JP6417401B2 - Ａｃｃ阻害剤及びその使用 - Google Patents
Ａｃｃ阻害剤及びその使用 Download PDFInfo
- Publication number
- JP6417401B2 JP6417401B2 JP2016513082A JP2016513082A JP6417401B2 JP 6417401 B2 JP6417401 B2 JP 6417401B2 JP 2016513082 A JP2016513082 A JP 2016513082A JP 2016513082 A JP2016513082 A JP 2016513082A JP 6417401 B2 JP6417401 B2 JP 6417401B2
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- JP
- Japan
- Prior art keywords
- compound
- sulfur
- membered
- nitrogen
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC**(C12)*(C)*C1*(C*)C(C)(*)[*@@](C(C)C)C2=NC Chemical compound CC**(C12)*(C)*C1*(C*)C(C)(*)[*@@](C(C)C)C2=NC 0.000 description 8
- PGQBDBZXFDIDSF-QFIPXVFZSA-N CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)OC1CCOCC1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=S Chemical compound CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)OC1CCOCC1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=S PGQBDBZXFDIDSF-QFIPXVFZSA-N 0.000 description 1
- GNTNTDQHLHMQLW-QFIPXVFZSA-N CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)OC1CCOCC1)c1c2cc(-c3ncc[o]3)[s]1)C2=O Chemical compound CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)OC1CCOCC1)c1c2cc(-c3ncc[o]3)[s]1)C2=O GNTNTDQHLHMQLW-QFIPXVFZSA-N 0.000 description 1
- HCKYPVIFCJOLSN-QFIPXVFZSA-N CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)Oc1ccncc1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=O Chemical compound CC(C)(C(O)=O)N(C=C(C[C@@H](c(cccc1)c1OC)Oc1ccncc1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=O HCKYPVIFCJOLSN-QFIPXVFZSA-N 0.000 description 1
- VLJUWKAIITYRLU-FQEVSTJZSA-N CC(C)(C(O)=O)N(C=C(C[C@@H](c(nccc1)c1OC)OC1CCOCC1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=O Chemical compound CC(C)(C(O)=O)N(C=C(C[C@@H](c(nccc1)c1OC)OC1CCOCC1)c1c2c(C)c(-c3ncc[o]3)[s]1)C2=O VLJUWKAIITYRLU-FQEVSTJZSA-N 0.000 description 1
- NKSGOUWLHFXUOX-SFHVURJKSA-N CC(C)O[C@@H](CC(c1c2c(C)c(C(F)(F)F)[s]1)=CN(C(C)(C)C(O)=O)C2=O)c(cccc1)c1OC Chemical compound CC(C)O[C@@H](CC(c1c2c(C)c(C(F)(F)F)[s]1)=CN(C(C)(C)C(O)=O)C2=O)c(cccc1)c1OC NKSGOUWLHFXUOX-SFHVURJKSA-N 0.000 description 1
- YPLYEGSFNIDVEN-KRWDZBQOSA-N CC(C)O[C@@H](CC(c1c2nc(-c3ncc[o]3)[o]1)=CN(CC(O)=O)C2=O)c(cccc1)c1OC Chemical compound CC(C)O[C@@H](CC(c1c2nc(-c3ncc[o]3)[o]1)=CN(CC(O)=O)C2=O)c(cccc1)c1OC YPLYEGSFNIDVEN-KRWDZBQOSA-N 0.000 description 1
- CACAWMGYQDAERJ-HNNXBMFYSA-N CC(C)O[C@@H](CN(c1c(C(N2CC(O)=O)=O)nc(-[n]3nccn3)[s]1)C2=O)c1ccccc1OC Chemical compound CC(C)O[C@@H](CN(c1c(C(N2CC(O)=O)=O)nc(-[n]3nccn3)[s]1)C2=O)c1ccccc1OC CACAWMGYQDAERJ-HNNXBMFYSA-N 0.000 description 1
- IGBQUNUUPTVHAU-QHCPKHFHSA-N Cc1c(-c2ncc[o]2)[s]c(C(C[C@@H](c(cccc2)c2OC)OC2CCOCC2)=CN2CCC#N)c1C2=O Chemical compound Cc1c(-c2ncc[o]2)[s]c(C(C[C@@H](c(cccc2)c2OC)OC2CCOCC2)=CN2CCC#N)c1C2=O IGBQUNUUPTVHAU-QHCPKHFHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361821824P | 2013-05-10 | 2013-05-10 | |
| US61/821,824 | 2013-05-10 | ||
| PCT/US2014/037360 WO2014182943A1 (en) | 2013-05-10 | 2014-05-08 | Acc inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526024A JP2016526024A (ja) | 2016-09-01 |
| JP2016526024A5 JP2016526024A5 (https=) | 2017-07-06 |
| JP6417401B2 true JP6417401B2 (ja) | 2018-11-07 |
Family
ID=51867752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513082A Active JP6417401B2 (ja) | 2013-05-10 | 2014-05-08 | Ａｃｃ阻害剤及びその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9988399B2 (https=) |
| EP (1) | EP2994138A4 (https=) |
| JP (1) | JP6417401B2 (https=) |
| KR (1) | KR20160007598A (https=) |
| CN (1) | CN105358152A (https=) |
| AR (1) | AR096241A1 (https=) |
| AU (1) | AU2014262636A1 (https=) |
| BR (1) | BR112015028171A8 (https=) |
| CA (1) | CA2911926A1 (https=) |
| CL (1) | CL2015003314A1 (https=) |
| EA (1) | EA201591959A1 (https=) |
| HK (2) | HK1221410A1 (https=) |
| MX (1) | MX2015015417A (https=) |
| WO (1) | WO2014182943A1 (https=) |
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| LT2776038T (lt) * | 2011-11-11 | 2018-04-25 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
| AU2014262547A1 (en) | 2013-05-10 | 2015-11-26 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| CA2911818A1 (en) | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
| MX2015015422A (es) | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
| EP3670496A3 (en) | 2013-10-17 | 2020-09-30 | Shionogi&Co., Ltd. | Acc2 inhibitors |
| JP2018501276A (ja) * | 2015-01-09 | 2018-01-18 | ギリアド アポロ， エルエルシー | 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法 |
| UY36586A (es) | 2015-03-26 | 2016-10-31 | Bayer Pharma AG | Heterociclilmetiltienouracilos y uso de los mismos |
| AR106472A1 (es) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| CA3004796C (en) * | 2015-11-25 | 2023-11-14 | Gilead Apollo, Llc | Pyrazole acc inhibitors and uses thereof |
| EP3380479B1 (en) | 2015-11-25 | 2022-12-07 | Gilead Apollo, LLC | Triazole acc inhibitors and uses thereof |
| HUE053175T2 (hu) | 2015-11-25 | 2021-06-28 | Gilead Apollo Llc | ACC-gátló észterek és azok alkalmazása |
| BR112018009212B1 (pt) | 2015-11-25 | 2022-06-14 | Gilead Apollo, Llc | Método para controlar patógenos fúngicos agrícolas |
| CN119977993A (zh) | 2016-03-02 | 2025-05-13 | 吉利德阿波罗公司 | 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法 |
| WO2018041771A1 (de) | 2016-09-02 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung |
| WO2018054846A1 (de) | 2016-09-23 | 2018-03-29 | Bayer Aktiengesellschaft | N3-cyclisch substituierte thienouracile und ihre verwendung |
| CN108341830B (zh) | 2017-01-22 | 2021-03-02 | 广东东阳光药业有限公司 | 噻吩并嘧啶衍生物及其在药物中的应用 |
| CN110431144B (zh) | 2017-03-24 | 2022-08-05 | 浙江海正药业股份有限公司 | 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| WO2018171698A1 (zh) * | 2017-03-24 | 2018-09-27 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| PT3600309T (pt) | 2017-03-28 | 2022-10-03 | Gilead Sciences Inc | Combinações terapêuticas para o tratamento de doenças hepáticas |
| US11680070B2 (en) | 2018-06-05 | 2023-06-20 | Medshine Discovery Inc. | Thieno[2,3-c]pyridazin-4(1H)-one derivative and application thereof |
