JP6341797B2 - Oral composition and oral preparation - Google Patents

Description

  The present invention relates to a composition for oral cavity and a preparation for oral cavity that can be supplied in the form of a mist in the entire oral cavity when sprayed with a spray and can suppress drying in the oral cavity.

The number of saliva secretions has decreased due to physical condition, aging and drug intake, and an increasing number of people complain of dry mouth. When the oral cavity dries, germs grow in the oral cavity and cause bad breath. In addition, aspiration pneumonia may be caused by aspiration of bacteria grown in the oral cavity.
When the dryness in the oral cavity is mild, dryness in the oral cavity can be prevented by taking measures such as frequent intake of water or licking of wrinkles. However, it is difficult to ingest water frequently in daily life. There is also a problem that caries tend to occur if the heels are frequently licked.

  In order to solve the above problems, for example, a gel for moisturizing the oral cavity has been developed. The oral moisturizing gel needs to be applied to the oral cavity using fingers or a sponge, and has not been easily used.

  In addition to the oral moisturizing gel, a dentifrice composition containing agar is disclosed for the purpose of maintaining wetness in the oral cavity (Patent Document 1). Moreover, the composition for oral cavity used by the aspect which contains water-soluble polymer, a drug, and a light silicic acid anhydride in a hydrophobic ointment base and is apply | coated is disclosed (patent document 2). In addition, a composition for oral cavity that contains a medicinal ingredient and gellan gum or a water-soluble polymer and is used in the form of a mouthwash or a mouse spray for the purpose of retaining the medicinal ingredient at a predetermined site in the oral cavity is disclosed. (Patent Documents 3 to 4). Furthermore, an oral spray that improves dryness in the oral cavity and has excellent sprayability is also disclosed (Patent Document 5).

  However, the toothpaste composition of Patent Document 1 needs to use a toothbrush or the like when applied to the oral cavity, and the toothpaste composition does not remain in the oral cavity due to cleaning after brushing, and for a certain amount of time in the oral cavity. By leaving the composition, it is different from the embodiment in which the mouth is moisturized and drying is suppressed. Moreover, the composition for oral cavity used by the aspect apply | coated to an oral cavity contains powder, such as a silicic acid anhydride, and when spraying by use of a spray, powder is clogged and is not suitable for the aspect sprayed. There is a problem. Furthermore, even if it is a composition for oral cavity used in the aspect of a mouthwash or a mouse spray like the composition for oral cavity of patent documents 3-5, the viscosity of an oral composition is 200 mPa * s or less, Since the viscosity is low and the adherence to the oral cavity is low, it may not stay in the oral cavity for a long time, and drying may not be sufficiently suppressed. Further, when the viscosity is 200 mPa · s or more, there is a problem that the oral composition is not supplied in the form of a mist in the entire oral cavity even when sprayed with a spray, and drying in the oral cavity is not sufficiently suppressed.

JP-A-6-219929 Japanese Patent Laid-Open No. 10-245329 Japanese Patent Laid-Open No. 11-12144 JP-A-8-3074 JP 2009-274967 A

  INDUSTRIAL APPLICABILITY The present invention provides an oral composition that can be supplied in the form of a mist when sprayed with a spray and can be prevented from drying in the oral cavity by adhering to the oral cavity and staying relatively long. The purpose is to provide.

  The present inventors can supply the whole oral cavity in a spray form by using a spray, and can prevent drying in the oral cavity by adhering to the oral cavity and staying relatively long. The present inventors have intensively studied to provide a composition for use. As a result, an oral composition comprising agar, at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum, and a nonionic surfactant achieves such an object. As a result, the present invention was completed.

  The composition for oral cavity of this invention can be supplied to the whole intraoral area by spraying with a spray. Moreover, the composition for oral cavity of this invention can suppress drying in an oral cavity by adhering in an oral cavity and staying comparatively long. The present invention does not require application of the oral composition with fingers, is hygienic, and can easily suppress dryness in the oral cavity by simple means using a spray container.

  The present invention relates to an oral composition that can be supplied to the entire oral cavity in a spray form by suppressing the dryness in the oral cavity, and is a group consisting of agar, sodium alginate, sodium carboxymethylcellulose, and gellan gum It contains at least one water-soluble polymer selected from the above, and a nonionic surfactant.

In order to improve adhesion to the oral cavity, it is conceivable to add a thickener to the composition. Examples of such a thickener include water-soluble polymers such as carboxymethyl cellulose or a salt thereof, hydroxyethyl cellulose or a salt thereof, gellan gum, xanthan gum, carrageenan, sodium alginate, gelatin, agar and the like.
However, if only one of these thickeners is included in the oral composition, the composition for oral cavity does not spread in the form of a mist due to the viscosity of the composition, even when a spray is used. There was a case that liquid came out.

  Among the thickeners, it has been found that the composition for oral cavity containing agar becomes a mist in a relatively wide range when a spray is used. However, agar easily promotes water separation, and the storage stability of the oral composition may not be sufficient when the oral composition contains agar.

  The composition for oral cavity of the present invention improves adhesion in the oral cavity by containing agar and at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum, It has been found that water storage is suppressed during storage and storage stability is improved. Furthermore, the composition for oral cavity of the present invention comprises a nonionic surfactant together with agar and at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum. It has been found that when used, the spray state of the oral composition is improved and can be diffused throughout the oral cavity.

  The oral composition of the present invention has a viscosity at 25 ° C. of preferably 450 to 15000 mPa · s, more preferably 500 to 12000 mPa · s, still more preferably 1000 to 11000 mPa · s, and particularly preferably 1500 to 10500 mPa · s. . Even when the viscosity at 25 ° C. is relatively high, the composition for oral cavity of the present invention can be diffused in a spray form throughout the oral cavity by using a spray, and can quickly moisten the dry oral cavity. Furthermore, since the composition for oral cavity of the present invention has a relatively high viscosity at 25 ° C., the oral composition sprayed by using the spray adheres to the oral cavity and stays for a relatively long time, thereby suppressing dryness in the oral cavity. can do.

The agar that can be used in the oral composition of the present invention may be in the form of powder, granules, or flakes that are commercially available as raw materials for pharmaceuticals, foods, and cosmetics. Examples of such agar include Ina Agar CS, Ina Agar CSG, Ultra Agar AX-100, and Ultra Agar Ena manufactured by Ina Food Industry Co., Ltd. In particular, Ultra Agar AX-100 and Ultra Agar Ena can be suitably used to improve the spraying state due to the use of the spray. The properties of the agar are not particularly limited, but the jelly strength in the gel state of the agar component is preferably 10 to 250 g / cm ² at a 1.5% agar concentration. Such agar is disclosed in Japanese Patent No. 3023244.

  The blending amount of the agar is such that at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum, and a nonionic surfactant, the viscosity of the composition is 450 to 15000 mPa · The amount is not particularly limited as long as the amount is s. The blending amount of the agar is 0.2 to 1 on the basis of the weight of the composition from the viewpoint of the diffusibility of the sprayed state when sprayed, the suppression of water separation of the composition, and the adhesion of the composition in the oral cavity. It is preferably 2% by mass. The blending amount of agar is more preferably 0.3 to 1.0% by mass, still more preferably 0.4 to 0.8% by mass, based on the weight of the composition.

  At least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum that can be used in the oral composition of the present invention is commercially available as a raw material for pharmaceuticals, foods and cosmetics. That's fine. Such sodium alginate is not particularly limited, and examples thereof include sodium alginate having a mass of 1% by mass and a viscosity measured by a BL type viscometer at 20 ° C. of 50 to 1200 mPa · s. Sodium alginate is 1% by mass, and the viscosity measured by a BL type rotational viscometer at 20 ° C. is preferably 100 to 1000 mPa · s, more preferably 100 to 800 mPa · s, still more preferably 100 to 600 mPa · s. .

