JP6301631B2 - 油中水型乳化組成物 - Google Patents
油中水型乳化組成物 Download PDFInfo
- Publication number
- JP6301631B2 JP6301631B2 JP2013228710A JP2013228710A JP6301631B2 JP 6301631 B2 JP6301631 B2 JP 6301631B2 JP 2013228710 A JP2013228710 A JP 2013228710A JP 2013228710 A JP2013228710 A JP 2013228710A JP 6301631 B2 JP6301631 B2 JP 6301631B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- water
- oil
- emulsion composition
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 37
- 239000007762 w/o emulsion Substances 0.000 title claims description 18
- 150000003839 salts Chemical class 0.000 claims description 25
- 229960000401 tranexamic acid Drugs 0.000 claims description 19
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 239000006097 ultraviolet radiation absorber Substances 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 229920001296 polysiloxane Polymers 0.000 claims description 8
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 6
- 239000002250 absorbent Substances 0.000 claims description 5
- 230000002745 absorbent Effects 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 125000005907 alkyl ester group Chemical group 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 239000000539 dimer Substances 0.000 claims description 2
- 229960005219 gentisic acid Drugs 0.000 claims description 2
- 239000007844 bleaching agent Substances 0.000 claims 1
- -1 etc.) Chemical compound 0.000 description 31
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 17
- 239000002537 cosmetic Substances 0.000 description 17
- 238000011156 evaluation Methods 0.000 description 15
- 230000002087 whitening effect Effects 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 14
- 239000006096 absorbing agent Substances 0.000 description 12
- 239000003921 oil Substances 0.000 description 12
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 11
- 229960005070 ascorbic acid Drugs 0.000 description 11
- 235000010323 ascorbic acid Nutrition 0.000 description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 description 8
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 8
- 239000011668 ascorbic acid Substances 0.000 description 7
- 229940008099 dimethicone Drugs 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 230000000475 sunscreen effect Effects 0.000 description 6
- 239000000516 sunscreening agent Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- DSSYKIVIOFKYAU-OIBJUYFYSA-N (S)-camphor Chemical compound C1C[C@]2(C)C(=O)C[C@H]1C2(C)C DSSYKIVIOFKYAU-OIBJUYFYSA-N 0.000 description 4
- 239000002211 L-ascorbic acid Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 4
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 4
- IEKHISJGRIEHRE-UHFFFAOYSA-N 16-methylheptadecanoic acid;propan-2-ol;titanium Chemical compound [Ti].CC(C)O.CC(C)CCCCCCCCCCCCCCC(O)=O.CC(C)CCCCCCCCCCCCCCC(O)=O.CC(C)CCCCCCCCCCCCCCC(O)=O IEKHISJGRIEHRE-UHFFFAOYSA-N 0.000 description 3
