JP6392355B2 - ペレット包含錠剤 - Google Patents

ペレット包含錠剤 Download PDF

Info

Publication number
JP6392355B2
JP6392355B2 JP2016542807A JP2016542807A JP6392355B2 JP 6392355 B2 JP6392355 B2 JP 6392355B2 JP 2016542807 A JP2016542807 A JP 2016542807A JP 2016542807 A JP2016542807 A JP 2016542807A JP 6392355 B2 JP6392355 B2 JP 6392355B2
Authority
JP
Japan
Prior art keywords
pellet
inner core
containing tablet
excipient
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016542807A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016530329A5 (enExample
JP2016530329A (ja
Inventor
ジー． ココラス、ハリー
ジー． ココラス、ハリー
ピー． ホリス、クリスタン
ピー． ホリス、クリスタン
Original Assignee
アール．ピー．シェーラー テクノロジーズ、エルエルシー
アール．ピー．シェーラー テクノロジーズ、エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アール．ピー．シェーラー テクノロジーズ、エルエルシー, アール．ピー．シェーラー テクノロジーズ、エルエルシー filed Critical アール．ピー．シェーラー テクノロジーズ、エルエルシー
Publication of JP2016530329A publication Critical patent/JP2016530329A/ja
Publication of JP2016530329A5 publication Critical patent/JP2016530329A5/ja
Application granted granted Critical
Publication of JP6392355B2 publication Critical patent/JP6392355B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
JP2016542807A 2013-09-13 2014-09-12 ペレット包含錠剤 Active JP6392355B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361877786P 2013-09-13 2013-09-13
US61/877,786 2013-09-13
PCT/US2014/055319 WO2015038854A1 (en) 2013-09-13 2014-09-12 Encased-pellet tablets

Publications (3)

Publication Number Publication Date
JP2016530329A JP2016530329A (ja) 2016-09-29
JP2016530329A5 JP2016530329A5 (enExample) 2017-08-31
JP6392355B2 true JP6392355B2 (ja) 2018-09-19

Family

ID=52666297

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016542807A Active JP6392355B2 (ja) 2013-09-13 2014-09-12 ペレット包含錠剤

Country Status (4)

Country Link
US (1) US9566248B2 (enExample)
EP (1) EP3043779B1 (enExample)
JP (1) JP6392355B2 (enExample)
WO (1) WO2015038854A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116270514B (zh) * 2023-03-22 2024-09-06 北京恒创星远医药科技有限公司 一种微丸片剂及其制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1598458A (en) * 1977-04-01 1981-09-23 Hoechst Uk Ltd Tableting of microcapsules
JP2514078B2 (ja) 1988-08-22 1996-07-10 エスエス製薬株式会社 圧縮成型製剤
DE4122217C2 (de) * 1991-07-04 1997-02-13 Merz & Co Gmbh & Co Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern
US5436011A (en) 1993-04-16 1995-07-25 Bristol-Myers Squibb Company Solid pharmaceutical dosage form and a method for reducing abrasion
GB9600390D0 (en) 1996-01-09 1996-03-13 Univ London Pharmacy Preparation of tablets
US5780055A (en) 1996-09-06 1998-07-14 University Of Maryland, Baltimore Cushioning beads and tablet comprising the same capable of forming a suspension
US6210716B1 (en) 1999-02-26 2001-04-03 Andrx Pharmaceuticals, Inc. Controlled release bupropion formulation
GB9921933D0 (en) 1999-09-17 1999-11-17 Univ Gent Solid shaped articles comprising biologically active substances and a method for their production
AR026148A1 (es) * 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
CA2412173C (en) 2000-06-20 2010-08-17 Sanwa Kagaku Kenkyusho Co., Ltd Nucleated molded article, method of producing the same, and device for producing the same
WO2003026560A1 (en) * 2001-09-26 2003-04-03 Sanwa Kagaku Kenkyusho Co.,Ltd Multi-cored molded article, method of producing the same, and device for producing the same
FR2838647B1 (fr) 2002-04-23 2006-02-17 Particules enrobees a liberation prolongee, leur procede de preparation et comprimes les contenant
WO2004091582A1 (en) * 2003-04-17 2004-10-28 Ipca Laboratories Limited Pharmaceutical preparations on the basis of moisture-protected granules and a process for producing them
WO2005097041A1 (ja) * 2004-04-09 2005-10-20 Sanwa Kagaku Kenkyusho Co., Ltd. 有核成型品とその製造方法
ES2509340T3 (es) 2004-08-26 2014-10-17 Kikusui Seisakusho Ltd. Máquina de conformado de compresión rotatoria que utiliza un punzón
US20060263429A1 (en) 2005-05-20 2006-11-23 Hengsheng Feng Compressible mixture, compressed pharmaceutical compositions, and method of preparation thereof
EP1834634A3 (en) * 2006-03-08 2007-10-03 Rentschler Pharma GmbH Pharmaceutical multiple-unit composition
WO2007122478A2 (en) * 2006-04-20 2007-11-01 Themis Laboratories Private Limited Multiple unit compositions
CA2677623C (en) * 2007-02-09 2015-04-07 Alphapharm Pty Ltd A dosage form containing two or more active pharmaceutical ingredients in different physical forms
US20100104656A1 (en) 2007-03-20 2010-04-29 Paul Wan Sia Heng Meltable Binder for Melt Granulation and/or Pelletization
US8133506B2 (en) * 2008-03-12 2012-03-13 Aptalis Pharmatech, Inc. Drug delivery systems comprising weakly basic drugs and organic acids
WO2009153635A1 (en) * 2008-06-19 2009-12-23 University Of Witwatersrand, Johannesburg A chronotherapeutic pharmaceutical dosage form
EP2299983A4 (en) 2008-07-24 2012-10-10 Handa Pharmaceuticals Llc ATYPICAL ANTIPSYCHOTIC FORMULATION STABILIZED
DE102008048729A1 (de) 2008-09-24 2010-03-25 Add Technologies Ltd Advanced Drug Delivery Multipartikuläre Tabletten und Verfahren zur deren Herstellung
WO2010064139A2 (en) 2008-12-04 2010-06-10 Intec Pharma Ltd. Zaleplon gastroretentive drug delivery system
UY32427A (es) * 2009-02-13 2010-09-30 Boheringer Ingelheim Internat Gmbh Composicion farmaceutica, forma farmaceutica, procedimiento para su preparacion, metodos de tratamiento y usos de la misma
ES2713330T3 (es) 2009-12-11 2019-05-21 Sumitomo Dainippon Pharma Co Ltd Comprimido recubierto en seco que se desintegra oralmente
EP2601936A4 (en) * 2010-08-03 2014-03-19 Eisai R&D Man Co Ltd COMPRESSED COMPOSITION
JP2012206978A (ja) * 2011-03-30 2012-10-25 Dainippon Printing Co Ltd 徐放性マイクロカプセル及びその製造方法