  Although it does not specifically limit as carboxymethylcellulose sodium which can be used for the composition for oral cavity of this invention, Etherification degree (degree of polymerization) becomes like this. Preferably it is 0.45-2.0, More preferably, it is 0.5-0. 8 sodium carboxymethylcellulose. Moreover, sodium carboxymethylcellulose is 1 mass%, and the viscosity measured by 25 degreeC and BL type viscometer becomes like this. Preferably it is 20-1500 mPa * s, More preferably, carboxymethylcellulose sodium is 100-1000 mPa * s.

  Gellan gum is a linear heteropolysaccharide and is usually composed of repeating units derived from four sugars, glucose, glucuronic acid, glucose and rhamnose. The gellan gum that can be used in the composition for oral cavity of the present invention is 1% by mass and has a viscosity measured by a BL type viscometer at 20 ° C., preferably 5000-20000 mPa · s, more preferably 8000-15000 mPa · s. Is mentioned.

  The blending amount of at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethyl cellulose and gellan gum is such that the viscosity at 25 ° C. of the composition is 450 to 15000 mPa · s, together with agar and nonionic surfactant. The amount is not particularly limited as long as it is such an amount. The blending amount of at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethyl cellulose and gellan gum is the composition from the viewpoint of improving the spraying state when sprayed and the adhesiveness of the composition in the oral cavity. It is preferable that it is 0.01-1.0 mass% on the basis of the weight of a thing. The blending amount of at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum is more preferably 0.03 to 0.8% by mass based on the weight of the composition, Preferably it is 0.05-0.5 mass%, Most preferably, it is 0.05-0.4 mass%.

  Nonionic surfactants that can be used in the oral composition of the present invention may be those commercially available as raw materials for pharmaceuticals, foods, and cosmetics. Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate, decaglyceryl laurate, and decaglyceryl myristate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, maltose fatty acid ester, and lactitol. Sugar alcohol fatty acid esters such as fatty acid esters, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, myristic acid mono Or fatty acid ethanolamide such as diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, poly Alkoxy polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid esters. Among these, polyoxyethylene hydrogenated castor oil and glycerin fatty acid ester having an average added mole number of ethylene oxide of 40 to 100 are preferable, and glycerin fatty acid ester for food is particularly preferable.

  The nonionic surfactant is blended in an amount of 450 to 15000 mPa · s at 25 ° C. of the composition together with agar and at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum. The amount is not particularly limited as long as it is such an amount. The compounding amount of the nonionic surfactant is 0.01 to 1.5% by mass on the basis of the weight of the composition from the viewpoint of improvement of the spraying state when sprayed and suppression of water separation of the composition. It is preferable. The compounding amount of the nonionic surfactant is more preferably from 0.03 to 1.2% by mass, further preferably from 0.05 to 1.0% by mass, and particularly preferably from 0.003% by mass, based on the weight of the composition. It is 05-0.5 mass%, Most preferably, it is 0.1-0.3 mass%.

  The oral composition of the present invention may contain a wetting agent. The wetting agent is not particularly limited as long as it can be used for pharmaceuticals, foods, and cosmetics. Examples of the wetting agent include polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol, polyethylene glycol, and polypropylene glycol. Of these, propylene glycol, 1,3-butylene glycol, and glycerin are preferable. These wetting agents are preferably blended by appropriately selecting one or a combination of two or more.

  The wetting agent is blended in such a manner that the viscosity at 25 ° C. of the composition containing agar, at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum, and a nonionic surfactant is 450. The amount is not particularly limited as long as the amount is ˜15000 mPa · s. The blending amount of the wetting agent is preferably 2 to 20% by mass based on the weight of the composition from the viewpoint of quickly moisturizing the oral cavity and suppressing dryness in the oral cavity. The blending amount of the wetting agent is more preferably 5 to 15% by mass based on the weight of the composition.

  The oral cavity composition of the present invention may contain a flavoring agent. As a corrigent, saccharin, sodium saccharin, disodium glycyrrhizinate, trisodium glycyrrhizinate, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, xylitol, inositol, D-sorbitol, D-mannitol, raffinose, Examples include lactulose, lactitol, erythritol, reduced palatinose, palatinose, palatinit, acesulfame K, maltose, and maltitol. Of these, sugar alcohols such as xylitol, erythritol, and maltitol are preferable. What is necessary is just to select and mix these 1 type, or 2 or more types of combinations suitably.

