JP6412499B2 - 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法 - Google Patents

数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法 Download PDF

Info

Publication number
JP6412499B2
JP6412499B2 JP2015535867A JP2015535867A JP6412499B2 JP 6412499 B2 JP6412499 B2 JP 6412499B2 JP 2015535867 A JP2015535867 A JP 2015535867A JP 2015535867 A JP2015535867 A JP 2015535867A JP 6412499 B2 JP6412499 B2 JP 6412499B2
Authority
JP
Japan
Prior art keywords
patient
model
dosing
response
predicted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015535867A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016500866A5 (enExample
JP2016500866A (ja
Inventor
ダイアン モールド，
ダイアン モールド，
Original Assignee
ダイアン モールド
ダイアン モールド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ダイアン モールド, ダイアン モールド filed Critical ダイアン モールド
Publication of JP2016500866A publication Critical patent/JP2016500866A/ja
Publication of JP2016500866A5 publication Critical patent/JP2016500866A5/ja
Application granted granted Critical
Publication of JP6412499B2 publication Critical patent/JP6412499B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00—Computing arrangements based on specific mathematical models
    • G06N7/01—Probabilistic graphical models, e.g. probabilistic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Databases & Information Systems (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Algebra (AREA)
  • Probability & Statistics with Applications (AREA)
  • General Engineering & Computer Science (AREA)
  • Computing Systems (AREA)
  • Pure & Applied Mathematics (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
  • Evolutionary Computation (AREA)
  • Computational Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mathematical Physics (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015535867A 2012-10-05 2013-10-07 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法 Active JP6412499B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261710330P 2012-10-05 2012-10-05
US61/710,330 2012-10-05
PCT/US2013/063691 WO2014055978A1 (en) 2012-10-05 2013-10-07 System and method for providing patient-specific dosing as a function of mathematical models

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018183803A Division JP6653365B2 (ja) 2012-10-05 2018-09-28 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法

Publications (3)

Publication Number Publication Date
JP2016500866A JP2016500866A (ja) 2016-01-14
JP2016500866A5 JP2016500866A5 (enExample) 2016-11-24
JP6412499B2 true JP6412499B2 (ja) 2018-10-24

Family

ID=50433375

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2015535867A Active JP6412499B2 (ja) 2012-10-05 2013-10-07 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
JP2018183803A Active JP6653365B2 (ja) 2012-10-05 2018-09-28 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
JP2020010887A Withdrawn JP2020080161A (ja) 2012-10-05 2020-01-27 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
JP2022094292A Active JP7632886B2 (ja) 2012-10-05 2022-06-10 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
JP2024178764A Pending JP2024180539A (ja) 2012-10-05 2024-10-11 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2018183803A Active JP6653365B2 (ja) 2012-10-05 2018-09-28 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
JP2020010887A Withdrawn JP2020080161A (ja) 2012-10-05 2020-01-27 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
JP2022094292A Active JP7632886B2 (ja) 2012-10-05 2022-06-10 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
JP2024178764A Pending JP2024180539A (ja) 2012-10-05 2024-10-11 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法

Country Status (9)

