JP6404834B2 - インスリン抵抗性の進行に関連するバイオマーカー及びこれを使用する方法 - Google Patents

インスリン抵抗性の進行に関連するバイオマーカー及びこれを使用する方法 Download PDF

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JP6404834B2
JP6404834B2 JP2015556042A JP2015556042A JP6404834B2 JP 6404834 B2 JP6404834 B2 JP 6404834B2 JP 2015556042 A JP2015556042 A JP 2015556042A JP 2015556042 A JP2015556042 A JP 2015556042A JP 6404834 B2 JP6404834 B2 JP 6404834B2
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JP2016509222A (ja
JP2016509222A5 (cg-RX-API-DMAC7.html
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ゴール、ウォルター
コブ、ジェフリー、エドモンド
パッパン、カーク、レイン
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メタボロン，インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16Z—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS, NOT OTHERWISE PROVIDED FOR
    • G16Z99/00—Subject matter not provided for in other main groups of this subclass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Data Mining & Analysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2015556042A 2013-01-31 2014-01-16 インスリン抵抗性の進行に関連するバイオマーカー及びこれを使用する方法 Active JP6404834B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361758924P 2013-01-31 2013-01-31
US61/758,924 2013-01-31
PCT/US2014/011759 WO2014120449A1 (en) 2013-01-31 2014-01-16 Biomarkers related to insulin resistance progression and methods using the same

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JP2016509222A JP2016509222A (ja) 2016-03-24
JP2016509222A5 JP2016509222A5 (cg-RX-API-DMAC7.html) 2017-02-09
JP6404834B2 true JP6404834B2 (ja) 2018-10-17

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US (2) US9910047B2 (cg-RX-API-DMAC7.html)
EP (2) EP2951313B1 (cg-RX-API-DMAC7.html)
JP (1) JP6404834B2 (cg-RX-API-DMAC7.html)
ES (2) ES2669620T3 (cg-RX-API-DMAC7.html)
WO (1) WO2014120449A1 (cg-RX-API-DMAC7.html)

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CA2907525A1 (en) * 2013-03-28 2014-10-02 Nestec S.A. Indoxyl sulfate as a biomarker of prebiotic efficacy for weight gain prevention
CA2917483A1 (en) * 2013-07-09 2015-01-15 Stemina Biomarker Discovery, Inc. Biomarkers of autism spectrum disorder
SG11201810254UA (en) * 2016-05-17 2018-12-28 Univ Osaka Blood sample analysis method and system, for determining diabetes
ES2953498T3 (es) 2016-06-02 2023-11-13 Metabolon Inc Método de espectrometría de masas para la detección y cuantificación de metabolitos
JP7393206B2 (ja) * 2016-12-19 2023-12-06 メタボロン，インコーポレイテッド 腎機能代謝産物の検出及び定量化のための質量分析アッセイ方法
WO2018150077A1 (en) * 2017-02-16 2018-08-23 Afekta Technologies Oy Betaine biomarkers for nutritional status, nutritional regimen, endogenous metabolism, or risk of cardiovascular or metabolic diseases
EP4617668A3 (en) * 2017-03-31 2025-12-24 Quest Diagnostics Investments LLC Methods for quantitation of insulin and c-peptide
EP3401683A1 (en) * 2017-05-10 2018-11-14 Eberhard Karls Universität Tübingen Medizinische Fakultät Diagnosing metabolic disease by the use of a biomarker
ES2999269T3 (en) * 2018-01-17 2025-02-25 Univ Southampton Methods to predict risk of and to stratify sarcopenia and nad deficiency
CN112740045A (zh) * 2018-09-27 2021-04-30 雀巢产品有限公司 在儿童期和青年期发展成胰岛素抗性的风险的标志物
US11041847B1 (en) 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
KR102231928B1 (ko) * 2019-09-19 2021-03-26 고려대학교 산학협력단 비만대사수술 이후 당뇨병 예후 예측용 바이오마커 조성물
CA3177108A1 (en) * 2020-04-27 2021-11-04 Wayne R. Matson Detection and modification of gut microbial population
CN112149311B (zh) * 2020-10-12 2021-10-26 北京中恒利华石油技术研究所 一种基于数量规约的非线性多元统计回归测井曲线预测方法
CN112843036A (zh) * 2021-01-29 2021-05-28 中国药科大学 β-羟基丙酮酸在制备人胰岛淀粉样多肽聚集抑制剂中的应用
CN116087485B (zh) * 2021-11-08 2023-10-20 中国医学科学院阜外医院 糖尿病患者早期预测心血管疾病（cvd）的生物标志物及其用途
CN114324662B (zh) * 2021-12-30 2022-09-16 中南大学 用于诊断或预防糖尿病的血清生物标志物的应用
WO2023194615A1 (en) * 2022-04-07 2023-10-12 Need4Health B.V. Method for determining insulin dosage
JP7736971B2 (ja) * 2022-10-18 2025-09-10 株式会社オルトメディコ 糖尿病境界域者のスクリーニング方法

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WO2001078652A2 (en) 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
WO2005094200A2 (en) 2003-06-20 2005-10-13 University Of Florida Biomarkers for differentiating between type 2 and type 2 diabetes
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
US8119358B2 (en) * 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
US8216848B2 (en) * 2006-03-24 2012-07-10 Metanomics Gmbh Means and method for diagnosing diabetes
MX341954B (es) * 2007-07-17 2016-09-08 Metabolon Inc Biomarcadores para prediabetes, enfermedades cardiovasculares y otros transtornos relacionados con sindrome metabolico, y metodos de uso de los mismos.
WO2010005982A2 (en) 2008-07-07 2010-01-14 The General Hospital Corporation Multiplexed biomarkers of insulin resistance
US20110113863A1 (en) * 2008-07-15 2011-05-19 Metanomics Health Gmbh Means and methods diagnosing gastric bypass and conditions related thereto
JP2012522989A (ja) * 2009-03-31 2012-09-27 メタボロン インコーポレイテッド インスリン抵抗性に関連するバイオマーカー、及びそれを使用する方法
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JP2013509588A (ja) 2009-10-29 2013-03-14 テシス バイオサイエンス， インコーポレイテッド ２型糖尿病の予防に対して一貫した改善をもたらすタンパク質バイオマーカーおよび脂質代謝物バイオマーカー
US20140303228A1 (en) * 2011-10-18 2014-10-09 Metabolon, Inc. Biomarkers for Amyotrophic Lateral Sclerosis and Methods Using the Same
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US20140343865A1 (en) * 2011-12-09 2014-11-20 Meredith V. Brown Biomarkers for Kidney Cancer and Methods Using the Same

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Publication number Publication date
HK1217516A1 (en) 2017-01-13
US9910047B2 (en) 2018-03-06
US20150362510A1 (en) 2015-12-17
ES2987582T3 (es) 2024-11-15
EP2951313B1 (en) 2018-03-07
EP2951313A1 (en) 2015-12-09
EP3321686A1 (en) 2018-05-16
ES2669620T3 (es) 2018-05-28
JP2016509222A (ja) 2016-03-24
EP3321686B1 (en) 2024-03-13
WO2014120449A1 (en) 2014-08-07
EP2951313A4 (en) 2016-11-02
US20180203021A1 (en) 2018-07-19

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