JP6378778B2 - 組織種類分離の助けを借りて磁気共鳴画像に基づき１つ以上のコンピュータ断層撮影画像を生成する方法及び装置 - Google Patents

組織種類分離の助けを借りて磁気共鳴画像に基づき１つ以上のコンピュータ断層撮影画像を生成する方法及び装置 Download PDF

Info

Publication number
JP6378778B2
JP6378778B2 JP2016559279A JP2016559279A JP6378778B2 JP 6378778 B2 JP6378778 B2 JP 6378778B2 JP 2016559279 A JP2016559279 A JP 2016559279A JP 2016559279 A JP2016559279 A JP 2016559279A JP 6378778 B2 JP6378778 B2 JP 6378778B2
Authority
JP
Japan
Prior art keywords
tissue
images
image data
substance
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016559279A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017508561A (ja
JP2017508561A5 (https=
Inventor
シャーデヴァルト，ニコーレ
シュルツ，ハインリヒ
ギュンター ヘレ，ミヒャエル
ギュンター ヘレ，ミヒャエル
レニッシュ，シュテフェン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Publication of JP2017508561A publication Critical patent/JP2017508561A/ja
Publication of JP2017508561A5 publication Critical patent/JP2017508561A5/ja
Application granted granted Critical
Publication of JP6378778B2 publication Critical patent/JP6378778B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7278—Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/032—Transmission computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/505—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5217—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data extracting a diagnostic or physiological parameter from medical diagnostic data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G01R33/481—MR combined with positron emission tomography [PET] or single photon emission computed tomography [SPECT]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • G01R33/4812—MR combined with X-ray or computed tomography [CT]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4828—Resolving the MR signals of different chemical species, e.g. water-fat imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T12/00—Tomographic reconstruction from projections
    • G06T12/30—Image post-processing, e.g. metal artefact correction
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T5/00—Image enhancement or restoration
    • G06T5/90—Dynamic range modification of images or parts thereof
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
    • A61N2005/1055—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using magnetic resonance imaging [MRI]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10081—Computed x-ray tomography [CT]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10072—Tomographic images
    • G06T2207/10088—Magnetic resonance imaging [MRI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Theoretical Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Pulmonology (AREA)
  • Optics & Photonics (AREA)
  • Artificial Intelligence (AREA)
  • Signal Processing (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
JP2016559279A 2014-03-28 2015-03-19 組織種類分離の助けを借りて磁気共鳴画像に基づき１つ以上のコンピュータ断層撮影画像を生成する方法及び装置 Active JP6378778B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14162319.9 2014-03-28
EP14162319 2014-03-28
PCT/EP2015/055738 WO2015144540A1 (en) 2014-03-28 2015-03-19 Method and device for generating one or more computer tomography images based on magnetic resonance images with the help of tissue class separation

Publications (3)

Publication Number Publication Date
JP2017508561A JP2017508561A (ja) 2017-03-30
JP2017508561A5 JP2017508561A5 (https=) 2018-03-01
JP6378778B2 true JP6378778B2 (ja) 2018-08-22

Family

ID=50478701

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016559279A Active JP6378778B2 (ja) 2014-03-28 2015-03-19 組織種類分離の助けを借りて磁気共鳴画像に基づき１つ以上のコンピュータ断層撮影画像を生成する方法及び装置

Country Status (5)

