JP6404211B2 - 体外血液改質のためのシステムおよび方法 - Google Patents

体外血液改質のためのシステムおよび方法 Download PDF

Info

Publication number
JP6404211B2
JP6404211B2 JP2015512646A JP2015512646A JP6404211B2 JP 6404211 B2 JP6404211 B2 JP 6404211B2 JP 2015512646 A JP2015512646 A JP 2015512646A JP 2015512646 A JP2015512646 A JP 2015512646A JP 6404211 B2 JP6404211 B2 JP 6404211B2
Authority
JP
Japan
Prior art keywords
antibody
polymer
antigen
subject
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015512646A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015516264A5 (https=
JP2015516264A (ja
Inventor
マカルヴィン，ジェームス，ビー．
ミズラヒ，ボアズ
コーエン，ダニエル，エス．
ワイリー，ライアン，ジー．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Original Assignee
Boston Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital filed Critical Boston Childrens Hospital
Publication of JP2015516264A publication Critical patent/JP2015516264A/ja
Publication of JP2015516264A5 publication Critical patent/JP2015516264A5/ja
Application granted granted Critical
Publication of JP6404211B2 publication Critical patent/JP6404211B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3618—Magnetic separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/256—Antibodies, e.g. immunoglobulins, vaccines

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • External Artificial Organs (AREA)
JP2015512646A 2012-05-14 2013-03-14 体外血液改質のためのシステムおよび方法 Active JP6404211B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261646674P 2012-05-14 2012-05-14
US61/646,674 2012-05-14
PCT/US2013/031744 WO2013172966A1 (en) 2012-05-14 2013-03-14 Systems and methods for extracorporeal blood modification

Publications (3)

Publication Number Publication Date
JP2015516264A JP2015516264A (ja) 2015-06-11
JP2015516264A5 JP2015516264A5 (https=) 2016-05-12
JP6404211B2 true JP6404211B2 (ja) 2018-10-10

Family

ID=49584139

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015512646A Active JP6404211B2 (ja) 2012-05-14 2013-03-14 体外血液改質のためのシステムおよび方法

Country Status (5)

Country Link
US (3) US20150132312A1 (https=)
EP (1) EP2849817B1 (https=)
JP (1) JP6404211B2 (https=)
ES (1) ES2725573T3 (https=)
WO (1) WO2013172966A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150071935A1 (en) * 2012-05-27 2015-03-12 Marv Enterprises, LLC Treatment for the rapid amelioration of clinical depression
ES2660595T3 (es) * 2013-06-07 2018-03-23 Baxter International Inc. Inmovilización de un agente activo sobre un sustrato empleando compuestos que incluyen grupos trihidroxifenilo
BR112016013876B1 (pt) * 2013-12-27 2022-03-22 Eliaz Therapeutics, Inc. Dispositivo para realização de plasmaferese
DE102015207228A1 (de) * 2015-04-21 2016-10-27 Vetter Pharma-Fertigung GmbH & Co. KG Primärpackmittel und Verfahren zur Herstellung eines Primärpackmittels
US10064653B2 (en) 2015-06-08 2018-09-04 The Board Of Trustees Of The Leland Stanford Junior University Intravascular magnetic wire for detection, retrieval or elimination of disease-associated biomarkers and toxins
JP7429343B2 (ja) 2018-01-05 2024-02-08 パス イーエックス，インク． 流体からの疾患材料の捕捉および除去のためのデバイス
JP2022548026A (ja) * 2019-09-13 2022-11-16 ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー 血液中のａｄｍａを調節するデバイスおよび方法
US12521475B2 (en) * 2020-04-08 2026-01-13 Arizona Board Of Regents On Behalf Of Arizona State University Method, device, and product for treating a body fluid of a patient with an inflammatory cytokine storm by binding an antibody to a cytokine antigen in the body fluid to form an antigen-antibody complex that is removed from the body fluid to reduce the amount of the cytokines in the body fluid
CN112090410B (zh) * 2020-07-29 2023-11-10 健帆生物科技集团股份有限公司 具有互穿网络包膜的血液净化吸附剂、制备方法及灌流器
WO2024030085A1 (en) * 2022-08-05 2024-02-08 Innowayrg Arastirma Gelistirme Ve Danismanlik Hizmetleri Sanayi Ve Ticaret Anonim Sirketi A device for cleaning heavy metal-bound mediators in body fluids and organs
WO2024076704A1 (en) * 2022-10-05 2024-04-11 Immunicom, Inc. Il-6 removal
KR102694305B1 (ko) * 2023-05-23 2024-08-13 주식회사 월드바이오텍 치열교정 브라켓

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523615A1 (de) * 1985-07-02 1987-01-15 Cytomed Medizintechnik Medizinisches geraet, insbesondere kanuele, katheter oder implantat
US5589563A (en) * 1992-04-24 1996-12-31 The Polymer Technology Group Surface-modifying endgroups for biomedical polymers
EP1315551B1 (en) * 1999-06-03 2015-11-04 Advanced Extravascular Systems One step removal of unwanted molecules from circulating blood
US6969367B2 (en) * 2000-02-02 2005-11-29 Xepmed, Inc. Extracorporeal pathogen reduction system
US20030120202A1 (en) * 2001-12-21 2003-06-26 Gordon Lucas S. Magnetic extracorporeal circuit for removal of medical agents
US20040028687A1 (en) * 2002-01-15 2004-02-12 Waelti Ernst Rudolf Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues
US8211310B2 (en) * 2006-11-20 2012-07-03 Cytosorbents, Inc. Size-selective polymer system
US20090191175A1 (en) * 2006-11-21 2009-07-30 University Of Southern California Therapeutic methods using peg-conjugated agents and devices for performing the same
US20110008404A1 (en) * 2007-12-19 2011-01-13 Georgia Tech Research Corporation Modification Of Biomaterials With Microgel Films
CA2728270A1 (en) * 2008-06-17 2009-12-23 Georgia Tech Research Corporation Superparamagnetic nanoparticles for removal of cells, pathogens or viruses
US8454547B2 (en) * 2009-02-25 2013-06-04 The Invention Science Fund I, Llc Device, system, and method for controllably reducing inflammatory mediators in a subject
CA2776613A1 (en) * 2009-10-07 2011-04-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N Devices, systems and methods for cell modification
WO2011112873A2 (en) * 2010-03-10 2011-09-15 Paul Tebbey Extracorporeal immunoadsorption treatment

Also Published As

Publication number Publication date
US20200171232A1 (en) 2020-06-04
US20150132312A1 (en) 2015-05-14
EP2849817B1 (en) 2019-03-13
WO2013172966A1 (en) 2013-11-21
JP2015516264A (ja) 2015-06-11
EP2849817A1 (en) 2015-03-25
US20200101214A1 (en) 2020-04-02
EP2849817A4 (en) 2016-01-20
ES2725573T3 (es) 2019-09-24

Similar Documents

Publication Publication Date Title
JP6404211B2 (ja) 体外血液改質のためのシステムおよび方法
US9964541B2 (en) Method and devices for capturing circulating tumor
Xie et al. Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
Myerson et al. Flexible nanoparticles reach sterically obscured endothelial targets inaccessible to rigid nanoparticles
CN107315086B (zh) 使用表面涂层对生物物质的捕获、纯化和释放
US10900969B2 (en) Biomimetic microfluid device for capturing circulating tumor cells
JPH02504635A (ja) 生体特異性ポリマー
US20180016352A1 (en) Targeting constructs for delivery of payloads
Lou et al. Fabrication of magnetic conjugation clusters via intermolecular assembling for ultrasensitive surface plasmon resonance (SPR) detection in a wide range of concentrations
JP2022519377A5 (https=)
JPH06504542A (ja) 体外除去による診断及び／又は治療剤の高インビボクリアランス方法及び系と上記目的に関する上記剤の用法
Shimizu et al. A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics: Shimizu et al.
Ahmed et al. Molecular imaging of a new multimodal microbubble for adhesion molecule targeting
Cova et al. Antibody-engineered nanoparticles selectively inhibit mesenchymal cells isolated from patients with chronic lung allograft dysfunction
Vorobii et al. Antifouling microparticles to scavenge lipopolysaccharide from human blood plasma
Singh et al. Unravelling the potential of zwitterionic polymers in molecular imprinting
US20210403897A1 (en) Chemical engineering of erythrocytes to display polypeptides and other biomacromolecules
KR0142876B1 (ko) 자성 단백질 결합체, 이의 제조방법, 및 이의 용도
Ji et al. Inhibition of tumor immune escape by blocking PD-1/PD-L1 engagement with dual-targeting molecularly imprinted polymer layer
CA3154234A1 (en) Non-hemolytic compositions and methods of use for recovering disease causing toxic constituents in the blood
Pawar et al. Effect of Uremic Toxins and Methoxy-PEO Chain Density on Plasma Protein Adsorption
Lauener et al. Functionalized magnetic nanoparticles remove donor-specific antibodies (DSA) from patient blood in a first ex vivo proof of principle study
Alikhani et al. High molecular weight blood group A trisaccharide‐polyacrylamide glycoconjugates as synthetic blood group A antigens for anti‐A antibody removal devices
US10765881B2 (en) Magnetic particle conjugates and methods of activating cell signaling
Kerby et al. Circulating IgSF proteins inhibit adhesion of antibody targeted microspheres to endothelial inflammatory ligands

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160314

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160314

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170131

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170131

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170501

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170630

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171130

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180328

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180820

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180912

R150 Certificate of patent or registration of utility model

Ref document number: 6404211

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250