| CA3119925A1 (en) * | 2018-11-20 | 2020-05-28 | The National Institutes Of Pharmaceutical Research And Development (Nip) | Spiro compound and medical uses thereof |
| US20220152164A1 (en) * | 2019-03-22 | 2022-05-19 | Kallyope, Inc. | Gpcr combination therapies |
| EP3995498A4 (en) | 2019-07-02 | 2023-03-01 | Sunshine Lake Pharma Co., Ltd. | THIENOPYRIMIDI DERIVATIVES WITH STEREO CONFIGURATION AND THEIR USE IN MEDICINE |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| JP7198968B2 (ja) * | 2019-12-05 | 2023-01-04 | ▲ザン▼州片仔▲ファン▼薬業股▲フン▼有限公司 | チエノ［２，３－ｃ］ピリダジン－４（１Ｈ）－オン系化合物の結晶形及びその製造方法並びに使用 |
| US11578081B1 (en) | 2019-12-05 | 2023-02-14 | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. | Crystal form as inhibitor of ACC1 and ACC2, and preparation method therefor and use thereof |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| CN111793566B (zh) * | 2020-07-31 | 2021-11-16 | 南京林业大学 | 一种杉木内生真菌及其生物防治应用 |
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| US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
| LT2776038T (lt) * | 2011-11-11 | 2018-04-25 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
| CA2911818A1 (en) * | 2013-05-10 | 2014-11-13 | Nimbus Apollo, Inc. | Acc inhibitors and uses thereof |
| MX2015015422A (es) | 2013-05-10 | 2016-06-21 | Nimbus Apollo Inc | Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos. |
| AU2014262547A1 (en) | 2013-05-10 | 2015-11-26 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
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- 2014-05-08 HK HK16109586.3A patent/HK1221410A1/zh unknown
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- 2014-05-08 CN CN201480036133.2A patent/CN105358152A/zh active Pending
- 2014-05-08 WO PCT/US2014/037360 patent/WO2014182943A1/en not_active Ceased
- 2014-05-08 BR BR112015028171A patent/BR112015028171A8/pt not_active Application Discontinuation
- 2014-05-08 US US14/890,308 patent/US9988399B2/en active Active
- 2014-05-08 EP EP14795076.0A patent/EP2994138A4/en not_active Withdrawn
- 2014-05-08 MX MX2015015417A patent/MX2015015417A/es unknown
- 2014-05-08 CA CA2911926A patent/CA2911926A1/en not_active Abandoned
- 2014-05-08 KR KR1020157035041A patent/KR20160007598A/ko not_active Withdrawn
- 2014-05-08 JP JP2016513082A patent/JP6417401B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| BR112015028171A8 (pt) | 2017-08-22 |
| AU2014262636A1 (en) | 2015-11-26 |
| US9988399B2 (en) | 2018-06-05 |
| EP2994138A1 (en) | 2016-03-16 |
| HK1221659A1 (zh) | 2017-06-09 |
| BR112015028171A2 (pt) | 2017-07-25 |
| CA2911926A1 (en) | 2014-11-13 |
| HK1221410A1 (zh) | 2017-06-02 |
| WO2014182943A1 (en) | 2014-11-13 |
| AR096241A1 (es) | 2015-12-16 |
| KR20160007598A (ko) | 2016-01-20 |
| JP2016526024A (ja) | 2016-09-01 |
| EA201591959A1 (ru) | 2016-03-31 |
| US20160108060A1 (en) | 2016-04-21 |
| CN105358152A (zh) | 2016-02-24 |
| MX2015015417A (es) | 2016-06-21 |
| CL2015003314A1 (es) | 2016-07-15 |
| EP2994138A4 (en) | 2016-12-28 |
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