JP2016507631A Active JP6420314B2 (ja) 2013-04-10 2014-04-09 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法
JP2018192578A Pending JP2019023219A (ja) 2013-04-10 2018-10-11 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法
JP2021043481A Pending JP2021091738A (ja) 2013-04-10 2021-03-17 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法
JP2023061783A Active JP7681054B2 (ja) 2013-04-10 2023-04-05 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法
JP2025078682A Pending JP2025109807A (ja) 2013-04-10 2025-05-09 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法

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JP2018192578A Pending JP2019023219A (ja) 2013-04-10 2018-10-11 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法
JP2021043481A Pending JP2021091738A (ja) 2013-04-10 2021-03-17 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法
JP2023061783A Active JP7681054B2 (ja) 2013-04-10 2023-04-05 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法
JP2025078682A Pending JP2025109807A (ja) 2013-04-10 2025-05-09 Ｍｅｔａｐ２阻害剤及び肥満症の治療方法

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US (8) US9173956B2 (enExample)
EP (2) EP3574922B1 (enExample)
JP (5) JP6420314B2 (enExample)
CN (2) CN105431426A (enExample)
AU (1) AU2014250983B2 (enExample)
BR (1) BR112015025892A2 (enExample)
CA (1) CA2908993C (enExample)
DK (2) DK2984085T3 (enExample)
EA (1) EA033912B1 (enExample)
ES (2) ES2749746T3 (enExample)
MX (2) MX371095B (enExample)
WO (1) WO2014169026A1 (enExample)

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CN114656371B (zh) * 2020-09-14 2024-03-12 广州药本君安医药科技股份有限公司 1,4-环己二胺桥连化合物及在制备治疗糖代谢紊乱疾病的药物中的应用
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US20200155545A1 (en) 2020-05-21
EP3574922A1 (en) 2019-12-04
EA033912B1 (ru) 2019-12-09
EP2984085A4 (en) 2016-12-07
CN105431426A (zh) 2016-03-23
US20170028014A1 (en) 2017-02-02
MX2015014329A (es) 2016-06-21
JP2019023219A (ja) 2019-02-14
US20160346244A1 (en) 2016-12-01
AU2014250983B2 (en) 2019-04-11
US20170326135A1 (en) 2017-11-16
MX386958B (es) 2025-03-19
EP2984085B1 (en) 2019-07-17
JP2025109807A (ja) 2025-07-25
US10010544B2 (en) 2018-07-03
JP2023082195A (ja) 2023-06-13
US9750737B2 (en) 2017-09-05
US11304944B2 (en) 2022-04-19
ES2902082T3 (es) 2022-03-24
CA2908993C (en) 2023-05-23
MX371095B (es) 2020-01-16
JP7681054B2 (ja) 2025-05-21
DK2984085T3 (da) 2019-10-21
US20150374657A1 (en) 2015-12-31
US20230048989A1 (en) 2023-02-16
US9757373B2 (en) 2017-09-12
US20140308235A1 (en) 2014-10-16
HK1216313A1 (en) 2016-11-04
BR112015025892A2 (pt) 2017-07-25
EP2984085A1 (en) 2016-02-17
EA201591943A1 (ru) 2016-07-29
WO2014169026A1 (en) 2014-10-16
US10588904B2 (en) 2020-03-17
US20180271856A1 (en) 2018-09-27
US9433600B2 (en) 2016-09-06
JP2021091738A (ja) 2021-06-17
US9173956B2 (en) 2015-11-03
JP2016519106A (ja) 2016-06-30
CN112494476A (zh) 2021-03-16
CA2908993A1 (en) 2014-10-16
AU2014250983A1 (en) 2015-10-29
DK3574922T3 (da) 2021-12-06
EP3574922B1 (en) 2021-09-15
ES2749746T3 (es) 2020-03-23

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