JP6364472B2 - 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 - Google Patents
抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 Download PDFInfo
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- JP6364472B2 JP6364472B2 JP2016503187A JP2016503187A JP6364472B2 JP 6364472 B2 JP6364472 B2 JP 6364472B2 JP 2016503187 A JP2016503187 A JP 2016503187A JP 2016503187 A JP2016503187 A JP 2016503187A JP 6364472 B2 JP6364472 B2 JP 6364472B2
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- pyridin
- methyl
- oxy
- carbamoyl
- pyrazol
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361789971P | 2013-03-15 | 2013-03-15 | |
US61/789,971 | 2013-03-15 | ||
PCT/US2014/029664 WO2014145028A2 (en) | 2013-03-15 | 2014-03-14 | N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018126337A Division JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016516724A JP2016516724A (ja) | 2016-06-09 |
JP2016516724A5 JP2016516724A5 (ru) | 2017-04-20 |
JP6364472B2 true JP6364472B2 (ja) | 2018-07-25 |
Family
ID=51529946
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016503187A Active JP6364472B2 (ja) | 2013-03-15 | 2014-03-14 | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
JP2018126337A Pending JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
JP2020068792A Active JP6985448B2 (ja) | 2013-03-15 | 2020-04-07 | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018126337A Pending JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
JP2020068792A Active JP6985448B2 (ja) | 2013-03-15 | 2020-04-07 | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
Country Status (16)
Country | Link |
---|---|
US (1) | US9382228B2 (ru) |
EP (1) | EP2968287B1 (ru) |
JP (3) | JP6364472B2 (ru) |
KR (2) | KR102333718B1 (ru) |
CN (3) | CN112047927A (ru) |
AU (2) | AU2014233414B2 (ru) |
BR (1) | BR112015022263B1 (ru) |
CA (1) | CA2903288C (ru) |
ES (1) | ES2817902T3 (ru) |
HK (1) | HK1220400A1 (ru) |
IL (2) | IL241523B (ru) |
MX (2) | MX366429B (ru) |
PH (1) | PH12015502336A1 (ru) |
RU (1) | RU2769607C2 (ru) |
SG (1) | SG11201508532VA (ru) |
WO (1) | WO2014145028A2 (ru) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018184416A (ja) * | 2013-03-15 | 2018-11-22 | デシフェラ ファーマシューティカルズ,エルエルシー | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
US11679110B2 (en) | 2018-12-28 | 2023-06-20 | Deciphera Pharmaceuticals, Llc | Methods of treating disorders using CSF1R inhibitors |
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JP5335056B2 (ja) | 2011-11-16 | 2013-11-06 | 住友電気工業株式会社 | ボルト用アルミニウム合金線及びボルト並びにそれらの製造方法 |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
TWI747873B (zh) | 2016-02-01 | 2021-12-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
KR101691954B1 (ko) | 2016-04-26 | 2017-01-02 | 고려대학교 산학협력단 | 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물 |
US11149021B2 (en) * | 2017-05-24 | 2021-10-19 | Abbisko Therapeutics Co., Ltd. | N-(azaaryl)cyclolactam-1-carboxamide derivative, preparation method therefor, and use thereof |
WO2018233526A1 (zh) * | 2017-06-19 | 2018-12-27 | 上海和誉生物医药科技有限公司 | 一种csf1r抑制剂及其制备方法和应用 |
DK3672977T3 (da) * | 2017-08-24 | 2022-09-26 | Merck Patent Gmbh | Boronsyrederivater |
CN109776401A (zh) * | 2017-11-14 | 2019-05-21 | 成都博腾药业有限公司 | 一种制备6-氯-5-三氟甲基-2-氨基吡啶的方法 |
SG11202007198WA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
CN110845476B (zh) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用 |
LT3921030T (lt) | 2019-02-06 | 2024-01-25 | Eli Lilly And Company | 1-((2-(2,2,2-trifluoroetoksi)piridin-4-il)metil)karbamido dariniai, kaip kcnq stiprikliai |
PE20220597A1 (es) | 2019-05-10 | 2022-04-22 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos |
JP2022531932A (ja) | 2019-05-10 | 2022-07-12 | デシフェラ・ファーマシューティカルズ,エルエルシー | ヘテロアリールアミノピリミジンアミドオートファジー阻害剤およびその使用方法 |
EP3983081A1 (en) | 2019-06-17 | 2022-04-20 | Deciphera Pharmaceuticals, LLC | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
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JP2018184416A (ja) * | 2013-03-15 | 2018-11-22 | デシフェラ ファーマシューティカルズ,エルエルシー | 抗がんおよび抗増殖活性を示すn−アシル−n’−(ピリジン−2−イル)尿素および類似体 |
US11679110B2 (en) | 2018-12-28 | 2023-06-20 | Deciphera Pharmaceuticals, Llc | Methods of treating disorders using CSF1R inhibitors |
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