JP6392256B2 - 医用画像 - Google Patents

医用画像 Download PDF

Info

Publication number
JP6392256B2
JP6392256B2 JP2015562331A JP2015562331A JP6392256B2 JP 6392256 B2 JP6392256 B2 JP 6392256B2 JP 2015562331 A JP2015562331 A JP 2015562331A JP 2015562331 A JP2015562331 A JP 2015562331A JP 6392256 B2 JP6392256 B2 JP 6392256B2
Authority
JP
Japan
Prior art keywords
liver
extracellular fluid
organ tissue
iron
iron content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015562331A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016513514A5 (https=
JP2016513514A (ja
Inventor
エリザベス タニクリフ
エリザベス タニクリフ
マスュー ロブソン
マスュー ロブソン
ラジャルシ バネルジー
ラジャルシ バネルジー
Original Assignee
オックスフォード ユニヴァーシティ イノヴェーション リミテッド
オックスフォード ユニヴァーシティ イノヴェーション リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オックスフォード ユニヴァーシティ イノヴェーション リミテッド, オックスフォード ユニヴァーシティ イノヴェーション リミテッド filed Critical オックスフォード ユニヴァーシティ イノヴェーション リミテッド
Publication of JP2016513514A publication Critical patent/JP2016513514A/ja
Publication of JP2016513514A5 publication Critical patent/JP2016513514A5/ja
Application granted granted Critical
Publication of JP6392256B2 publication Critical patent/JP6392256B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/50—NMR imaging systems based on the determination of relaxation times, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0044—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4244—Evaluating particular parts, e.g. particular organs liver
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/023—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the heart
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10088—Magnetic resonance imaging [MRI]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30048—Heart; Cardiac
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30056—Liver; Hepatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Physiology (AREA)
  • Theoretical Computer Science (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2015562331A 2013-03-15 2014-03-14 医用画像 Active JP6392256B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1304728.7 2013-03-15
GBGB1304728.7A GB201304728D0 (en) 2013-03-15 2013-03-15 Medical imaging
PCT/GB2014/050815 WO2014140635A1 (en) 2013-03-15 2014-03-14 Medical imaging

Publications (3)

Publication Number Publication Date
JP2016513514A JP2016513514A (ja) 2016-05-16
JP2016513514A5 JP2016513514A5 (https=) 2017-04-13
JP6392256B2 true JP6392256B2 (ja) 2018-09-19

Family

ID=48226431

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015562331A Active JP6392256B2 (ja) 2013-03-15 2014-03-14 医用画像

Country Status (12)

Country Link
US (1) US10162031B2 (https=)
EP (1) EP2967419B1 (https=)
JP (1) JP6392256B2 (https=)
AU (1) AU2014229726B2 (https=)
CA (1) CA2906163C (https=)
ES (1) ES2902982T3 (https=)
GB (2) GB201304728D0 (https=)
MY (1) MY170136A (https=)
PL (1) PL2967419T3 (https=)
PT (1) PT2967419T (https=)
SG (1) SG11201507628WA (https=)
WO (1) WO2014140635A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201121406D0 (en) 2011-12-13 2012-01-25 Isis Innovation Systems and methods
GB201121404D0 (en) 2011-12-13 2012-01-25 Isis Innovation Diagnosis
GB201304728D0 (en) 2013-03-15 2013-05-01 Isis Innovation Medical imaging
GB2524587A (en) * 2014-03-28 2015-09-30 Perspectum Diagnostics Ltd Method and apparatus for non-invasive detection of inflammation of a visceral organ
GB201406304D0 (en) * 2014-04-08 2014-05-21 Isis Innovation Medical imaging
ES2822201T3 (es) * 2014-06-12 2021-04-29 Commissariat Energie Atomique Método de IRM para cuantificar la cantidad de hierro en tejidos utilizando difusión por imágenes de resonancia magnética
US20190204402A1 (en) * 2016-09-13 2019-07-04 Inserm (Institut National De La Sante De La Recherche Medicale) Method for post-processing mri images to obtain hepatic perfusion and transport parameters
US20190328310A1 (en) * 2016-11-07 2019-10-31 Oxford University Innovation Limited Correction method for magnetic resonance t1-mapping of visceral organs in the presence of elevated iron and elevated fat levels, and in the presence of off-resonance frequencies
WO2018106713A1 (en) * 2016-12-06 2018-06-14 Darmiyan, Inc. Methods and systems for identifying brain disorders
US10613173B2 (en) 2017-04-07 2020-04-07 Siemens Healthcare Gmbh Method and magnetic resonance apparatus for generating a fat fraction-corrected T1 parameter map
DE102018209584A1 (de) * 2018-06-14 2019-12-19 Siemens Healthcare Gmbh Magnetresonanz-Fingerprinting-Verfahren
EP3629048A1 (de) 2018-09-27 2020-04-01 Siemens Healthcare GmbH Niederfeld-magnetresonanz-fingerprinting
EP3845919B1 (en) * 2020-01-03 2025-04-23 Siemens Healthineers AG Method for reducing the effects of b0-inhomogeneity in magnetic resonance imaging
WO2022076775A1 (en) * 2020-10-09 2022-04-14 Massachusetts Institute Of Technology Methods and systems for assessment of liver fibrosis and steatosis
GB2603896B (en) * 2021-02-12 2024-01-10 Perspectum Ltd Method of analysing medical images

