JP6377123B2 - 癌の治療のためのｍｄｍ２阻害剤としてのヘテロアリール酸モルホリノン化合物 - Google Patents
癌の治療のためのｍｄｍ２阻害剤としてのヘテロアリール酸モルホリノン化合物 Download PDFInfo
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- JP6377123B2 JP6377123B2 JP2016502187A JP2016502187A JP6377123B2 JP 6377123 B2 JP6377123 B2 JP 6377123B2 JP 2016502187 A JP2016502187 A JP 2016502187A JP 2016502187 A JP2016502187 A JP 2016502187A JP 6377123 B2 JP6377123 B2 JP 6377123B2
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- cancer
- methyl
- pharmaceutical composition
- chlorophenyl
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- QPWPHXQCCIMHAL-PICXLURJSA-N CC(C)(C)S(CC(C1CC1)N(C(C(c1cc(Cl)ccc1)O[C@]1(C)Cc(nc2)ccc2C(O)=O)C(/C=C\C(\Cl)=C(/C)\F)=C)C1=O)(=O)=O Chemical compound CC(C)(C)S(CC(C1CC1)N(C(C(c1cc(Cl)ccc1)O[C@]1(C)Cc(nc2)ccc2C(O)=O)C(/C=C\C(\Cl)=C(/C)\F)=C)C1=O)(=O)=O QPWPHXQCCIMHAL-PICXLURJSA-N 0.000 description 1
- IRQSKJQDKUAART-UHFFFAOYSA-N COC(c1cnc(CBr)cc1)=O Chemical compound COC(c1cnc(CBr)cc1)=O IRQSKJQDKUAART-UHFFFAOYSA-N 0.000 description 1
- WNPSSFSXORYRAN-WXOOSPASSA-N C[C@@](CC=C)(C(N(C(CO)C1CC1)C1c(cc2F)ccc2Cl)=O)O[C@@H]1c1cc(Cl)ccc1 Chemical compound C[C@@](CC=C)(C(N(C(CO)C1CC1)C1c(cc2F)ccc2Cl)=O)O[C@@H]1c1cc(Cl)ccc1 WNPSSFSXORYRAN-WXOOSPASSA-N 0.000 description 1
- HKNCPEFDFMIXFA-PZEHHVJRSA-N C[C@@](Cc(nc1)ccc1C(OC)=O)(C(N(C(CO)C1CC1)C1c(cc2)cc(F)c2Cl)=O)O[C@@H]1c1cc(Cl)ccc1 Chemical compound C[C@@](Cc(nc1)ccc1C(OC)=O)(C(N(C(CO)C1CC1)C1c(cc2)cc(F)c2Cl)=O)O[C@@H]1c1cc(Cl)ccc1 HKNCPEFDFMIXFA-PZEHHVJRSA-N 0.000 description 1
- WNPSSFSXORYRAN-WZCQUIKNSA-N C[C@](CC=C)(C(N(C(CO)C1CC1)C1c(cc2)cc(F)c2Cl)=O)O[C@@H]1c1cc(Cl)ccc1 Chemical compound C[C@](CC=C)(C(N(C(CO)C1CC1)C1c(cc2)cc(F)c2Cl)=O)O[C@@H]1c1cc(Cl)ccc1 WNPSSFSXORYRAN-WZCQUIKNSA-N 0.000 description 1
- HKNCPEFDFMIXFA-HEXBMGIASA-N C[C@](Cc(nc1)ccc1C(OC)=O)(C(N(C(CO)C1CC1)C1c(cc2)cc(F)c2Cl)=O)O[C@@H]1c1cc(Cl)ccc1 Chemical compound C[C@](Cc(nc1)ccc1C(OC)=O)(C(N(C(CO)C1CC1)C1c(cc2)cc(F)c2Cl)=O)O[C@@H]1c1cc(Cl)ccc1 HKNCPEFDFMIXFA-HEXBMGIASA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784230P | 2013-03-14 | 2013-03-14 | |
| US61/784,230 | 2013-03-14 | ||
| PCT/US2014/026584 WO2014151863A1 (en) | 2013-03-14 | 2014-03-13 | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513660A JP2016513660A (ja) | 2016-05-16 |
| JP2016513660A5 JP2016513660A5 (US07794700-20100914-C00152.png) | 2017-03-30 |
| JP6377123B2 true JP6377123B2 (ja) | 2018-08-22 |
Family
ID=50442720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502187A Active JP6377123B2 (ja) | 2013-03-14 | 2014-03-13 | 癌の治療のためのｍｄｍ２阻害剤としてのヘテロアリール酸モルホリノン化合物 |
Country Status (7)
Families Citing this family (33)
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| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| US9376425B2 (en) | 2011-09-27 | 2016-06-28 | Amgen, Inc. | Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| CA2906538C (en) | 2013-03-14 | 2021-02-02 | Ana Gonzalez Buenrostro | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| AP2016009243A0 (en) | 2013-11-11 | 2016-05-31 | Amgen Inc | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
| CN107428734A (zh) | 2015-01-20 | 2017-12-01 | 阿尔维纳斯股份有限公司 | 用于雄激素受体的靶向降解的化合物和方法 |
| US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| US20180147202A1 (en) | 2015-06-05 | 2018-05-31 | Arvinas, Inc. | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE |
| WO2017030814A1 (en) | 2015-08-19 | 2017-02-23 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
| CA3209295A1 (en) | 2016-11-01 | 2018-06-07 | Arvinas, Inc. | Tau-protein targeting protacs and associated methods of use |
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| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| US10723717B2 (en) | 2016-12-23 | 2020-07-28 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides |
| EP3559006A4 (en) | 2016-12-23 | 2021-03-03 | Arvinas Operations, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FETAL LIVER KINASE POLYPEPTIDES |
| CA3047586A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas Operations, Inc. | Egfr proteolysis targeting chimeric molecules and associated methods of use |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| US10604506B2 (en) | 2017-01-26 | 2020-03-31 | Arvinas Operations, Inc. | Modulators of estrogen receptor proteolysis and associated methods of use |
| CN110959005B (zh) * | 2017-07-28 | 2024-01-19 | 巴斯夫欧洲公司 | 取代的3-芳基-5-三氟甲基-1,2,4-噁二唑类的制备 |
| WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
| WO2019038042A1 (en) | 2017-08-21 | 2019-02-28 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR THE CONTROL OF PHYTOPATHOGENIC FUNGI |
| US11065231B2 (en) | 2017-11-17 | 2021-07-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides |
| JP2021521112A (ja) | 2018-04-04 | 2021-08-26 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | タンパク質分解の調節因子および関連する使用方法 |
| WO2019219464A1 (en) | 2018-05-15 | 2019-11-21 | Basf Se | Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi |
| JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解 |
| IL293396A (en) | 2019-12-05 | 2022-07-01 | Basf Se | Preparation of converted aromatic carboxamides |
| US20230339847A1 (en) | 2020-04-29 | 2023-10-26 | Basf Se | Preparation of aromatic carboxyamides by a palladium-catalyzed carbonylation reaction |
| US20230167050A1 (en) | 2020-04-29 | 2023-06-01 | Basf Se | Preparation of aromatic carboxyamides by palladium-catalyzed carbonylation reaction |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| US11957759B1 (en) | 2022-09-07 | 2024-04-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use |
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| AU2014236812A1 (en) | 2015-09-17 |
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