JP6276862B2 - 高温で成熟胞子接種及び鉄イオン媒介ハーバー・ワイス反応によるヘマトコッカスプルビアリス内アスタキサンチン生産量増進方法 - Google Patents
高温で成熟胞子接種及び鉄イオン媒介ハーバー・ワイス反応によるヘマトコッカスプルビアリス内アスタキサンチン生産量増進方法 Download PDFInfo
- Publication number
- JP6276862B2 JP6276862B2 JP2016541591A JP2016541591A JP6276862B2 JP 6276862 B2 JP6276862 B2 JP 6276862B2 JP 2016541591 A JP2016541591 A JP 2016541591A JP 2016541591 A JP2016541591 A JP 2016541591A JP 6276862 B2 JP6276862 B2 JP 6276862B2
- Authority
- JP
- Japan
- Prior art keywords
- astaxanthin
- haematococcus
- production
- spurbiaris
- conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 title claims description 104
- 235000013793 astaxanthin Nutrition 0.000 title claims description 104
- 239000001168 astaxanthin Substances 0.000 title claims description 104
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 title claims description 104
- 229940022405 astaxanthin Drugs 0.000 title claims description 104
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims description 74
- 229910052742 iron Inorganic materials 0.000 title claims description 51
- 241000168525 Haematococcus Species 0.000 title claims description 43
- 238000004519 manufacturing process Methods 0.000 title claims description 43
- 238000006993 Weiss annulation reaction Methods 0.000 title description 22
- 230000001404 mediated effect Effects 0.000 title description 15
- 230000001651 autotrophic effect Effects 0.000 claims description 44
- -1 iron ion Chemical class 0.000 claims description 43
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 32
- 229910052760 oxygen Inorganic materials 0.000 claims description 24
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 23
- 239000001301 oxygen Substances 0.000 claims description 23
- 230000001965 increasing effect Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 21
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 16
- 239000001569 carbon dioxide Substances 0.000 claims description 16
- 241000168517 Haematococcus lacustris Species 0.000 claims description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 206010011732 Cyst Diseases 0.000 claims description 7
- 208000031513 cyst Diseases 0.000 claims description 7
- 230000002950 deficient Effects 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 7
- 230000009105 vegetative growth Effects 0.000 claims description 7
- 238000012258 culturing Methods 0.000 claims description 6
- 230000001678 irradiating effect Effects 0.000 claims description 4
- 230000029553 photosynthesis Effects 0.000 claims description 4
- 238000010672 photosynthesis Methods 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 description 25
- 210000004027 cell Anatomy 0.000 description 23
- 239000002609 medium Substances 0.000 description 21
- 238000003786 synthesis reaction Methods 0.000 description 18
- 238000009825 accumulation Methods 0.000 description 14
- 102000019197 Superoxide Dismutase Human genes 0.000 description 12
- 108010012715 Superoxide dismutase Proteins 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 238000011081 inoculation Methods 0.000 description 11
- 230000003834 intracellular effect Effects 0.000 description 11
- 230000008569 process Effects 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 8
- 230000003647 oxidation Effects 0.000 description 8
- 238000007254 oxidation reaction Methods 0.000 description 8
- 239000002028 Biomass Substances 0.000 description 7
- 150000002632 lipids Chemical class 0.000 description 7
- 235000021466 carotenoid Nutrition 0.000 description 6
- 150000001747 carotenoids Chemical class 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 230000003078 antioxidant effect Effects 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- FIKAKWIAUPDISJ-UHFFFAOYSA-L paraquat dichloride Chemical compound [Cl-].[Cl-].C1=C[N+](C)=CC=C1C1=CC=[N+](C)C=C1 FIKAKWIAUPDISJ-UHFFFAOYSA-L 0.000 description 4
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 4
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 235000013734 beta-carotene Nutrition 0.000 description 3
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 3
- 239000011648 beta-carotene Substances 0.000 description 3