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02243134A (ja) 1989-03-17 1990-09-27 Toshiba Corp 磁気共鳴イメージング装置
US5322682A (en) 1992-08-06 1994-06-21 The Regents Of The University Of California Method for quantitatively measuring and mapping stored iron in tissue using MRI
JPH0779939A (ja) * 1993-09-14 1995-03-28 Toshiba Corp 磁気共鳴診断装置
US5908386A (en) 1995-12-14 1999-06-01 Regents Of The Universotiy Of Minnesota Fast MRI for assessment of myocardial perfusion with arrythmia insensitive magnetization preparation
US6245027B1 (en) 1998-04-10 2001-06-12 Noam Alperin Method of measuring intracranial pressure
US5993398A (en) 1998-04-10 1999-11-30 Alperin; Noam Method of measuring intracranial pressure
US6605943B1 (en) * 1999-08-24 2003-08-12 Inner Vision Biometrics Pty Ltd Method of mapping proton transverse relaxation time constants or functions thereof in a target subject to localised movement using nuclear magnetic resonance imaging
US7572231B2 (en) 2000-01-31 2009-08-11 Pearlman Justin D Method of and system for signal separation during multivariate physiological monitoring
US20040102692A1 (en) * 2002-11-27 2004-05-27 General Electric Company Magnetic resonance imaging system and methods for the detection of brain iron deposits
US6798199B2 (en) 2003-02-06 2004-09-28 Siemens Medical Solutions Usa, Inc. Method for synchronizing magnetic resonance imaging data to body motion
US7439737B2 (en) 2004-05-14 2008-10-21 Koninklijke Philips Electronics N.V. Contrast prepared MRI involving non-cartesian trajectories with oversampling of the center of k-space
ITPI20050053A1 (it) * 2005-05-12 2006-11-13 Cnr Consiglio Naz Delle Ricerche Apparecchiatura per la valutazione dell' accumulo marziale nel miocardio mediante elaborazione di immagini di risonanza magnetica
US7468605B2 (en) * 2006-04-25 2008-12-23 The Board Of Trustees Of The Leland Stanford Junior University Simultaneous chemical species separation and T2* measurement using MRI
US20080150532A1 (en) 2006-12-21 2008-06-26 General Electric Company Method and apparatus for measuring t1 relaxation
WO2008144391A1 (en) 2007-05-16 2008-11-27 Mayo Foundation For Medical Education And Research Portal vein pressure measurement using elastography
SE0702063L (sv) * 2007-05-31 2009-01-13 Colloidal Resource Ab Metod, system, datoravläsbart medium och användning för magnetisk resonanstomografi
WO2009127827A1 (en) * 2008-04-18 2009-10-22 The University Of Manchester Imaging technique
JP5537142B2 (ja) 2009-02-05 2014-07-02 株式会社東芝 磁気共鳴イメージング装置及び磁気共鳴撮像方法
DE102009011382A1 (de) 2009-03-05 2010-09-09 Rheinisch-Westfälische Technische Hochschule Aachen Verfahren und Vorrichtung zur Quantifizierung der Bildgüte und zur bewegungssynchronen Erfassung einer tomografischen Schnittaufnahme eines Objektes
US20110028828A1 (en) 2009-08-01 2011-02-03 Dania Daye T1 rho magnetic resonance imaging for staging of hepatic fibrosis
DE102010001145A1 (de) 2010-01-22 2011-07-28 Siemens Aktiengesellschaft, 80333 Verfahren und Vorrichtung zur Magnetresonanzbildgebung zum Erstellen von T1-Karten
US9993156B2 (en) * 2010-10-14 2018-06-12 Syntheticmr Ab Methods and apparatuses for relating multiple magnetic resonance physical parameters to myelin content in the brain
CA2817999C (en) 2010-11-29 2018-12-18 Crown Packaging Technology, Inc. Closure
RU2014117040A (ru) 2011-09-28 2015-11-10 Конинклейке Филипс Н.В. Способ и система для количественного определения жира в печени человека
GB201121406D0 (en) 2011-12-13 2012-01-25 Isis Innovation Systems and methods
GB201121404D0 (en) * 2011-12-13 2012-01-25 Isis Innovation Diagnosis
EP2873017B1 (en) 2012-07-11 2021-09-01 University of Mississippi Medical Center Method for the detection and staging of liver fibrosis from image acquired data
GB201304728D0 (en) 2013-03-15 2013-05-01 Isis Innovation Medical imaging
GB2524587A (en) 2014-03-28 2015-09-30 Perspectum Diagnostics Ltd Method and apparatus for non-invasive detection of inflammation of a visceral organ
GB201406304D0 (en) 2014-04-08 2014-05-21 Isis Innovation Medical imaging