Country Link
US (1) US10223794B2 (https=)
EP (1) EP3123443B1 (https=)
JP (1) JP6378778B2 (https=)
CN (1) CN106133790B (https=)
WO (1) WO2015144540A1 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2721932C2 (ru) 2015-03-20 2020-05-25 Конинклейке Филипс Н.В. Альтернативное решение для неопределенных областей в изображениях mrcat
US10102451B2 (en) 2015-10-13 2018-10-16 Elekta, Inc. Pseudo-CT generation from MR data using tissue parameter estimation
CN106474634A (zh) * 2015-11-17 2017-03-08 南京中硼联康医疗科技有限公司 基于医学影像数据的几何模型建立方法
JP6748207B2 (ja) * 2015-12-18 2020-08-26 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 患者特有の局所的に変化するマージンを決定する方法
CN108778418B (zh) * 2016-03-10 2021-01-29 皇家飞利浦有限公司 合成计算机断层摄影成像
WO2018048507A1 (en) 2016-09-06 2018-03-15 Han Xiao Neural network for generating synthetic medical images
CN108310677B (zh) * 2017-01-11 2020-02-28 南京中硼联康医疗科技有限公司 基于医学影像数据的平滑几何模型建立方法
US11000255B2 (en) * 2017-02-24 2021-05-11 Bayer Healthcare Llc Systems and methods for generating simulated computed tomography (CT) images
EP3379281A1 (en) * 2017-03-20 2018-09-26 Koninklijke Philips N.V. Image segmentation using reference gray scale values
CN107133996B (zh) * 2017-03-21 2020-08-04 上海联影医疗科技有限公司 产生用于pet数据重建的衰减图的方法及pet/ct系统
EP3431007B1 (en) * 2017-07-21 2020-06-17 Koninklijke Philips N.V. Creation of electron density datasets from spectral ct datasets
CN109420259A (zh) 2017-08-24 2019-03-05 上海联影医疗科技有限公司 治疗系统和使用治疗系统的方法
US11883685B2 (en) 2017-08-24 2024-01-30 Shanghai United Imaging Healthcare Co., Ltd. Therapeutic system and method
EP3723030A4 (en) * 2017-12-05 2021-06-16 DSI Corporation AUTOMATIC TECHNICAL COST CALCULATION SYSTEM, AUTOMATIC TECHNICAL COST CALCULATION PROCESS AND PROGRAM
EP3521849A1 (en) * 2018-02-02 2019-08-07 Koninklijke Philips N.V. Mri with fat/water separation
CN109215014B (zh) * 2018-07-02 2022-03-04 中国科学院深圳先进技术研究院 Ct图像预测模型的训练方法、装置、设备及存储介质
CN109389603B (zh) * 2018-09-10 2021-09-24 北京大学 一种基于预加重策略的全自动腰椎图像分割方法
JP7129869B2 (ja) * 2018-10-01 2022-09-02 富士フイルム株式会社 疾患領域抽出装置、方法及びプログラム
US11497566B2 (en) * 2018-10-26 2022-11-15 Biosense Webster (Israel) Ltd. Loose mode for robot
EP3654278A1 (en) * 2018-11-19 2020-05-20 Koninklijke Philips N.V. Characterizing lesions in radiology images
CN109978965B (zh) * 2019-03-21 2025-09-30 江南大学 一种模拟ct图像生成方法、装置、计算机设备和存储介质
EP3751524A1 (en) * 2019-06-13 2020-12-16 RaySearch Laboratories AB Method, computer program product and computer system for providing an approximate image
CN112535488A (zh) * 2019-09-23 2021-03-23 佳能医疗系统株式会社 解析装置
JP6738003B1 (ja) * 2019-10-30 2020-08-12 日本テクトシステムズ株式会社 Ｍｒｉ画像に基づく解剖学的部位の抽出装置，方法，プログラム
WO2021206157A1 (ja) * 2020-04-08 2021-10-14 キヤノンメディカルシステムズ株式会社 医用情報処理装置及び医用情報処理方法
JP7563925B2 (ja) * 2020-04-08 2024-10-08 キヤノンメディカルシステムズ株式会社 医用情報処理装置及び医用情報処理方法
CN113706541B (zh) * 2020-05-20 2024-04-19 青岛海信医疗设备股份有限公司 一种图像处理方法及装置
US12602773B2 (en) * 2020-08-07 2026-04-14 Washington University Deep-learning-based T1-enhanced selection of linear coefficients (DL-TESLA) for PET/MR attenuation correction
US12347100B2 (en) 2020-11-19 2025-07-01 Mazor Robotics Ltd. Systems and methods for generating virtual images

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2229981A1 (en) 2009-03-17 2010-09-22 Paul Scherrer Institut A method for evaluating radiation model data in particle beam radiation applications
JP5364009B2 (ja) * 2010-02-12 2013-12-11 富士フイルム株式会社 画像生成装置、画像生成方法、及びそのプログラム
US8588498B2 (en) 2011-09-30 2013-11-19 General Electric Company System and method for segmenting bones on MR images
JP5706389B2 (ja) 2011-12-20 2015-04-22 富士フイルム株式会社 画像処理装置および画像処理方法、並びに、画像処理プログラム
US9342903B2 (en) 2012-03-28 2016-05-17 National Institute Of Radiological Services Method for generating image for PET attenuation correction from MR image and computer program

Also Published As

Publication number Publication date
WO2015144540A1 (en) 2015-10-01
CN106133790B (zh) 2020-09-29
US10223794B2 (en) 2019-03-05
EP3123443A1 (en) 2017-02-01
CN106133790A (zh) 2016-11-16
US20180174298A1 (en) 2018-06-21
JP2017508561A (ja) 2017-03-30
EP3123443B1 (en) 2018-06-13

Similar Documents

Publication Publication Date Title
JP6378778B2 (ja) 組織種類分離の助けを借りて磁気共鳴画像に基づき１つ以上のコンピュータ断層撮影画像を生成する方法及び装置
US8787648B2 (en) CT surrogate by auto-segmentation of magnetic resonance images
JP6567179B2 (ja) 特徴回帰モデルを用いたｍｒデータからの疑似ｃｔ生成
JP7184774B2 (ja) 変形可能テンプレートを使用して最適化された電極位置を有するｔｔフィールドを用いて患者を治療する
US11443441B2 (en) Deep inspiration breath-hold setup using x-ray imaging
US8953856B2 (en) Method and system for registering a medical image
US10803354B2 (en) Cross-modality image synthesis
US10149987B2 (en) Method and system for generating synthetic electron density information for dose calculations based on MRI
JP2017508561A5 (https=)
JP2018535732A (ja) 組織パラメータ推定を用いたｍｒデータからの擬似ｃｔ生成
EP3468668B1 (en) Soft tissue tracking using physiologic volume rendering
CN103562960B (zh) 用于生成图像的图像区域与元素类之间的分配的装置
CN107865658B (zh) 用于修正合成电子密度图的方法和设备
Eiben et al. Symmetric biomechanically guided prone-to-supine breast image registration
Yip et al. Development and evaluation of an articulated registration algorithm for human skeleton registration
CN105339804B (zh) 根据MR Dixon数据的皮质骨分割
Khmelinskii et al. Articulated whole-body atlases for small animal image analysis: construction and applications
US8265361B2 (en) Automatic transfer of outlined objects from one data set into another data set
Dowling et al. Image synthesis for MRI-only radiotherapy treatment planning
EP4449353A1 (en) Ct-less free breathing image contour for planning radiation treatment
Li et al. Automatic inter-subject registration of whole body images
Balasubramanian et al. Registration of PET and MR images of human brain using normalized cross correlation algorithm and spatial transformation techniques

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180117

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180117

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20180117

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20180320

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180327

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180619

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180703

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180727

R150 Certificate of patent or registration of utility model

Ref document number: 6378778

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250