JP6380777B2 - ＰＩ３Ｋ、ｍＴＯＲ阻害薬としての縮合キノリン化合物 - Google Patents

ＰＩ３Ｋ、ｍＴＯＲ阻害薬としての縮合キノリン化合物 Download PDF

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JP6380777B2
JP6380777B2 JP2017502270A JP2017502270A JP6380777B2 JP 6380777 B2 JP6380777 B2 JP 6380777B2 JP 2017502270 A JP2017502270 A JP 2017502270A JP 2017502270 A JP2017502270 A JP 2017502270A JP 6380777 B2 JP6380777 B2 JP 6380777B2
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alkyl
phenyl
trifluoromethyl
hexadeca
pentaazatetracyclo
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JP2017534569A (ja
JP2017534569A5 (OSRAM
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チェン，グオキン，ポール
ヤン，チャンレン
リアレ，マイケル
チェン，モニカ
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アドヴェンチェン ファーマスーティカルズ，ナンジン リミテッド
アドヴェンチェン ファーマスーティカルズ，ナンジン リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017502270A 2014-07-14 2015-07-11 ＰＩ３Ｋ、ｍＴＯＲ阻害薬としての縮合キノリン化合物 Active JP6380777B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462024192P 2014-07-14 2014-07-14
US62/024,192 2014-07-14
PCT/US2015/040076 WO2016010869A2 (en) 2014-07-14 2015-07-11 FUSED QUINOLINE COMPUNDS AS PI3K, mTOR INHIBITORS

Publications (3)

Publication Number Publication Date
JP2017534569A JP2017534569A (ja) 2017-11-24
JP2017534569A5 JP2017534569A5 (OSRAM) 2018-07-26
JP6380777B2 true JP6380777B2 (ja) 2018-08-29

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JP2017502270A Active JP6380777B2 (ja) 2014-07-14 2015-07-11 ＰＩ３Ｋ、ｍＴＯＲ阻害薬としての縮合キノリン化合物

Country Status (9)

Country Link
US (1) US10112945B2 (OSRAM)
EP (1) EP3169687B1 (OSRAM)
JP (1) JP6380777B2 (OSRAM)
KR (1) KR102426138B1 (OSRAM)
CN (1) CN105722840B (OSRAM)
AU (1) AU2015290007B2 (OSRAM)
CA (1) CA2954999C (OSRAM)
ES (1) ES2714100T3 (OSRAM)
WO (1) WO2016010869A2 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105311030B (zh) 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
CN105311029A (zh) 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
AU2015360095B2 (en) 2014-12-09 2020-02-27 Advenchen Laboratories Nanjing Ltd Quinoline derivative against non-small cell lung cancer
US9751859B2 (en) 2015-05-04 2017-09-05 Advenchen Pharmaceuticals, LLC Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts
US10730878B2 (en) 2015-07-11 2020-08-04 Advenchen Pharmaceuticals, LLC Fused quinoline compounds as PI3K/mTOR inhibitors
CN107296811B (zh) 2016-04-15 2022-12-30 正大天晴药业集团股份有限公司 一种用于治疗胃癌的喹啉衍生物
CN107037153B (zh) * 2017-04-21 2019-05-14 常州佳德医药科技有限公司 高效液相色谱法检测al58805原料药或药物制剂中基因毒性杂质的方法
AU2019227391B2 (en) 2018-03-02 2024-06-13 Advenchen Laboratories Nanjing Ltd. Crystal of compound as c-Met kinase inhibitor and preparation method therefor and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
GB0510390D0 (en) * 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US9370508B2 (en) * 2007-02-20 2016-06-21 Novartis Ag Imidazoquinolines as dual lipid kinase and mTOR inhibitors
US8163923B2 (en) 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
US8148532B2 (en) 2007-03-14 2012-04-03 Guoqing Paul Chen Spiro substituted compounds as angiogenesis inhibitors
US20110212053A1 (en) * 2008-06-19 2011-09-01 Dapeng Qian Phosphatidylinositol 3 kinase inhibitors
IT1393351B1 (it) 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi
CN103664892B (zh) 2010-08-01 2015-09-02 正大天晴药业集团股份有限公司 喹啉衍生物的结晶
AU2011301518B2 (en) * 2010-09-16 2014-07-03 Hutchison Medipharma Limited Fused heteroaryls and their uses
MX2015008543A (es) 2013-01-18 2015-11-16 Advenchen Pharmaceuticals Llc Proceso para preparar el agente antitumoral 6-(7-((1-aminoaciclopr opil)metoxi)-6-metoxiquinolin-4-iloxi)-n-metil-1-naftamida y su cristalino.
CN105311030B (zh) 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
CN105311029A (zh) 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
US9751859B2 (en) 2015-05-04 2017-09-05 Advenchen Pharmaceuticals, LLC Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts

Also Published As

Publication number Publication date
ES2714100T3 (es) 2019-05-27
AU2015290007B2 (en) 2019-11-21
EP3169687A2 (en) 2017-05-24
JP2017534569A (ja) 2017-11-24
WO2016010869A2 (en) 2016-01-21
KR20170035944A (ko) 2017-03-31
WO2016010869A3 (en) 2016-04-07
CA2954999C (en) 2020-01-07
CN105722840A (zh) 2016-06-29
AU2015290007A1 (en) 2017-02-23
KR102426138B1 (ko) 2022-07-28
EP3169687B1 (en) 2019-01-02
CN105722840B (zh) 2018-01-05
US20170174687A1 (en) 2017-06-22
CA2954999A1 (en) 2016-01-21
US10112945B2 (en) 2018-10-30
EP3169687A4 (en) 2018-01-03

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