Also Published As

Publication number Publication date
EP2967419B1 (en) 2021-10-20
WO2014140635A1 (en) 2014-09-18
MY170136A (en) 2019-07-06
CA2906163A1 (en) 2014-09-18
GB2513474A (en) 2014-10-29
PT2967419T (pt) 2022-01-20
PL2967419T3 (pl) 2022-02-14
SG11201507628WA (en) 2015-10-29
GB201404628D0 (en) 2014-04-30
EP2967419A1 (en) 2016-01-20
GB2513474B (en) 2017-11-29
US10162031B2 (en) 2018-12-25
US20160025831A1 (en) 2016-01-28
CA2906163C (en) 2022-04-05
AU2014229726B2 (en) 2019-06-06
AU2014229726A1 (en) 2015-09-10
ES2902982T3 (es) 2022-03-30
GB201304728D0 (en) 2013-05-01
HK1213459A1 (en) 2016-07-08
JP2016513514A (ja) 2016-05-16

Similar Documents

Publication Publication Date Title
JP6392256B2 (ja) 医用画像
Hoffman et al. T1 mapping, T2 mapping and MR elastography of the liver for detection and staging of liver fibrosis
Mammarappallil et al. New developments in imaging idiopathic pulmonary fibrosis with hyperpolarized xenon magnetic resonance imaging
Morrell et al. Magnetic resonance imaging of the fibrotic kidney
Tunnicliffe et al. A model for hepatic fibrosis: the competing effects of cell loss and iron on shortened modified Look‐Locker inversion recovery T1 (shMOLLI‐T1) in the liver
Feier et al. The diagnostic efficacy of quantitative liver MR imaging with diffusion-weighted, SWI, and hepato-specific contrast-enhanced sequences in staging liver fibrosis—a multiparametric approach
US20140330106A1 (en) Multi-parametric magnetic resonance diagnosis & staging of liver disease
US10228432B2 (en) Systems and methods for gated mapping of T1 values in abdominal visceral organs
Lee et al. Cross-sectional investigation of correlation between hepatic steatosis and IVIM perfusion on MR imaging
Unal et al. Multiparametric or practical quantitative liver MRI: towards millisecond, fat fraction, kilopascal and function era
Yarnykh et al. Fast macromolecular proton fraction mapping of the human liver in vivo for quantitative assessment of hepatic fibrosis
Jochimsen et al. Whole-brain mapping of venous vessel size in humans using the hypercapnia-induced BOLD effect
WO2015144916A1 (en) Method and apparatus for non-invasive detection of inflammation of a visceral organ
Qu et al. Magnetic resonance quantitative susceptibility mapping in the evaluation of hepatic fibrosis in chronic liver disease: a feasibility study
Li et al. Evaluation of liver function in patients with chronic hepatitis B using Gd-EOB-DTPA-enhanced T1 mapping at different acquisition time points: A feasibility study
Hou et al. Detecting early‐stage liver fibrosis using macromolecular proton fraction mapping based on spin‐lock MRI: preliminary observations
Fujita et al. Estimation of gadolinium-based contrast agent concentration using quantitative synthetic MRI and its application to brain metastases: a feasibility study
Bechtel et al. Establishing a hemoglobin adjustment for 129Xe gas exchange MRI and MRS
Tang et al. Renal fat deposition measured on dixon-based MRI is significantly associated with early kidney damage in obesity
Suo et al. Apparent diffusion coefficient measurements of bilateral kidneys at 3 T MRI: effects of age, gender, and laterality in healthy adults
Molinari et al. Ultrashort echo time MRI of pulmonary water content: assessment in a sponge phantom at 1.5 and 3.0 Tesla
Dillman et al. Quantitative abdominal magnetic resonance imaging in children—special considerations
EP3535595B1 (en) Correction method for magnetic resonance t1-mapping of visceral organs in the presence of elevated iron and elevated fat levels, and in the presence of off-resonance frequencies
Mokry et al. Diffusivity mapping of the ovaries: Variability of apparent diffusion and kurtosis variables over the menstrual cycle and influence of oral contraceptives
Robson et al. T1 mapping of the kidney

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170309

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170309

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180112

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180123

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180423

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180731

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180822

R150 Certificate of patent or registration of utility model

Ref document number: 6392256

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250