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 3
- 235000000069 L-ascorbic acid Nutrition 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 3
- 239000012964 benzotriazole Substances 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 229920006037 cross link polymer Polymers 0.000 description 3
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical compound C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- DBSABEYSGXPBTA-RXSVEWSESA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DBSABEYSGXPBTA-RXSVEWSESA-N 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- UAFHRUBCOQPFFM-UHFFFAOYSA-N 1-(aminomethyl)cyclohexane-1-carboxylic acid Chemical compound NCC1(C(O)=O)CCCCC1 UAFHRUBCOQPFFM-UHFFFAOYSA-N 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 2
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 description 2
- 229940120145 3-o-ethylascorbic acid Drugs 0.000 description 2
- SFUCGABQOMYVJW-UHFFFAOYSA-N 4-(4-Hydroxyphenyl)-2-butanol Chemical compound CC(O)CCC1=CC=C(O)C=C1 SFUCGABQOMYVJW-UHFFFAOYSA-N 0.000 description 2
- MRIXVKKOHPQOFK-UHFFFAOYSA-N 4-methoxysalicylic acid Chemical compound COC1=CC=C(C(O)=O)C(O)=C1 MRIXVKKOHPQOFK-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- AVWTXYWHGFHGQD-ZKCHVHJHSA-N CNC(=O)[C@H]1CC[C@H](CN)CC1 Chemical compound CNC(=O)[C@H]1CC[C@H](CN)CC1 AVWTXYWHGFHGQD-ZKCHVHJHSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 150000000996 L-ascorbic acids Chemical class 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- 229960000271 arbutin Drugs 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 229940119217 chamomile extract Drugs 0.000 description 2
- 235000020221 chamomile extract Nutrition 0.000 description 2
- 229930016911 cinnamic acid Natural products 0.000 description 2
- 235000013985 cinnamic acid Nutrition 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 description 2
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 description 2
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000686 essence Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 2
- 229910000271 hectorite Inorganic materials 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940091554 lauryl peg-9 polydimethylsiloxyethyl dimethicone Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 2
- QUAMTGJKVDWJEQ-UHFFFAOYSA-N octabenzone Chemical compound OC1=CC(OCCCCCCCC)=CC=C1C(=O)C1=CC=CC=C1 QUAMTGJKVDWJEQ-UHFFFAOYSA-N 0.000 description 2
- 229960000601 octocrylene Drugs 0.000 description 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 2
- 229940088608 peg-9 polydimethylsiloxyethyl dimethicone Drugs 0.000 description 2
- 229960000969 phenyl salicylate Drugs 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- OYAQUBKYAKSHOA-UHFFFAOYSA-N tetrahydro-magnolol Natural products CCCC1=CC=C(O)C(C=2C(=CC=C(CCC)C=2)O)=C1 OYAQUBKYAKSHOA-UHFFFAOYSA-N 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- AFQOCSDOKGNDNA-OBEHBXMUSA-N (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one (Z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCC\C=C/CCCCCCCC(O)=O AFQOCSDOKGNDNA-OBEHBXMUSA-N 0.000 description 1
- VBURMNYQYXSQEL-VFAVKCLXSA-N (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one (Z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O VBURMNYQYXSQEL-VFAVKCLXSA-N 0.000 description 1
- IRVNEGRHQKGRGD-WPXUHFOISA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;hexadecanoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCC(O)=O IRVNEGRHQKGRGD-WPXUHFOISA-N 0.000 description 1
- PBTPTBMYJPCXRQ-MGMRMFRLSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;hexadecanoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCC(O)=O PBTPTBMYJPCXRQ-MGMRMFRLSA-N 0.000 description 1
- MHUOEHQATDLJFZ-WPXUHFOISA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;octadecanoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O MHUOEHQATDLJFZ-WPXUHFOISA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- CWLGEPSKQDNHIO-JOBJLJCHSA-N (e)-n-[(e)-benzylideneamino]-1-phenylmethanimine Chemical compound C=1C=CC=CC=1/C=N/N=C/C1=CC=CC=C1 CWLGEPSKQDNHIO-JOBJLJCHSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 229940043375 1,5-pentanediol Drugs 0.000 description 1
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 description 1
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 description 1
- 239000004808 2-ethylhexylester Substances 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- 229940078578 2-o-ethyl ascorbic acid Drugs 0.000 description 1
- VSDNNWKISVRDNT-UHFFFAOYSA-N 2-octoxybenzoic acid Chemical compound CCCCCCCCOC1=CC=CC=C1C(O)=O VSDNNWKISVRDNT-UHFFFAOYSA-N 0.000 description 1
- GXRFOOHMMLYYNW-UJURSFKZSA-N 3-o-Ethyl-L-ascorbic acid Chemical compound CCOC1=C(O)[C@@H]([C@@H](O)CO)OC1=O GXRFOOHMMLYYNW-UJURSFKZSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- JOKBLKCZHGIRNO-UHFFFAOYSA-N 5-benzoyl-2-hydroxybenzoic acid Chemical compound C1=C(O)C(C(=O)O)=CC(C(=O)C=2C=CC=CC=2)=C1 JOKBLKCZHGIRNO-UHFFFAOYSA-N 0.000 description 1
- RDBLNMQDEWOUIB-UHFFFAOYSA-N 5-methyl-2-phenyl-1,3-benzoxazole Chemical compound N=1C2=CC(C)=CC=C2OC=1C1=CC=CC=C1 RDBLNMQDEWOUIB-UHFFFAOYSA-N 0.000 description 1
- IZZIWIAOVZOBLF-UHFFFAOYSA-N 5-methyloxysalicylic acid Natural products COC1=CC=C(O)C(C(O)=O)=C1 IZZIWIAOVZOBLF-UHFFFAOYSA-N 0.000 description 1
- XVNQDRSYPPDDQF-UHFFFAOYSA-N 7-[2-(2,5,6,7-tetrasulfo-3h-benzimidazol-4-yl)phenyl]-1h-benzimidazole-2,4,5,6-tetrasulfonic acid Chemical compound OS(=O)(=O)C1=C(S(O)(=O)=O)C(S(O)(=O)=O)=C2NC(S(=O)(=O)O)=NC2=C1C1=CC=CC=C1C1=C(S(O)(=O)=O)C(S(O)(=O)=O)=C(S(O)(=O)=O)C2=C1N=C(S(O)(=O)=O)N2 XVNQDRSYPPDDQF-UHFFFAOYSA-N 0.000 description 1
- LITUBCVUXPBCGA-WMZHIEFXSA-N Ascorbyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O LITUBCVUXPBCGA-WMZHIEFXSA-N 0.000 description 1
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 1
- UEQVLKWMHAYVLO-MGCOHNPYSA-N C1C[C@@H](CN)CC[C@@H]1C(=O)OC1=CC=C(O)C=C1C(O)=O Chemical compound C1C[C@@H](CN)CC[C@@H]1C(=O)OC1=CC=C(O)C=C1C(O)=O UEQVLKWMHAYVLO-MGCOHNPYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- XDBMXUKHMOFBPJ-ZAFYKAAXSA-N L-ascorbic acid 2-sulfate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OS(O)(=O)=O)=C1O XDBMXUKHMOFBPJ-ZAFYKAAXSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- YQINWFJNFJEWHH-UCLHFMLVSA-N OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCC(O)=O Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCC(O)=O YQINWFJNFJEWHH-UCLHFMLVSA-N 0.000 description 1
- QDTPSCIFGGYXJD-IPKXSQMUSA-N OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O QDTPSCIFGGYXJD-IPKXSQMUSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 229940123973 Oxygen scavenger Drugs 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- SEAWNAPUMUTEMD-UHFFFAOYSA-N S(=O)(=O)(O)C1=CC2=C(N=CN2)C=C1.C1(=CC=CC=C1)C=1NC2=C(N1)C=CC=C2 Chemical compound S(=O)(=O)(O)C1=CC2=C(N=CN2)C=C1.C1(=CC=CC=C1)C=1NC2=C(N1)C=CC=C2 SEAWNAPUMUTEMD-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GYDJEQRTZSCIOI-UHFFFAOYSA-N Tranexamic acid Chemical compound NCC1CCC(C(O)=O)CC1 GYDJEQRTZSCIOI-UHFFFAOYSA-N 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- LNQVTSROQXJCDD-UHFFFAOYSA-N adenosine monophosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)C(OP(O)(O)=O)C1O LNQVTSROQXJCDD-UHFFFAOYSA-N 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- UBNYRXMKIIGMKK-RMKNXTFCSA-N amiloxate Chemical compound COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1 UBNYRXMKIIGMKK-RMKNXTFCSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229940062909 amyl salicylate Drugs 0.000 description 1
- 229940051879 analgesics and antipyretics salicylic acid and derivative Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229940071097 ascorbyl phosphate Drugs 0.000 description 1
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 1
- 229940022405 astaxanthin Drugs 0.000 description 1
- 235000013793 astaxanthin Nutrition 0.000 description 1
- 239000001168 astaxanthin Substances 0.000 description 1
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- FWLORMQUOWCQPO-UHFFFAOYSA-N benzyl-dimethyl-octadecylazanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 FWLORMQUOWCQPO-UHFFFAOYSA-N 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- WXNRYSGJLQFHBR-UHFFFAOYSA-N bis(2,4-dihydroxyphenyl)methanone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=C(O)C=C1O WXNRYSGJLQFHBR-UHFFFAOYSA-N 0.000 description 1