- 229960002747 betacarotene Drugs 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 210000003763 chloroplast Anatomy 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 210000002377 thylakoid Anatomy 0.000 description 3
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 2
- 241000081271 Phaffia rhodozyma Species 0.000 description 2
- 241000694540 Pluvialis Species 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229940118019 malondialdehyde Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000879 optical micrograph Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 210000002706 plastid Anatomy 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- PXEZTIWVRVSYOK-UHFFFAOYSA-N 2-(3,6-diacetyloxy-2,7-dichloro-9h-xanthen-9-yl)benzoic acid Chemical compound C1=2C=C(Cl)C(OC(=O)C)=CC=2OC2=CC(OC(C)=O)=C(Cl)C=C2C1C1=CC=CC=C1C(O)=O PXEZTIWVRVSYOK-UHFFFAOYSA-N 0.000 description 1
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- CXURGFRDGROIKG-UHFFFAOYSA-N 3,3-bis(chloromethyl)oxetane Chemical compound ClCC1(CCl)COC1 CXURGFRDGROIKG-UHFFFAOYSA-N 0.000 description 1
- 241000238017 Astacoidea Species 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- DHCLVCXQIBBOPH-UHFFFAOYSA-N Glycerol 2-phosphate Chemical compound OCC(CO)OP(O)(O)=O DHCLVCXQIBBOPH-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 150000001749 carotenones Chemical class 0.000 description 1
- 235000005472 carotenones Nutrition 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000005431 greenhouse gas Substances 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000013028 medium composition Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- WVJKHCGMRZGIJH-UHFFFAOYSA-N methanetriamine Chemical compound NC(N)N WVJKHCGMRZGIJH-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 235000021085 polyunsaturated fats Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2014-0045962 | 2014-04-17 | ||
KR20140045962 | 2014-04-17 | ||
PCT/KR2015/003668 WO2015160154A1 (ko) | 2014-04-17 | 2015-04-13 | 고온에서 성숙 포자 접종 및 철이온매개 하버-바이스 반응에 의한 해마토코쿠스 플루비알리스 내 아스타잔틴 생산량 증진 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017513455A JP2017513455A (ja) | 2017-06-01 |
JP6276862B2 true JP6276862B2 (ja) | 2018-02-07 |
Family
ID=54324287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016541591A Active JP6276862B2 (ja) | 2014-04-17 | 2015-04-13 | 高温で成熟胞子接種及び鉄イオン媒介ハーバー・ワイス反応によるヘマトコッカスプルビアリス内アスタキサンチン生産量増進方法 |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP6276862B2 (ko) |
KR (1) | KR101725976B1 (ko) |
CN (1) | CN105916993B (ko) |
WO (1) | WO2015160154A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106676010B (zh) * | 2017-01-19 | 2021-02-19 | 宁波大学 | 一种用钨酸钠提高三角褐指藻中岩藻黄素含量的方法 |
CN107868811A (zh) * | 2017-11-13 | 2018-04-03 | 湖南农业大学 | 营养型定向调控雨生红球藻厚壁孢子增殖破壁提取虾青素的方法 |
KR102249214B1 (ko) * | 2019-06-21 | 2021-05-07 | 전북대학교산학협력단 | 헤마토코쿠스의 적색세포로 부터 편모를 생성시키는 단계를 포함하는 배양생산방법 |
KR102350706B1 (ko) * | 2019-09-17 | 2022-01-14 | 한국지역난방공사 | 미세조류 배양 시스템을 이용한 아스타잔틴 생산방법 |
KR102434347B1 (ko) * | 2020-02-20 | 2022-08-18 | 고려대학교 산학협력단 | 바이오광물화를 이용한 헤마토코쿠스 플루비알리스 생산방법 |
CN114836324B (zh) * | 2022-05-26 | 2022-12-09 | 珠海元育生物科技有限公司 | 雨生红球藻耐高温突变株及其应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3163127B2 (ja) * | 1991-09-11 | 2001-05-08 | ヒガシマル醤油株式会社 | アスタキサンチンの製造方法 |
JP2001061466A (ja) * | 2000-07-31 | 2001-03-13 | Higashimaru Shoyu Co Ltd | アスタキサンチンの製造方法 |
JP2004033070A (ja) * | 2002-07-01 | 2004-02-05 | Yamaha Motor Co Ltd | 緑藻ヘマトコッカスへの外来遺伝子導入方法 |
CN1181184C (zh) * | 2002-07-26 | 2004-12-22 | 中国科学院武汉植物研究所 | 一种培养雨生红球藻生产虾青素的方法 |
US20080254056A1 (en) * | 2005-09-06 | 2008-10-16 | Yamaha Hatsudoki Kabushiki Kaisha | Green Alga Extract with High Astaxanthin Content and Method of Producing the Same |
CN101144058A (zh) * | 2007-08-22 | 2008-03-19 | 厦门大学 | 一种虾青素的微藻培养基 |
KR101046310B1 (ko) * | 2008-03-04 | 2011-07-07 | 서희동 | 해양 심층수를 이용하여 해마토코쿠스 조류를 배양하는 방법과 이를 이용한 아스타크산틴을 생산하는 방법 |
CN101586140B (zh) * | 2009-06-09 | 2011-09-07 | 宁波大学 | 一种培养雨生红球藻生产虾青素的简易方法 |
CN101974599B (zh) * | 2010-10-14 | 2011-11-09 | 山东理工大学 | 利用油菜素内酯刺激雨生红球藻快速生产虾青素的方法 |
CN101974598A (zh) * | 2010-10-14 | 2011-02-16 | 山东理工大学 | 利用茉莉酸促进雨生红球藻生产虾青素的方法 |