Country Link
US (6) US10083400B2 (enExample)
EP (2) EP2904388B1 (enExample)
JP (5) JP6412499B2 (enExample)
KR (3) KR102370479B1 (enExample)
AU (4) AU2013326801A1 (enExample)
CA (1) CA2887072C (enExample)
IL (3) IL238115B (enExample)
SG (2) SG10201907682RA (enExample)
WO (1) WO2014055978A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9238100B2 (en) 2012-06-07 2016-01-19 Tandem Diabetes Care, Inc. Device and method for training users of ambulatory medical devices
EP2904388B1 (en) 2012-10-05 2023-06-07 Diane R. Mould System and method for providing patient-specific dosing as a function of mathematical models
US9238144B2 (en) * 2013-03-14 2016-01-19 Neuropace, Inc. Optimizing data retrieval from an active implantable medical device
EP3082848B1 (en) * 2013-12-06 2023-10-18 Bioverativ Therapeutics Inc. Population pharmacokinetics tools and uses thereof
US9667321B2 (en) * 2014-10-31 2017-05-30 Pearson Education, Inc. Predictive recommendation engine
EP3213232A1 (en) 2014-10-30 2017-09-06 Pearson Education, Inc. Content database generation
ITMI20142149A1 (it) * 2014-12-16 2016-06-16 L I A Di Giuseppe Capasso Apparato di diagnosi differenziale in medicina adattato per determinare la sequenza di test ottimale atta ad identificare una patologia secondo criteri di appropriatezza diagnostica
EP3271718A4 (en) * 2015-03-18 2018-11-14 The Regents of the University of California Phenotypic personalized medicine: adaptive optimization of patient-specific combination therapy
SG10202009369SA (en) * 2015-04-09 2020-10-29 Diane Mould Systems and methods for patient-specific dosing
WO2017146067A1 (ja) * 2016-02-26 2017-08-31 株式会社豊崎会計事務所 情報処理装置
SG11201808475XA (en) * 2016-04-15 2018-10-30 Baxalta Inc Method and apparatus for providing a pharmacokinetic drug dosing regiment
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
GB201708624D0 (en) * 2017-05-31 2017-07-12 Sensidose Ab System for evaluating dosage parameters
US20190065684A1 (en) * 2017-08-24 2019-02-28 Fitmylife Health Analytics Inc. Computer program products, methods, and systems for assisting a user to achieve a health-related goal
EP3732690A1 (en) * 2017-08-30 2020-11-04 Koninklijke Philips N.V. Coronary artery health state prediction based on a model and imaging data
US10803540B2 (en) 2018-03-14 2020-10-13 Motorola Solutions, Inc. System for validating and appending incident-related data records in a distributed electronic ledger
WO2019195733A1 (en) * 2018-04-05 2019-10-10 University Of Maryland, Baltimore Method and apparatus for individualized administration of medicaments for delivery within a therapeutic range
WO2019209845A1 (en) * 2018-04-23 2019-10-31 Mould Diane R Systems and methods for modifying adaptive dosing regimens
WO2019213619A1 (en) 2018-05-04 2019-11-07 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
EP3815107A1 (en) * 2018-06-28 2021-05-05 Koninklijke Philips N.V. Method and system for personalized hypertension treatment
US10810293B2 (en) * 2018-10-16 2020-10-20 Motorola Solutions, Inc. Method and apparatus for dynamically adjusting biometric user authentication for accessing a communication device
CN111104054B (zh) * 2018-10-29 2023-10-27 伊姆西Ip控股有限责任公司 管理输入/输出操作的方法、装置和计算机程序产品
BE1027052A1 (fr) * 2019-02-14 2020-09-07 Aardex Group Procede d'assistance a la prise ou a l'acte d'un traitement therapeutique
CA3132823A1 (en) * 2019-03-08 2020-09-17 Diane R. Mould Systems and methods for drug-agnostic patient-specific dosing regimens
KR102876164B1 (ko) * 2019-03-31 2025-10-28 레즈메드 아이엔씨. 사용자로부터의 1개 이상의 분석물을 분석하는 방법 및 장치
KR102062157B1 (ko) * 2019-04-29 2020-01-03 오케스트로 주식회사 가상 머신 배치 방법 및 이를 구현하는 가상 머신 배치 장치
JP7342491B2 (ja) * 2019-07-25 2023-09-12 オムロン株式会社 推論装置、推論方法、及び推論プログラム
KR102527404B1 (ko) * 2019-10-29 2023-05-02 고려대학교 산학협력단 인슐린 투여량 조절 방법
US11823782B2 (en) 2020-03-03 2023-11-21 Optum, Inc. Systems, methods, apparatuses, and computer program products for administering pain management solutions remotely
US11075010B1 (en) 2020-03-19 2021-07-27 Insight RX, Inc. Pharmacology model optimization based on distributed data acquisition
US20210304846A1 (en) * 2020-03-29 2021-09-30 Stephen J. Brown Personalized compounding of therapeutic components and tracking of their influence on a measured parameter using a complex interaction model
EP4143846A1 (en) * 2020-04-29 2023-03-08 Novartis AG A computer-implemented system and method for assessing a level of activity of a disease or condition in a patient's eye
US20210375455A1 (en) * 2020-05-27 2021-12-02 MediSync, Inc. Artificial intelligence systems that incorporate expert knowledge related to heart failure
US12205705B2 (en) * 2020-07-22 2025-01-21 Optimdosing Llc Smart nutrition dosing
KR102559883B1 (ko) * 2020-09-03 2023-07-25 한양대학교 산학협력단 마르코프 의사결정 과정을 이용하는 투약 전략 생성 방법
AU2022286921A1 (en) 2021-05-29 2024-01-18 Steven Molnar Systems and methods for monoclonal antibody nomograms
KR20230036545A (ko) 2021-09-07 2023-03-14 서울대학교산학협력단 적응적 설계 최적화 기반으로 하는 실험 최적화 시스템 및 그 방법
US12046341B2 (en) * 2021-10-05 2024-07-23 Bradford Rabin Methods and systems for electronically adjusting a dosing pattern of a patient undergoing a medical regimen
KR102815903B1 (ko) * 2021-12-21 2025-05-30 충남대학교산학협력단 감염 환자에서 반코마이신 최적 용량을 결정하는 방법
KR102821516B1 (ko) * 2022-02-28 2025-06-17 한국전자기술연구원 목표 농도 조절 주입을 지원하는 약물 투여 장치 및 방법
US20250312243A1 (en) * 2022-04-28 2025-10-09 Regents Of The University Of Michigan Closed-loop architecture for distributing and administering medicines to patients
KR102447046B1 (ko) * 2022-06-03 2022-09-26 주식회사 인투인월드 인공지능 기반 임상시험 프로토콜 설계 방법, 장치 및 시스템
US12073931B2 (en) * 2022-06-15 2024-08-27 Express Scripts Strategic Development, Inc. Alternate dose regimen identification system
WO2024059692A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
KR102873330B1 (ko) * 2022-09-23 2025-10-21 재단법인 아산사회복지재단 머신러닝 기술을 활용한 항응고제 초기 적정 용량 예측 방법 및 장치