- SODJJEXAWOSSON-UHFFFAOYSA-N bis(2-hydroxy-4-methoxyphenyl)methanone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(OC)C=C1O SODJJEXAWOSSON-UHFFFAOYSA-N 0.000 description 1
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- HFTGWHYUKOUNOV-ZKCHVHJHSA-N chembl1221905 Chemical compound NCC[C@H]1CC[C@H](C(O)=O)CC1 HFTGWHYUKOUNOV-ZKCHVHJHSA-N 0.000 description 1
- CMDKPGRTAQVGFQ-RMKNXTFCSA-N cinoxate Chemical compound CCOCCOC(=O)\C=C\C1=CC=C(OC)C=C1 CMDKPGRTAQVGFQ-RMKNXTFCSA-N 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 description 1
- FGEUKKGODAGXOD-FMIVXFBMSA-N cyclohexyl (e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound C1=CC(OC)=CC=C1\C=C\C(=O)OC1CCCCC1 FGEUKKGODAGXOD-FMIVXFBMSA-N 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- KCDAMWRCUXGACP-DHZHZOJOSA-N ethyl (e)-2-cyano-3-phenylprop-2-enoate Chemical compound CCOC(=O)C(\C#N)=C\C1=CC=CC=C1 KCDAMWRCUXGACP-DHZHZOJOSA-N 0.000 description 1
- XRLCQRMNGQRGOC-MDZDMXLPSA-N ethyl (e)-3-[2,4-di(propan-2-yl)phenyl]prop-2-enoate Chemical compound CCOC(=O)\C=C\C1=CC=C(C(C)C)C=C1C(C)C XRLCQRMNGQRGOC-MDZDMXLPSA-N 0.000 description 1
- NYNCZOLNVTXTTP-UHFFFAOYSA-N ethyl 2-(1,3-dioxoisoindol-2-yl)acetate Chemical compound C1=CC=C2C(=O)N(CC(=O)OCC)C(=O)C2=C1 NYNCZOLNVTXTTP-UHFFFAOYSA-N 0.000 description 1
- XCRHYAQWBYDRGV-UHFFFAOYSA-N ethyl 3-(4-propan-2-ylphenyl)prop-2-enoate Chemical compound CCOC(=O)C=CC1=CC=C(C(C)C)C=C1 XCRHYAQWBYDRGV-UHFFFAOYSA-N 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 239000008309 hydrophilic cream Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 239000008308 lipophilic cream Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940091250 magnesium supplement Drugs 0.000 description 1
- SJOXEWUZWQYCGL-DVOMOZLQSA-N menthyl salicylate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1=CC=CC=C1O SJOXEWUZWQYCGL-DVOMOZLQSA-N 0.000 description 1
- 229960004665 menthyl salicylate Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- YKWKFUUHPFWRNV-UHFFFAOYSA-N methyl 3-[2,4-di(propan-2-yl)phenyl]prop-2-enoate Chemical compound COC(=O)C=CC1=CC=C(C(C)C)C=C1C(C)C YKWKFUUHPFWRNV-UHFFFAOYSA-N 0.000 description 1
- PABHEXWDYRTPBQ-UHFFFAOYSA-N methyl 3-[2,5-di(propan-2-yl)phenyl]prop-2-enoate Chemical compound COC(=O)C=CC1=CC(C(C)C)=CC=C1C(C)C PABHEXWDYRTPBQ-UHFFFAOYSA-N 0.000 description 1
- MJVGBKJNTFCUJM-UHFFFAOYSA-N mexenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=C(C)C=C1 MJVGBKJNTFCUJM-UHFFFAOYSA-N 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- VIKVSUVYUVJHOA-UHFFFAOYSA-N octyl 3-phenylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C=CC1=CC=CC=C1 VIKVSUVYUVJHOA-UHFFFAOYSA-N 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- LYXOWKPVTCPORE-UHFFFAOYSA-N phenyl-(4-phenylphenyl)methanone Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(=O)C1=CC=CC=C1 LYXOWKPVTCPORE-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 description 1