  The oral composition of the present invention may contain a moisturizing agent. The humectant is not particularly limited as long as it can be used for pharmaceuticals, foods, and cosmetics. Examples of the humectant include natural extract components such as amino acids or salts thereof, pyrrolidone carboxylic acid, hyaluronic acid or salts thereof, chondroitin sulfate, trehalose, collagen, polyquaterniums, and tea extract. What is necessary is just to select and mix these 1 type, or 2 or more types of combinations suitably.

  The oral composition of the present invention may contain a pH adjuster. Since the composition for oral cavity of the present invention is used in the oral cavity, its pH is preferably in the range of 5.5 to 8.0. The pH adjuster that can be used in the composition of the present invention is not particularly limited as long as it can be used in foods. For example, phosphoric acid, sodium monohydrogen phosphate, sodium dihydrogen phosphate, monophosphoric acid Examples thereof include potassium hydrogen, potassium dihydrogen phosphate, citric acid, malic acid, pyrophosphoric acid, tartaric acid, acetic acid, and salts thereof. What is necessary is just to select and mix these 1 type, or 2 or more types of combinations suitably.

The composition for oral cavity of the present invention contains water in the balance.
The oral composition of the present invention may further contain additives such as fragrances, preservatives, and coloring agents in a range that does not impair the water supply ability and viscosity of the composition. Moreover, you may add active ingredients, such as an antibacterial agent and a vitamin agent, to the oral cavity composition of this invention in anticipation of the dry state of an oral cavity, and the treatment and prevention effect of the disease accompanying it. A fragrance | flavor, antiseptic | preservative, a coloring agent, an antibacterial agent, a vitamin agent etc. will not be specifically limited if it can be used for a pharmaceutical, foodstuffs, and cosmetics.

  Examples of the fragrance include l-menthol, peppermint, spearmint, and fruit fragrance. The perfume also has the advantage of stimulating salivation. Examples of the colorant include natural or synthetic dyes such as edible tar dyes, caramel dyes, gardenia dyes, anthocyanin dyes, safflower dyes, and the like. What is necessary is just to select these 1 type, or 2 or more types of combinations suitably.

  Examples of preservatives include parabens (paraoxybenzoate esters) such as methylparaben, ethylparaben, isopropylparaben, propylparaben, butylparaben, isobutylparaben, and benzylparaben, alcohols such as ethanol, phenoxyethanol, sorbic acid, benzoic acid, Examples include dehydroacetic acid, propionic acid, and salts thereof. What is necessary is just to select and mix these 1 type, or 2 or more types of combinations suitably.

  Examples of the colorant include natural or synthetic pigments such as edible tar pigments, caramel pigments, gardenia pigments, anthocyanin pigments, safflower pigments, and copper chlorophyllin sodium. These 1 type, or 2 or more types of combinations can be selected suitably, and can be mix | blended.

  Examples of the antibacterial agent include chlorhexidine, cetylpyridinium chloride, a zinc compound, and triclosan. What is necessary is just to select these 1 type, or 2 or more types of combinations suitably.

Examples of vitamins include vitamin A such as retinoic acid and β-carotene, pantothenic acid or its salts, vitamin B such as niacin and biotin, vitamin C such as ascorbic acid or its salts and derivatives, α-tocopherol and the like Vitamin E, folic acid, etc. are mentioned. What is necessary is just to select these 1 type, or 2 or more types of combinations suitably.
The amount of each component such as a fragrance, an antiseptic, a colorant, an antibacterial agent, and a vitamin is not particularly limited, but is generally 0.001 to 5. based on the weight of the composition. A range of 0% by mass is appropriate, and a range of 0.01 to 1.0% by mass is more preferable.

  The oral composition of the present invention is applied to the oral cavity in which a liquid or liquid oral composition is contained in a spray container and sprayed into the oral cavity from a spray part having a spray mechanism such as a pump dispenser provided in the container. A preparation is preferred. A spray container will not be specifically limited if it has a container which accommodates a composition for oral cavity, and a spray part which has a spray mechanism. The spray container is generally equipped with a spray part in the opening of the container body, and the liquid in the container is sprayed by pressing a spray button that operates a spray mechanism of the spray part.

  The spray container containing the composition for oral cavity is not particularly limited in the shape of the container, the spray mechanism of the spray part, the nozzle hole diameter or the shape, and can be freely used as long as it is generally used. Commercially available spray containers may be used. Although the spray part to which the composition for oral cavity is sprayed is not specifically limited, the nozzle hole diameter (diameter) of a spray part is 0.1-1 mm, Especially 0.3-0.8 mm is suitable. It is preferable that the spray amount of the one push of a spray part is 0.01-0.5 mL, especially 0.05-0.5 mL. Although a container is not specifically limited, It is preferable that an opening diameter is 1.0-5.0 cm. The height of the container is preferably 40 to 120 mm, particularly 50 to 100 mm. It is preferable that the capacity of the container is 5 to 100 mL, particularly 5 to 50 mL. The spray container can be used freely as long as the material is generally used. Generally, polyethylene, polypropylene, polyacetal, etc. can be used as the material of the spray part. The material of the container can be polyethylene, polypropylene, polyethylene terephthalate, or the like.

  The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

[Examples 1 to 20 and Comparative Examples 1 to 15]
Examples 1 to 20 prepared oral compositions having the compositions shown in Tables 1 and 2 below. Comparative Examples 1 to 15 prepared oral compositions having the compositions shown in Tables 3 to 4 below. The unit of the numerical value of the blending amount of each composition shown in Tables 1 to 4 is mass (g). The following were used for each composition shown in Tables 1-4. The composition for oral cavity was manufactured by adding purified water to each component shown in Tables 1 to 4 so that the total amount was 100 g. The pH of the oral compositions of Examples 1 to 20 was in the range of 5.5 to 7.0. The pH of the compositions for oral cavity of Comparative Examples 1 to 15 was also in the range of 5.5 to 7.0.
Nonionic surfactant: Glycerin fatty acid ester (polyglyceryl myristate-10: decaglyceryl myristate) (trade name: Sunsoft Q-14YC, manufactured by Taiyo Kagaku)
Nonionic surfactant: polyoxyethylene hydrogenated castor oil (PEG-50 hydrogenated castor oil) (trade name: Actinol HC-50, manufactured by Matsumoto Yushi Seiyaku Co., Ltd.)
Agar: Agar (trade name: Ultra Agar AX-100, manufactured by Ina Food Industry Co., Ltd.)
Sodium carboxymethylcellulose (CMCNa): Sodium carboxymethylcellulose (degree of etherification 0.6 to 0.7, 25 ° C., 1 mass% viscosity 350 to 500 mPa · s with BL type viscometer (60 rotations)) (trade name: Serogen F-SH, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.)
Sodium alginate: Sodium alginate (20 ° C., 1% by mass with a BL type viscometer has a viscosity of 300 to 400 mPa · s) (trade name: Duck Algin NSPM, manufactured by Kikkoman Biochemifa)
Gellan Gum: Gellan Gum (20 ° C., 1 mass% viscosity of 8000 to 1500 mPa · s with BL type viscometer) (trade name: Kelco Gel, CP Kelco)
Xanthan gum: Xanthan gum (25 ° C., 1% by mass with a BL type viscometer is 900 to 2000 mPa · s) (trade name: Echo Gum T, manufactured by DSP Gokyo Food & Chemical)
Glycerin: Glycerin for food additives (glycerin: 95% by mass or more) (manufactured by Sakamoto Pharmaceutical Co., Ltd.)
Water: Purified water

The oral cavity compositions of Examples 1 to 20 and Comparative Examples 1 to 15 were subjected to the following tests. The results of each test are shown in Tables 1-4.
[Viscosity measurement method]
The viscosity was measured at 25 ° C. using a B-type viscometer BL (manufactured by Tokyo Keiki Co., Ltd.).

[Water separation test]
The sample (composition for oral cavity) was centrifuged at 2000 rpm for 2 minutes, and then whether or not it was separated into two layers of gel and liquid was visually confirmed and evaluated. What divided into two layers was set as x, and what was not divided into two layers was set as (circle).

[Adhesion test]
40 mL of a sample (composition for oral cavity) was sprayed into a spray container (spray piece: SC-03, polypropylene, nozzle hole diameter 6.0-8.0 mm, one-push spray amount 0.06-0.08 mL, pump part: M- 75-05, container: made of H03-050 polyethylene, height: 99.2 mm, capacity: 50 mL, (manufactured by Mitani Valve Co., Ltd.), and 1 cm away from the spray port of the spray part of the spray container, vertically The sprayed part was pushed once onto a standing plastic plate (made of polystyrene) and sprayed, and the degree of dripping of the sprayed specimen was visually confirmed and evaluated. When the specimen sprayed on the plastic plate immediately flows down, it was rated as x.

[Sprayability test]
40 mL of a sample (composition for oral cavity) was sprayed into a spray container (spray piece: SC-03, polypropylene, nozzle hole diameter 6.0-8.0 mm, one-push spray amount 0.06-0.08 mL, pump part: M- 75-05, container: made of H03-050 polyethylene, height: 99.2 mm, capacity: 50 mL, (manufactured by Mitani Valve Co., Ltd.), and 5 cm away from the spray port of the spray part of the spray container, vertically A spray part was pushed once on a standing plastic plate (made of polystyrene) and sprayed, and the radius of the specimen adhered to the plastic plate was measured. Considering the variation of the test, the test was performed three times, and the average value of the radius of each test was evaluated. The case where the average value of the radius of the specimen adhering to the plastic plate was less than 60 mm was evaluated as x, the case where it was 60 mm or more and less than 65 mm was evaluated as Δ, and the case where the radius was 65 mm or more was evaluated as ○.

[Consideration of results]
As shown in Tables 1-2, the compositions for oral cavity of Examples 1-20 are agar, at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum, and nonion. By containing a surfactant, there is no water separation, and by using a spray, the radius can be spread to 60-65 mm with a one-push spray, which can be diffused and supplied throughout the oral cavity, with high adhesion, It was confirmed that it adhered to the oral cavity and could stay for a relatively long time.
On the other hand, as shown in Comparative Examples 1 to 15 in Tables 3 to 4, agar, at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum, and a nonionic surfactant Among these, the composition for oral cavity which does not contain any one of them resulted in inferior one or more of water separation, adhesion and spray spread.

  The composition for oral cavity of the present invention can be supplied to the entire oral cavity by spraying by use of a spray, adheres in the oral cavity and stays for a relatively long time, so that the oral cavity can be quickly moistened and dried. It can be suppressed and is industrially useful. In addition, the oral preparation of the present invention does not need to apply the oral composition with fingers, is hygienic, and can easily suppress drying in the oral cavity by a simple means using a spray container, Industrially useful.

Claims (6)

And agar, sodium alginate, formed by accommodating at least one water soluble polymer selected from the group consisting of sodium carboxymethylcellulose and gellan gum, as well as including mouth luminal cavity composition and a nonionic surfactant to the spray container An oral preparation for suppressing dryness in the oral cavity . The oral preparation of Claim 1 whose viscosity in 25 degreeC of a composition is 450-15000 mPa * s. The oral preparation according to claim 1 or 2, wherein the agar compounding amount is 0.2 to 1.2% by mass based on the weight of the composition. The blending amount of at least one water-soluble polymer selected from the group consisting of sodium alginate, sodium carboxymethylcellulose and gellan gum is 0.01 to 1.0 mass% based on the weight of the composition. The oral preparation according to any one of 1 to 3. The oral preparation according to any one of claims 1 to 4, wherein the compounding amount of the nonionic surfactant is 0.01 to 1.5% by mass based on the weight of the composition. The oral preparation according to any one of claims 1 to 5, wherein the nonionic surfactant is a glycerin fatty acid ester.