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5694950A (en) 1992-08-21 1997-12-09 J & W Mcmichael Software, Inc. Method and system for use in treating a patient with immunosuppresants using whole blood level criteria to prevent an adverse immune response
US5365948A (en) 1992-08-21 1994-11-22 J & W Mcmichael Software Inc. Method for use in treating a patient with FK 506 to prevent an adverse immune response
US6575169B2 (en) 1999-07-06 2003-06-10 The Rxfiles Corporation Method and apparatus for use in treating a patient with any drug to optimize therapy and prevent an adverse drug
US6581606B2 (en) 1999-07-06 2003-06-24 The Rx Files Corporation Method, apparatus and system for use in treating patient with a drug having an antineoplastic effect to optimize therapy and prevent an adverse drug response
US6581607B2 (en) 1999-07-06 2003-06-24 The Rx Files Corporation Method and system for use in treating a patient with a biological substance to optimize therapy and prevent an adverse response
US6267116B1 (en) 1999-07-06 2001-07-31 The Rxfiles Corporation Method and system for use in treating a patient with any drug to optimize therapy and prevent an adverse drug
US7585847B2 (en) 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
JP2004510961A (ja) 2000-09-15 2004-04-08 ビルコ・ビーブイビーエイ 疾患の処置のための薬物療法を最適化するシステムおよび方法
US6883521B2 (en) 2001-08-24 2005-04-26 Dimensional Dosing Systems, Inc. Method and apparatus for dosing single and multi-agent therapy
US6578582B2 (en) 2001-08-24 2003-06-17 The Rxfiles Corporation Method and apparatus using IDS™ for multi-agent therapy
US7490085B2 (en) 2002-12-18 2009-02-10 Ge Medical Systems Global Technology Company, Llc Computer-assisted data processing system and method incorporating automated learning
US20040122719A1 (en) 2002-12-18 2004-06-24 Sabol John M. Medical resource processing system and method utilizing multiple resource type data
US20070099926A1 (en) 2003-07-02 2007-05-03 Rodger Ian W Combination therapy for treating chronic inflammatory diseases
MXPA06008588A (es) * 2004-01-27 2006-08-28 Aspect Medical Systems Inc Sistema para la distribucion adaptable de farmaco.
JP2007526455A (ja) 2004-02-03 2007-09-13 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法
US20050187789A1 (en) * 2004-02-25 2005-08-25 Cardiac Pacemakers, Inc. Advanced patient and medication therapy management system and method
US20060036619A1 (en) * 2004-08-09 2006-02-16 Oren Fuerst Method for accessing and analyzing medically related information from multiple sources collected into one or more databases for deriving illness probability and/or for generating alerts for the detection of emergency events relating to disease management including HIV and SARS, and for syndromic surveillance of infectious disease and for predicting risk of adverse events to one or more drugs
WO2007047997A2 (en) 2005-10-19 2007-04-26 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
CA2911569C (en) * 2005-11-29 2019-11-26 Children's Hospital Medical Center Optimization and individualization of medication selection and dosing
US8781566B2 (en) * 2006-03-01 2014-07-15 Angel Medical Systems, Inc. System and methods for sliding-scale cardiac event detection
US8540517B2 (en) * 2006-11-27 2013-09-24 Pharos Innovations, Llc Calculating a behavioral path based on a statistical profile
US8010476B2 (en) * 2007-06-04 2011-08-30 Siemens Medical Solutions Usa, Inc. System and method for medical predictive models using likelihood gamble pricing
CA2687562C (en) 2007-06-27 2015-11-24 F. Hoffmann-La Roche Ag System and method for developing patient specific therapies based on modeling of patient physiology
US20110229471A1 (en) * 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
WO2010124127A1 (en) * 2009-04-23 2010-10-28 Automedics Medical Systems, Inc. Integrated patient management and control system for medication delivery
WO2011059824A2 (en) 2009-10-29 2011-05-19 Medtronic, Inc. Methods and materials for optimized hepatitis c therapeutic regimens
US8843321B2 (en) 2010-01-26 2014-09-23 Roche Diagnostics Operations, Inc. Methods and systems for processing glucose data measured from a person having diabetes
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
US8951192B2 (en) * 2010-06-15 2015-02-10 Flint Hills Scientific, Llc Systems approach to disease state and health assessment
EP2904388B1 (en) 2012-10-05 2023-06-07 Diane R. Mould System and method for providing patient-specific dosing as a function of mathematical models
US20140114676A1 (en) 2012-10-23 2014-04-24 Theranos, Inc. Drug Monitoring and Regulation Systems and Methods
EP2989569B1 (en) 2013-04-24 2021-06-23 Fresenius Kabi Deutschland GmbH Method of operating a control device for controlling an infusion device
JP2016526542A (ja) 2013-06-20 2016-09-05 バクスアルタ インコーポレイティッド 薬物動態学的な薬剤投与計画の装置および方法
SG10202009369SA (en) 2015-04-09 2020-10-29 Diane Mould Systems and methods for patient-specific dosing

Also Published As

Publication number Publication date
AU2019232874A1 (en) 2019-10-10
EP2904388C0 (en) 2023-06-07
US20200334561A1 (en) 2020-10-22
US20140100829A1 (en) 2014-04-10
KR20220032641A (ko) 2022-03-15
JP2016500866A (ja) 2016-01-14
JP2019016388A (ja) 2019-01-31
US20190171962A1 (en) 2019-06-06
SG10201907682RA (en) 2019-10-30
IL238115B (en) 2019-01-31
EP2904388B1 (en) 2023-06-07
IL264125B (en) 2020-03-31
JP2020080161A (ja) 2020-05-28
US10268966B2 (en) 2019-04-23
AU2023278028A1 (en) 2023-12-21
IL272760A (en) 2020-04-30
US20140351197A1 (en) 2014-11-27
JP2024180539A (ja) 2024-12-26
IL272760B (en) 2022-03-01
EP2904388A4 (en) 2016-06-22
US20220044782A1 (en) 2022-02-10
CA2887072A1 (en) 2014-04-10
EP2904388A1 (en) 2015-08-12
US10740687B2 (en) 2020-08-11
KR102450486B1 (ko) 2022-10-04
HK1213983A1 (en) 2016-07-15
WO2014055978A1 (en) 2014-04-10
JP2022111352A (ja) 2022-07-29
KR102370479B1 (ko) 2022-03-04
IL264125A (en) 2019-01-31
US20180032892A1 (en) 2018-02-01
AU2021245151A1 (en) 2021-11-04
US10706364B2 (en) 2020-07-07
JP6653365B2 (ja) 2020-02-26
KR20150100626A (ko) 2015-09-02
KR20210025697A (ko) 2021-03-09
EP4224482A1 (en) 2023-08-09
CA2887072C (en) 2024-04-16
US10083400B2 (en) 2018-09-25
KR102223018B1 (ko) 2021-03-05
AU2013326801A1 (en) 2015-04-16
JP7632886B2 (ja) 2025-02-19
US11373743B2 (en) 2022-06-28
SG11201502616WA (en) 2015-05-28

Similar Documents

Publication Publication Date Title
JP6412499B2 (ja) 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
US20250342928A1 (en) Systems and methods for patient-specific dosing
Vigueras et al. A PopPBPK-RL approach for precision dosing of benazepril in renal impaired patients
HK40098325A (en) System and method for providing patient-specific dosing as a function of mathematical models
HK40079892A (en) Systems and methods for patient-specific dosing
Faccone et al. PNS191 A COMPARISON OF HIGH-DIMENSIONAL PROPENSITY SCORE AND TRADITIONAL PROPENSITY SCORE MATCHING METHODS USING COMMERCIAL HEALTH CARE CLAIMS DATA
HK1213983B (en) System and method for providing patient-specific dosing as a function of mathematical models

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20160226

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20160226

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161006

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161006

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20171006

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171108

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180205

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180326

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180508

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180829

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180928

R150 Certificate of patent or registration of utility model

Ref document number: 6412499

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250