Also Published As

Publication number Publication date
US9566248B2 (en) 2017-02-14
JP2016530329A (ja) 2016-09-29
US20150079167A1 (en) 2015-03-19
EP3043779B1 (en) 2018-05-16
WO2015038854A1 (en) 2015-03-19
EP3043779A4 (en) 2017-04-19
EP3043779A1 (en) 2016-07-20

Similar Documents

Publication Publication Date Title
US9629915B2 (en) Sustained release dosage form
RU2385712C2 (ru) Рецептура с контролируемым высвобождением
AU2008288106B2 (en) Extended release compositions comprising mycophenolate sodium and processes thereof
JPH09502738A (ja) 制御放出のための新規ビーズおよびそれらを含有する医薬製剤
JP2011225592A (ja) 放出制御トラマドールの漸増投薬処方
JP2013504562A (ja) アルコールで誘発される用量ダンピングを低減するための医薬組成物
EP3791867A1 (en) Medicament-containing hollow particle
CN109310642B (zh) 美沙拉嗪的口服药物组合物
CN113423390B (zh) 阿法比星制剂及其制备方法
CA2858478C (en) Disintegrant-free delayed release doxylamine and pyridoxine formulation and process of manufacturing
CN101820866B (zh) 用于固体剂型的机械保护层
CN109152772B (zh) 烟酰胺的口服药物组合物
CN108201535A (zh) 一种维利帕尼缓控释药物组合物及其用途
KR20160076928A (ko) 푸마르산 에스테르를 함유하는 미니-정제 형태의 약제학적 제제
JP2016530329A (ja) ペレット包含錠剤
EP2632428B1 (en) Modified starch derivative-based matrix for colon targeting
JP5919173B2 (ja) 徐放性塩酸アンブロキソール口腔内崩壊錠
JP5819680B2 (ja) 塩酸アンブロキソールの小型徐放性製剤
Kumar et al. A Comprehensive Review on Modified-Release Tablets
WO2023044024A9 (en) Novel ph dependent coating drug delivery system
JP6396719B2 (ja) 塩酸アンブロキソールの小型徐放性製剤
HK40049256A (en) Medicament-containing hollow particle
MXPA01002821A (en) Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170719

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170719

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180312

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180320

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180620

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180724

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180822

R150 Certificate of patent or registration of utility model

Ref document number: 6392355

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250