KR101356477B1 (ko) * | 2011-06-27 | 2014-01-29 | 고려대학교 산학협력단 | 광민감성 증가로 인한 아스타잔틴 생산력이 향상된 고광유발 헤마토코쿠스 돌연변이체 및 이의 선별방법 |
CN102337215A (zh) * | 2011-10-20 | 2012-02-01 | 烟台华融生物科技有限公司 | 培养雨生红球藻及生产虾青素的方法 |
CN103571906B (zh) * | 2012-07-27 | 2018-12-11 | 上海泽元海洋生物技术有限公司 | 一种利用微藻高效生产虾青素的新方法 |
CN103044304B (zh) * | 2012-12-21 | 2014-12-03 | 宁波红龙生物科技有限公司 | 从雨生红球藻粉中制备虾青素提取物的方法 |
CN102994603B (zh) * | 2012-12-21 | 2014-09-10 | 丽江程海保尔生物开发有限公司 | 一种培养雨生红球藻生产虾青素的转化方法 |
CN103114121A (zh) * | 2013-01-31 | 2013-05-22 | 宁波大学 | 一种雨生红球藻生产虾青素的方法 |
CN103232375B (zh) * | 2013-04-03 | 2015-04-29 | 大连医诺生物有限公司 | 雨生红球藻中虾青素的高效提取工艺 |
CN103695314B (zh) * | 2013-12-26 | 2015-11-04 | 宁波大学 | 一种雨生红球藻营养细胞的保存方法 |
-
2015
- 2015-04-06 KR KR1020150048444A patent/KR101725976B1/ko active IP Right Grant
- 2015-04-13 WO PCT/KR2015/003668 patent/WO2015160154A1/ko active Application Filing
- 2015-04-13 JP JP2016541591A patent/JP6276862B2/ja active Active
- 2015-04-13 CN CN201580004953.8A patent/CN105916993B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN105916993B (zh) | 2019-09-27 |
KR20150120288A (ko) | 2015-10-27 |
WO2015160154A1 (ko) | 2015-10-22 |
CN105916993A (zh) | 2016-08-31 |
JP2017513455A (ja) | 2017-06-01 |
KR101725976B1 (ko) | 2017-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6276862B2 (ja) | 高温で成熟胞子接種及び鉄イオン媒介ハーバー・ワイス反応によるヘマトコッカスプルビアリス内アスタキサンチン生産量増進方法 | |
Kang et al. | Comparison of heterotrophic and photoautotrophic induction on astaxanthin production by Haematococcus pluvialis | |
Panahi et al. | Impact of cultivation condition and media content onChlorella vulgaris composition | |
Zhang et al. | Enhancing astaxanthin accumulation in Haematococcus pluvialis by coupled light intensity and nitrogen starvation in column photobioreactors | |
Garbayo et al. | Identification and physiological aspects of a novel carotenoid‐enriched, metal‐resistant microalga isolated from an acidic river in huelva (spain) 1 | |
CN106906142A (zh) | 一种高含量虾青素血球藻的规模化生产方法 | |
Pan-utai et al. | Effect of inducing agents on growth and astaxanthin production in Haematococcus pluvialis: Organic and inorganic | |
Abu-Rezq et al. | Optimum culture conditions required for the locally isolated Dunaliella salina | |
JP2010530241A5 (ko) | ||
CN104450529A (zh) | 一种裂殖壶菌菌株及其诱变方法和应用 | |
CN105199957A (zh) | 一种杜氏盐藻的优化培育方法 | |
CN106566775B (zh) | 含高活力雨生红球藻细胞制备方法 | |
Dechatiwongse et al. | Mixotrophic growth of astaxanthin-rich alga haematococcus pluvialis using refined crude glycerol as carbon substrate: batch and fed-batch cultivations | |
CN106480155B (zh) | 一种适合在高温条件下促进雨生红球藻生产虾青素的方法 | |
MARTIN | Optimization Of Photobioreactor For Astaxanthin Production In Chlorella Zofingiensis. | |
RU2541455C1 (ru) | Способ культивирования одноклеточной зеленой водоросли haematococcus pluvialis для получения астаксантина | |
Lim et al. | Use of an extremophile red microalga (Galdieria sulphuraria) to produce phycocyanin from tangerine peel waste | |
EP4036217A1 (en) | Method for producing astaxanthin by heterotrophic culture of haematococcus pluvialis | |
Cai et al. | Effects of iron electrovalence and species on growth and astaxanthin production of Haematococcus pluvialis | |
Putri et al. | The growth comparison of Haematococcus pluvialis in two different medium | |
Badar et al. | Growth evaluation of microalgae isolated from palm oil mill effluent in synthetic media | |
Pongpadung et al. | Stimulation of Hydrogen Photoproduction in Chlorella sorokiniana Subjected to Simultaneous Nitrogen Limitation and Sulfur-and/or Phosphorus-Deprivation. | |
KR101670703B1 (ko) | 지질 함량이 증진된 미세조류의 배양방법 | |
Oliveira et al. | Hydrogen photoproduction using Chlorella sp. through sulfur-deprived and hybrid system strategy | |
CN102618592A (zh) | 一种利用类波氏真眼点藻生产epa的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170815 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20171115 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20171226 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180112 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6276862 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |