JP6254531B2 - 殺菌組成物及び該殺菌組成物の使用方法 - Google Patents
殺菌組成物及び該殺菌組成物の使用方法 Download PDFInfo
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- JP6254531B2 JP6254531B2 JP2014546073A JP2014546073A JP6254531B2 JP 6254531 B2 JP6254531 B2 JP 6254531B2 JP 2014546073 A JP2014546073 A JP 2014546073A JP 2014546073 A JP2014546073 A JP 2014546073A JP 6254531 B2 JP6254531 B2 JP 6254531B2
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Classifications
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
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Description
PHMB:(ポリ(ヘキサメチレンビグアニド))、コスモシル(商標登録)CQ、アーチ・ケミカル・ロット・11RC116995)
ALEX:(アレキシジン二塩酸塩)、トロント・リサーチ・ケミカルズ、ロット 4−WG−119−2
CHG:(クロルヘキシジングルコン酸塩)、スペクトラム・ケミカルズ、ロット ZQ1023
P−407:(ポロキサマー 407、プルロニック F127)、スペクトラム・ケミカルズ、ロット 1AD0265
TW80:(ツイン(登録商標)80、ポリソルベート80)、スペクトラム・ケミカルズ、ロット XF0356
HPMC:(ヒドロキシプロピルメチルセルロース、ヒプロメロース)、スペクトラム・ケミカルズ、ロット 1AC0441、2% 溶液粘度=50mPa.s
EDTA−2:(エチレンジアミン四酢酸二ナトリウム)、スペクトラム・ケミカルズ、ロット 1AE0430
EDTA−3:(エチレンジアミン四酢酸三ナトリウム塩)、スペクトラム・ケミカルズ、ロット YL0044
SC50:(センシバ(登録商標)SC50、グリセリン1−(2−エチルヘキシル)エーテル)、シュルケ・アンド・マイヤー社、ロット 1179743
SC10:(センシバ(登録商標)SC10.12−ジヒドロキシオクタン)、シュルケ・アンド・マイヤー社、ロット 1178933
GML:(モノラウリン酸グリセリン、ラウリシジン(登録商標))、メド−ケム・ラボラトリーズ、ロット 4010608422
SAN:(サンダルウッドオイル、東インドサンダルウッドツリー、サンタラム・アルバム)、ビロキス社
塩化ナトリウム:スペクトラム・ケミカル、ロット 1AA0110
水:(精製、USP)、リッカ・ケミカル社、ロット 1102304
を含む。
また、乾燥した溶液4の吸着試験が、(a)重い排液性の創傷のために使用されたレーヨン/ポリエステル混紡のCVS包帯スポンジと、(b)傷包帯及び創傷充填のために使用された綿100%のCVSガーゼスポンジと、(c)体液吸収のためのレーヨン/ポリエステル混紡のCVS包帯と、(d)目を被覆及び保護するためのレーヨン/ポリエステル混紡のCVS眼帯とを含む包帯材料で実施された。表5は、傷包帯材料a−dに取り込まれた溶液4の乾燥された成分の量の結果を示す。
溶液4の全ての成分の濃度を増加させるために、粘性溶液及びゲルは、溶液4の濃度の2、5及び10倍(2X、5X及び10X)の濃度に調製された。前記溶液は包帯上で乾燥されたときに、表6で使用された手段は、等張と比較して、有意に高い塩濃度となるので、塩化ナトリウムの添加は、溶液4に由来する2X、5X及び10Xの溶液では排除される。10X溶液は堅牢なゲルであったが、2X及び5X溶液は粘性溶液であり、2X溶液と比較して、5X溶液ははるかに粘性が増した。この種類の濃縮溶液が、包帯材料に塗布又は表面上に塗布することができ、表1の溶液と比較して高い殺菌活性を与えた。
Claims (18)
- 少なくとも0.05重量%の量の少なくとも1つの高分子ビグアニドと、
0.01〜1重量%の濃度のキレート剤と、
少なくとも1つのビシナールジオールとを含む患者の生物膜を減少、除去するための抗菌組成物であって、
前記ビシナールジオールは、1,2−ジヒドロキシオクタン(カプリリルグリコール)及びグリセリン1−(2−エチルヘキシル)エーテル(オクトキシグリセリン、2−エチルヘキシルグリセリン、3−(2−エチルヘキシルオキシ)プロパン−1,2−ジオールとしても知られる)を含み、
前記少なくとも1つの高分子ビグアニドと前記少なくとも1つのビシナールジオールの重量比は、1:0.05から1:500までの範囲であることを特徴とする、抗菌組成物。 - 前記少なくとも1つの高分子ビグアニドが抗菌組成物の総重量に基づき、0.05から1.5重量%までの範囲の量で含まれるか、前記少なくとも1つのビシナールジオールが抗菌組成物の総重量に基づき、0.05から6.0重量%の範囲の量で含まれるか、又は前記少なくとも1つの高分子ビグアニドが抗菌組成物の総重量に基づき、0.05から1.5重量%までの範囲の量で含まれるとともに、前記少なくとも1つのビシナールジオールが抗菌組成物の総重量に基づき、0.05から6.0重量%の範囲の量で含まれることを特徴とする請求項1に記載の抗菌組成物。
- 前記高分子ビグアニドが、ポリ(ヘキサメチレンビグアニド)及びその塩を含むことを特徴とする請求項1又は2に記載の抗菌組成物。
- 前記高分子ビグアニドは、10ppmから350ppmの濃度のビス(ビグアニド)を含むことを特徴とする請求項1〜3のいずれか1項に記載の抗菌組成物。
- 前記ビス(ビグアニド)は、アレキシジン及びクロルヘキシジンと、それらの塩とを含むことを特徴とする請求項4に記載の抗菌組成物。
- モノカプリル酸スクロース、モノラウリン酸スクロース、モノミリスチン酸スクロース及びモノパルミチン酸スクロースと、それらの組み合わせをさらに含むことを特徴とする請求項1〜5のいずれか1項に記載の抗菌組成物。
- 疎水性の長鎖又は分岐モノアルキルアルコールをさらに含むことを特徴とする請求項1〜6のいずれか1項に記載の抗菌組成物。
- 前記疎水性の長鎖又は分岐モノアルキルアルコールは、1−オクタノール、1−ノナノール、1−デカノール、1−ウンデカノール、1−ドデカノール、1−トリデカノール、1−テトラデカノール、1−ペンタデカノール、1−ヘキサデカノール、1−ヘプタデカノール、1−オクタデカノール、3,7,11,15−テトラメチル−2−ヘキサデセン−1−オール(フィトール)を含むことを特徴とする請求項7に記載の抗菌組成物。
- 前記キレート剤は、エチレンジアミン四酢酸(EDTA)、ニトリロ三酢酸、ニトリロトリプロピオン酸、ジエチレントリアミン五酢酸、2−ヒドロキシエチルエチレンジアミン三酢酸、1,6−ジアミノヘキサメチレン四酢酸、1,2−ジアミノシクロヘキサン四酢酸、O,O’−ビス(2−アミノエチル)エチレングリコール四酢酸、1,3−ジアミノプロパン四酢酸、N,N’−ビス(2−ヒドロキシベンジル)エチレンジアミン−N,N’−二酢酸、エチレンジアミン−N,N’−二酢酸、エチレンジアミン−N,N’−ジプロピオン酸、トリエチレンテトラミン六酢酸、エチレンジアミン−N,N’−ビス(メチレンホスホン酸)、イミノ二酢酸、N,N−ビス(2−ヒドロキシエチル)グリシン、1,3−ジアミノ−2−ヒドロキシプロパン四酢酸、1,2−ジアミノプロパン四酢酸、エチレンジアミンテトラキス(メチレンホスホン酸)、N−(2−ヒドロキシエチル)イミノ二酢酸、ビスホスホナート類、エジトロナート及びそれらの塩から選択される0.01重量%から1重量%の濃度のキレート剤を含むことを特徴とする請求項1〜8のいずれか1項に記載の抗菌組成物。
- 0.1重量%から4重量%までの濃度の界面活性剤をさらに含むことを特徴とする請求項1〜9のいずれか1項に記載の抗菌組成物。
- 前記界面活性剤は、ポロキサマー類、ポロキサミン類、プルロニック、エチレンオキシド及び/又はプロピレンオキシドのジアミノブロック共重合体、脂肪酸のポリエチレングリコールエステル類、高級アルカン類(C12−C18)のポリオキシエチレン又はポリオキシプロピレンエーテル類、ポリソルベート20、ポリソルベート80、ポリオキシエチレンラウリルエーテル、ポリオキシエチレンステアラート、ポリオキシエチレンプロピレングリコールステアラート、ノニルフェノールエトキシラート類、ノニルフェノールエトキシラート類、ツイン80、ミラノール、コカミドプロピルベタイン(cocoamidopropyl betaine)、デシルグルコシド、ラウリルグルコシド及びそれらの組み合わせからなる群から選択されることを特徴とする請求項10に記載の抗菌組成物。
- メチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、カルボキシメチルセルロース、ポリクオタニウム−1、ポリクオタニウム−6、ポリクオタニウム−10、グアー、ヒドロキシプロピルグアー、ヒドロキシプロピルメチルグアー、カチオン性グアー、カルボキシメチルグアー、ヒドロキシプロピルキトサン、カルボキシメチルキトサン、N−[(2−ヒドロキシ−3−トリメチルアンモニウム)プロピル]キトサンクロリド、水溶性キトサン、ヒアルロン酸及びその塩、コンドロイチン硫酸、ヘパリン、デルマタン硫酸、アミロース、アミロペクチン、ペクチン、ローカストビーンガム、アルギン酸、デキストラン、カラギーナン、キサンタンゴム、ジェランガム、スクレログルカン、シゾフィラン、アラビアゴム、ガティガム、カラヤゴム、トラガカントゴム、ペクチン、でんぷん、タマリンドガム、ポリ(ビニルアルコール)、ポリ(エチレンオキシド)、ポリ(エチレングリコール)、ポリ(メチルビニルエーテル)、ポリアクリルアミド、ポリ(N,N−ジメチルアクリルアミド)、ポリ(N−ビニルアセトアミド)、ポリ(N−ビニルホルムアミド)、ポリ(2−ヒドロキシエチルメタクリラート)、ポリ(グリセリルメタクリラート)、ポリ(N−ビニルピロリドン)、ポリ(N−イソプロピルアクリルアミド)、ポリ(N−ビニルカプロラクタム)、ポリ(ジメチルアミノエチルメタクリラート)、ポリ(ジメチルアミノプロピルアクリルアミド)、ポリビニルアミン及びそれらの組み合わせを含む0.01重量%から10重量%までの濃度の水溶性ポリマーをさらに含むことを特徴とする請求項1〜11のいずれか1項に記載の抗菌組成物。
- 0.05重量%から1.0重量%までのポリ(ヘキサメチレンビグアニド)と、0.05重量%から4.0重量%までのグリセリン1−(2−エチルヘキシル)エーテル及び1,2−ジヒドロキシオクタンとを含むことを特徴とする請求項1〜12のいずれか1項に記載の抗菌組成物。
- pH範囲が4.9から7.0までであることを特徴とする請求項1〜13のいずれか1項に記載の抗菌組成物。
- 前記抗菌溶液が、傷洗浄剤の1つであることを特徴とする請求項1〜14のいずれか1項に記載の抗菌組成物。
- 0.1重量%から4重量%までの界面活性剤と、0.01重量%から10重量%までの水溶性ポリマーとをさらに含むことを特徴とする請求項15に記載の抗菌組成物。
- 請求項1〜16のいずれか1項に記載の抗菌組成物を含むことを特徴とする患者の生物膜を減少、除去するための製品。
- 請求項1〜17のいずれか1項に記載の抗菌組成物を表面に塗布することを含む包帯を処理する方法。
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