- 229940099549 polyglycerin-3 Drugs 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- XATKDVHSLQMHSY-RMKNXTFCSA-N propan-2-yl (e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound COC1=CC=C(\C=C\C(=O)OC(C)C)C=C1 XATKDVHSLQMHSY-RMKNXTFCSA-N 0.000 description 1
- WZXKPNYMUZGZIA-RMKNXTFCSA-N propyl (e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound CCCOC(=O)\C=C\C1=CC=C(OC)C=C1 WZXKPNYMUZGZIA-RMKNXTFCSA-N 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 1
- 229960001755 resorcinol Drugs 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- SJOXEWUZWQYCGL-UHFFFAOYSA-N salicylic acid menthyl ester Natural products CC(C)C1CCC(C)CC1OC(=O)C1=CC=CC=C1O SJOXEWUZWQYCGL-UHFFFAOYSA-N 0.000 description 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000006884 silylation reaction Methods 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 description 1
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
〔1〕
下記の成分を含有してなる油中水型乳化組成物
(A)美白剤
(B)HLB2〜7のポリオキシアルキレン・アルキル共変性シリコーン及び/またはHLB2〜7のポリグリセリン・アルキル共変性シリコーンから選ばれる一種または二種以上の界面活性剤
〔2〕
(A)がアスコルビン酸、その誘導体又は塩、トラネキサム酸、その誘導体又は塩から選ばれる1種又は2種以上である請求項1記載の油中水型乳化組成物
〔3〕
さらに(C)紫外線吸収剤を含有することを特徴とする請求項1又は2記載の油中水型乳化組成物
〔4〕
(C)の紫外線吸収剤として油溶性紫外線吸収剤と水溶性紫外線吸収剤の2種併用することを特徴とする請求項1から3のいずれかに記載の油中水型乳化組成物
2−L−アスコルビン酸リン酸ジエステル等のアスコルビン酸無機酸エステル類;パルミチン酸L−アスコルビルリン酸等のL−アスコルビン酸−2−リン酸エステルの脂肪酸エステル;L−アスコルビン酸モノステアレート、L−アスコルビン酸モノパルミテート、L−アスコルビン酸モノオレエート等のアスコルビン酸モノアルキルエステル類;L−アスコルビン酸ジステアレート、L−アスコルビン酸ジパルミテート、L−アスコルビン酸ジオレエート等のアスコルビン酸ジエステル類;L−アスコルビン酸トリステアレート、L−アスコルビン酸トリパルミテート、L−アスコルビン酸トリオレエート等のアスコルビン酸トリエステル類;L−アスコルビン酸テトラヘキシルデカン酸エステル等のアスコルビン酸テトラエステル類;2−O−エチルアスコルビン酸、3−O−エチルアスコルビン酸などのO−アルキルアスコルビン酸類;アスコルビン酸−2−グルコシド等のアスコルビン酸グルコシドなどが挙げられる。また、これらアスコルビン酸及びその誘導体の塩としては、アルカリ金属塩(Na塩、K塩等)、アルカリ土類金属塩(Ca塩、Mg塩等)、アンモニウム塩、アルカノールアミン塩、アミノ酸塩などが挙げられ、好ましくはアルカリ金属塩、アルカリ土類金属塩である。
主鎖の一部が架橋したものの例としてはPEG−10ラウリルジメチコンクロスポリマー、PEG−15ラウリルジメチコンクロスポリマーなどが知られている。これらが含有された原料としてKSG−310、KSG−320、KSG−330、KSG−340(いずれも信越化学工業社製)などが入手可能であり、いずれのものも使用可能である。
主鎖の一部が分岐したものの例としてはラウリルPEG−9ポリジメチルシロキシエチルジメチコンなどが知られており、KF−6038(信越化学工業社製)の商品名で入手できる。感触の観点からは主鎖の一部が分岐したものがより好ましい。
主鎖の一部が分岐したものの例としてはラウリルポリグリセリル-3ポリジメチルシロキシエチルジメチコン等の名称が知られておりKF−6105(信越化学工業社製)の商品名で入手することができる。感触の観点からは主鎖の一部が分岐したものがより好ましい。
成分(B)の配合量は、当業者であれば、適宜決定できるが、例えば0.1〜10質量%であればよく、0.2〜5質量%が好ましく、0.5〜3質量%含有するのが特に好ましい。
表1に示す組成の油中水型組成物を下記製造方法により調製し、「1.製剤安定性」について、以下に示す評価方法及び判定基準により評価判定し、結果を併せて表1に示した。
A:成分(1)〜(9)を混合する。
B:成分(10)〜(16)を混合する。
C:AにBを加えて乳化し、油中水型組成物を得た。
得られた油中水型組成物を5℃、50℃の恒温槽に保管し、定期的に状態観察を行った。
[評価] :[判定]
問題なし :◎
わずかに状態変化が見られる :○
分離が見られるが使用可能 :△
分離、変色、沈殿など使用上問題がある :×
表2に示す組成の油中水型日中用美容液を下記製造方法により調製し、「1.製剤安定性」「2.しっとり感」について、以下に示す評価方法及び判定基準により評価判定し、結果を併せて表2に示した。
A:成分(1)〜(6)を混合する。
B:成分(7)〜(16)を混合する。
