JP6359032B2 - 経皮薬物送達用のマルチポリマー組成物 - Google Patents

経皮薬物送達用のマルチポリマー組成物 Download PDF

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Publication number
JP6359032B2
JP6359032B2 JP2015550786A JP2015550786A JP6359032B2 JP 6359032 B2 JP6359032 B2 JP 6359032B2 JP 2015550786 A JP2015550786 A JP 2015550786A JP 2015550786 A JP2015550786 A JP 2015550786A JP 6359032 B2 JP6359032 B2 JP 6359032B2
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polymer
amine
drug
polymer matrix
composition
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Japanese (ja)
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JP2016504368A5 (enExample
JP2016504368A (ja
Inventor
ジョシュア クラコフスキー
ジョシュア クラコフスキー
プチュン リュウ
プチュン リュウ
Original Assignee
ノーヴェン ファーマシューティカルズ インコーポレイテッド
ノーヴェン ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015550786A 2012-12-28 2013-12-27 経皮薬物送達用のマルチポリマー組成物 Active JP6359032B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261747117P 2012-12-28 2012-12-28
US61/747,117 2012-12-28
PCT/US2013/077934 WO2014106016A1 (en) 2012-12-28 2013-12-27 Multi-polymer compositions for transdermal drug delivery

Publications (3)

Publication Number Publication Date
JP2016504368A JP2016504368A (ja) 2016-02-12
JP2016504368A5 JP2016504368A5 (enExample) 2017-02-09
JP6359032B2 true JP6359032B2 (ja) 2018-07-18

Family

ID=49956518

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015550786A Active JP6359032B2 (ja) 2012-12-28 2013-12-27 経皮薬物送達用のマルチポリマー組成物

Country Status (8)

Country Link
US (2) US9295726B2 (enExample)
EP (1) EP2938335B1 (enExample)
JP (1) JP6359032B2 (enExample)
AU (1) AU2013370297A1 (enExample)
CA (1) CA2896347A1 (enExample)
ES (1) ES2864327T3 (enExample)
MX (1) MX366230B (enExample)
WO (1) WO2014106016A1 (enExample)

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US8614716B2 (en) 2010-10-01 2013-12-24 Apple Inc. Recording a command stream with a rich encoding format for capture and playback of graphics content
US9314470B2 (en) 2012-12-28 2016-04-19 Noven Pharmaceuticals, Inc. Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol
WO2014159582A1 (en) 2013-03-14 2014-10-02 Noven Pharmaceuticals, Inc Amphetamine transdermal compositions with acrylic block copolymer
AR095260A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones de anfetaminas transdérmicas estables y métodos de fabricación
AR095259A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria
CN105607772B (zh) * 2014-11-13 2020-11-03 现代自动车株式会社 触摸输入装置以及包括该装置的车辆
JP6807848B2 (ja) 2015-02-06 2021-01-06 ノーヴェン ファーマシューティカルズ インコーポレイテッド 経皮薬物送達のための感圧粘着剤
US10406116B2 (en) 2015-02-06 2019-09-10 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
CA3047354A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
CN115813888A (zh) 2016-12-20 2023-03-21 罗曼治疗系统股份公司 包含阿塞那平的透皮治疗系统
JP2020525545A (ja) 2017-06-26 2020-08-27 エルテーエス ローマン テラピー−ジステーメ アーゲー アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム
CN118806732A (zh) 2018-06-20 2024-10-22 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
JP7502199B2 (ja) 2018-06-20 2024-06-18 エルテーエス ローマン テラピー－ジステーメ アーゲー アセナピンを含有する経皮治療システム
US11572339B2 (en) 2021-01-07 2023-02-07 Noven Pharmaceuticals, Inc. Amphetamine carbamate compounds and methods
WO2022150430A1 (en) 2021-01-07 2022-07-14 Noven Pharmaceuticals, Inc. Transdermal amphetamine compositions with low levels of carbamate

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JPH0676321B2 (ja) * 1987-02-18 1994-09-28 久光製薬株式会社 クロニジン経皮投与製剤
US5719197A (en) 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5234957A (en) 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5474783A (en) 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
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US6024974A (en) 1995-01-06 2000-02-15 Noven Pharmaceuticals, Inc. Composition and methods for transdermal delivery of acid labile drugs
CA2223588C (en) 1995-06-07 2004-01-06 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
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US8343538B2 (en) * 2004-10-08 2013-01-01 Noven Pharmaceuticals, Inc. Compositions and methods for controlling the flux of a drug from a transdermal drug delivery systems
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US7989496B2 (en) 2006-10-27 2011-08-02 Noven Pharmaceuticals, Inc. Transdermal delivery of ketoprofen polar derivatives
US8231906B2 (en) 2008-07-10 2012-07-31 Noven Pharmaceuticals, Inc. Transdermal estrogen device and delivery
US9320742B2 (en) 2009-12-01 2016-04-26 Noven Pharmaceuticals, Inc. Transdermal testosterone device and delivery
WO2012092165A1 (en) 2010-12-29 2012-07-05 Noven Pharmaceuticals, Inc. Transdermal drug delivery system comprising levonorgestrel acetate
EP2700401B1 (en) * 2011-04-18 2020-01-15 Hisamitsu Pharmaceutical Co., Inc. Method for producing adhesive patch, and adhesive patch
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JP2015535253A (ja) 2012-10-25 2015-12-10 ノーヴェン ファーマシューティカルズ インコーポレイテッド アンフェタミンの組成物及びアンフェタミンを経皮送達する方法
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KR20150103077A (ko) 2012-12-28 2015-09-09 노벤 파머수티컬즈, 인코퍼레이티드 비스테로이드성 항염증제의 경피 전달을 위한 조성물 및 방법

Also Published As

Publication number Publication date
ES2864327T3 (es) 2021-10-13
AU2013370297A1 (en) 2015-07-16
US9295726B2 (en) 2016-03-29
MX2015008286A (es) 2015-12-09
CA2896347A1 (en) 2014-07-03
US20170007548A1 (en) 2017-01-12
EP2938335B1 (en) 2021-03-17
WO2014106016A1 (en) 2014-07-03
EP2938335A1 (en) 2015-11-04
US20140186424A1 (en) 2014-07-03
MX366230B (es) 2019-07-03
JP2016504368A (ja) 2016-02-12

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