C:AにBを加えて乳化し、日中用美容液を得た。
化粧品評価専門パネル10名に、実施例及び比較例を使用し、肌の「しっとり感」について、各自が以下の評価基準に従って5段階評価し、更に全パネルの評点の平均点を以下の判定基準に従って判定した。
[判定基準] :[評点]
とてもしっとりする :5
かなりしっとりする :4
しっとりする :3
あまりしっとりしない :2
しっとりしない :1
[評点の平均点] :[判定]
4.5以上 :◎
3.5以上〜4.5未満 :○
2.5以上〜3.5未満 :△
2.5未満 :×
表3に示す組成の日焼け止めを下記製造方法により調製し、「1.製剤安定性」、「3.べたつき」、「4.きしみ」の各項目について、以下に示す評価方法及び判定基準により評価判定し、結果を併せて表3に示した。
A:成分(1)〜(9)を混合する。
B:成分(10)〜(18)を混合する。
C:AにBを加えて乳化し、日焼け止めを得た。
化粧品評価専門パネル10名に、実施例を使用し、使用途中からとまり際の「べたつき」について、各自が以下の評価基準に従って5段階評価し、更に全パネルの評点の平均点を以下の判定基準に従って判定した。
[判定基準] :[評点]
まったくべたつかない :5
ほとんどべたつかない :4
わずかにべたつく :3
ややべたつく :2
かなりべたつく :1
[評点の平均点] :[判定]
4.5以上 :◎
3.5以上〜4.5未満 :○
2.5以上〜3.5未満 :△
2.5未満 :×
化粧品評価専門パネル10名に、実施例を使用し、とまり際から使用後の「きしみ」について、各自が以下の評価基準に従って5段階評価し、更に全パネルの評点の平均点を以下の判定基準に従って判定した。
[判定基準] :[評点]
まったくきしまない :5
ほとんどきしまない :4
わずかにきしむ :3
ややきしむ :2
かなりきしむ :1
[評点の平均点] :[判定]
4.5以上 :◎
3.5以上〜4.5未満 :○
2.5以上〜3.5未満 :△
2.5未満 :×
(成分) (質量%)
1.ハイドロゲンジメチコン処理微粒子酸化亜鉛 2.0
2.ジメチルポリシロキサン処理微粒子酸化チタン 5.0
3.トリ(カプリル・カプリン酸)グリセリル 5.0
4.トリ2−エチルヘキサン酸グリセリル 3.0
5.パルミチン酸オクチル 3.0
6.パラメトキシケイ皮酸2−エチルヘキシル 8.0
7.ジエチルアミノヒドロキシベンゾイル安息香酸ヘキシル 1.0
8.ジメチコジエチルベンザルマロネート 1.0
9.オクチルトリアゾン 0.5
10.デカメチルシクロペンタシロキサン 10.0
11.ラウリルポリグリセリル−3−
ポリジメチルシロキシエチルジメチコン 注1 2.0
12.ソルビン酸 0.05
13.コウジ酸 0.5
14.乳酸 0.05
15.乳酸ナトリウム 0.1
16.精製水 残量
17.Tinosorb(登録商標)M 注8 2.0
18.ジプロピレングリコール 5.0
19.エタノール 5.0
20.オレンジ油 適量
注8 BASF社製
(1)成分1〜4をローラーにて均一に分散する。
(2)成分5〜11を溶解させた後、(1)を添加し均一に混合溶解する。
(3)成分13〜19を混合溶解させた後、室温で(2)へ添加し乳化する。
(4)(3)に成分20を添加混合し、容器に充填しシェーキングタイプ日焼け止め
を得た。
(成分) (%)
1.ラウリルPEG−9ポリジメチルシロキシエチルジメチコン 注2 2.0
2.PEG−9ポリジメチル
シロキシエチルジメチコン 注3 1.0
3.ジメチルポリシロキサン 5.0
4.イソプロピルトリイソステアロイルチタネート
処理赤酸化鉄 0.6
5.イソプロピルトリイソステアロイルチタネート
処理黄酸化鉄 1.8
6.イソプロピルトリイソステアロイルチタネート
処理黒酸化鉄 0.2
7.オクチルシリル化処理酸化チタン 10.0
8.金属石鹸処理タルク 5.0
9 ポリメチルシルセスキオキサン 注9 2.0
10.パラメトキシケイ皮酸2−エチルヘキシル 5.0
11.ジメチルジステアリルアンモニウムヘクトライト 1.5
12.ベンジルジメチルステアリルアンモニウムヘクトライト 0.5
13.アスタキサンチン 0.05
14.リノール酸 0.05
15.大豆リン脂質 0.5
16.精製水 残量
17.1,3−ブチレングリコール 15.0
18.ペンチレングリコール 1.0
19.カミツレエキス 0.1
20.塩化ナトリウム 0.5
21.アルブチン 0.5
22.アデノシンモノリン酸 0.1
23.香料 適量
注9 トスパール2000B (モメンティブ社製)
(1)成分1〜15をローラーにて均一に分散する。
(2)成分16〜22を均一に混合する。
(3)(1)に(2)を添加し、乳化する。
(4)(5)に成分23を加えて、ファンデーションを得た。
Claims (3)
- 下記の成分を含有してなる油中水型乳化組成物。
(A)トラネキサム酸、トラネキサム酸の二量体、トラネキサム酸とハイドロキノンのエステル体、トラネキサム酸とゲンチシン酸のエステル体、トラネキサム酸のアミド体、トラネキサム酸のアルキルエステル、及びこれらの塩から選ばれる1種又は2種以上の美白剤
(B)HLB2〜7のポリオキシアルキレン・アルキル共変性シリコーン及び/またはHLB2〜7のポリグリセリン・アルキル共変性シリコーンから選ばれる一種または二種以上の界面活性剤:0.5〜3質量% - さらに(C)紫外線吸収剤を含有することを特徴とする請求項1記載の油中水型乳化組成物。
- (C)の紫外線吸収剤として油溶性紫外線吸収剤と水溶性紫外線吸収剤の2種併用することを特徴とする請求項2に記載の油中水型乳化組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013228710A JP6301631B2 (ja) | 2012-11-05 | 2013-11-01 | 油中水型乳化組成物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012243935 | 2012-11-05 | ||
JP2012243935 | 2012-11-05 | ||
JP2013228710A JP6301631B2 (ja) | 2012-11-05 | 2013-11-01 | 油中水型乳化組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014111584A JP2014111584A (ja) | 2014-06-19 |
JP6301631B2 true JP6301631B2 (ja) | 2018-03-28 |
Family
ID=51169016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013228710A Active JP6301631B2 (ja) | 2012-11-05 | 2013-11-01 | 油中水型乳化組成物 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP6301631B2 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017031081A (ja) * | 2015-07-30 | 2017-02-09 | 富士フイルム株式会社 | 油中水型皮膚外用剤 |
JP7380111B2 (ja) * | 2019-11-14 | 2023-11-15 | 日油株式会社 | 美白日焼け止め化粧料 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007126444A (ja) * | 2005-10-03 | 2007-05-24 | Kose Corp | 皮膚外用剤 |
US20070173599A1 (en) * | 2006-01-25 | 2007-07-26 | The Procter & Gamble Company | Water-in-oil emulsion composition |
EP2349198A1 (en) * | 2008-11-24 | 2011-08-03 | The Procter & Gamble Company | Cosmetic compositions |
JP5731138B2 (ja) * | 2010-07-02 | 2015-06-10 | 日光ケミカルズ株式会社 | 油中水型乳化剤組成物及び該組成物を用いた油中水型乳化組成物並びに化粧料 |
-
2013
- 2013-11-01 JP JP2013228710A patent/JP6301631B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2014111584A (ja) | 2014-06-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6766018B2 (ja) | 日焼け止め用組成物 | |
EP2915524B1 (en) | Sunscreen cosmetic | |
JP5974843B2 (ja) | シリコーン油中水型マクロエマルジョン化粧料組成物 | |
ES2538010T3 (es) | Composición cosmética de protección solar de tipo emulsión de agua en aceite | |
JP5813745B2 (ja) | 油中水型乳化日焼け止め化粧料 | |
JP2014097936A (ja) | シリコーン油中水型マクロエマルジョン化粧料組成物 | |
JP4866066B2 (ja) | 化粧料 | |
JP2017105825A (ja) | スキンケア化粧料 | |
JP2011195510A (ja) | 水中油型乳化皮膚外用組成物 | |
JP6600455B2 (ja) | 水中油型乳化化粧料 | |
WO2020158402A1 (ja) | 皮膚外用剤および紫外線防御効果の向上方法 | |
JP6301631B2 (ja) | 油中水型乳化組成物 | |
JP2017500322A (ja) | スキンケア有効成分の高い浸透性を与える美容組成物及び方法 | |
JP2004307353A (ja) | 水中油型乳化組成物 | |
JP2009019049A (ja) | 油中水型乳化皮膚外用剤 | |
JP6741836B2 (ja) | 水中油型乳化化粧料 | |
JP2010090113A (ja) | 皮膚化粧料 | |
JP7347993B2 (ja) | 日焼け止め用組成物 | |
JP5694818B2 (ja) | 日焼け止め化粧料 | |
JPH09255523A (ja) | 化粧料 | |
JP2013063935A (ja) | 水中油型乳化皮膚化粧料 | |
JP6418626B2 (ja) | 油中水型乳化組成物及び該組成物を用いた油中水型乳化化粧料 | |
JP2013199451A (ja) | 美白日焼け止め化粧料 | |
JP6865522B2 (ja) | 水中油型紫外線防御化粧料 | |
JPH1149655A (ja) | 皮膚外用剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160401 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20160401 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170228 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170321 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170519 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20171003 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171227 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20180104 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180206 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180301 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6301631 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |